| 2 | A multimodal integrative approach to model transcriptional addiction of thyroid cancer on RUNX2显示文摘Dear Editor Aberrant gene expression sustains massive proliferation and stress adaptation under the regulation of oncogenic transcription factors(TFs)whose binding across the genome orchestrates in space and time transcription.Transcriptional dependency defines the addiction of cancer cells to TFs on top of the regulatory hierarchy governing cancer dysregulated programs[1].These factors and their dependent mechanisms are an attractive and unexplored reservoir of potential targets for new anticancer drugs.Still,while the transcriptional landscape of many cancer-supportive TFs has been revealed,this information remains purely descriptive and confined to in vitro models.To foster transferability,new approaches that integrate clinical data into the transcriptional networks are needed. | Emanuele Vitale Elisabetta Sauta Mila Gugnoni Federica Torricelli Veronica Manicardi Alessia Ciarrocchi | 2022 | Cancer Communications2022，42，9： | 0 |
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