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| 1 | Immunologic role of nitric oxide in acute rejection of golden hamster to rat liver xenotransplantation显示文摘AIM: To evaluate the immunologic role and expressionsignificances of nitric oxide(NO), nitric oxide synthase(NOS),and its isoenzyme in acute rejection to liverxenografts from golden hamster in rat.METHODS: Liver transplantations were randomlydivided into five groups(n=6-9):isografts (group I );xenografts (groupⅡ); xenografts plus cyclosporinetreatment (group Ⅲ), xenografts pluscyclophosphamide treatment combined withsplenectomy (group Ⅳ), and xenografts usingcyclophosphamide in combination with splenectomy(group Ⅳ) and xenografts using splenectomy inaddition to cyclophosphamide and cyclosporinetreatments(group V) .The levels of ALT, TNF- α, andnitric oxide production(NOx) in serum of reciprentswere examined,and expressions of type Ⅱ (iNOS) andtypeⅢ (cNOS) nitric oxide synthase(NOS)-inducibleNOS(iNOS) and constitutive NOS(cNOS) wereobserved by NADPH diaphorase histochemical andimmunohistochemical staining.RESULTS: The level of serum ALT, activity of serumTNF-α and systemic levels of NO metabolite in groupsⅡand Ⅳ were higher than those of groups Ⅰ andy(serum ALT, 2416±475, 2540±82.5) nkat. L-1 vs(556.8±43.5, 677.30±38.2 ) nkat. L-1, P<0.01;(serum TNF-α, 353.5±16.1,444.6±28.1) ng.L-1 vs38.5±5.2, 52.0±5.7) ng.L-1, P<0.01; (serum NOx514.6 ± 18.1, 336.0 ± 43.0 )nmol.g-1, vs 26.1 ± 5.7, 27.7±6.0) nmol.g-1, P<0.01.Cyclosporine in group Ⅲcan repress the cellular immune response and thesynthesis of nitric oxide and the expression of NOsynthase,but not prolong the liver xenograftsurvival.The over-expression of NOS, iNOS and cNOSin liver xenograft rejection in groups Ⅱand Ⅳ weredetected by NADPH diaphorase histochemical andimmunohistochemical staining.CONCLUSION: The degrees of acute rejection can beeffectively repressed in golden hamster to rat liverxenografts with splenectomy and cyclosporine. Nitricoxide metabolites, and nitric oxide synthase and itsisoenzymes,above all inducible NOS (iNOS) can beused as potential diagnostic markers for acuterejection in liver transplantation. The cellularlocalization of nitric oxide varies according to theimmunologic status of liver xenografts, thus thinkingthat hepatocyte derived nitric oxide may be protectivein the hyporesponsive state, but hepatic injury is likelytriggered by centrilobular iNOS expression in thesuperresponsive state. | Tong-Jin Diao Tong-Ye Yuan You-Lin Li Department of General Surgery and Hepatobiliary Surgery,the Chinese PLA Navy 401 Hospital Qingdao 266071,China | 2002 | World Journal of Gastroenterology2002，8，4： | 10 |
| 2 | Effects of L-arginine during ischemia-reperfusion injury in rat orthotopic liver transplantation显示文摘EfectsofLarginineduringischemiareperfusioninjuryinratorthotopiclivertransplantationDIAOTongJin1,YAOXiaoPing2,JIBing1,YANG... | DIAO Tong Jin 1, YAO Xiao Ping 2, JI Bing 1, YANG Jia Mei 2, WU Meng Chao 2 and ZHANG Shao Geng 3 1Department of General Surgery, Chinese PLA 401 Navy Hospital, Qingdao 266071, Shandong Province, China 2Eastern Hospital of Hepa | 1998 | World Journal of Gastroenterology1998，4，3： | 4 |
