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| 1 | Photodynamic therapy prolongs metal stent patency in patients with unresectable hilar cholangiocarcinoma显示文摘AIM:To evaluate the effect of photodynamic therapy (PDT) on metal stent patency in patients with unresectable hilar cholangiocarcinoma (CC). METHODS:This was a retrospective analysis of patients with hilar CC referred to our institution from December, 1999 to January, 2011. Out of 232 patients, thirty-three patients with unresectable hilar CC were treated. Eighteen patients in the PDT group were treated with uncovered metal stents after one session of PDT. Fifteen patients in the control group were treated with metal stents alone. Porfimer sodium (2 mg/kg) was administered intravenously to PDT patients. Fortyeight hours later, PDT was administered using a diffusing fiber that was advanced across the tumor by either endoscopic retrograde cholangiopancreatography or percutaneous cholangiography. After performance of PDT, uncovered metal stents were inserted to ensure adequate decompression and bile drainage. Patient survival rates and cumulative stent patency were calculated using Kaplan-Meier analysis with the log-rank test. RESULTS:The PDT and control patients were comparable with respect to age, gender, health status, pretreatment bilirubin, and hilar CC stage. When compared to control, the PDT group was associated with significantly prolonged stent patency (median 244 ± 66 and 177 ± 45 d, respectively, P = 0.002) and longer patient survival (median 356 ± 213 and 230 ± 73 d, respectively, P = 0.006). Early complication rates were similar between the groups (PDT group 17%, control group 13%) and all patients were treated conservatively. Stent malfunctions occurred in 14 PDT patients (78%) and 12 control patients (80%). Of these 26 patients, twenty-two were treated endoscopically and four were treated with external drainage. CONCLUSION:Metal stenting after one session of PDT may be safe with acceptable complication rates. The PDT group was associated with a significantly longer stent patency than the control group in patients with unresectable hilar CC. | Tae Yoon Lee Young Koog Cheon Chan Sup Shim Young Deok Cho | 2012 | World Journal of Gastroenterology2012，18，39： | 28 |
| 2 | Right trisegmentectomy with thoracoabdominal approach after transarterial embolization for giant hepatic hemangioma显示文摘Hepatic hemangiomas need to be treated surgically in cases where they are accompanied with symptoms, have a risk of rupture, or are hardly distinguishable from malignancy. The present authors conducted embolization of the right hepatic artery one day before an operation for a huge hemangioma accompanied with symptoms and confirmed a decrease in its size. The authors performed a right trisegmentectomy through a J-shape incision, using a thoracoabdominal approach, and safely removed a giant hemangioma of 32.0 cm × 26.5 cm × 8.0 cm in size and 2300 g in weight. Even for inexperienced surgeons, a J-shape incision with a thoracoabdominal approach is considered a safe and useful method when right-side hepatectomy is required for a large mass in the right liver. | Hyung-Il Seo Hong Jae Jo Mun Sup Sim Suk Kim | 2009 | World Journal of Gastroenterology2009，15，27： | 22 |
| 3 | Occult hepatitis B virus infection and blood transfusion显示文摘Transfusion-transmitted infections including hepatitis B virus(HBV) have been a major concern in transfusion medicine. Implementation of HBV nucleic acid testing(NAT) has revealed occult HBV infection(OBI) in blood donors. In the mid-1980 s, hepatitis B core antibody(HBc) testing was introduced to screen blood donors in HBV non-endemic countries to prevent transmission of non-A and non-B hepatitis. That test remains in use for preventing of potential transmission of HBV from hepatitis B surface antigen(HBs Ag)-negative