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| 1 | Estimating the spatial distribution of organic carbon density for the soils of Ohio, USA显示文摘包含 1424 引用 geo 的土壤侧面的国家土壤调查中心的历史的数据库在这研究被使用为美国俄亥俄的土壤估计器官的碳(SOC ) 。学习的特定的目的是估计 SOC 密度的空间分发(C 存货每统一区域) 到为用地理上加权的回归(GWR ) 的俄亥俄的土壤的 1.0-m 深度,并且把结果与那从多重线性回归(MLR ) 获得了作比较。大约 80% 分析数据被用于刻度并且 20% 为确认。包括使用数据被用于印射 SOC 密度的地面属性,气候数据,基岩地质学,和土地的 20 个变量的一个总数。结果证明 GWR 向更好的评价提供了最低(3.81 kg m2 ) 根均方差(RMSE ) 比 MLR 途径。为在俄亥俄的土壤的全部的估计的 SOC 水池从 727 ~ 742 Tg 。这研究表明那,本地空间统计技术, GWR 能在作为与象 MLR 那样的另外的全球空间统计技术相比越过学习区域捕获 SOC 的空间分发更好表现。因此, GWR 为印射 SOC 密度提高精确性。 | Sandeep KUMAR Rattan LAL Desheng LIU Rashid RAFIQ | 2013 | Journal of Geographical Sciences2013，23，2： | 15 |
| 2 | Euglycemic diabetic ketoacidosis:A missed diagnosis显示文摘Euglycemic diabetic ketoacidosis(DKA)is an acute life-threatening metabolic emergency characterized by ketoacidosis and relatively lower blood glucose(less than 11 mmol/L).The absence of hyperglycemia is a conundrum for physicians in the emergency department and intensive care units;it may delay diagnosis and treatment causing worse outcomes.Euglycemic DKA is an uncommon diagnosis but can occur in patients with type 1 or type 2 diabetes mellitus.With the addition of sodium/glucose cotransporter-2 inhibitors in diabetes mellitus management,euglycemic DKA incidence has increased.The other causes of euglycemic DKA include pregnancy,fasting,bariatric surgery,gastroparesis,insulin pump failure,cocaine intoxication,chronic liver disease and glycogen storage disease.The pathophysiology of euglycemic DKA involves a relative or absolute carbohydrate deficit,milder degree of insulin deficiency or resistance and increased glucagon/insulin ratio.Euglycemic DKA is a diagnosis of exclusion and should be considered in the differential diagnosis of a sick patient with a history of diabetes mellitus despite lower blood glucose or absent urine ketones.The diagnostic workup includes arterial blood gas for metabolic acidosis,serum ketones and exclusion of other causes of high anion gap metabolic acidosis.Euglycemic DKA treatment is on the same principles as for DKA with correction of dehydration,electrolytes deficit and insulin replacement.The dextrosecontaining fluids should accompany intravenous insulin to correct metabolic acidosis,ketonemia and to avoid hypoglycemia. | Prashant Nasa Sandeep Chaudhary Pavan Kumar Shrivastava Aanchal Singh | 2021 | World Journal of Diabetes2021，12，5： | 11 |
| 3 | Over expression of resistin in adipose tissue of the obese induces insulin resistance显示文摘AIM: To compare resistin mRNA expression in subcutaneous adipose tissue (SAT) and its correlation with insulin resistance (IR) in postmenopausal obese women. METHODS: A total of 68 postmenopausal women (non obese = 34 and obese = 34) were enrolled for the study. The women of the two groups were age matched (49-70 years). Fasting blood samples were collected at admission and abdominal SAT was obtained during surgery for gall bladder stones or hysterectomy. Physical parameters [age, height, weight, body mass index (BMI)] were measured. Biochemical (plasma insulin and plasma glucose) parameters were estimated by enzymatic methods. RNA was isolated by the Trizol method.SAT resistin mRNA expression was done by real time- reverse transcription polymerase chain reaction (RT-PCR) by using Quanti Tect SYBR Green RT-PCR master mix. Data was analyzed using independent Student's t test, correlation and simple linear regression analysis. RESULTS: The mean weight (52.81 ± 8.04 kg vs 79.56 ± 9.91 kg; P < 0.001), BMI (20.23 ± 3.05 kg/m 2 vs 32.19 ± 4.86 kg/m 2 ; P < 0.001), insulin (8.47 ± 3.24 U/mL vs 14.67 ± 2.18 U/mL; P < 0.001), glucose (97.44 ± 11.31 mg/dL vs 109.67 ± 8.02 mg/dL; P < 0.001) and homeostasis model assessment index (2.01 ± 0.73 vs 3.96 ± 0.61; P < 0.001) were significantly higher in postmenopausal obese women compared to postmenopausal non obese women. The mean serum resistin level