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| 1 | Noncontrast-enhanced MRI-based Noninvasive Score for Portal Hypertension(CHESS1802):An International Multicenter Study显示文摘Background and Aims:This study aimed to determine the performance of the non-invasive score using noncontrastenhanced MRI(CHESS-DIS score)for detecting portal hy-pertension in cirrhosis.Methods:In this international multicenter,diagnostic study(ClinicalTrials.gov,NCT03766880),patients with cirrhosis who had hepatic venous pressure gradient(HVPG)measurement and noncontrast-enhanced MRI were prospectively recruited from four university hospitals in China(n=4)and Turkey(n=1)between December 2018 and April 2019.A cohort of patients was retrospectively recruited from a university hospital in Italy between March 2015 and November 2017.After segmentation of the liver on fat-suppressed T1-weighted MRI maps,CHESS-DIS score was calculated automatically by an in-house developed code based on the quantification of liver surface nodularity.Results:A total of 149 patients were included,of which 124 were from four Chinese hospitals(training cohort)and 25 were from two international hospitals(validation cohort).A positive correlation between CHESS-DIS score and HVPG was found with the correlation coefficients of 0.36(p<0.0001)and 0.55(p<0.01)for the training and validation cohorts,respectively.The area under the receiver operating characteristic curve of CHESS-DIS score in detection of clinically significant portal hypertension(CSPH)was 0.81 and 0.9 in the training and validation cohorts,respectively.The intra-class correlation coefficients for assessing the inter-and intra-observer agreement were 0.846 and 0.841,respectively.Conclusions:A non-invasive score using noncontrast-enhanced MRI was developed and proved to be significantly correlated with invasive HVPG.Besides,this score could be used to detect CSPH in patients with cirrhosis. | Yanna Liu Tianyu Tang NecatiÖrmeci Yifei Huang Jitao Wang Xiaoguo Li Zhiwei Li Weimin An Dengxiang Liu Chunqing Zhang Changchun Liu Jinqiang Liu Chuan Liu Guangchuan Wang Cristina Mosconi Alberta Cappelli Antonio Bruno Seray Akçalar EmrecanÇelebioğlu EvrenÜstüner Sadık Bilgiç Zeynep Ellik ÖzgünÖmer Asiller Lei Li Haijun Zhang Ning Kang Dan Xu Ruiling He Yan Wang Yang Bu Ye Gu Shenghong Ju Rita Golfieri Xiaolong Qi | 2021 | Journal of Clinical and Translational Hepatology2021，9，6： | 3 |
| 2 | Application of ultl~sonication or high-pressure extraction of flavonoids from litchi fruit pericarp 显示文摘 | PR~t~SAD K N YANG B ZI-L~ O M M | 2009 | J Food Process Eng2009，32，： | 1 |
| 3 | Fishing ground prediction using a knowledge-based expert system geographical information system model in the South and Central Sulawesi coastal waters of Indonesia 显示文摘 | Sadly M Hendiarti N Sachoemar S I | 2009 | International Journal of Remote Sensing2009，30，24： | 1 |
| 4 | Vascular complications after liver transplantation: evaluation with Doppler US显示文摘 | Sad?k Tamsel Gulgun Demirpolat Refik Killi Unal Ayd?n Murat K?l?c Murat Zeytunlu Mustafa Par?ldar Ismail Oran Hakan Ucar | 2007 | Abdominal Imaging2007，，3： | 1 |
| 5 | Induction of parthenogenetic haploid embryos after pollination by irradiated pollen in water melon显示文摘 | Sad N K Abak M Pitrat | 1994 | HortScience1994，29，10： | 1 |
| 6 | Low platelet count is associated with ductus arteriosus patency in preterm newborns显示文摘 | Alyamac Dizdar E Ozdemir R Sad F N | 2012 | Early Hum Dev2012，88，10： | 1 |
| 7 | Is bioaugmentation a feasible strategy for pollutant removal and site remediation 显示文摘 | SAD E F SPIROS N A | 2005 | Current Opinion in Microbiology2005，8，3： | 1 |
| 8 | Protective Effects of N-Acetylcysteine on Cyclosporine-A-Induced Nephrotoxicity显示文摘 | Mehmet Duru Ahmet Nacar Zafer Y?nden Güven Kuvand?k Mehmet Rami Helvac? Ahmet Ko? Ye?im Akayd?n Hüseyin ?ksüz Sad?k S??üt | 2008 | Renal Failure2008，，4： | 1 |
| 9 | Neural correlates of training-related memory improvement in adulthood and aging显示文摘 | Lars N Johan S Sad J | 2003 | PNAS2003，100，13： | 1 |
| 10 | Helminthic infections of laboratory animal house of Shiraz University of medical sciences and the potential risks of zoonotic infections for researchens显示文摘 | Tanideh N Sad Jjadi SM Mohammadzadeh T | 2010 | IR Red Crescent Med J2010，12，2： | 1 |
| 11 | Efciency of bumblebees on the yield and quality of eggplant and tomato grown in unheated glasshouses显示文摘 | Abak K gaftanogh O Sad N Paksoy M Yeninar H | 1995 | Acta Holt1995，421，： | 1 |
| 12 | Fishing ground prediction using a knowledge-based expert system geographical information system model in the South amt Central Sulawesi coastal waters of Indonesia显示文摘 | SADLY M HENDIARTI N SACHOEMAR S I | 2009 | International Journal of Remote Sensing2009，30，： | 1 |
| 13 | Stability of Pfluger's column with imperfections 显示文摘 | Atanackovic T M Sad N | 1987 | Journal of Applied Mathematics and Physics (ZAMP)1987，38，6： | 1 |
| 14 | Ecological specialization promotes diversity and diversification in the Eastern Mediterranean genus Ricotia (Brassicaceae)显示文摘Despite its amazing biodiversity,the Eastern Mediterranean remains a highly understudied region when compared with the Western Mediterranean,restricting our understanding of diversity across the entire Mediterranean.Here we use a combination of molecular markers and presence/absence data from all species of the Eastern Mediterranean genus Ricotia collected across its full geographic range to determine historical,ecological,and evolutionary factors responsible for lineage-specific diversification in the Eastern Mediterranean.Network analysis based on molecular data revealed a high genetic structure within all lineages,and phylogenetic reconstructions based on the multispecies coalescent showed that within-lineage diversification corresponded to the onset of the Mediterranean climate.Reconstruction of ancestral histories indicates that the genus originated within Anatolia and spread across the Eastern Mediterranean and Levant using the Taurus mountains.Ecological niche models suggest that local populations did not go through any major distributional shifts and have persisted in present-day habitats since the Last Glacial Maximum.Furthermore,niche differentiation tests revealed significant differences between closely related species and showed the main variables predicting species limits to be different for each species.Our results give crucial information on the patterns and processes shaping diversity in the Eastern Mediterranean and show the main factors promoting diversification to be local environmental dynamics and ecological specialization and not large-scale latitudinal movements,as often reported for southern Europe.By determining local and regional patterns of diversification in an Eastern Mediterranean genus,we further our understanding of the major trends influencing plant diversity in the Mediterranean basin as a whole. | Barış Özüdoğru Çağaşan Karacaoğlu Galip Akaydın Sadık Erik Klaus Mummenhoff İsmail Kudret Sağlam | 2022 | Journal of Systematics and Evolution2022，60，2： | 0 |
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