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| 1 | 钛合金网架髋臼重建术显示文摘目的观察自体植骨 ,钛合金网架重建内陷性髋臼的临床效果。方法1993年1月~1995年8月 ,25侧内陷性髋臼应用局部自体植骨 ,钛合金网架重建术。男11髋 ,女14髋 ,年龄45~76岁 ,平均69岁。术前诊断类风湿性关节炎11髋 ,骨关节炎8髋 ,股骨头缺血性坏死4髋 ,髋臼发育不良2髋。平均随访4.5年 (3~5年 )。结果25髋按Merled Aubigne标准评分,平均为10.2分 ,优良率88 % ,全部植骨获得骨性融合。无髋臼帽松动 ,髋臼内壁无一发生骨折或金属网架断裂。结论自体植骨同时用钛合金网架加固 ,能有效重建内陷性髋臼。 | 任先军 GA Fuchs Juergen Wacker | 2000 | 中华骨科杂志2000,20,4: | 3 |
| 2 | Hypoxic preconditioning induces stroke tolerance in mice via a cascading HIF , sphingosine kinase, and CCL 2 signaling pathway显示文摘 | Bradley K. Wacker Jennifer L. Perfater Jeffrey M. Gidday | 2012 | J. Neurochem2012,,6: | 3 |
| 3 | Procalcitonin as a diagnostic marker for sepsis: a systematic review and meta-analysis显示文摘 | Christina Wacker Anna Prkno Frank M Brunkhorst Peter Schlattmann | 2013 | The Lancet Infectious Diseases2013,,5: | 2 |
| 4 | 光敏剂间-四羟基苯二氢卟酚及其复合物对人T淋巴细胞白血病细胞的作用显示文摘目的 观察光敏剂间-四羟基苯二氢卟酚(mTHPC)及其复合物HSA-mTHPC对人T淋巴细胞白血病细胞(Jurkat)的作用,探讨人血白蛋白(HSA)纳米颗粒作为mTHPC载体的可行性.方法 利用流式细胞仪测定Jurkat细胞对mTHPC及HSA-mTHPC的摄取率,通过测定不同浓度mTHPC及HSA-mTHPC孵育Jurkat细胞后的存活率、细胞膜完整性和增殖率,评价两种药物的摄取率和细胞毒性.结果 浓度1.0 mg/L,孵育4、24 h Jurkat细胞的摄取率为:mTHPC单体:98.07%、99.07% HSA-mTHPG中mTHPC:98.13%、99.19% HSA单体:2.77%、4.84%.光照后Jurkat细胞活性和增殖率呈显著剂量、时间依赖的下降,mTHPC浓度为1.0 mg/L时,4、24、48 h存活率和增殖率分别为13.27%、5.46%、4.99%和2.68%、0.91%、0.62%,HSA-mTHPC对细胞生长和增殖的抑制与mTHPC单体比较未见下降(P>0.05).光照后LDH活性呈现显著剂量、时间依赖的上升,mTHPC浓度为1.0mg/L时,4、24、48 h LDH活性分别为:80.99%、99.38%、100.67%.结论 mTHPC是一种杀伤力强的光敏剂型,能有效进入肿瘤细胞,并导致细胞损害.HSA纳米颗粒不影响细胞对mTHPC的摄取,可以作为其载体. | 郑顺贞 Karin Low Matthis Wacker Arno Wiehe Sylvia Wagner Klaus Langer Hagen von Briesen 邹声泉 | 2010 | 中华实验外科杂志2010,27,10: | 2 |
| 5 | The DNA bind- ing and catalytic domains of poly(ADP-ribose) polymerase 1 cooperate in the regulation of chromatin structure and transcription 显示文摘 | Wacker D A Ruhl D D Balagamwala E H | 2007 | Mol Cell Biol2007,27,21: | 1 |
| 6 | Modified Mohs micrographic surgery in the therapy of dermatofi brosarcoma protuberans:analysis of 22 patients显示文摘 | Wacker J Khan-DuraniB Hartschuh W | 2004 | Ann Surg Oncol2004,11,4: | 1 |
| 7 | High hepatotoxicity of pyrazinamide and ethambutol for treatment of latent tuberculosis 显示文摘 | Younossian AB Ketterer JP Wacker J | 2005 | Eur Respir2005,26,3: | 1 |
| 8 | An augmented reality system for MR image-guided needle biopsy:initial results in a swine model显示文摘 | Wacker F Vogt S Khamene A | 2006 | Radiology2006,,02: | 1 |
| 9 | Immuno-PCR: High sensitivity detection of proteins by nucleic acid amplification 显示文摘 | Niemeyer C M Adler M Wacker R | 2005 | Trends Biotechnol2005,23,4: | 1 |