was also significantly higher in postmeno-pausal obese women compared to postmenopausal non obese women (9.05 ± 5.15 vs 13.92 ± 6.32, P < 0.001). Furthermore, the mean SAT resistin mRNA expression was also significantly (0.023 ± 0.008 vs 0.036 ± 0.009; P < 0.001) higher and over expressed 1.62 fold (upregulated) in postmenopausal obese women compared to postmenopausal non obese women. In postmeno-pausal obese women, the relative SAT resistin mRNA expression showed positive (direct) and significant correlation with BMI (r = 0.78, P < 0.001) and serum resistin (r = 0.76, P < 0.001). Furthermore, the SAT resistin mRNA expression in postmenopausal obese women also showed significant and direct association (r = 0.45, P < 0.01) with IR, while in postmenopausal non obese women it did not show any association (r = -0.04, P > 0.05). CONCLUSION: Increased SAT resistin mRNA expres-sion probably leads to inducing insulin resistance and thus may be associated with obesity-related disorders in postmenopausal obese women. | Sadashiv Sunita Tiwari S Dhananjai Bhola N Paul Sandeep Kumar Abhijit Chandra Mahendra PS Negi | 2012 | World Journal of Diabetes2012，3，7： | 10 |
| 4 | Evaluation of phenolic composition, antioxidant, anti-inflammatory and anticancer activities of Polygonatum verticillatum(L.)显示文摘Objective: Polygonatum verticillatum(L.) All.(Ruscaceae), one of the Ashtawarga plants, is widely used for treatment of various ailments. The present study was undertaken to determine the phenolic composition,antioxidant, anti-inflammatory and anticancer activities of several extracts(petroleum ether, dichloromethane, chloroform, ethanol, and aqueous) from the rhizomes of the plant.Methods: Coarsely powdered dry rhizome was successively extracted with different solvents of increasing polarity(petroleum ether, dichloromethane, chloroform, ethanol and water). The phenolic compositions, in terms of total phenolic content(TPC), total flavonoid content(TFC) and total condensed tannin content(TTC), were evaluated with the Folin–Ciocalteu assay, aluminum chloride colorimetric assay and vanillin spectrophotometric assay, respectively. Total antioxidant capacity, 1,1-diphenyl-2-picrylhydrazyl and 2,20-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) assays were used to assess the antioxidant potential of each extract. A protein denaturation model and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay were used to evaluate in vitro anti-inflammatory and anticancer activities, respectively. Gas chromatography–mass spectrometry(GC/MS) analysis was carried out to demonstrate various phytoconstituents in each extract. Correlation studies were also performed between phenolic composition(TPC, TFC and TTC) and different biological activities.Results: Ethanol extract showed maximum TPC(0.126 mg/g, gallic acid equivalent in dry sample), TFC(0.094 mg/g, rutin equivalent in dry sample) and TTC(29.32 mg/g, catechin equivalent in dry sample),as well as antioxidant and anti-inflammatory properties. Chloroform extract exhibited the strongest cytotoxicity against the human breast cancer cell line, MCF-7. GC/MS analysis revealed the presence of 90 different phytoconstituents among the extracts. Antioxidant and anti-inflammatory activities had a positive correlation with TPC, TFC and TTC. However, the anticancer activity showed a negative correlation with TPC, TFC and TTC.Conclusion: From the present study, it can be concluded that P. verticillatum possessed remarkable antioxidant, anti-inflammatory, and anticancer activities, which could be due to different secondary metabolites of the plant. Phenolic compounds are likely responsible for antioxidant and antiinflammatory activities. However, flavonoids and other compounds might contribute to the anticancer potential of the plant. | SANDeep Kumar Singh Arjun Patra | 2018 | Journal of Integrative Medicine2018，16，4： | 7 |
