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| 1 | Expression of Notch pathway components (Numb, Itch, and Siah-1) in colorectal tumors: A clinicopathological study显示文摘BACKGROUND The role of the Notch pathway in carcinogenesis and tumor progression has been demonstrated in many organs,including the colon.Accordingly,studies aimed at developing therapies targeting this pathway in various cancers require the identification of several factors that may play a role in regulating Notch-1 expression.Although Numb,Itch,and seven in absentia homolog-1(Siah-1)have been shown to contribute to the regulation of Notch signaling,their role in colorectal carcinogenesis and tumor progression has not been fully elucidated to date.AIM To evaluate Numb,Itch,and Siah-1 expression in colorectal tumors to clarify their relationship with Notch-1 expression and their role in carcinogenesis and tumor behavior.METHODS Expression of Notch-1,Numb,Itch,and Siah-1 was investigated in 50 colorectal carcinomas,30 adenomas,and 20 healthy colonic tissues by immunohistochemistry and quantitative real-time polymerase chain reaction(PCR)analyses.RESULTS In contrast to Notch-1,which is expressed at higher levels in tumor tissues and adenomas,expression of Numb,Itch,and Siah-1 was stronger and more frequent in normal mucosa(P<0.01).There was a positive correlation between Notch-1 expression and high histological grade,the presence of lymph node metastasis,and advanced-stage tumors,whereas expression of Numb,Itch,and Siah-1 was absent or reduced in tumors with these clinicopathological parameters(P<0.05).In survival analysis,expression of Notch was related to poor prognosis but that of Numb,Itch,and Siah-1 correlated with improved survival(P<0.05).Multivariate analysis revealed Notch-1 expression and loss of Numb expression to be independent prognostic parameters together with lymph node metastasis(P<0.05).CONCLUSION Our findings support the role of Notch-1 in colorectal carcinoma and indicate that loss of Numb,Itch,and Siah-1 expression is associated with carcinogenesis.Our data also suggest that these three proteins might be involved in the Notch-1 pathway during colorectal carcinoma(CRC)progression and might play an essential role in approaches targeting Notch as novel molecular therapies for CRC. | Sinem Cil Gonulcu Betul Unal Ibrahim Cumhur Bassorgun Mualla Ozcan Hasan Senol Coskun Gulsum Ozlem Elpek | 2020 | World Journal of Gastroenterology2020，26，26： | 5 |
| 2 | Sertraline-induced reproductive toxicity in male rats: evaluation of possible underlying mechanisms显示文摘 | Ozlem Atli Merve Baysal Gozde Aydogan-Kilic Volkan Kilic Seyda Ucarcan Burak Karaduman Sinem Ilgin | 2017 | Asian Journal of Andrology2017，19，6： | 4 |
| 3 | Eicosanoid pathway in colorectal cancer:Recent updates显示文摘Enzymatic metabolism of the 20 C polyunsaturated fatty acid(PUFA) arachidonic acid(AA) occurs via the cyclooxygenase(COX) and lipoxygenase(LOX) pathways, and leads to the production of various bioactive lipids termed eicosanoids. These eicosanoids have a variety of functions, including stimulation of homeostatic responses in the cardiovascular system, induction and resolution of inflammation, and modulation of immune responses against diseases associated with chronic inflammation, such as cancer. Because chronic inflammation is essential for the development of colorectal cancer(CRC), it is not surprising that many eicosanoids are implicated in CRC. Oftentimes, these autacoids work in an antagonistic and highly temporal manner in inflammation; therefore, inhibition of the pro-inflammatory COX-2 or 5-LOX enzymes may subsequently inhibit the formation of their essential products, or shunt substrates from one pathway to another, leading to undesirable side-effects. A better understanding of these different enzymes and their products is essential not only for understanding the importance of eicosanoids, but also for designing more effective drugs that solely target the inflammatory molecules found in both