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| 1 | Effectiveness of Saccharomyces boulardii in a rat model of colitis显示文摘AIM:To investigate the effects of Saccharomyces boulardii(S.boulardii) in an experimental rat model of trinitrobenzene sulfonic acid(TNBS)-induced colitis.METHODS:Thirty-two Wistar albino female rats were categorized into five groups.On the first day of the study,50 mg TNBS was administered via a rectal catheter in order to induce colitis in all rats,except those in the control group.For 14 d,the rats were fed a standard diet,without the administration of any additional supplements to either the control or TNBS groups,in addition to 1 mg/kg per day S.boulardii to the S.boulardii group,1 mg/kg per day methyl prednisolone(MP) to the MP group.The animals in the S.boulardii + MP group were coadministered these doses of S.boulardii and MP.During the study,weight loss,stool consistency,and the presence of obvious blood in the stool were evaluated,and the disease activity index(DAI) for colitis was recorded.The intestines were examined and colitis was macro-and microscopically scored.The serum and tissue levels of tumor necrosis factor-α(TNF-α) and nitric oxide(NO) were determined,and fungemia was evaluated in the blood samples.RESULTS:The mean DAI scores for the MP and S.boulardii + MP groups was significantly lower than the TNBS group(3.69 ± 0.61 vs 4.46 ± 0.34,P = 0.018 and 3.77 ± 0.73 vs 4.46 ± 0.34,P = 0.025,respectively).While no significant differences between the TNBS and the S.boulardii or MP groups could be determined in terms of serum NO levels,the level of serum NO in the S.boulardii + MP group was significantly higher than in the TNBS and S.boulardii groups(8.12 ± 4.25 μmol/L vs 3.18 ± 1.19 μmol/L,P = 0.013;8.12 ± 4.25 μmol/L vs 3.47 ± 1.66 μmol/L,P = 0.012,respectively).The tissue NO levels in the S.boulardii,MP and S.boulardii + MP groups were significantly lower than the TNBS group(16.62 ± 2.27 μmol/L vs 29.72 ± 6.10 μmol/L,P = 0.002;14.66 ± 5.18 μmol/Lvs 29.72 ± 6.10 μmol/L,P = 0.003;11.95 ± 2.34 μmol/Lvs 29.72 ± 6.10 μmol/L,P = 0.002,respectively).The tissue NO levels in the S.boulardii,MP and S.boulardii + MP groups were similar.The mean serum and tissue TNF-α levels were determined to be 12.97 ± 18.90 pg/mL and 21.75 ± 15.04 pg/mL in the control group,18.25 ± 15.44 pg/mL and 25.27 ± 11.95 pg/mL in the TNBS group,20.59 ± 16.15 pg/mL and 24.39 ± 13.06 pg/mL in the S.boulardii group,9.05 ± 5.13 pg/mL and 24.46 ± 10.85 pg/mL in the MP group,and 13.95 ± 10.17 pg/mL and 24.26 ± 10.37 pg/mL in the S.boulardii + MP group.Significant differences in terms of the levels of serum and tissue TNF-α and the macroscopic and microscopic scores were not found between the groups.S.boulardii fungemia was not observed in any of the rats.However,Candida fungemia was detected in one rat(14%) in the TNBS group,two rats(28%) in the S.boulardii group,three rats(50%) in the MP group,and three rats(42%) in S.boulardii + MP group.CONCLUSION:S.boulardii does not demonstrate considerable effects on the DAI,pathological scores,or cytokine levels but does decrease the tissue NO levels. | Mujde Soyturk Saba Mukaddes Saygili Huseyin Baskin Ozgul Sagol Osman Yilmaz Fatih Saygili Hale Akpinar | 2012 | World Journal of Gastroenterology2012，18，44： | 6 |
| 2 | Comparison of Milan and UCSF criteria for liver transplantation to treat hepatocellular carcinoma显示文摘AIM:To assess the validity of the Milan and University of California San Francisco(UCSF) criteria and examine the long-term outcome of orthotopic liver transplantation(OLT) in patients with hepatocellular carcinoma(HCC) in a single-center study.METHODS:This study is a retrospective review of prospectively collected data.Between 1998 and 2009,56 of 356 OLTs were performed in patients with HCC.Based on pathological examination of liver explants,patients were retrospectively categorized into 3 groups:Milan +(n = 34),Milan-/UCSF +(n = 7) and UCSF-(n = 14).RESULTS:Median follow-up period was 39.5(1-124) mo.The 5-year overall survival rates in the Milan +,Milan-/UCSF + and UCSF-groups were 87.7%,53.6% and 33.3%,respectively(P < 0.000).Within