| 5 | Hepatic stem cells: A viable approach for the treatment of liver cirrhosis显示文摘Liver cirrhosis is characterized by distortion of liver architecture, necrosis of hepatocytes and regenerative nodules formation leading to cirrhosis. Various types of cell sources have been used for the management and treatment of decompensated liver cirrhosis.Knowledge of stem cells has offered a new dimension for regenerative therapy and has been considered as one of the potential adjuvant treatment modality in patients with end stage liver diseases(ESLD). Human fetal hepatic progenitor cells are less immunogenic than adult ones. They are highly propagative and challenging to cryopreservation. In our earlier studies we have demonstrated that fetuses at 10-18 wk of gestation age contain a large number of actively dividing hepatic stem and progenitor cells which possess bipotent nature having potential to differentiate into bile duct cells and mature hepatocytes. Hepatic stem cell therapy for the treatment of ESLD is in their early stage of the translation. The emerging technology of decellularization and recellularization might offer a significant platform for developing bioengineered personalized livers to come over the scarcity of desired number of donor organs for the treatment of ESLD. Despite these significant advancements long-term tracking of stem cells in human is the most important subject nowadays in order to answer several unsettles issues regarding the route of delivery, the choice of stem cell type(s), the cell number and the timepoint of cell delivery for the treatment in a chronic setting. Answering to these questions will further contribute to the development of safer, noninvasive, and repeatable imaging modalities that could discover better cell therapeutic approaches from bench to bedside. Combinatorial approach of decellularization and nanotechnology could pave a way towards the better understanding in determination of cell fate posttransplantation. | Md Aejaz Habeeb Sandeep Kumar Vishwakarma Avinash Bardia Aleem Ahmed Khan | 2015 | World Journal of Stem Cells2015，7，5： | 5 |
| 6 | Epidemiology of pelvic fractures in adults: Our experience at a tertiary hospital显示文摘Purpose: Pelvic fractures are severe injuries and are often associated with multiple system injuries, exacerbating the overall outcome. In India, the incidence of pelvic fractures is on a rise due to suboptimal roads and traffics but related literature regarding the overall epidemiology of these injuries is scarce and scanty. Our aim was to study the epidemiology of patients admitted with pelvic fractures at a level 1 trauma centre in India. Methods: A 16-month (between September 2015 and December 2016) prospective observational study was carried out on trauma patients with pelvic fractures at a level 1 trauma centre of a tertiary care hospital. Demography of patients, mechanism of injuries and complications were recorded prospectively. Results: We observed 75 patients who presented with pelvic fractures, where 56 were males and 19 were females. Mean age of the study populationwas 37.57 years. Road traffic accidents were the most common mode of injuries. Lateral compression injuries were the most common pattern. Associated injuries frequently encountered were lower extremities and acetabulum fractures, blunt abdominal trauma, urogenital injuries and head injuries. Out of the 75 patients, 52 were treated surgically and 23 were managed by conservative methods. Associated injuries of the extremities, head, abdomen and urogenital system indicated a longer hospital stay. Conclusion: Pelvic fractures, although belong to a relatively rare trauma subset, cause a high morbidity and mortality with considerable burden on the economy. Proper road safety training and driving etiquettes along with its strict implementation in true sense and spirit are the need of the hour. | Subhajit Ghosh Sameer Aggarwal Vishal Kumar Sandeep Patel Prasoon Kumar | 2019 | Chinese Journal of Traumatology2019，22，3： | 5 |
