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| 1 | Crohn's disease environmental factors in the developing world: A case-control study in a statewide catchment area in Brazil显示文摘AIM To identify environmental risk factors associated with the development of Crohn's disease(CD) in order to reassess the hygiene hypothesis.METHODS A hospital-based, case-control study was carried out with CD patients(n = 145) and controls(n = 163)representing a socioeconomically diverse statewide catchment area in Brazil. Controls were recruited from caregivers of patients seen in different outpatient clinics at the same hospital. A multi-item survey with 94 questions regarding family history of CD, perinatal and childhood circumstances, living conditions, tobacco use and familial socioeconomic status was carried out by interviewers. RESULTS On the univariate analysis, predictive variables for CD included being male, under age of 40, a high education level, urban dweller, smaller family size, exposure to enteric pathogens and user of treated water(P < 0.005). On the multivariate analysis, variables significantly associated with CD were male gender(OR = 2.09), under age 40(OR = 3.10), white(OR = 2.32), from a small family in childhood(OR = 2.34) and adulthood(OR = 3.02), absence of viral infections in childhood(OR = 2.23), exposure to enteric pathogens(OR = 2.41), having had an appendectomy(OR = 2.47) and prior or current smoker(OR = 2.83/1.12). CONCLUSION Most variables supporting the 'hygiene hypothesis' are associated with the development of CD but are not independent predictors of the diagnosis. | Valéria Cristina Loureiro Salgado Ronir Raggio Luiz Neio Boechat Bianca C Schorr Isabella S Leao Tiago Nunes Cyrla Zaltman | 2017 | World Journal of Gastroenterology2017，23，30： | 2 |
| 2 | Determinants of individual engagement in knowledge sharing显示文摘 | Cabrera A Collins W C Salgado J F | 2006 | International Journal of HumanResource Management2006，17，2： | 1 |
| 3 | Effect offunctionalized carbon as Pt electrocatalyst support on themethanol oxidation reaction显示文摘 | Salgado J R C Duarte D G Ilharco L M | 2011 | Applied Catalysis B: En-vironmental2011，102，： | 1 |
| 4 | The scale depend- ent nuclear effects in parton distributions for practical appli- cations显示文摘 | Eskola K J Kolhinen V J Salgado C A | 1999 | Eur PhysJ1999，9，： | 1 |
| 5 | Optimation of PGNAA instrument design for cement raw materials using the MCNP code显示文摘 | Oliveira C Salgado J Carvallio F G | 1997 | Journal of Radioanalytical and Nuclear Chemistry1997，216，2： | 1 |
| 6 | Cellular inflammation in nonarteritic anterior ischemic optic neuropathy and its primate model 显示文摘 | Salgado C Vilson F Miller NR | 2011 | Arch Ophthalmol2011，129，12： | 1 |
| 7 | Direct membrane damaging effect of sertaconazole on Candida albicans as a mechanism of its fungicidal activity 显示文摘 | Agut J Palacin C Salgado J | 1992 | Arzneimittelforschung1992，42，5： | 1 |
| 8 | Liver metastases from colorectal adenocarcimomas grow in three patterns with different angiogenesis and desmoplasia显示文摘 | Vermeulen P B Colpaert C Salgado R | 2001 | J Pathol2001，195，3： | 1 |
| 9 | Determinants of individual engagement in knowledge sharing 显示文摘 | Cabrera A Collins W C Salgado J F | 2006 | The International Journal of Human Resource Management2006，，2： | 1 |
| 10 | Treatment ofauricular pseudocyst with aspiration and local pressure显示文摘 | Salgado C J Hardy J E Mardini S | 2006 | J Plast Reconstr Aesthet Surg2006，59，12： | 1 |
| 11 | Ex vivo analysis of root canal cleaning using Endo-PTC associated to NaOC1 and different irrigant solutions 显示文摘 | Yamazaki AK Moura-Netto C Salgado R J | 2010 | Braz Oral Res2010，24，1： | 1 |
| 12 | A novel alternatively spliced transcript of cytosolic alanine aminotransferase gene associated with enhanced gluconeogenesis in liver of Sparus aurata 显示文摘 | Anemaet I G Met6n I Salgado M C | 2008 | The International Journal of Biochemistry & CelIBiology2008，40，12： | 1 |
| 13 | Polymorphisms in the thymidylate synthase and dihydropyrimidine dehydrogenase genes predict response and toxicity to capecitabine-raltitrexed in colorectal cancer 显示文摘 | SALGADO J ZABALEGUI N GIL C | 2007 | Oncol Rep2007，17，2： | 1 |
| 14 | Determinants of individual engagement in knowledge sharing 显示文摘 | Cabrera A Collins W C Salgado J F | 2006 | International Journal of Human Resource Management2006，17，： | 1 |
| 15 | Purification and substrate specificity of an angiotensin coverting elas- tase-2 from the rat mesenteric arterial bed perfusate显示文摘 | PAULA C A SOUSA M V SALGADO M C | 1998 | Biochimaica et Biophysica Acta1998，1338，1： | 1 |
| 16 | Pt-Co/C electrocatalysts for oxygen reduction in H2/O2 PEMFCs synthesized by borohydride method显示文摘 | Salgado J R C Antolini E Gonzalez E R | 2004 | J Electrochem Soc2004，151，12： | 1 |
| 17 | Structure and activity of carbon-supported Pt-Co electrocatalysts for oxygen reduction显示文摘 | Salgado J R C Antolini E Gonzalez E R | 2004 | J Phys Chem B2004，108，17： | 1 |
| 18 | Latitudinal variation in palatability ofsalt-marsh plants:are differences constitutive?显示文摘 | Salgado C S Pennings S C | 2005 | Ecology2005，86，： | 1 |
| 19 | Carbon supported Pt70Co30 electrocatalyst prepared by the formic acid method for the oxygen reduction reaction in polymer electrolyte fuel cells显示文摘 | Salgado J R C Antolini E Gonzalez E R | 2005 | J Power Sources2005，141，1： | 1 |
| 20 | Urokinase - type plasminogen activator gene therapy in liver cirrhosis is mediatedby collagens gene expression down - regulation of MMMPs, HGF and VEGF显示文摘 | Bueno M Salgado S Beas - zarate C | 2006 | Gene Med2006，8，： | 1 |
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