blood donors, even though anti-hepatitis C virus testshave been introduced. Studies of anti-HBc-positive donors have revealed an HBV DNA positivity rate of 0%-15%. As of 2012, 30 countries have implemented HBV NAT. The prevalence of OBI in blood donors was estimated to be 8.55 per 1 million donations, according to a 2008 international survey. OBI is transmissible by blood transfusion. The clinical outcome of occult HBV transmission primarily depends on recipient immune status and the number of HBV DNA copies present in the blood products. The presence of donor anti-HBs reduces the risk of HBV infection by approximately five-fold. The risk of HBV transmission may be lower in endemic areas than in non-endemic areas, because most recipients have already been exposed to HBV. Blood safety for HBV, including OBI, has substantially improved, but the possibility for OBI transmission remains. | Dong Hee Seo Dong Hee Whang Eun Young Song Kyou Sup Han | 2015 | World Journal of Hepatology2015，7，3： | 13 |
| 4 | Endoscopic ultrasonography does not differentiate neoplastic from non-neoplastic small gallbladder polyps显示文摘AIM:To assess the ability of endoscopic ultrasonography(EUS) to differentiate neoplastic from non-neoplastic polypoid lesions of the gallbladder(PLGs) .METHODS:The uses of EUS and transabdominal ultrasonography(US) were retrospectively analyzed in 94 surgical cases of gallbladder polyps less than 20 mm in diameter.RESULTS:The prevalence of neoplastic lesions with a diameter of 5-10 mm was 17.2%(10/58) ;11-15 mm,15.4%(4/26) ,and 16-20 mm,50%(5/10) .The overall diagnostic accuracies of EUS and US for small PLGs were 80.9% and 63.9%(P < 0.05) ,respectively.EUS correctly distinguished 12(63.2%) of 19 neoplastic PLGs but was less accurate for polyps less than 1.0 cm(4/10,40%) than for polyps greater than 1.0 cm(8/9,88.9%) (P = 0.02) .CONCLUSION:Although EUS was more accurate than US,its accuracy for differentiating neoplastic from non-neoplastic PLGs less than 1.0 cm was low.Thus,EUS alone is not suffi cient for determining a treatment strategy for PLGs of less than 1.0 cm. | Young Koog Cheon Won Young Cho Tae Hee Lee Young Deok Cho Jong Ho Moon Joon Seong Lee Chan Sup Shim | 2009 | World Journal of Gastroenterology2009，15，19： | 12 |
| 5 | Self-expandable metallic stents for palliation of patients with malignant gastric outlet obstruction caused by stomach cancer显示文摘AIM: To ascertain clinical outcome and complications of self-expandable metal stents for endoscopic palliation of patients with malignant obstruction of the gastrointestinal (GI) tract. METHODS: A retrospective review was performed throughout August 2000 to June 2005 of 53 patients with gastric outlet obstruction caused by stomach cancer. All patients had symptomatic obstruction including nausea, vomiting, and decreased oral intake. All received self-expandable metallic stents. RESULTS: Stent implantation was successful in all 53 (100%) patients. Relief of obstructive symptoms was achieved in 43 (81.1%) patients. No immediate stent-related complications were noted. Seventeen patients had recurrent obstruction (tumor ingrowth in 14 patients, tumor overgrowth in 1 patient, and partial distal stent migration in 2 patients). The mean survival was 145 d. Median stent patency time was 187 d. CONCLUSION: Endoscopic placement of self-expandable metallic stents is a safe and effective treatment for the palliation of patients with inoperable malignant gastric outlet obstruction caused by stomach cancer. | Tae Oh Kim Dae Hwan Kang Gwang Ha Kim Jeong Heo Geun Am Song Mong Cho Dong Heon Kim Mun Sup Sim | 2007 | World Journal of Gastroenterology2007，13，6： | 11 |