| 7 | myocardial 以后梗塞巨人让室的 pseudoaneurysm 与严重的心失败介绍显示文摘 Left ventricle(LV) pseudoaneurysm is a late mechanical complication of myocardial infarction.A giant LV pseudoaneurysm is a rare presentation.We report a case of giant LV pseudoaneurysm in a post-MI patient who presented with gross congestive heart failure.The patient had a successful surgical repair of the aneurysm and had a favorable 3-mo outcome.The imaging modality and surgical treatment of the pseudoaneurysm are discussed. | Rajesh Vijayvergiya Alok Kumar Sandeep S Rana Harkant Singh Goverdhan D Puri Manphool Singhal | 2012 | World Journal of Cardiology2012，4，11： | 3 |
| 8 | Climatic periodicities recorded in lake sediment magnetic susceptibility data:Further evidence for solar forcing on Indian summer monsoon显示文摘The Indian summer monsoon exhibits considerable spatio-temporal variability.It is therefore important to understand its dynamics and the inherent periodicities.In this study,we have performed spectral and wavelet analyses of magnetic susceptibility data for sediments from Thimmannanayakanakere(TK)-a small lake in southern India.The main objective of this investigation is to identify and explain the possible origin of the prominent periodicities present in the magnetic susceptibility data.Significant periodicities in the TK χ_(lf)data are centered at 906,232,147,128,96,61,54 and 44 years,which might have a solar origin.The wavelet power spectrum of the raw and detrended χ_(lf)data confirms the findings of spectral analysis and also provides temporal variations of the significant cyclicities during the past3700 cal.years B.P.Positive correlation is documented between sunspot activity and TK xif data;crossspectral analysis of the reconstructed sunspot data and TK xif data suggest that there is a strong coherence between the two datasets as significant periodicities are documented in both.There is a good match between the TK xif and the reconstructed total solar irradiance data for the past 1200 years.However,an out-of-phase relationship is documented at certain time-intervals,which may be attributed to uncertainties in the age-depth model.The results obtained from this study show that solar variations are the main controlling factor of the southwest monsoon and,like other archives from different regions in India,the TK lake sediments have also recorded these solar signatures. | Anish Kumar Warrier Kizhur Sandeep Rajasekharaiah Shankar | 2017 | Geoscience Frontiers2017，8，6： | 3 |
| 9 | Chemical composition and source apportionment of PM2.5 and PM2.5-10 in Trombay (Mumbai, India), a coastal industrial area显示文摘 | Sandeep Police Sanjay Kumar Sahu Mahesh Tiwari Gauri Girish Pandit | 2018 | Particuology2018，16，2： | 3 |
| 10 | 柚皮苷改善束缚性应激引起的小鼠生化指标及行为变化的一氧化氮调节机制(英文)显示文摘目的:研究柚皮苷对束缚性应激引起的小鼠生化指标改变、行为变化及线粒体功能紊乱的影响。方法:将小鼠按照体质量随机分组,分别给予不同药物治疗14 d。在第15天让所有小鼠接受束缚性应激刺激6 h,然后在接受各种不同的行为测试后处死。取小鼠的大脑匀浆进行各种生化指标测量和线粒体功能分析。结果:6 h的急性束缚性应激刺激能显著改变小鼠的行为(焦虑和记忆),引起生化指标变化和线粒体功能紊乱。用柚皮苷预处理(50或100 mg/kg口服)14 d则能显著减轻急性束缚性应激刺激引起的小鼠行为和生化指标变化以及线粒体功能紊乱(P<0.05);而使用一氧化氮的前体左旋精氨酸预处理(50 mg/kg腹腔注射)可以拮抗柚皮苷的保护效应(P<0.05)。此外,采用左旋精氨酸甲酯预处理(5 mg/kg腹腔注射)则导致柚皮苷的保护效应增强。结论:柚皮苷对束缚性应激刺激引起的小鼠行为和生化指标变化以及线粒体功能紊乱的保护作用与氮能神经通路有关。 | Gollapalle L.Viswanatha Hanumanthappa Shylaja K.Sadashiva Sandeep Rao Yathiraj Ashwini V.Ramaiah Santhosh Kumar C.Gangadharaiah Mohan Venkate Gowda Sunil M.Venkateshappa Sarvesh Kumar Subbanna Rajesh | 2011 | 中西医结合学报2011，9，11： | 3 |
