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	题名	作者	年代	出处	被引量
1	Anti-rods/rings autoantibody generation in hepatitis Cpatients during interferon-α/ribavirin therapy显示文摘Chronic inflammation associated with hepatitis C virus(HCV) infection can lead to disabling liver diseases with progression to liver cirrhosis and hepatocellular carcinoma. Despite the recent availability of more effective and less toxic therapeutic options, in most parts of the world the standard treatment consists of a weekly injection of pegylated interferon α(IFN-α) together with a daily dose of ribavirin. HCV patients frequently present circulating non-organ-specific autoantibodies demonstrating a variety of staining patterns in the indirect immunofluorescence assay for antinuclear antibodies(ANA). Between 20% to 40% of HCV patients treated with IFN-α and ribavirin develop autoantibodies showing a peculiar ANA pattern characterized as rods and rings(RR) structures. The aim of this article is to review the recent reports regarding RR structures and anti-rods/rings(antiRR) autoantibody production by HCV patients after IFN-α/ribavirin treatment. Anti-RR autoantibodies first appear around the sixth month of treatment and reach a plateau around the twelfth month. After treatment completion, anti-RR titers decrease/disappear in half the patients and remain steady in the other half. Some studies have observed a higher frequency of anti-RR antibodies in relapsers, i.e., patients in which circulating virus reappears after initially successful therapy. The main target of anti-RR autoantibodies in HCV patients is inosine-5'-monophosphate dehydrogenase 2(IMPDH2), the rate-limiting enzyme involved in the guanosine triphosphate biosynthesis pathway. Ribavirin is a direct IMPDH2 inhibitor and is able to induce the formation of RR structures in vitro and in vivo. In conclusion, these observations led to the hypothesis that anti-RR autoantibody production is a human model of immunologic tolerance breakdown that allows us to explore the humoral autoimmune response from the beginning of the putative triggering event: exposure to ribavirin and interferon.	Gerson Dierley Keppeke S John Calise Edward KL Chan Luis Eduardo C Andrade	2016	World Journal of Gastroenterology2016，22，6：	4
2	Nonlinear flight control using neural networks显示文摘	Kim B S Calise A J	1997	Joumal of Guidance Control and Dynamics1997，20，1：	1
3	Hydrodynamic coefficients for vertical cir cular cylinders at finite depth 显示文摘	Sabuncu T Calisal S	1981	Ocean Engineering1981，，8：	1
4	Nonlinear flight control using neural networks 显示文摘	Byoung S Kim Athony J Calise	1997	Journal of Guidance Control and Dynamics1997，20，1：	1
5	Three-dimensional effects and arm effects on modeling a vertical axis tidal current turbine显示文摘	LI Y CALISAL S	2010	Renewable Energy2010，35，10：	1
6	Nonlinear flight control using neural networks显示文摘	Calise A J	1997	Journal of Guidance Control and Dynamics1997，20，1：	1
7	Nonlinear Flight Control Using Neural Networks显示文摘	Kim B S Calise A J	1997	AIAA J of Guidance Control and Dynamics1997，20，1：	1
8	Nonlinear Flight Control Using Neural Networks 显示文摘	Kim B S Calise A J	1997	Journal of Guidance Control and Dynamics1997，20，1：	1
9	Hydrodynamic coefficients for vertical circular zylinder at finite depth 显示文摘	Sabuncu T Calisal S	1981	Ocean Engineering1981，，8：	1
10	Development of a Recon Figurable Flight Control Law for Tailess Aircraft显示文摘	Calise A J Lee S Sharma M	2001	AIAA J of Guidance Control and Dynamics2001，24，5：	1
11	Singular Perturbations and Time Scales in Guidance and Control of Aerospace Systems:A Survey显示文摘	Naidu D S Calise A J	2001	Journal of Guidance Control and Dynamics2001，24，6：	1
12	Biodegradable microspheres as depot system for parenteral delivery ofpeptide drugs显示文摘	Mehta R Jeyanthi R Calis S		0，，3：	1
13	Adsorption of salmon calcitonin to PLGA microspheres显示文摘	Calis S Jeyanthi R Tsai T		0，，7：	1
14	Nonlinear flight control using neural networks 显示文摘	Kim B S Calise A J	1997	Journal of Guidance Control and Dynamics1997，20，1：	1
15	Three-dimensional effects and arm effects on modeling a vertical axis tidal current turbine显示文摘	Li Y Calisal S M	2010	Renewable Energy2010，35，10：	1
16	Development of a reconfigurable flight control law for tailless aircraft 显示文摘	Calise A J Lee S Sharma M	2001	AIAA Journal of Guidance Control and Dynamics2001，24，5：	1
17	Three-dimensional effects and arm effects on modeling a vertical axis tidal current tur- bine显示文摘	Li Y Calisal S	2010	Renewable Energy2010，35，10：	1
18	Hydrodynamic coefficients for vertical circular cylinders at f'mite depth显示文摘	SABUNCU T CALISAL S	1981	Ocean Engineering1981，，8：	1
19	Guidance laws for spacecraft pursuit-evasion and rendezvous 显示文摘	Menon P K A Calise A J Leung S K M	1988	AIAA Journal1988，4134，：	1
20	Singular perturbations and time scales in guidance and control of aerospace systems: a survey显示文摘	Naidu D S Calise A J	2001	AIAA Journal of Guidance Control and Dynamics2001，24，6：	1

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