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| 1 | 血浆亲环蛋白A水平对冠状动脉疾病患者预后的影响显示文摘氧化应激状态下,血管平滑肌细胞、炎症细胞分泌亲环蛋白A(cyclophilin A,CyPA),并激活血小板功能。最近研究表明,血浆CyPA水平是诊断冠状动脉疾病的新型生物标志物。血浆CyPA水平对这些患者的预后是否有影响仍未阐明。方法:连续纳入接受诊断性冠状动脉造影的患者511例,测定血浆CyPA水平、高敏C反应蛋白(high-sensitivity C-reactive protein,hsCRP)和血浆脑钠尿肽水平, | Ohtsuki T Satoh K Omura J Kikuchi N Satoh T Kurosawa R Nogi M Sunamura S Yaoita N Aoki T Tatebe S Sugimura K Takahashi J Miyata S Shimokawa H 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，2： | 9 |
| 2 | Elucidation of the relationship of BNIP3 expression to gemcitabine chemosensitivity and prognosis显示文摘AIM: To evaluate the significance of BNIP3 in the pathogenesis of pancreatic cancer, we analyzed the relationship between the expression of BNIP3 and survival rate of the patients with pancreatic cancer, or chemosensitivities in pancreatic cancer cell lines, particularly for gemcitabine, the first-line anti-tumor drug for pancreatic cancer. METHODS: To compare the expression level of BNIP3 with the resistance to gemcitabine, eight pancreatic cancer cell lines were subjected to gemcitabine treatment and the quantitative real-time RT-PCR method was used to evaluate BNIP3 expression. Immunohistochemical analysis was also performed using 22 pancreatic cancer specimens to study relationship between BNIP3 expression and survival rate. RESULTS: Although no significantly positive association between BNIP3 mRNA level and gemcitabine chemosensitivity was observed, pancreatic cancer cell lines that were sensitive to gemcitabine treatment tended to show high levels of BNIP3 expression. The converse, an absence of BNIP3 expression, was not correlated with gemcitabine resistance. We further compared the BNIP3 expression profiles of resected primary pancreaticcancer specimens with the prognosis of the patients, and found a tendency of favorable prognosis and low BNIP3 expression. CONCLUSION: High levels of BNIP3 expression cannot be used as one of the predicting factors for gemcitabine chemosensitivity, and some yet to be known factors will have to fill the gap for the accurate prediction of pancreatic cancer chemosensitivity to gemcitabine. However, BNIP3 expression may have an impact on prediction of prognosis of patients with pancreatic cancer. | Masaharu Ishida Makoto Sunamura Toru Furukawa Masanori Akada Hiroko Fujimura Emiko Shibuya Shinichi Egawa Michiaki Unno Akira Horii | 2007 | World Journal of Gastroenterology2007，13，34： | 8 |
| 3 | Classification of types of intraductal papillary-mucinous neoplasm of the pancreas: a consensus study显示文摘 | Toru Furukawa Günter Kl?ppel N. Volkan Adsay Jorge Albores-Saavedra Noriyoshi Fukushima Akira Horii Ralph H. Hruban Yo Kato David S. Klimstra Daniel S. Longnecker Jutta Lüttges G. Johan A. Offerhaus Michio Shimizu Makoto Sunamura Arief Suriawinata Kyoichi | 2005 | Virchows Archiv2005，，5： | 3 |
| 4 | Heine oxygenase-1 accelerates tumor angiogeuesis of human pancreatic cancer显示文摘 | DUDA D G GHATrAS M H | 2003 | Angiogenesis2003，6，： | 1 |
| 5 | Nanometer-Scale Switches Using Copper Sulfide显示文摘 | Sakarnoto T Sunamura H Kawaura H | 2003 | Applied Physics Letters2003，82，18： | 1 |
| 6 | RNA interference targeting aurora kinase as suppresses tumor growth and enhances the taxane-chemosensitivity in human pancreatic cancer cells显示文摘 | Hata T Furukawa T Sunamura M | 2005 | Cancer Res2005，65，7： | 1 |
| 7 | Nanometer- scale switches using copper sulfide显示文摘 | Sakamoto T Sunamura H Kawaura H | 2003 | Applied Physics Letters2003，82，18： | 1 |
| 8 | Efficacy of novel hypoxic cell sensitiser doranidazole in the treatment of locally advanced pancreatic cancer:long-term results of a placebo-conrolled randomised study显示文摘 | KARASAWA K SUNAMURA M OKAMOTO A | | 0，，02： | 1 |
| 9 | Heme oxygenase-1 accelerates tumor angiogenesis of human pancreatic cancer显示文摘 | Makoto Sunamura Dan G. Duda Maivel H. Ghattas Lucian Lozonschi Fuyuhiko Motoi Jun-Ichiro Yamauchi Seiki Matsuno Shigeki Shibahara Nader G. Abraham | 2003 | Angiogenesis2003，，1： | 1 |
| 10 | Abundance of Zetaproteobacteria within crustal fluids in back-arc hydrothermal fields of the southern Mariana trough 显示文摘 | Kato S Yanagawa K Sunamura M | 2009 | Environmental Microbiology2009，11，： | 1 |
| 11 | Nanometer-scale switches using copper sulfide 显示文摘 | SAKAMOTO T SUNAMURA H KAWAURA H | 2003 | Applied Physics Letters2003，82，18： | 1 |
| 12 | Gene therapy for pancreatic cancer using an adenovirus vector encoding soluble flt-1 vascular endothelial growth factor receptor显示文摘 | Hoshida T Sunamura M Duda DG | 2002 | Pancreas2002，25，： | 1 |
| 13 | Restoration of SMAD4 by gene therapy reverses the invasive phenotype in pancreatic adenocar- cinoma cells显示文摘 | Duda DG Sunamura M Lefter LP | 2003 | Oncogene2003，22，44： | 1 |
| 14 | Early Microcirculatory Derangement in Mild and Severe Pancreatitis Models in Mice显示文摘 | Han-Ming Chen Makoto Sunamura Kazuhiko Shibuya Jun-ichiro Yamauchi Yoshihiro Sakai Shoji Fukuyama Yukio Mikami Kazunori Takeda Seiki Matsuno | 2001 | Surgery Today2001，，7： | 1 |
| 15 | Restoration of SMAD4 by gene therapy reverses the invasive phenotype in pancreatic adenocarcinoma cells显示文摘 | Duda D G Sunamura M Lefter L P | 2003 | Oncogene2003，22，44： | 1 |
| 16 | Effect of continuous arterialinfusion of protease inhibitor on experiment acute pancrestitis induced by closed duodenal loop obstruction显示文摘 | Kakugawa Y Takeda K Sunamura M | 1990 | Nippon Shokakibyo Gakkai Zasshi1990，87，6： | 1 |
| 17 | The antiang iogenesis effect ofinter leukin 12 duringearly grovcth of human pancreatic cancer in SCID mice 显示文摘 | Sunamura M Sun L Lozoschl L | 2000 | Pancreas2000，20，： | 1 |
| 18 | Quantitative predictions of beaehface slopes显示文摘 | Sunamura T | 1984 | Gelolgcal Society of American Bulletin1984，95，： | 1 |
| 19 | Inserting chromosome 18into pancreatic cancer cells switches them to a dormant metastaticphenotype显示文摘 | Lefter LP Sunamura M Furukawa T | 2003 | Clin Cancer Res2003，9，： | 1 |
| 20 | Molecular mechanisms of pancreatic carcinogenesis 显示文摘 | Furukawa T Sunamura M Horii A | 2006 | Cancer Sci2006，97，1： | 1 |
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