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| 1 | Role of ATG16L,NOD2 and IL23R in Crohn's disease pathogenesis显示文摘Inflammatory bowel disease is a group of diseases that includes Crohn's disease (CD) and ulcerative colitis.CD is characterized as a chronic inflammatory disease of the gastrointestinal tract,ranging from the mouth to the anus.Although there are gross pathological and histological similarities between CD and Johne's disease of cattle,the cause of CD remains controversial.It is vital to understand fully the cause of this disease because it affects approximately 500 000 people in North America and Europe.It ranges from 27 to 48 cases per 100 000 people.There are many theories on the cause of CD ranging from possible association with environmental factors including microorganisms to imbalance in the intestinal normal flora of the patients.Regardless of the environmental trigger,there is strong evidence that a genetic disposition is a major key in acquiring CD.Many studies have proven the link between mutations in the ATG16L,NOD2/CARD15,IBD5,CTLA4,TNFSF15 and IL23R genes,and CD.The purpose of this review is to examine all genetic aspects and theories of CD,including up to date multiple population studies performed worldwide. | Saleh A Naser Melissa Arce Anam Khaja Marlene Fernandez Najih Naser Sammer Elwasila Saisathya Thanigachalam | 2012 | World Journal of Gastroenterology2012，18，5： | 5 |
| 2 | Correlation between rpoB gene mutation in Mycobacterium avium subspecies paratuberculosis and clinical rifabutin and rifampicin resistance for treatment of Crohn’s disease显示文摘AIM: To investigate overlapping regions of the rpoB gene previously involved with rifamycin resistance in M. tuberculosis and seek correlation between rpoB mutations in clinical MAP strains with susceptibility to RIF and RFB. METHODS: We designed a molecular-based PCR method for the evaluation of rifabutin (RFB) and rifampicin (RIF) resistance based on probable determinant regions within the rpoB gene of MAP, including the 81 bp variable site located between nucleotides 1363 and 1443. The minimum inhibitory concentration (MIC) for RIF was also determined against 11 MAP isolates in attempt to seek correlation with rpoB sequences. RESULTS: We determined that MAP strain 18 had an MIC of > 30 mg/L and ≤ 5 mg/L for RIF and RFB respectively, and a significant and novel rpoB mutation C1367T, compared to an MIC of ≤ 1.0 mg/L for both drugs in the wild type MAP. The 30-fold increase in the MIC was a direct result of the rpoB mutation C1367T, which caused an amino acid change Thr456 to Ile456 in the drug’s binding site. In addition, MAP strain 185 contained five silent rpoB mutations and exhibited an MIC comparable to the wild-type. Moreover, our in vitroselected mutation in MAP strain UCF5 resulted in the generation of a new resistant strain (UCF5-RIF16r) that possessed T1442C rpoB mutation and an MIC > 30 mg/L and > 10 mg/L for RIF and RFB respectively. Sequencing of the entire rpoB gene in MAP strains UCF4, 18, and UCF5-RIF16r revealed an rpoB mutation A2284C further downstream of the 81 bp variable region in UCF4, accounting for observed slight increase in MIC. In addition, no other significant mutations were found in strains 18 and UCF-RIF16r. CONCLUSION: The data clearly illustrates that clinical and in vitro-selected MAP mutants with rpoB mutations result in resistance to RIF and RFB, and that a single amino acid change in the beta subunit may have a significant impact on RIF resistance. Unconventional drug susceptibility testing such as our molecular approach will be beneficial for evaluation of antibiotic effectiveness. This molecular approach may also serve as a model for other drugs used for treatment of MAP infections. | Daniel R Beckler Sammer Elwasila George Ghobrial John F Valentine Saleh A Naser | 2008 | World Journal of Gastroenterology2008，14，17： | 2 |
| 3 | Rapid nongenomic effects of aldosterone on the renal vasculature in humans显示文摘 | Schmidt BM Sammer U Fleischmann I | 2006 | Hypertension2006，47，4： | 1 |