| 6 | Quantum phase transition and entanglement in Li atom system显示文摘By use of the exact diagonalization method, the quantum phase transition and en- tanglement in a 6-Li atom system are studied. It is found that entanglement appears before the quantum phase transition and disappears after it in this exactly solvable quantum system. The present results show that the von Neumann entropy, as a measure of entanglement, may reveal the quantum phase transition in this model. | SI LiMing1 & HOU JiXuan2 1 Department of Electronic Engineering, School of Information Science and Technology, Beijing Institute of Technology, Beijing 100081, China 2 Laboratoire de Chimie, UMR 5182 CNRS, Ecole Normale Supérieure de Lyon, 46, Allée d’Italie, F-69364 Lyon Cedex 07, France | 2008 | Science China(Physics,Mechanics & Astronomy)2008，51，11： | 6 |
| 7 | Differential diagnosis of left-sided abdominal pain:Primary epiploic appendagitis vs colonic diverticulitis显示文摘AIM:To investigate the clinical characteristics of left primary epiploic appendagitis and to compare them with those of left colonic diverticulitis.METHODS:We retrospectively reviewed the clinical records and radiologic images of the patients who presented with left-sided acute abdominal pain and had computer tomography(CT) performed at the time of presentation showing radiological signs of left primary epiploic appendagitis(PEA) or left acute colonic diverticulitis(ACD) between January 2001 and December 2011. A total of 53 consecutive patients were enrolled and evaluated. We also compared the clinical characteristics,laboratory findings,treatments,and clinical results of left PEA with those of left ACD.RESULTS:Twenty-eight patients and twenty-five patients were diagnosed with symptomatic left PEA and ACD,respectively. The patients with left PEA had focal abdominal tenderness on the left lower quadrant(82.1%). On CT examination,most(89.3%) of the patients with left PEA were found to have an oval fatty mass with a hyperattenuated ring sign. In cases of left ACD,the patients presented with a more diffuse abdominal tenderness throughout the left side(52.0%vs 14.3%; P = 0.003). The patients with left ACD had fever and rebound tenderness more often than those with left PEA(40.0% vs 7.1%,P = 0.004; 52.0% vs14.3%,P = 0.003,respectively). Laboratory abnormalities such as leukocytosis were also more frequently observed in left ACD(52.0% vs 15.4%,P = 0.006).CONCLUSION:If patients have left-sided localized abdominal pain without associated symptoms or laboratory abnormalities,clinicians should suspect the diagnosis of PEA and consider a CT scan. | Jeong Ah Hwang Sun Moon Kim Hyun Jung Song Yu Mi Lee Kyung Min Moon Chang Gi Moon Hoon Sup Koo Kyung Ho Song Yong Seok Kim Tae Hee Lee Kyu Chan Huh Young Woo Choi Young Woo Kang Woo Suk Chung | 2013 | World Journal of Gastroenterology2013，19，40： | 6 |
| 8 | Acute mediastinitis arising from pancreatic mediastinal fistula in recurrent pancreatitis显示文摘Acute mediastinitis is a fatal disease that usually originates from esophageal perforation and surgical infection.Rare cases of descending necrotizing mediastinitis can occur following oral cavity and pharynx infection or can be a complication of pancreatitis.The most common thoracic complications of pancreatic disease are reactive pleural effusion and pneumonia,while rare complications include thoracic conditions,such as pancreaticopleural fistula with massive pleural effusion or hemothorax and extension of pseudocyst into the mediastinum.There have been no reports of acute mediastinitis originating from pancreatitis in South Korea.In this report,we present the case of a 50-year-old female suffering from acute mediastinitis with pleural effusion arising from recurrent pancreatitis that improved after surgical intervention. | In Soo Choe Yong Seok Kim Tae Hee Lee Sun Moon Kim Kyung Ho Song Hoon Sup Koo Jung Ho Park Jin Sil Pyo Ji Yeong Kim In Seok Choi | 2014 | World Journal of Gastroenterology2014，20，40： | 6 |