| 10 | Sedative and anxiolytic effects of zopiclone's enantiomers and metabolite 显示文摘 | Rene Haskew Jennifer Wacker | 2001 | European Journal of Pharmacology2001,415,: | 1 |
| 11 | Exercise myocardial imaging显示文摘 | Wacker FJT | 1994 | J Nucl Med1994,35,: | 1 |
| 12 | MR tomagraphy in autologous plastic repaire of the anterior cruciate ligament: a comparision of 2 surgical methods显示文摘 | Wacker F Schilling A Dihlmann SW | 1995 | Rofo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr1995,162,: | 1 |
| 13 | ATM gene and lymphoid malignancies显示文摘 | Pause FG Wacker P Sappino AP | 2004 | Leukemia2004,18,2: | 1 |
| 14 | Increased pancreatic fat fraction is present in obese adolescents with metabolic syndrome显示文摘 | Maggio A B Mueller P Wacker J | 2012 | J Pediatr Gastroenterol Nutr2012,54,6: | 1 |
| 15 | Bats:A new tool for AMS data reduction显示文摘 | Wacker L Christl M Synal H A | 2010 | Nuclear Instruments and Methods in Physics Research Section B:Beam Interactions with Materials and Atoms2010,268,7: | 1 |
| 16 | 氦气有中度抗炎作用,但在人体缺血-再灌注损伤中没有内皮保护作用显示文摘背景惰性气体氦气没有麻醉作用但对心肌有预处理的作用。我们假设氦气吸入可以对人体前臂的缺血.再灌注内皮功能不全有保护作用。方法这是一项交叉设计的研究,包括8例健康男性受检者。每个志愿者在前臂缺血15分钟时被随机分成吸氦气或不吸氦气组。氦气的呼气末浓度达50vol%。从缺血前15分钟开始吸氦气直到再灌注后5分钟(“氦气状态”)。充血反应是一种一氧化氮生物利用率和内皮功能的标记物。应用静脉阻塞体积描记术在再灌注的15分钟和30分钟时测定前臂充血反应。再灌注期用流式细胞计测定促炎症标记物CDllb、ICAM-1、PSGL-1和Dselectin(CD62L)在白细胞上的表达以及P-selectin(CD62P)、PSGL-1和CD42b在血小板上的表达。结果缺血。再灌注持续地降低再灌注15分钟和30分钟时阻塞后的内皮依赖性充血反应。围缺血期吸入50vol%氦气不能改善阻塞后充血反应。氦气降低促炎症标记物CDllb和ICAM-1在白细胞上的表达,也降低促凝标记物CD42b和PSGL-1在血小板上的表达。结论虽然吸入氦气可以消除缺血后的炎性反应,但本研究表明50vol%氦气不能保护人在体内皮。内皮是所有重要器官的主要组成成分。这与七氟醚的研究结果相反,七氟醚在低浓度、亚麻醉浓度下有人体内皮的保护作用。 | Eliana Lucchinetti, PhD Johannes Wacker, MD Christian Maurer, MD Marius Keel, MD Luc Hairter, PhD Kathrin Zaugg, MD, PhD Michael Zaugg, MD 周全红(译) | 2012 | 麻醉与镇痛2012,8,1: | 1 |
| 17 | The role of the nucleus ae- cumbens and rostral anterior eingulate cortex in anhedonia: Integration of resting EEG, fMRI, and volumetric techniques 显示文摘 | Wacker J Dillon DG Pizzagalli DA | 2009 | Neuro- Image2009,46,: | 1 |
| 18 | Procalcitonin-guided therapy in intensive care unit patients with severe sepsis and septic shock- a systematic review and meta-analysis 显示文摘 | Prkno A Wacker C Brunkhorst FM | 2013 | Crit Care2013,17,6: | 1 |
| 19 | Hsp70 and Hsp40 attenuate formation of spherical and annular polyglutamine oligomers by partitioning monomer显示文摘 | WACKER J ZAREIE M FONG H | 2004 | Nat Struct Mol Biol2004,11,12: | 1 |
| 20 | ATM alterations in childhood non-Hodgkin lymphoma 显示文摘 | Gumy-Pause F Wacker P Maillet P | 2006 | Cancer Genet Cytogenet2006,166,2: | 1 |