| 3 | COMPARISON OF THE EFFECTS OF DIFFERENT STRENGTHENING NETS IN MAXILLARY COMPLETE DENTURE RESIN BASE BY THREE-DIMENSIONAL FINITE ELEMENT METHODS显示文摘Diastema often occured in maxillary complete denture resin base in the clinic,although ' Lucitone 199' had been used with more tensile strength.Mechanical ex-periments have proved the high transverse tensile stress (σ_x^+) concentrating in anteri-or teeth region and their palatal surface of maxillary complete denture resin basewhile it was exposed to vertical loading in center occlusion.Setting strengtheningnet in resin base has achieved better results.For evaluating purpose,twenty | Y.B.Wang~1 Y.Dong~1 S.F.Zhang~1 J.S.Liu~2 Y.G.Zheng~21 Department of Prosthodontic,Stomatological College,4th Military medical University,Xi’an 710032,China2 401 Research Institute,Xi’an Electrical Science and Technology University,Xi’an 710054,China | 1993 | Chinese Journal of Biomedical Engineering(English Edition)1993，2，3： | 2 |
| 4 | Efficacy of donepezil in mild cognitive impairment:a randomized placebo-controlled trial显示文摘 | Salloway S Ferris S Kluger A Goldman R Griesing T Kumar D Richardson S Donepezil 401 Study Group | | 0，，04： | 1 |
| 5 | INFLUENCE OF LOADING RATE AND SPECIMEN HEIGHT ON FLEXURAL STRENGTH OF Al_2O_3 AT HIGH TEMPERATURES显示文摘1.IntroductionWiththedevelopmentofaerospacetechnology,thehigh-temperaturestructuralceramicswouldbewidelyusedbecauseofitsspec... | S.H. Bai, S.R. Qiao, S.R. Zhou and M.K. Kang Faculty 401, Northwestern Polytechnical University, Xian 710072, China | 1999 | Acta Metallurgica Sinica(English Letters)1999，12，1： | 1 |
| 6 | 核电站抗震设计规范第一次编制工作会议在北京召开[J]显示文摘 | 工力所401组 | 1985 | 世界地震工程1985，，3： | 1 |
| 7 | RATE MEASUREMENTS OF THERMOLYSIS OF O,O-DIETHYL-S-TRIFLUOROMETHYLTHIOLOPHOSPHATE BY ^(31)p-NMR显示文摘The thermolysis of (EtO)2P(O)SCF3 was measured by 31P-NMR with external standard method. Kinetic parameters of the reaction, i.e., order, rate constant, pre-exponential, activation energy were obtained. For constant external-standard method, It is better to choose the value of 31P peak area of standard substance slightly greater than the middle value of the area of the measured compounds. | Wen Xiang HU~(**) Hua Tang XU Xuan Long XU Beijing Institute of Pharmaceutical Chemistry No. 401, Po Box 1044, Beijing 102205 | 1992 | Chinese Chemical Letters1992，3，7： | 0 |
| 8 | Thermodynamics of Bainitic Formation in Carbon-depleted Region in Fe-C Alloys显示文摘Thermodynamic analysis for the formation of bainitic ferrite in carbon -depleted region has been conducted. The results show that the driving force of bainitic formation increases with depleting of carbon in parent austenite and with decreasing the transformation temperature. The critical driving force (absolute value) at the Bs temperature is 600-1 200 J / mol, which increases as the mean carbon content of Fe-C alloys increases. The freshly-formed bainitic ferrite has partial supersaturation of carbon, which increases smoothly with decreasing the transformation temperature Therefore, the displacive formation of bainitic ferrite in carbon-depleted region is thermodynamically feasible in the whole temperature range of bainitic reaction. | Xiaolei WU Xiangkang MENG Xiyan ZHANG Yanqing YANG and Mokuang KANG(Dept. of Materials Science and Technology, 401, Northwestern Polytech. University, Xi’an, 710072, China) | 1994 | Journal of Materials Science & Technology1994，10，6： | 0 |
| 9 | EFFECTS OF WAVEFORM AND FREQUENCY OF CYCLIC LOADING ON CORROSION FATIGUE CRACK PROPAGATION FOR GC-4 STEEL IN 3.5%NaCl SOLUTION显示文摘EFFECTSOFWAVEFORMANDFREQUENCYOFCYCLICLOADINGONCORROSIONFATIGUECRACKPROPAGATIONFORGC-4STEELIN3.5%NaClSOLUTIONEFFECTSOFWAVEFORM... | Lu Minxu Liu Xiaokun Wang JianJiin Fu Xiangping Zheng Xiulin(Faculty 401,Northwestern Polytechnical University,Xi’an,China,710072) | 1994 | Chinese Journal of Aeronautics1994，7，1： | 0 |
| 10 | 吻合血管的带蒂空肠移植重建食道治疗小儿食管狭窄显示文摘作者用吻合血管的带蒂空肠移植治疗小儿良性食管狭窄!共报告3例.结果显示,本手术疗效满意,术后对儿童发育无不良影响。本文详细介绍了手术方法,并讨论了手术操作的重点。 | 徐培冲 庄虔贞 田世昌 刘家玉 程国良 林彬 方光荣 徐正平海军401医院 | 1989 | 修复重建外科杂志1989，3，2： | 0 |
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