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| 1 | Fructose as a key player in the development of fatty liver disease显示文摘We aimed to investigate whether increased consumption of fructose is linked to the increased prevalence of fatty liver.The prevalence of nonalcoholic steatohepatitis(NASH) is 3% and 20% in nonobese and obese subjects,respectively.Obesity is a low-grade chronic inflam-m-atory condition and obesity-related cytokines such as interleukin-6,adiponectin,leptin,and tumor necrosis factor-α may play important roles in the developm-ent of nonalcoholic fatty liver disease(NAFLD).Additionally,the prevalence of NASH associated with both cirrhosis and hepatocellular carcinom-a was reported to be high am-ong patients with type 2 diabetes with or without obesity.Our research group previously showed that consumption of fructose is associated with adverse alterations of plasma lipid profiles and metabolic changes in m-ice,the Am-erican Lifestyle-Induced Obesity Syndrom-e m-odel,which included consum-ption of a high-fructose corn syrup in amounts relevant to that consum-ed by som-e Am-ericans.The observation reinforces the concerns about the role of fructose in the obesity epidem-ic.Increased availability of fructose(e.g.,high-fructose corn syrup) increases not only abnorm-al glucose flux but also fructose m-etabolism-in the hepatocyte.Thus,the anatomic position of the liver places it in a strategic buffering position for absorbed carbohydrates and am-ino acids.Fructose was previously accepted as a beneficial dietary com-ponent because it does not stim-ulate insulin secretion.However,since insulin signaling plays an important role in central m-echanism-s of NAFLD,this property of fructose m-ay be undesirable.Fructose has a selective hepatic m-etabolism,and provokes a hepatic stress response involving activation of c-Jun N-term-inal kinases and subsequent reduced hepatic insulin signaling.As high fat diet alone produces obesity,insulin resistance,and som-e degree of fatty liver with m-inim-al inflam-m-ation and no fibrosis,the fast food diet which includes fructose and fats produces a gene expression signature of increased hepatic fibrosis,inflam-m-ation,endoplasm-ic reticulumstress and lipoapoptosis.Hepatic de novo lipogenesis(fatty acid and triglyceride synthesis) is increased in patients with NAFLD.Stable-isotope studies showed that increased de novo lipogenesis(DNL) in patients with NAFLD contributed to fat accum-ulation in the liver and the developm-ent of NAFLD.Specifically,DNL was responsible for 26% of accum-ulated hepatic triglycerides and 15%-23% of secreted very low-density lipoprotein triglycerides in patients with NAFLD com-pared to an estim-ated less than 5% DNL in healthy subjects and 10% DNL in obese people with hyperinsulinem-ia.In conclusion,understanding the underlying causes of NAFLD form-s the basis for rational preventive and treatm-ent strategies of this m-ajor form-of chronic liver disease. | Metin Basaranoglu Gokcen Basaranoglu Tevfik Sabuncu Hakan Sentürk | 2013 | World Journal of Gastroenterology2013，19，8： | 14 |
| 2 | Comment on: Statin use and risk of diabetes mellitus显示文摘In manuscript named 'Statin use and risk of diabetes mellitus' by Chogtu et al, authors defined that pravastatin 40 mg/dL reduced the risk of diabetes by 30% in West of Scotland Coronary Prevention study. In fact, pravastatin 40 mg/d L reduced coronary heart disease risk approximately 30% in mentioned study. | Mehmet Ali Eren Tevfik Sabuncu Hüseyin Karaaslan | 2016 | World Journal of Diabetes2016，7，8： | 2 |
| 3 | An ant colony for solving budget unconstrained dynamic facility layout problem显示文摘 | BAYKASOGLU A DERELI T SABUNCU I | 2006 | Omega2006，34，4： | 1 |
| 4 | The clinical characteristics of latent autoimmune diabetes in adults and its relation with chronic complications in metabolically poor controlled Turkish patients with Type 2 diabetes mellitus显示文摘 | Ariken E Sabuncu T Ozer ZM | 2005 | J Diabetes Complications2005，19，： | 1 |
| 5 | Hydrodynamic coefficients for vertical cir cular cylinders at finite depth 显示文摘 | Sabuncu T Calisal S | 1981 | Ocean Engineering1981，，8： | 1 |
| 6 | An ant colony algorithm for solving budget constrained and unconstrained dynamic facility layout problems显示文摘 | BAYKASOGLU A DERELI T SABUNCU I | 2006 | International Journal of Management Science2006，34，4： | 1 |
| 7 | Oxidative stress in polycystic ovary syndrome and its contribution to the risk of cardiovascular disease显示文摘 | Sabuncu T Vural H Harma M | 2001 | Clin Biochem2001，34，5： | 1 |
| 8 | A generative model for image segmentation based on label fusion 显示文摘 | Sabuncu M R Yeo B T T Van Leemput K | 2010 | IEFE Transactions on Medical Imaging2010，29，10： | 1 |
| 9 | Sihutramine has a posi- tive effect on clinical and metabolic parameters in obese patients with polycystic ovary syndrome 显示文摘 | Sabuncu T Harma M Nazlignl Y | 2003 | Fert Steril2003，80，5： | 1 |
| 10 | Melatonin Inhibits Lipid per-Oxidation and Stimulates the Antioxidant Status of Diabetic Rats显示文摘 | Vural H Sabuncu T Arslan S O | 2001 | JPined Res2001，31，3： | 1 |
| 11 | An ontology-based retrieval system using semantic indexing 显示文摘 | KARA S ALAN O SABUNCU O | 2012 | Information Systems2012，37，4： | 1 |
| 12 | The dynamics of cortical and hippocampal atrophy in Alzheimer disease显示文摘 | SABUNCU M R DESIKAN R S SEPULCRE J | 2011 | ArchNeurol2011，68，8： | 1 |
| 13 | Using spanning graphs for efficient image registration 显示文摘 | Sabuncu M R Ramadge P | 2008 | IEEE Trans on Image Processing2008，17，5： | 1 |
| 14 | Hydrodynamic coefficients for vertical circular cylinders atfinite depth显示文摘 | Tafik Sabuncu Sander Calisal | 1981 | Ocean Engineering1981，8，1： | 1 |
| 15 | Hydrodynamic coefficients for vertical circular zylinder at finite depth 显示文摘 | Sabuncu T Calisal S | 1981 | Ocean Engineering1981，，8： | 1 |
| 16 | Hydrodynamic coefficients for vertical compos- ite cylinders显示文摘 | Ealisal S Sabuncu T | 1984 | Ocean Engineering1984，11，5： | 1 |
| 17 | Quantum optical coherence can survive photon losses using a continuous-variable quantum erasure-correcting code显示文摘 | Lassen M Sabuncu M Huck A | | 0，，10： | 1 |
| 18 | Hydrodynamic coefficients for vertical circular cylinders at f'mite depth显示文摘 | SABUNCU T CALISAL S | 1981 | Ocean Engineering1981，，8： | 1 |
| 19 | An Ontology-Based Retrieval System Using Semantic Indexing显示文摘 | Soner Kara Ozgur Alan Orkunt Sabuncu Samet Akpinar Nihan K.Cicekli Ferda N.Alpaslan | | 0，，： | 1 |
| 20 | An ant colo- ny algorithm for solving budget constrained and unconstrained dynamic facility layout problems显示文摘 | BAYKASOGLU A DERELI T SABUNCU I | 2006 | The International Jour- nal of Management Science2006，34，4： | 1 |
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