| 4 | Training of executive functions in Parkinson' s disease显示文摘 | Sammer G Reuter I Hullmann K | 2006 | J Neurol Sciences2006，248，： | 1 |
| 5 | Chronic pelvic pain syndrome: neurostimulation, neuromodulation and acupuncture 显示文摘 | Walter M Sammer U Kessler TM | 2012 | Urologe A2012，51，12： | 1 |
| 6 | Training of executive functions in Parkinson's disease 显示文摘 | Gebhard Sammer Iris Reuter Katharina Hullmann | 2006 | Journal of the Neurological Sciences2006，248，： | 1 |
| 7 | Ulnar impaction 显示文摘 | Sammer DM Rizzo M | 2010 | Hand Clin2010，26，： | 1 |
| 8 | Outcomes using an internal ostemomy and distraction device for corrective osteotomy of distal radius malunions requiring correction in multiple planes显示文摘 | Sammer D M Kawamura K Chung K C | 2006 | J Hand Surg (Am)2006，31，10： | 1 |
| 9 | Assessment of Myocardial Viability With Contrast-Enhanced Magnetic Resonance Imaging: Comparison With Positron Emission Tomography显示文摘 | Christoph Klein Stephan G. Nekolla Frank M. Bengel Mitsuru Momose Andrea Sammer Felix Haas Bernhard Schnackenburg Wolfram Delius Harald Mudra Dieter Wolfram Markus Schwaiger | 2002 | Circulation: Journal of the American Heart Association2002，，2： | 1 |
| 10 | Modified acrylic-based superabsorbent polymers (dependence on particle size and salinity) 显示文摘 | Omidian H Hashemi S A Sammers P G | 1999 | Polymer1999，40，： | 1 |
| 11 | Wrist surgery:management of chronic scapholunate and lunotriquetral ligament injuries显示文摘 | Sammer DM Shin AY | | 0，，01： | 1 |
| 12 | Association of angiotensin converting enzyme gene polymorphisms with left ventricular hypertrophy 显示文摘 | Mohammad S Danish S Sammer S | 2005 | Hypertens Res2005，28，4： | 1 |
| 13 | Training of executive functions in Parkinson's disease显示文摘 | Sammer G Reuter I Hullmann K | 2006 | J Neurol Sci2006，248，： | 1 |
| 14 | Outcomes using an internal osteotomy and distraction device for corrective osteotomy of distal radius malunions requiring correction in multiple planes显示文摘 | Sammer DM Kawamura K Chung KC | 2006 | J Hand Surg Am2006，31，10： | 1 |
| 15 | Outcomes using an internal osteotomy and distraction device for corrective osteotomy of distal radius malunions requiring correction in multiple planes显示文摘 | Sammer DM Kawamura K Chung KC | 2006 | J Hand Surg Am2006，31，10： | 1 |
| 16 | An acupoint-originated human interstitial fluid circulatory network显示文摘To the Editor:Since 1027,when the Tian Sheng Bronze Statue showing acupoints and meridians was first introduced for medical practitioners,it has evolved to the currently used acupoints and meridians atlas in traditional Chinese medicine(TCM).[1]To date,the acupoints represent defined areas on the body surface relative to certain landmarks.The acupoints in the extremity endings would connect anatomically with diverse associated visceral organs or tissues,forming a Meridian and Collateral network.Illustrated on the atlas,each main meridian is usually a virtual line connecting a group of adjacent acupoints that correlate with certain visceral organ.In modern medical science,the anatomical structures of main meridians remain largely unclarified. | Hong-Yi Li Fang Wang Min Chen Zhi-Jian Zheng Ya-Jun Yin Jun Hu Hua Li Andreas Sammer Georg Feigl Norbert Maurer Chao Ma Fu-Sui Ji | 2021 | Chinese Medical Journal2021，，19： | 1 |
| 17 | A comparative study of fragment-specific versus volar plate fixation of dis- tal radius fractures显示文摘 | Sammer DM Fuller DS Kim HM | 2008 | Plast Reconstr Surg2008，122，5： | 1 |
| 18 | Ulnar impaction 显示文摘 | Sammer DM Rizzo M | 2010 | Hand Clin2010，26，4： | 1 |
| 19 | Hemi-contralateral C7 transfer in traumatic brachial plexus injuries: outcomes and complications显示文摘 | Sammer DM Kircher MF Bishop AT | 2012 | J Bone Joint Surg Am2012，94，2： | 1 |
| 20 | The incidence and risk factors for hypotension during emergent decompressive craniotomy in children with traumatic brain injury显示文摘 | Miller P Mack CD Sammer M | 2006 | Anesth Analg2006，103，4： | 1 |
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