chronic inflammation and cancer. In this review, we have evaluated the cancer promoting and anti-cancer roles of different eicosanoids in CRC, and highlighted the most recent literature which describes how those molecules affect not only tumor tissue, but also the tumor microenvironment. Additionally, we have attempted to delineate the roles that eicosanoids with opposing functions play in neoplastic transformation in CRC through their effects on proliferation, apoptosis, motility, metastasis, and angiogenesis. | Sinem Tuncer Sreeparna Banerjee | 2015 | World Journal of Gastroenterology2015，21，41： | 4 |
| 4 | Channel Estimation Techniques Based on Pilot Arrangement in OFDM Systems显示文摘 | Sinem Coleri Mustafa Ergen Anuj Puri | | 0，，48： | 1 |
| 5 | Ion-imprinted beads for molecular recognition based mercury removal from human serum显示文摘 | Muge Andac Sinem Mirel Serap Senel | 2007 | International Journal of Biological Macromolecules2007，40，： | 1 |
| 6 | Gradual detorsion of torsioned rat testis attenuates ischemia reperfusion injury显示文摘 | Bülent Ak?ora Muhammed E. Altu? Ali Balc? Sibel Hakverdi Zafer Y?nden Ali Akba? Atakan ?ztürk Sinem Karazincir Hüseyin ?zyurt | 2008 | Journal of Pediatric Surgery2008，，10： | 1 |
| 7 | Relationshipofsocioeconomicstatuswithhealthbehaviorsandself-perceivedhealthintheelderly:acommunity-basedstudy,Turkey显示文摘 | HaticeS Sinem D RefikB etal | 2013 | GeriatrGerontolInt2013，10，： | 1 |
| 8 | Channel estimation techniques based on pilot arrangement in OFDM systems显示文摘 | Sinem Coleri Mustafa Ergen Anuj Puri Ahmad Bahai | 2002 | IEEE Transactions on Broadcasting2002，48，3： | 1 |
| 9 | Channel estimation techniques based on pilot arrangement in OFDM Systems显示文摘 | Sinem Coleri Mustafa Ergen Anuj Puri | 2002 | IEEE Transactions on Broadcasting2002，48，3： | 1 |
| 10 | Evaluation of the turbinate hypertrophy by computed tomography in patients with deviated nasal septum显示文摘 | Ertap Akog lu Sinem Karazincir Ali Balc | 2007 | Otolaryngology-Head and Neck Surgery2007，136，3： | 1 |
| 11 | Modifying In- terpretation in a Clinically Depressed Sample Using Cog- nitive Bias Modification-Errors': A Double Blind Random- ized Controlled Trial 显示文摘 | JENNY Y JONG S L SINEM T | 2014 | Cognitive Therapy and Re- search2014，38，2： | 1 |
| 12 | The Serum protein and lipid oxidation marker levels in Alzheimer's disease and effects of cholinesterase inhibitors and antipsychotic drugs therapy显示文摘 | Sinem F Dildar K Gfikhan E | 2010 | Curr Alzheimer Res2010，7，： | 1 |
| 13 | Traffic Measurementand Vehicle Classification with a Single MagneticSensor 显示文摘 | SING Y C SINEM C BARIS D | 2005 | Journal of the Transportation ResearchBoard2005，1917，： | 1 |
| 14 | Channel Esfimarion Techniques Based on Pilot Arrangement in OFDM Systems显示文摘 | Sinem Coleri Mustafa Ergen Anuj Puri | 2002 | IEEE Transactions on Broadcasting2002，48，22： | 1 |
| 15 | Channel Estimation Techniques Based on Pilot Arrange ment in OFDM Systems显示文摘 | Coleri Sinem Ergen Mustafa Purl Anuj | 2002 | IEEE Transactions on Broadcast2002，48，3： | 1 |
| 16 | Comparison of com- posite whole body insulin sensitivity index derived {rom mixed meal test and oral glucose tolerance test in insulin resistant obese subjects显示文摘 | Hadi S Cevdet D Sinem K | 2009 | Endocr2009，36，： | 1 |
| 17 | Adsorption characteristics of sulfamethoxazole and metronidazole on activated carbon显示文摘 | ?al??kan Elif G?ktürk Sinem | 2010 | Separ Sci Technol2010，45，2： | 1 |
| 18 | Channel estimation techniques based on pilot arrangement in OFDM Systems 显示文摘 | Sinem Coleri Mustatfa Ergen Anuj Puri | 2002 | IEEE Transactions on Broad - casting2002，48，3： | 1 |
| 19 | Quadruple Thinking: Hopeful Thinking显示文摘 | Sinem Tarhan Hasan Bacanl? Mehmet Ali Dombayc? Metin Demir | 2011 | Procedia - Social and Behavioral Sciences2011，，： | 1 |
| 20 | Tongue Pressure Changes Before, During and After Crib Appliance Therapy显示文摘 | Sinem Taslan Sibel Biren Cenk Ceylanoglu | 2010 | Angle Orthodontist2010，80，3： | 1 |
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