these groups,tumor recurrence was determined in 5.8%,14.3% and 40% of patients,respectively(P < 0.011).Additionally,the presence of microvascular invasion within the explanted liver had a negative effect on the 5-year disease free survival(74.7% vs 46.7%,P < 0.044).CONCLUSION:The Milan criteria are reliable in the selection of suitable candidates for OLT for the treatment of HCC.For cases of OLT involving living donors,the UCSF criteria may be applied. | Tarkan Unek Sedat Karademir Naciye Cigdem Arslan Tufan Egeli Gulsen Atasoy Ozgul Sagol Funda Obuz Ibrahim Astarcioglu | 2011 | World Journal of Gastroenterology2011，17，37： | 2 |
| 3 | Prognostic significance of matrix metalloproteinase-2, cathepsin D, and tenasein- C expression in colorectal carcinoma显示文摘 | Sis B Sagol O Kupelioglu A etal | 2004 | Pathol Res Pract2004，200，5： | 1 |
| 4 | Role of apoptosis,bcl-2 and bax protein expression in premature ruptureof fetal membranes显示文摘 | Sagol S Sagol O Ozkal S | 2002 | J Reprod Med2002，47，： | 1 |
| 5 | The importance of cyclin DI and Ki67 expression on the biological behavior of pancreatic adenocarcinomas显示文摘 | Lebe B Sagol O Ulukus C | 2004 | Pathol Res Pract2004，200，5： | 1 |
| 6 | Does angiogenesis predict recurrence in superficial transitional cell carcinoma of the bladder 显示文摘 | Sagol O Yorukogiu K Sis B | 2001 | Urology2001，57，5： | 1 |
| 7 | The effect of apoptotic activity, survivin, Ki-67, and P-glycoprotein expression on prognosis in pancreatic carcinoma 显示文摘 | Sagol O Yavuzsen T Oztop I | 2005 | Pancreas2005，30，4： | 1 |
| 8 | Combined Segmental and Focal Adenomyomatosis Involving the Body of the Gallbladder显示文摘 | Secil M Karasu S Sagol O | 2005 | J Clin Ultrasound2005，33，5： | 1 |
| 9 | Comparison of microvascularization in diagnostic needle biopsies and radical prostatectomies in prostate carcinoma显示文摘 | Sagol O Ozkara E | 1999 | Eur Urol1999，35，2： | 1 |
| 10 | The importance of cyclin D1andKi67expression on the biological behavior of pancreatic adenocar-cinomas显示文摘 | Lebe B Sagol O Ulukus C | 2004 | Pathol Res Pract2004，200，5： | 1 |
| 11 | The importance of cyclin D1 andKi - 67 expression on the biological behavior of pancreatic adeno-carcinomas 显示文摘 | Lebe B Sagol 0 Ulukus C | 2004 | Pathol Res Pract2004，200，5： | 1 |
| 12 | The importance of cyclin D1 and Ki67 expression on the biological behavior of pancreatic cadenocarcinomas显示文摘 | Lebe B Sagol O Ulukus C | 2004 | Pathol Res Pract2004，200，5： | 1 |
| 13 | Expression of transforming growth factor-beta-1 and p27Kip1 in pancreatic adenocarcinomas: relation with cell-cycle-associated proteins and clinicopathologic characteristics 显示文摘 | Culhaci N Sagol O Karademir S | 2005 | BMC Cancer2005，5，： | 1 |
| 14 | InGaAsP/InGaAs tandem cells for a solar cell configuration with more than three junctions显示文摘 | SZABO N SAGOL B E SEIDEL U | 2008 | Physica Status Solidi-Rapid Research Letters2008，2，6： | 1 |
| 15 | The immunohistochemical evaluation of VEGF in placenta biopsies of pregnancies complicated by preeclampsia显示文摘 | Fuat Akercan Teksin Cirpan M. Cosan Terek H. Tayfun Ozcakir Gulsen Giray Sermet Sagol Nedim Karadadas | 2008 | Archives of Gynecology and Obstetrics2008，，2： | 1 |
| 16 | Contribution of diffusion-weighted MRI to the differential diagnosis of hepatic masses显示文摘 | Obuz F Sagol O | 2007 | Diagn Interv Radiol2007，13，： | 1 |
| 17 | Comparison of the reduction of postoperative adhesions by two barriers, one solution, and two pharmacologic agents in the rat uterine model显示文摘 | Yoldemir T Sagol S Adakan S | 2002 | Fertil Steril2002，78，2： | 1 |
| 18 | Prognostic significance of matrix metalloproteinase-2,cathepsin D,and tenascin-C expression in colorectal carcinoma显示文摘 | Sis B Sagol O Kupeliou A | 2004 | Pathol Res Pract2004，200，： | 1 |
| 19 | Is rectal washout necessary in an- terior resection for rectal cancer A prospective clinical study 显示文摘 | Terzi C Unek T Sagol O | 2006 | World J Surg2006，30，2： | 1 |
| 20 | The importance of cyclin D1 and Ki67 expression on the biological behavior of pancreatic adenocarcinomas显示文摘 | Lebe B Sagol O Ulukus C | 2004 | Pathol Res Pract2004，200，5： | 1 |
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