| 9 | Adeno-associated virus mediated endostatin gene therapy in combination with topoisomerase inhibitor effectively controls liver tumor in mouse model显示文摘rAAV mediated endostatin gene therapy has beenexamined as a new method for treating cancer. However,a sustained and high protein delivery is required to achievethe desired therapeutic effects. We evaluated the impactof topoisomerase inhibitors in rAAV delivered endostatingene therapy in a liver tumor model. | SungYiHong MyunHeeLee WooJinHyung SungHoonNoh SeungHoChoi Kyung Sup Kim HyunCheolJung JaeKyungRoh | 2004 | World Journal of Gastroenterology2004，10，8： | 6 |
| 10 | How to improve patient satisfaction during midazolam sedation for gastrointestinal endoscopy?显示文摘AIM To determine the procedure-related factors that affect sedation satisfaction and to make a suggestion to improve it.METHODS We prospectively enrolled a total of 456 patients who underwent outpatient endoscopy procedures with midazolam sedation between March 2014 and August 2014. All patients completed both pre- and postendoscopy questionnaires about sedation expectations and satisfaction. RESULTS The study cohort included 167 (36.6%) patients whounderwent esophagogastroduodenoscopy (EGD), 167 (36.6%) who underwent colonoscopy, and 122(26.8%) who underwent a combined procedure (EGD and colonoscopy). Over 80% of all patients were satisfied with sedation using midazolam. In univariate and multivariate analyses, total procedure time in the EGD group, younger age (≤ 50 years), and longer colonoscopy withdrawal time in the colonoscopy group were related to decreased satisfaction with sedation. However, in active monitoring and intervention group, there was no decrease in grade of satisfaction despite longer procedure time due to more procedures during colonoscopy. Younger age (≤ 50 years), longer interprocedure time gap, and colonoscopy withdrawal time were related to decreased satisfaction in the combined EGD and colonoscopy group. CONCLUSION Midazolam is still a safe and effective sedative for gastrointestinal endoscopy. Satisfaction with sedation depends on several factors including age(≤ 50 years) and procedure time duration. To improve patient satisfaction with sedation, active monitoring of sedation status by the endoscopist should be considered for patients who require long procedure time. | Eun Hyo Jin Kyoung Sup Hong Young Lee Ji Yeon Seo Ji Min Choi Jaeyoung Chun Sang Gyun Kim Joo Sung Kim Hyun Chae Jung | 2017 | World Journal of Gastroenterology2017，23，6： | 6 |
| 11 | xMax的类正弦波调制技术显示文摘通过对xMax技术指标的分析,阐述了实现xMax的方法.在此基础上提出了一种能实现xMax的类正弦波调制技术.该调制技术通过对类正弦波信号的单周期调制,实现信号对信息的携带,且能达到xMax主带宽窄、边带功率谱密度低、发射功率低、传输速率高等性能指标.通过理论分析和仿真验证,该调制技术功率谱主峰值带宽为300 kHz;边带功率谱密度比峰值功率谱低40 dB,使边带能很好地隐藏在背景噪声中;传输速率达到7.5 Mbit/s. | 赵成仕 王树彬 杨程 KWAK Kyung Sup 周正 | 2007 | 北京邮电大学学报2007，30，6： | 5 |
| 12 | Experimental investigation of friction coefficient in tube hydroforming显示文摘The friction coefficient between tube and die in guide zone of tube hydroforming was obtained. In hydroforming, the tube is expanded by an internal pressure against the tool wall. By pushing the tube through tool, a friction force at the contact surface between the tube and the tool occurs. In guiding zone, the friction coefficients between tube and die can be estimated from the measured axial feeding forces. In expansion zone, the friction coefficients between tube and die can be evaluated from the measured geometries of expanded tubes and FE analysis. | Hyae Kyung YI Hong Sup YIM Gun Yeop LEE Sung Mun LEE Gi Suk CHUNG Young-Hoon MOON | 2011 | Transactions of Nonferrous Metals Society of China2011，21，A01： | 5 |
| 13 | Aggregation-induced emission (ALE) dye loaded polymer nanoparticles for gene silencing in pancreatic cancer and their in vitro and in vivo biocompatibility evaluation显示文摘 | Rui Hu Chengbin Yang Yucheng Wang Guimiao Lin Wei Qin Qingling Ouyang Wing-Cheung Law Quoc Toan Nguyen Ho Sup Yoon Xiaomei Wang Ken-Tye Yong Ben Zhong Tang | 2015 | Nano Research2015，8，5： | 4 |
