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| 1 | Brain-derived neurotrophic factor plasma levels and premature cognitive impairment/dementia in type 2 diabetes显示文摘AIM To assess the relationship of brain-derived neurotrophic factor(BDNF) with cognitive impairment in patients with type 2 diabetes. METHODS The study included 40 patients with diabetes mellitus type 2(DM2), 37 patients with chronic kidney disease in hem dialysis hemodialysis therapy(HD) and 40 healthy subjects. BDNF in serum was quantified by ELISA. The Folstein Mini-Mental State Examination was used to evaluate cognitive impairment.RESULTS The patients with DM2 and the patients in HD were categorized into two groups, with cognitive impairment and without cognitive impairment. The levels of BDNF showed significant differences between patients with DM2(43.78 ± 9.05 vs 31.55 ± 10.24, P = 0.005). There were no differences between patients in HD(11.39 ± 8.87 vs 11.11 ± 10.64 P = 0.77); interestingly, ferritin levels were higher in patients with cognitive impairment(1564 ± 1335 vs 664 ± 484 P = 0.001). The comparison of BDNF values, using a Kruskal Wallis test, between patients with DM2, in HD and healthy controls showed statistical differences(P < 0.001).CONCLUSION Low levels of BDNF are associated with cognitive impairment in patients with DM2. The decrease of BDNF occurs early and progressively in patients in HD. | Blanca Murillo Ortíz Joel Ramírez Emiliano Edna Ramos-Rodríguez Sandra Martínez-Garza Hilda Macías-Cervantes Sergio Solorio-Meza Texar Alfonso Pereyra-Nobara | 2016 | World Journal of Diabetes2016，7，20： | 7 |
| 2 | Constant serum levels of secreted asialoglycoprotein receptor sH2a and decrease with cirrhosis显示文摘AIM: To investigate the existence and levels of sH2a, a soluble secreted form of the asialoglycoprotein receptor in human serum. METHODS: Production of recombinant sH2a and development of a monoclonal antibody and an enzyme-linked immunosorbent assay (ELISA). This assay was used to determine the presence and concentration of sH2a in human sera of individuals of both sexes and a wide range of ages. RESULTS: The recombinant protein was produced successfully and a specific ELISA assay was developed. The levels of sH2a in sera from 62 healthy individuals variedminimally (147 ± 19 ng/mL). In contrast, 5 hepatitis C patients with cirrhosis showed much decreased sH2a levels (50 ± 9 ng/mL). CONCLUSION: Constant sH2a levels suggest constitutive secretion from hepatocytes in healthy individuals. This constant level and the decrease with cirrhosis suggest a diagnostic potential. | Ron Benyair Maria Kondratyev Elena Veselkin Sandra Tol-chinsky Marina Shenkman Yoav Lurie Gerardo Z Lederkremer | 2011 | World Journal of Gastroenterology2011，17，48： | 3 |
| 3 | Photocatalytic degradation of lignin and lignin models, using titanium dioxide: the role of the hydroxyl radical显示文摘 | Antonio Eduardo H Machadoa Aline M Furuyamaa Sandra Z Falone | 2000 | Chemosphere2000，，40： | 1 |
| 4 | Two-dimensionalprotein map of an “ale”-brewing yeast strain: proteomedynamics during fermentation显示文摘 | Dominique K Sandra Z Serge P | 2004 | FEMS Yeast Research2004，5，3： | 1 |
| 5 | Upregulation of dorsal root ganglion a2d calcium channel subunit and its ca-relation with allodynia in spinal nerve-injured rats显示文摘 | DAVID Z SANDRA R CHAPLAN E S | 2001 | The Journal of Neuroscience2001，21，6： | 1 |
| 6 | Deletion of the inhibitor of growth 4(ING4)tumor suppressor gene is prevalent in human epidermal growth factor 2(HER2)-positive breast cancer显示文摘 | Coya T Inti Z Sandra S | | 0，，： | 1 |
| 7 | First record of Calodium hepaticum and Taenia taeniaeformis liver infection in wild Norway rats (Rattus norvegicus) in Serbia 显示文摘 | Milena K Lidija Z Sandra B | 2010 | Arch Biol Sci2010，62，2： | 1 |
| 8 | Dramatic effects of truncation and sub-cellular targeting on the accumulation of recombinant microbial cellulase in tobacco显示文摘 | THOMAS Z JOHN A R SANDRA A P | 2001 | Molecular Breeding2001，8，2： | 1 |
| 9 | The use of new ionic liquids in two-phase catalytic hydrogenation reaction by rhodium complexes显示文摘 | Jeanc E L Dullius Sandra Einloft | 1996 | Polyhedron1996，15，7： | 1 |
| 10 | Extraction without organic solvents in the determination of fumonisins B-1,B-2,and B-3 in maize by HPLC-FLD and ELISA tests显示文摘 | SANDRA J MILICA Z B ZELJKO M | 2015 | Food Analytical Methods2015，8，6： | 1 |
| 11 | Effect of Atorvastatin on endothelium-dependent vasodilation in postmenopausal women with average serum cholesterol levels显示文摘 | Giuseppe M Sandra Z Francesca S | 2002 | Am J Cardiol2002，90，： | 1 |
| 12 | Genomewide Location Analysis of Candida albicans Upc2p,a Regulator of Sterol Metabolism and Azole Drug Resistance显示文摘 | Sadri Z Sandra W Perrine B | | 0，，05： | 1 |
| 13 | Photocatalytic degradation of lignin and lignin models, using titanium dioxide: the role of the hydroxyl radical显示文摘 | Antonio Eduardo H Machadoa Aline M Furuyamaa Sandra Z Falone | 2000 | Chemosphere2000，，40： | 1 |
| 14 | Role of nitric oxide in the modulation of angiogenesis显示文摘 | Lucia M Sandra D Marina Z | 2003 | Curr Pharm Des2003，9，7： | 1 |
| 15 | Identification of midkine as a mediator for intercellular transfer of drug resistance 显示文摘 | Bernard L Sandra C Xin Z | 2005 | Oncogene2005，24，49： | 1 |
| 16 | Potato starch edible films to control oxidative rancidity of polyunsaturated lipids: effects of film composition, thickness and water activity显示文摘 | Javier O Sandra N Khalid Z | 2009 | International Journal of Food Science and Tech- nology2009，44，7： | 1 |
| 17 | Photocatalytic degradation fo lognin and lignin models, using titanium dioxide: the role of the hydocyl radical 显示文摘 | Antonio E H Machado Aline M Furuyama Sandra Z Falone | 2000 | Chemosphere2000，，40： | 1 |
| 18 | 显示文摘 | Jeane E L D Sandra E | 1996 | Polyhedron1996，7，： | 1 |
| 19 | Cardiovascular effects of carbon monoxide and cigarette smoking 显示文摘 | Shoshana Z Sandra S Steven G G | 2001 | Journal of the American College of Cardiology2001，38，6： | 1 |
| 20 | A fungal multicopper oxidase restores iron homeostasis in aceruloplasminemia 显示文摘 | Leah H Z Sandra R Davis K | 2004 | Blood2004，103，23： | 1 |
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