| 11 | Efficient Gene Targeting in Maize Using Inducible CRISPR-Cas9 and Marker-free Donor Template显示文摘CRISPR-Cas9 is a powerful tool for generating targeted mutations and genomic deletions.However,precise gene insertion or sequence replacement remains a major hurdle before application of CRISPR-Cas9 technology is fully realized in plant breeding.Here,we report high-frequency,selectable marker-free intra-genomic gene targeting(GT)in maize.Heat shock-inducible Cas9 was used for generating targeted double-strand breaks and simultaneous mobilization of the donor template from pre-integratad T-DNA.The construct was designed such that release of the donor template and subsequent DNA repair activated expression of the selectable marker gene within the donor locus.This approach generated up to 4.7%targeted insertion of the donor sequence into the target locus in TO plants,with up to 86%detected donor template release and 99%mutation rate being observed at the donor loci and the genomic target site,respectively.Unlike previous in planta or intra-genomic homologous recombination reports in which the original chimeric GT plants required extensive progeny screening in the next generation to identify non-chimeric GT individuals,our method provides non-chimeric heritable GT in one generation. | Pierluigi Barone Emily Wu Brian Lenderts Ajith Anand William Gordon-Kamm Sergei Svitashev Sandeep Kumar | 2020 | Molecular Plant2020，13，8： | 3 |
| 12 | Pharmacokinetic, pharmacodynamic, and neurochemical investigations of lamotrigine-pentylenetetrazole kindled mice to ascertain it as a reliable model for clinical drug-resistant epilepsy显示文摘Background:Pentylenetetrazole kindling has long been used for the screening of investigational antiseizure drugs.The presence of lamotrigine,at a very low dose,does not hamper kindling in mice;rather it modifies this epileptogenesis process into drug-resistant epilepsy.The lamotrigine-pentylenetetrazole kindled mice show resistance to lamotrigine,phenytoin,and carbamazepine.It may also be possible that other licensed antiseizure drugs,like the mentioned drugs,remain ineffective in this model;therefore,this was the subject of this study.Methods:Swiss albino mice were kindled with pentylenetetrazole for 35 days in the presence of either methylcellulose vehicle or lamotrigine(subtherapeutic dose,ie,5 mg/kg).Vehicle vs lamotrigine-kindled mice were compared in terms of(a)resistance/response toward nine antiseizure drugs applied as monotherapies and two drug combinations;(b)lamotrigine bioavailability in blood and brain;(c)blood-brain barrier integrity;and(d)amino acids and monoamines in the cerebral cortex and hippocampus.Results:Lamotrigine vs vehicle-kindled mice are similar(or not significantly different P>.05 from each other)in terms of(a)response toward drug combinations;(b)lamotrigine bioavailability;and(c)blood-brain barrier integrity except for,significantly(P<.05)reduced taurine and increased glutamate in the cerebral cortex and hippocampus.Aside from these,lamotrigine-kindled mice show significant(P<.05)resistant to lamotrigine(15 mg/kg),levetiracetam(40 mg/kg);carbamazepine(40 mg/kg),zonisamide(100 mg/kg),gabapentin(224 mg/kg),pregabalin(30 mg/kg),phenytoin(35 mg/kg),and topiramate(300 mg/kg).Conclusion:Lamotrigine-pentylenetetrazole kindling takes longer to develop(~5 weeks)in comparison to lamotrigine-amygdale(~4 weeks)and lamotriginecorneal(~2 weeks)kindling models.However,drug screening through this model may yield superior drugs with novel antiseizure mechanisms. | Sandeep Kumar Rajesh K.Goel | 2020 | Animal Models and Experimental Medicine2020，3，3： | 2 |
| 13 | Digitally controlled oscillator design with a variable capacitance XOR gate显示文摘A digitally controlled oscillator(DCO) using a three-transistor XOR gate as the variable load has been presented.A delay cell using an inverter and a three-transistor XOR gate as the variable capacitance is also proposed. Three-,five- and seven-stage DCO circuits have been designed using the proposed delay cell.The output frequency is controlled digitally with bits applied to the delay cells.The three-bit DCO shows output frequency and power consumption variation in the range of 3.2486-4.0267 GHz and 0.6121-0.3901 mW,respectively,with a change in the control word 111-000.The five-bit DCO achieves frequency and power of 1.8553-2.3506 GHz and 1.0202-0.6501 mW,respectively,with a change in the control word 11111-00000.Moreover,the seven-bit DCO shows a frequency and power consumption variation of 1.3239-1.6817 GHz and 1.4282-0.9102 mW,respectively, with a varying control word 1111111-0000000.The power consumption and output frequency of the proposed circuits have been compared with earlier reported circuits and the present approaches show significant improvements. | Manoj Kumar Sandeep K.Arya Sujata Pandey | 2011 | Journal of Semiconductors2011，32，10： | 2 |
