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| 1 | Chronic constipation in hemiplegic patients显示文摘AIM: To assess the prevalence of bowel dysfunction in hemiplegic patients, and its relationship with the site of neurological lesion, physical immobilization and pharmacotherapy. METHODS: Ninety consecutive hemiplegic patients and 81 consecutive orthopedic patients were investigated during physical motor rehabilitation in the same period, in the same center and on the same diet. All subjects were interviewed ≥ 3 mo after injury using a questionnaire inquiring about bowel habits before injury and at the time of the interview. Patients’ mobility was evaluated by the Adapted Patient Evaluation Conference System. Drugs considered for the analysis were nitrates, angiogenic converting enzyme (ACE) inhibitors, calcium antagonists, anticoagulants, antithrombotics, antidepressants, anti-epileptics. RESULTS: Mobility scores were similar in the two groups. De novo constipation (OR = 5.36) was a frequent outcome of the neurological accident. Hemiplegics showed an increased risk of straining at stool (OR: 4.33), reduced call to evacuate (OR: 4.13), sensation of incomplete evacuation (OR: 3.69), use of laxatives (OR: 3.75). Logistic regression model showed that constipation was significantly and independently associated with hemiplegia. A positive association was found between constipation and use of nitrates and antithrombotics in both groups. Constipation was not related to the site of brain injury. CONCLUSION: Chronic constipation is a possible outcome of cerebrovascular accidents occurring in 30% of neurologically stabilized hemiplegic patients. Its onset after a cerebrovascular accident appears to be independent from the injured brain hemisphere, and unrelated to physical inactivity. Pharmacological treatment with nitrates and antithrombotics may represent an independent risk factor for developing chronic constipation. | F Bracci D Badiali P Pezzotti G Scivoletto U Fuoco L Di Lucente A Petrelli E Corazziari | 2007 | World Journal of Gastroenterology2007，13，29： | 15 |
| 2 | Oxaliplatin-based Chemotherapy: A New Option in Advanced Hepatocellular Carcinoma. A Systematic Review and Pooled Analysis显示文摘 | F. Petrelli A. Coinu K. Borgonovo M. Cabiddu M. Ghilardi V. Lonati S. Barni | 2014 | Clinical Oncology2014，，： | 2 |
| 3 | Colorectal villous and tubulovillous adenomas equal to or greater than four centimeters 显示文摘 | Stulc JP Petrelli NJ Herrera L | 1988 | Ann Surg1988，207，： | 2 |
| 4 | Clinical cancer advances 2009: major research advances in cancer treatment, pre vention, and scrccning-A report from the American society of clinical oncology显示文摘 | PETRELLI N J WINER EP BRAHMER J | 2009 | J Clin Oncol2009，27，35： | 1 |
| 5 | Phase Ⅲ randomized trial of preoperative versus postoperative multimodality therapy in patients with carcinoma of the rectum (NSABP R-03)显示文摘 | Roh M S Petrelli N Wieand S | 2001 | Proceedings of ASCO2001，20，20： | 1 |
| 6 | A clinical trial to evaluate the worth of preoperative multimodality thera py in patients with operable carcinoma of the rectum: a progress report of National Surgical Adjuvant Breast and Bowel Project Protocol R-03显示文摘 | Hyams DM Mamounas EP Petrelli N | 1997 | Dis Colon Rectum1997，40，2： | 1 |
| 7 | Nerve growth factor:from neurotrophin to neurokine显示文摘 | Levi-Montalcini R Skaper SD Dal Toso R Petrelli L Leon A | 1996 | Trends Neurosci1996，19，11： | 1 |
| 8 | Nasogastric decompression following elective colorectal surgery: a prospec- tive randomized study 显示文摘 | Petrelli N J Stulc JP Rodriguez - Bigas M | 1993 | Am Surg1993，59，10： | 1 |
| 9 | Extending the frontiers of surgical therapy for hepatic colorectal metastases: is there a limit? 显示文摘 | Khatri VP Petrelli N J Belghiti J | 2005 | J Clin Oncol2005，23，： | 1 |
| 10 | Modern multimodality approach to hepatic colorectal metastases: Solutions and controversies显示文摘 | Vijay P. Khatri Karen G. Chee Nicholas J. Petrelli | 2007 | Surgical Oncology2007，，1： | 1 |
| 11 | 5-Fluorouracil or capecitabine in the treatment of advanced colorectal cancer:apooled-analysis of randomized trials显示文摘 | Petrelli F Cabiddu M Barni S | 2012 | Med Oncol2012，29，2： | 1 |
| 12 | Clinical cancer advances 2009:Major research advances in cancer treatment,prevention,and screening-A report from the American Society of Clinical Oncology显示文摘 | Nicholas J Petrelli Eric P Winer Julie Brahmer | 2009 | JCO2009，26，： | 1 |
| 13 | Biological agents alone or in combination as second-line therapy in advanced non-small-cell lung canc-er:systematic review of randomized studies显示文摘 | Petrelli F Borgonovo K Cabiddu M | 2012 | Expert Rev Anticancer T-her2012，12，10： | 1 |
| 14 | A clinical trial to evaluate the worth of preoperative multimodality therapy in patients with operable carcinoma of the rectum:a progress report of National Surgical Breast and Bowel Project Protocol R-03显示文摘 | Hyams DM Mamounas EP Petrelli N | 1997 | Dis Colon Rectum1997，40，： | 1 |
| 15 | Reduction in fertility in male greenhouse workers exposed to pesticides 显示文摘 | Petrelli G Figa-Talamanca 1 | 2001 | Eur J Epidemb oh 20012001，，： | 1 |
| 16 | Postprandial blood glucose is a stronger predictor of cardiovascular events than fasting blood glucose in type 2 diabetes mellitus,particularly in women:lessons from the San Luigi Gonzaga Diabetes Study显示文摘 | Cavalot F Petrelli A Traversa M | 2006 | J Clin Endocrinol Metab2006，91，3： | 1 |
| 17 | Hepatic resection:thelast surgical frontier for colorectal cancer 显示文摘 | Petrelli NJ Abbruzzese J Mansfield P | 2005 | Clin Oncol2005，23，： | 1 |
| 18 | NMN/NaMN adenylyltransferase (NMNAT) and NAD kinase (NADK) inhibitors: chemistry and potential therapeutic applications 显示文摘 | Petrelli R K Felczak L Cappellacci | 2011 | Curr Med Chem2011，18，13： | 1 |
| 19 | Prognostic value of different cut-off levels of Ki-67 in breast cancer: a systematic review and meta- analysis of 64,196 patients显示文摘 | Petrelli F Viale G Cabiddu M etal | 2015 | Breast Cancer Res Treat2015，153，3： | 1 |
| 20 | Radiotherapy with concurrent cisplatin-based doublet or weekly cisplatin for cervical cancer: a systematic review and recta-analysis 显示文摘 | Petrelli F De Stefani A Raspagliesi F | 2014 | Gynecol Oncol2014，134，1： | 1 |
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