| 14 | Bevacizumab as a second- or later-line of treatment for metastatic colorectal cancer显示文摘AIM: To determine the efficacy of bevacizumab in patients with metastatic colorectal cancer (MCRC) who have failed prior chemotherapy without bevacizumab. METHODS: Between March 2002 and June 2010, 40 patients in South Korea with MCRC who were treated with bevacizumab plus chemotherapy as a second or later-line treatment were analyzed retrospectively for their overall response rate (ORR), overall survival (OS), and progression-free survival (PFS). The tumor responses were assessed using the RECIST (Response Evaluation Criteria in Solid Tumors) guidelines. RESULTS: All of the patients had progressed under prior chemotherapy without bevacizumab. Three patients (7.5%) exhibited an ORR, twenty one patients (52.5%) exhibited stable disease (SD), and fifteen patients (37.5%) exhibited disease progression. The median duration of the OS and PFS were 14.0 and 6.13 mo respectively. The median OSs were 16.60, 14.07 and 13.00 mo for second-line, third-line and fourth- or later-line treatments, respectively. The median PFSs were 7.23, 7.30 and 3.87 mo for the second-line, third-line and fourth- or later-line treatments, respectively. CONCLUSION: In patients with MCRC, bevacizumab combined chemotherapy may be beneficial during second- or later-line treatment. | Lee Chun Park Ho Sup Lee Seong Hoon Shin Seun Ja Park Moo In Park Sung Yong Oh Hyuk Chan Kwon Jin ho Baek Young Jin Choi Myoung Joo Kang Yang Soo Kim | 2012 | World Journal of Gastroenterology2012，18，10： | 3 |
| 15 | A novel device for endoscopic submucosal dissection,the Fork knife显示文摘瞄准:用一台新奇设备介绍并且评估功效和内视镜的粘膜下层解剖(ESD ) 的技术方面,叉刀。方法:从 2004 年 3 月到 2008 年 4 月, ESD 在一个单个第三级的工作分派中心用 Flexknife (组 B ) 在使用一把叉刀(Endo FSregister )( 组 A ) 的 265 胃的损害上并且在 72 胃的损害上被执行。我们回顾地比较了 resected 标本的肿瘤,病理检查所见,和尺寸的内视镜的特征。我们也比较了在二个组之间的整块切除术率,完全的切除术率,复杂并发症,和过程时间。结果:resected 标本的吝啬的尺寸是 4.27 +/- 在组 A 和 4.29 +/- 的 1.26 厘米在组 B 的 1.48 厘米。整块切除术率是 95.8%(254/265 损害) 在组 A 并且 93.1%(67/72 ) 在组 B。没有 resected 边缘的肿瘤房间侵略的完全的 ESD 在 81.1% 被获得(215/265 ) 组 A 并且在 73.6%(53/72 ) 组 B。穿孔率是 0.8%(2/265 ) 在组 A 并且 1.4%(1/72 ) 在组 B。吝啬的过程时间是 59.63 +/- 在组 A 和 76.65 +/- 的 56.12 min 在组 B 的 70.75 min (P <
0.05 ) 。结论:叉刀(Endo FSregister ) 为临床的实践是有用的并且有的优点减少过程时间。 | Hyun Gun Kim Joo Young Cho Gene Hyun Bok Won Young Cho Wan Jung Kim Bong Min Ko Jin Oh Kim Joon Seong Lee Moon Sung Lee Chan Sup Shim | 2008 | World Journal of Gastroenterology2008，14，43： | 3 |
| 16 | Function of flavonoids on different types of programmed cell death and its mechanism:a review显示文摘Cell death in the living system plays a vital role in maintaining the homeostasis and balancing the cell count in the body.Programmed cell death(PCD)is a crucial component of several development and defense mechanisms.PCD is also important in terms of aging which avoids the accumulation of cellular damage by maintaining cell division.Depending on the execution of cell death and its role in destruction,PCD is categorized into several subtypes.The major different forms of PCD in animals are apoptosis,autophagy and necrosis,which can be distinct in morphological terms.More intense investigations of cell death have given close insight showing other important types of cellular destruction and their pivotal roles in treating disease conditions like cancer.Flavonoids have been acquired a great interest for disease therapies and chemoprevention through activation of several PCD mechanisms.The significant potential of natural flavonoids in the induction of distinct signaling cascades is being a massive approach for targeting uncontrolled cell growth.For these reasons,understanding PCD mechanisms is a promising approach for the interventions in treating cancer.Thus,it is intriguing that