| 14 | Chlorination roasting-coupled water leaching process for potash recovery from waste mica scrap using dry marble sludge powder and sodium chloride显示文摘The present paper reports the effective utilization of marble sludge powder(MSP)for the recovery of potash values from waste mica scrap using chlorination roasting-water leaching method.Characterization studies indicated the presence of dolomite as the major mineral phase in MSP,whereas muscovite and quartz were observed in the mica sample.The acid leaching studies suggest a maximum of 22%potash recovery under conditions:4 M H2SO4 acid,particle size of^100μm,stirring speed of 600 r/min,leaching temperature of 75℃,and leaching time of 90 min.The chlorination roasting-water leaching process was adopted to achieve the lowest level of 80%-90%potash recovery.The optimum conditions for the recovery of^93%potash from mica(~8.6wt%K2O)requires 900℃ roasting temperature,30 min roasting time,and 1:1:0.75 mass ratio of mica:MSP:NaCl.The roasting temperature and amount of NaCl are found to be the most important factors for the recovery process.The reaction mechanism suggests the formation of different mineral phases,including sylvite(KCl),wollastonite,kyanite,and enstatite,during roasting,which were confirmed by X-ray diffraction(XRD)analyses and scanning electron microscopy(SEM)morphologies.The MSP-blended NaCl additive is more effective for potash recovery compared with the other reported commercial roasting additives. | Sandeep Kumar Jena Jogeshwar Sahu Geetikamayee Padhy Swagatika Mohanty Ajit Dash | 2020 | International Journal of Minerals,Metallurgy and Materials2020，27，9： | 2 |
| 15 | Association of vitamin D and knee osteoarthritis in younger individuals显示文摘BACKGROUND The incidence of primary osteoarthritis knee is gradually increasing among young individuals.The increasing prevalence of obesity,sedentary lifestyle,sporting activity,and vitamin D deficiency(VDD)has been hypothesized for this shifting disease trend.This study was designed to look for the association of serum vitamin D among these young arthritic patients.AIM To look for the association of serum vitamin D in younger knee osteoarthritis(KOA)patients.METHODS In a 2-year observational study,146 non-obese KOA patients of 35-60 years were evaluated clinically(Knee injury and Osteoarthritis Outcome Score,KOOS)and radiologically(Kellegren-Lawrence stage,KL).The serum 25(OH)D level of these patients and 146 normal healthy individuals of same age group were estimated.RESULTS Both the groups were comparable in terms of age and sex.The average serum 25(OH)D level in healthy individuals and KOA patients was 45.83 ng/mL and 34.58 ng/mL,respectively(P<0.001).Inadequate serum 25(OH)D level(<30 ng/mL)was found in 46.57%of KOA patients and 24%of normal healthy participants indicating a significant positive association(odds ratio 2.77,95%CI:1.67-4.54,P<0.001).The 25(OH)D level in KL grade I,II,III and IV was 43.40,30.59,31.56 and 33.93 ng/mL respectively(no difference,P=0.47).Similarly,the KOOS score in sufficient,insufficient and deficient groups were 65.31,60.36 and 65.31,respectively(no difference,P=0.051).CONCLUSION The serum 25(OH)D level is significantly low in younger KOA patients.However,the clinical and radiological severities have no association with serum vitamin D level. | Sujit Kumar Tripathy Amrit Gantaguru Saurav Narayan Nanda Sandeep Velagada Anand Srinivasan Manaswini Mangaraj | 2020 | World Journal of Orthopedics2020，11，10： | 2 |
