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	题名	作者	年代	出处	被引量
1	Cellular metabolic energy modulation by tangeretin in 7,12-dimethylbenz(a) anthracene-induced breast cancer显示文摘Breast cancer is the leading cause of death among women worldwide.Chemoprevention and chemotherapy play beneficial roles in reducing the incidence and mortality of cancer.Epidemiological and experimental studies showed that naturally-occurring antioxidants present in the diet may act as anticancer agents.Identifying the abnormalities of cellular energy metabolism facilitates early detection and management of breast cancer.The present study evaluated the effect of tangeretin on cellular metabolic energy fluxes in 7,12-dimethylbenz(a)anthracene(DMBA)-induced proliferative breast cancer.The results showed that the activities of glycolytic enzymes significantly increased in mammary tissues of DMBA-induced breast cancer bearing rats.The gluconeogenic tricarboxylic acid(TCA) cycle and respiratory chain enzyme activities significantly decreased in breast cancer-bearing rats.In addition,proliferating cell nuclear antigen(PCNA) was highly expressed in breast cancer tissues.However,the activities of glycolytic enzymes were significantly normalized in the tangeretin pre- and post-treated rats and the TCA cycle and respiratory chain enzyme activities were significantly increased in tangeretin treated rats.Furthermore,tangeretin down-regulated PCNA expression on breast cancerbearing rats.Our study demonstrates that tangeretin specifically regulates cellular metabolic energy fluxes in DMBA-induced breast cancer-bearing rats.	Kuppusamy Periyasamy Venkatachalam Sivabalan Kuppusamy Baskaran Kannayiram Kasthuri Dhanapal Sakthisekaran	2016	The Journal of Biomedical Research2016，30，2：	3
2	Preliminary studies on induction of apoptosis by genistein on HepG2 cell line显示文摘	Chodon D Ramamurty N Sakthisekaran D	2007	Texicology in vitro:an international journal published in assoeiation with BIBRA2007，21，5：	1
3	Preliminary studies on induction of apoptosis by genistein on HepG2 cell line显示文摘	CHODON D RAMAMURTY N SAKTHISEKARAN D	2007	Toxicol In Vitro2007，21，5：	1
4	Effect of dietary seleite on N-nitrososiethylamine-induced and phenobarbital promoted muhistade hepatocarcinogenesis in rat;reflection in some minerals显示文摘	Thirunavukkarasu C Sakthisekaran D	2003	Biomed Pharmacother2003，57，9：	1
5	Preliminary studies on induction of apoptosis by genistein on HepG2 cell line 显示文摘	Chodon D Ramamurty N Sakthisekaran D	2007	Toxicol In Vitro2007，21，5：	1
6	Effect of selenium on N-nitrosodiethylamine-induced multistage hepatocarcinogenesis with reference to lipid peroxidation and enzymic antioxidants显示文摘	Thirunavukkarasu C Sakthisekaran D	2001	Cell Biochem Funct2001，19，1：	1
7	Preliminary studies on induction of apoptosis by genistein on HepG2 cell line 显示文摘	Chodon D Ramamurty N Sakthisekaran D	2007	Toxicology in Vitro:an International Journal Published in Associ- ation with BIBRA2007，21，5：	1
8	In vivo effect of piperine on serum and tissue glycoprotein levels in benzo(a)pyrene induced lung carcinogenesis in Swiss albino mice显示文摘	Selvendiran K Prince Vijeya Singh J Sakthisekaran D	2006	Pulm Pharmacol Ther2006，19，2：	1
9	Chcmopreventive effect of piperine on modulating lipid peroxidation and membrane bound enzymes in benzo(a)pyrene induced lung carcinogenesis 显示文摘	Selvendiran K Sakthisekaran D	2004	Biomedecine & pharmacotherapie2004，58，4：	1
10	Cytoprotective effect of mangiferin on benzo(a)pyrene-induced lung carcinogenesis in swiss albino mice显示文摘	Rajendran P Ekambaram G Sakthisekaran D		0，，02：	1
11	Effect of vitamin E and taurine treatment on lipid peroxidation and antioxidant defense in perchloroethylene-induced cytoxicity in mice显示文摘	Ebrabin AS Sakthisekaran D	1997	Journal of Nutritional Biochemistry1997，8，5：	1
12	In vivo effect of piperine on serum and tissue glycoprotein levels in benzo (a) pyrene induced lung carcinogenesis in Swiss albino mice显示文摘	Selvendiran K Prince Vijeya Singh J Sakthisekaran D	2006	Pulm Pharmacol Ther2006，19，2：	1
13	Effect of vitamin E and taurine treatment on lipid peroxidation and antioxidant defense in perchloroethylene-induced cytotoxicity in mice显示文摘	Ebrahim AS Sakthisekaran D	1997	J Nutrit Biochem1997，8，5：	1
14	Therapeutic effect of paclitaxel and propolis on lipid peroxidation and antioxidant system in 7,12 dimethyl benz( a )anthracene-induced breast cancer in female Sprague Dawley rats显示文摘	Radhakrishnan Padmavathi Palaniyandi Senthilnathan Dechen Chodon Dhanapal Sakthisekaran	2005	Life Sciences2005，，24：	1
15	Effect of vitamin E and taurine treatment on lipid peroxidation and antioxidant defense in perchloroethylene-induced cytotoxicity in mice显示文摘	Ebrahim AS Sakthisekaran D	1997	Journal of Nutritional Biochemistry1997，8，5：	1
16	Influence ofsodium selenite on glycoprotein contents in normal andN-nitrosodiethylamine initiated and phenobarbitalpromoted rat liver tumors显示文摘	Thirunavukkarasu C Sakthisekaran D	2003	Pharmacological Research2003，48，2：	1
17	Protective effect of piperine on benzo(a)pyrene-induced lung carcinogenesis in Swiss albino mice显示文摘	Banu SM Sakthisekaran D	2004	Clin Chim Acta2004，350，12：	1
18	Effect of mangiferin on benzo(a)pyrene induced lung carcinogenesis in experimental Swiss albino mice显示文摘	Rajendran P Ekambaram G Sakthisekaran D	2008	Nat Prod Res2008，20，22：	1
19	Prelimi- nary studies on induction of apoptosis by genistein on HepG2 cell line 显示文摘	DECHEN C NALINI R SAKTHISEKARAN D	2007	Toxicology in Vitro2007，21，：	1
20	Preliminary studies on induction of apoptosis by genistein on HepG2 cell line显示文摘	Chodon D Rarnamurty N Sakthisekaran D	2007	Toxicol In Vitro2007，21，5：	1

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