understanding the different forms of PCD mechanism induced by flavonoids with more accurate descriptions on the biochemical and cellular processes are gaining more significance in cancer research.Here,we provide a brief overview on the different types of PCD and aim to discuss the functional role of flavonoids in promoting different types of cell death as well as an extensive brief review on their mechanism of action has been highlighted. | Preethi Vetrivel Seong Min Kim Venu Venkatarame Gowda Saralamma Sang Eun Ha Eun Hee Kim Tae Sun Min Gon Sup Kim | 2019 | The Journal of Biomedical Research2019，33，6： | 3 |
| 17 | Nuclear PTEN Regulates the APC-CDH1 Tumor-Suppressive Complex in a Phosphatase-Independent Manner显示文摘 | Min Sup Song Arkaitz Carracedo Leonardo Salmena Su Jung Song Ainara Egia Marcos Malumbres Pier Paolo Pandolfi | 2011 | Cell2011，，2： | 3 |
| 18 | Hepatotoxicity Associated with a Short Course of Rosuvastatin显示文摘Statins reduce cardiovascular morbidity and mortality with dyslipidemia.Although generally well-tolerated,dose-dependent adverse events develop in 10%-15% patients.In addition,up to 3% patients have mildly elevated serum aminotransferase levels within the 1st year of therapy that are rarely associated with symptoms.We report a case of clinically significant hepatotoxicity after a very brief course of rosuvastatin in a statin-naive patient. | Na Kyoung Hwang Jin Sup Park Kwang Soo Cha Jin Suk Kang | 2015 | Chinese Medical Journal2015，，12： | 3 |
| 19 | Prevalence and risk of colorectal neoplasms in asymptomatic, average-risk screenees 40 to 49 years of age显示文摘 | Sung Noh Hong Jeong Hwan Kim Won Hyeok Choe Hye Seung Han In Kyung Sung Hyung Seok Park Chan Sup Shim | 2010 | Gastrointestinal Endoscopy2010，，3： | 3 |
| 20 | Biodegradable nanocarriers for small interfering ribonucleic acid (siRNA) co-delivery strategy increase the chemosensitivity of pancreatic cancer cells to gemcitabine显示文摘Ribonucleic acid (RNA) interference (RNAi) therapies are promising cancertreatment modalities that can specifically target abnormal proto-oncogenes, thusimproving the therapeutic effect. For the treatment of pancreatic cancer, targetingone mutant proto-oncogene by RNAi usually does not yield the desired therapeuticefficiency. Both K-ras gene mutations and Notch1 overexpression are commonsymptoms in pancreatic cancer patients, and play a crucial role in pancreaticcancer cell drug resistance. In this study, biodegradable charged polyester-basedvectors (BCPVs) were synthesized for the co-delivery of K-ras and Notch1 smallinterfering ribonucleic acid (siRNA) into MiaPaCa-2 cells (pancreatic cancercell line) to overcome drug resistance to gemcitabine (GEM), a first-line chem-otherapeutic drug used in the clinic. BCPVs could effectively absorb negative siRNAto form a capsule-like structure, prevent siRNA from nuclease digestion in theserum, and promote effective siRNA cell internalization and endosomal escape.Through K-ras and Notch1 gene silencing in MiaPaCa-2 cells, BCPV-siRNAKsiRNAN^tcm nanocomplexes effectively reversed the epithelia-mesenchymaltransition (EMT) in MiaPaCa-2 cells, thereby greatly enhancing the sensitivity ofMiaPaCa-2 cells to GEM. MiaPaCa-2 cell proliferation, migration, and invasionwere effectively inhibited, and cell apoptosis was also significantly enhanced bythe synergistic antitumor effect of BCPV-siRNAK siRNAN^t~l nanocomplexesand GEM. These results suggest that this combination RNAi therapy can be usedto improve cancer cell sensitivity to chemotherapeutic drugs. Specifically, thisnewly develooed strate^v has a great potential for treating pancreatic cancer. | Chengbin Yang Kok Ken Chan Wen-Jen Lin Alana Mauluidy Soehartono Guimiao Lin Huiting Toh Ho Sup Yoon Chih-Kuang Chen Ken-Tye Yong | 2017 | Nano Research2017，10，9： | 3 |
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