| 16 | Inhibition of proliferation of retinal vascular endothelial cells more effectively than choroidal vascular endothelial cell proliferation by bevacizumab显示文摘● AIM: To evaluate the differential inhibitory effects of bevacizumab on cell proliferation of vascular endothelial growth factor(VEGF)-stimulated choroidal vascular endothelial cells(CVECs) and retinal vascular endothelial cells(RVECs) in vitro.● METHODS: VEGF(400 ng/m L) enriched CVECs and RVECs were treated with escalating doses of bevacizumab(0.1, 0.5, 1, 1.5 and 2 mg/m L). Cell proliferation changes were analyzed with WST-1 assay and trypan blue exclusion assay at 48, 72 h and 1wk. Morphological changes were recorded with bright field microscopy.● RESULTS: VEGF enriched RVECs showed significantly more decline of cell viability than CVECs after bevacizumab treatment. One week after treatment, RVEC cell proliferation decreased by 29.7%, 37.5%, 52.8%, 35.9% and 45.6% at 0.1, 0.5, 1.0, 1.5 and 2 mg/m L bevacizumab respectively compared to CVEC proliferation decrease of 4.1%, 7.7%, 2.4%, 4.1% and 17.7%(P<0.05) by WST-1 assay. Trypan blue exclusion assay also revealed similar decrease in RVEC proliferation of 20%, 60%, 73.3%, 80% and 93.3% compared to CVEC proliferation decrease of 4%, 12%, 22.9%, 16.7% and 22.2% respectively(P<0.05). The maximum differential effect between the two cell types was observed at bevacizumab doses of 1.0 and 1.5 mg/mL at all time points. RVECs were 22 fold more sensitive(P<0.01) compared to CVECs(52.8% vs 2.4%) at concentration of 1.0 mg/mL, and 8.7 fold more at 1.5 mg/mL(35.9% vs 4.1%) 1wk after treatment(P<0.05 respectively).● CONCLUSION: VEGF-enriched RVECs are more susceptible to bevacizumab inhibition than CVECs at clinically used dosage of 1.25 mg and this differential sensitivity between two cell types should be taken into consideration in dosage selection. | Bharani Krishna Mynampati Kumar Sambhav Sandeep Grover Kakarla V.Chalam | 2017 | International Journal of Ophthalmology(English edition)2017，10，1： | 2 |
| 17 | Laser-induced plasma generated by a 532nm pulsed laser in bulk water:unexpected line-intensity variation with water temperature and the possible underlying physics显示文摘The effect of the matrix temperature on laser-induced plasma generated in bulk water by using a532 nm pulsed laser beam has been studied.Ca Ⅰ and Ⅱ emission line intensities were recorded for an aqueous solution of CaCl2 in the temperature range of 7℃-70℃.The emission line intensities did not follow the matrix temperature in our experiments.Maximum intensities were observed at ~18℃ for both lines.Herein,a possible mechanism responsible for the observed variation in intensity is suggested,in which laser-produced bubbles play important roles.Bubble formation is essential to ignite plasma in the liquid and more feasible at the higher liquid temperature.However,the abundant bubbles at the higher temperature can scatter the incident laser beam more effectively to decrease the energy delivered for the laser-induced plasma.Thus,these two roles have effects on the optical emission intensities in opposite ways.The validity of the suggested mechanism is discussed based on the plasma temperature,temperature dependence of the refractive index of water,plasma electron density,scattered light intensity,and plasma ignition threshold energy.Our result indicates that the temperature of the liquid is also an important parameter to be considered in the laser-induced breakdown spectroscopy analysis of bulk liquid samples and its application in deep-sea exploration. | Sandeep KUMAR 朴頂 南相好 韓宋姬 李勇勳 | 2020 | Plasma Science and Technology2020，22，7： | 2 |
