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| 1 | Crohn's disease environmental factors in the developing world: A case-control study in a statewide catchment area in Brazil显示文摘AIM To identify environmental risk factors associated with the development of Crohn's disease(CD) in order to reassess the hygiene hypothesis.METHODS A hospital-based, case-control study was carried out with CD patients(n = 145) and controls(n = 163)representing a socioeconomically diverse statewide catchment area in Brazil. Controls were recruited from caregivers of patients seen in different outpatient clinics at the same hospital. A multi-item survey with 94 questions regarding family history of CD, perinatal and childhood circumstances, living conditions, tobacco use and familial socioeconomic status was carried out by interviewers. RESULTS On the univariate analysis, predictive variables for CD included being male, under age of 40, a high education level, urban dweller, smaller family size, exposure to enteric pathogens and user of treated water(P < 0.005). On the multivariate analysis, variables significantly associated with CD were male gender(OR = 2.09), under age 40(OR = 3.10), white(OR = 2.32), from a small family in childhood(OR = 2.34) and adulthood(OR = 3.02), absence of viral infections in childhood(OR = 2.23), exposure to enteric pathogens(OR = 2.41), having had an appendectomy(OR = 2.47) and prior or current smoker(OR = 2.83/1.12). CONCLUSION Most variables supporting the 'hygiene hypothesis' are associated with the development of CD but are not independent predictors of the diagnosis. | Valéria Cristina Loureiro Salgado Ronir Raggio Luiz Neio Boechat Bianca C Schorr Isabella S Leao Tiago Nunes Cyrla Zaltman | 2017 | World Journal of Gastroenterology2017，23，30： | 2 |
| 2 | Treatment ofauricular pseudocyst with aspiration and local pressure显示文摘 | Salgado C J Hardy J E Mardini S | 2006 | J Plast Reconstr Aesthet Surg2006，59，12： | 1 |
| 3 | Latitudinal variation in palatability ofsalt-marsh plants:are differences constitutive?显示文摘 | Salgado C S Pennings S C | 2005 | Ecology2005，86，： | 1 |
| 4 | Urokinase - type plasminogen activator gene therapy in liver cirrhosis is mediatedby collagens gene expression down - regulation of MMMPs, HGF and VEGF显示文摘 | Bueno M Salgado S Beas - zarate C | 2006 | Gene Med2006，8，： | 1 |
| 5 | The evaluation of tumor- infiltrating lymphocytes (TILs) in breast cancer: recommendations by an International TILs Working Group 2014 显示文摘 | Salgado R Denkert C Demaria S | 2014 | Ann Oncol2014，26，2： | 1 |
| 6 | Effects of late loss kf arterial inflow on free flap survival显示文摘 | Salgado C J Smich A Kim S | 2002 | J Reconstr Midrosurg2002，18，7： | 1 |
| 7 | In vitro induction of hexaploid plants from triploid hybrids of Pennisetum purpareum显示文摘 | CAMPOS J M S DAVIDE L C SALGADO C C | | 0，，： | 1 |
| 8 | Reconstruction of the esophagus and voice 显示文摘 | Mardini S Salgado C J Kim Evans KF | 2010 | Plast Reconstr Surg2010，126，： | 1 |
| 9 | Participative multi-criteria anaiysis for the evatuation of water governance alternatives: a case in the Costa del Sol (Malaga) 显示文摘 | Salgado P P Quintana S C Pereira A G | 2006 | Ecological Economics2006，，10： | 1 |
| 10 | Reconstruction of mandibular defects显示文摘 | Chim H Salgado C Mardini S | 2010 | Seminars in Plastic Surgery2010，24，： | 1 |
| 11 | Treatment of auricular pseudocyst with aspiration and local pressure显示文摘 | Salgado C J Hardy J E Mardini S | 2006 | Plastic Reconstruc Aesth Surg2006，59，12： | 1 |
| 12 | Treatment of auricular pseudocyst with aspiration and local pressure 显示文摘 | Salgado C J Hardy J E Mardini S | 2006 | J Plast Reconstr Aesthet Surg2006，59，12： | 1 |
| 13 | Adjusted optimal power flow solutions via parameterized formulation显示文摘 | Moyano C F Salgado R S | 2010 | Electric Power Systems Research2010，80，： | 1 |
| 14 | An approach to re-dispatch generators based on the modified power flow Jiacobian matrix显示文摘 | LEME R C de SOUZA A C Z SALGADO R S | 2007 | IEEE Lausanne Power Tech2007，，7： | 1 |
| 15 | A model for chronic osteomyelitis using Staphyloco ccus aureus in goats显示文摘 | Salgado C J Jamali AA Mardini S etal | 2005 | Clin Orthop Relat Rese2005，436，： | 1 |
| 16 | Treatment of auricular pseudocyst with aspiration and local pressure 显示文摘 | SALGADO C J HARDY J E MARDINI S | 2006 | J Plast Reconstr Aesthet Surg2006，59，： | 1 |
| 17 | Reconstruction of mandibular defects显示文摘 | Chim H Salgado C J Ma dini S | 2010 | Semin Plast Surg2010，24，2： | 1 |
| 18 | Urokinase-type plasminogen activator gene therapy in liver cirrhosis ismediated by collagens gene expression down-u-lation and up-regulation of MMPs,HGF and VEGF显示文摘 | Bueno M Salgado S Beas-Zárate C | 2006 | J GeneMed2006，8，11： | 1 |
| 19 | Treatment of auricular pseudocyst with aspiration and local pressure显示文摘 | SALGADO C J HARDY J E MARDINI S | 2006 | J Plast Reconstr Aesthet Surg2006，59，： | 1 |
| 20 | Urokinase-type plasminogen activator gene therapy in liver cirrhosis is mediated by collagens gene expression down-regulation and up-regulation of MMPs,HGF and VEGF显示文摘 | Bueno M Salgado S Beas-Zárate C | 2006 | J Gene Medicine2006，8，11： | 1 |
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