| 18 | Multilayer Neural Network Based Speech Emotion Recognition for Smart Assistance显示文摘Day by day,biometric-based systems play a vital role in our daily lives.This paper proposed an intelligent assistant intended to identify emotions via voice message.A biometric system has been developed to detect human emotions based on voice recognition and control a few electronic peripherals for alert actions.This proposed smart assistant aims to provide a support to the people through buzzer and light emitting diodes(LED)alert signals and it also keep track of the places like households,hospitals and remote areas,etc.The proposed approach is able to detect seven emotions:worry,surprise,neutral,sadness,happiness,hate and love.The key elements for the implementation of speech emotion recognition are voice processing,and once the emotion is recognized,the machine interface automatically detects the actions by buzzer and LED.The proposed system is trained and tested on various benchmark datasets,i.e.,Ryerson Audio-Visual Database of Emotional Speech and Song(RAVDESS)database,Acoustic-Phonetic Continuous Speech Corpus(TIMIT)database,Emotional Speech database(Emo-DB)database and evaluated based on various parameters,i.e.,accuracy,error rate,and time.While comparing with existing technologies,the proposed algorithm gave a better error rate and less time.Error rate and time is decreased by 19.79%,5.13 s.for the RAVDEES dataset,15.77%,0.01 s for the Emo-DB dataset and 14.88%,3.62 for the TIMIT database.The proposed model shows better accuracy of 81.02%for the RAVDEES dataset,84.23%for the TIMIT dataset and 85.12%for the Emo-DB dataset compared to Gaussian Mixture Modeling(GMM)and Support Vector Machine(SVM)Model. | Sandeep Kumar MohdAnul Haq Arpit Jain C.Andy Jason Nageswara Rao Moparthi Nitin Mittal Zamil S.Alzamil | 2023 | Computers, Materials & Continua2023，，1： | 2 |
| 19 | Identifying who best tolerates moderate sedation:Results from a national database of gastrointestinal endoscopic outcomes显示文摘BACKGROUND With increasing volume and cost of gastrointestinal endoscopic procedures,the proper selection of patients for moderate sedation becomes increasingly relevant.The current literature lacks consistent findings that allow for appropriate selection of patients for moderate sedation.AIM To analyze a nationwide registry of patients to identify patient and procedural factors associated with lower sedation requirements for endoscopy.METHODS The Clinical Outcomes Research Initiative National Endoscopic Database was queried to assess adult patients undergoing moderate sedation for esophagogastroduodenoscopy(EGD)and colonoscopy from 2008 to 2014.Patients were stratified into two groups[low dose(LD)and high dose sedation]based on sedation requirements.Anthropometric,procedural,and anesthesia data were compared,and multivariable analysis was performed to identify factors associated with LD sedation.RESULTS Of the 371102 patients included in the study,63137 where stratified into the LD sedation group and 307965 were in the high dose group.Moderate sedation was managed primarily by endoscopists(50%)and anesthesia providers(47%).Patients undergoing EGDs and procedures performed in the inpatient setting,in ambulatory surgery centers,intensive care units or hospital wards,required less sedation than colonoscopies,outpatient procedures and procedures done in endoscopy suites,respectively(P<0.0001 for all).On multivariable analysis,factors predictive of tolerance with lower sedation requirements for EGDs and colonoscopies were female gender,age≥50,non-White race,Hispanic descent,body mass index≤25 kg/m^(2),and higher American Society of Anesthesia Class(P<0.0001 for all).CONCLUSION Clinicians should consider these patient profiles in determining which patients will better tolerate moderate sedation vs those better suited for alternative sedation methods. | Monica Passi Farial Rahman Sandeep Gurram Sheila Kumar Christopher Koh | 2021 | World Journal of Gastrointestinal Endoscopy2021，13，4： | 2 |
| 20 | Aging temperature and abrasive wear behaviour of cast Al–(4%,12%,20%)Si–0.3% Mg alloys显示文摘 | K.B. Shah Sandeep Kumar D.K. Dwivedi | 2006 | Materials and Design2006，，： | 2 |
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