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| 1 | Feasibility of drug delivery to the eye’s posterior segment by topical instillation of PLGA nanoparticles显示文摘We investigated the delivery of drugs to the posterior segment of the eye by non-invasive topical instillation using submicron-sized poly(D,L-lactide-co-glycolide)(PLGA) nanoparticles(NPs). Surface-modified PLGA NPs were developed to improve the drug delivery efficiency to the retina and were administered as topical eye drops to mice. Chitosan(CS) and glycol chitosan(GCS), which are mucoadhesive polymers, and polysorbate 80(P80) were used as surface modifiers, and have been reported to increase the association of NPs with cells.Coumarin-6 was used as a model drug and fluorescent marker, and after ocular administration of PLGA NP eye drops, the fluorescence intensity of coumarin-6 was observed in the retina. The fluorescence image analysis indicated that there are several possible routes to the retina and fates of PLGA NPs in ocular tissue, and that these pathways involved the corneal,non-corneal, or uveal routes. Delivery to the mouse retina segments after topical administration was increased by surface modification with CS, GCS, or P80. Surface-modified PLGA NPs are a promising method for retinal drug delivery via topical instillation. | Kohei Tahara Keiichi Karasawa Risako Onodera Hirofumi Takeuchi | 2017 | Asian Journal of Pharmaceutical Sciences2017，12，4： | 3 |
| 2 | Thermo-chemo-radiotherapy for advanced bile duct carcinoma显示文摘AIM: Complete resection of the bile duct carcinoma is sometimes difficult by subepithelial spread in the duct wall or direct invasion of adjacent blood vessels. Nonresected extrahepatic bile duct carcinoma has a dismal prognosis,with a life expectancy of about 6 mo to 1 year. To improve the treatment results of locally advanced bile duct carcinoma, we have been conducting a clinical trial using regional hyperthermia in combination with chemoradiation therapy.METHODS: Eight patients complaining of obstructive jaundice with advanced extrahepatic bile duct underwent thermo-chemo-radiotherapy (TCRT). All tumors were located in the upper bile duct and involved hepatic bifurcation, and obstructed the bile duct completely.Radiofrequency capacitive hyperthermia was administered simultaneously with chemotherapeutic agents once weekly immediately following radiotherapy at 2 Gy.We administered heat to the patient for 40 min after the tumor temperature had risen to 42 ℃. The chemotherapeutic agents employed were cis-platinum (CDDP,50 mg/m2) in combination with 5-fluorouracil (5-FU,800 mg/m2) or methotrexate (MTX, 30 mg/m2) in combination with 5-FU (800 mg/m2). Number of heat treatments ranged from 2 to 8 sessions. The bile duct at autopsy was histologically examined in three patients treated with TCRT.RESULTS: In respect to resolution of the bile duct, there were three complete regression (CR), two partial regression (PR), and three no change (NC). Mean survival was 13.2±10.8 mo (mean±SD). Four patients survived for more than 20 mo. Percutaneous transhepatic biliary drainage (PTBD) tube could be removed in placement of self-expandable metallic stent into the patency-restored bile duct after TCRT. No major side effects occurred. At autopsy, marked hyalinization or fibrosis with necrosis replaced extensively bile duct tumor and wall, in which suppressed cohesiveness of carcinoma cells and degenerative cells were sparsely observed.CONCLUSION: Although the number of cases is rather small, TCRT in the treatment of locally advanced bile duct carcinoma is promising in raising local control and thus,long-term survival. | Terumi Kamisawa Yuyang Tu Naoto Egawa Katsuyuki Karasawa Tadayoshi Matsuda Kouji Tsuruta Atsutake Okamoto | 2005 | World Journal of Gastroenterology2005，11，27： | 2 |
| 3 | Stereotactic Body Radiotherapy (SBRT) for Operable Stage I Non–Small-Cell Lung Cancer: Can SBRT Be Comparable to Surgery?显示文摘 | Hiroshi Onishi Hiroki Shirato Yasushi Nagata Masahiro Hiraoka Masaharu Fujino Kotaro Gomi Katsuyuki Karasawa Kazushige Hayakawa Yuzuru Niibe Yoshihiro Takai Tomoki Kimura Atsuya Takeda Atsushi Ouchi Masato Hareyama Masaki Kokubo Takuyo Kozuka Takuro Arimo | 2011 | International Journal of Radiation Oncology, Biology, Physics2011，，5： | 2 |
| 4 | Extracorporeal shock wave lithotripsy of pancreatic duct stones and patient factors related to stone disintegration显示文摘 | Yasuyuki Karasawa Shigeyuki Kawa Yuji Aoki Yasuhide Ochi Hiroshi Unno Kendo Kiyosawa Tomofumi Watanabe | 2002 | Journal of Gastroenterology2002，，5： | 2 |
| 5 | Acute Hydrocephalus in Posterior Fossa Injury显示文摘 | Karasawa H Furuya H Naito H | 1997 | J Neurosurg1997，86，： | 1 |
| 6 | Effect of nozzle configuration on atomization of a steady spray显示文摘 | Karasawa T Tanaka M Abe K | 1992 | Atomization and Sprays1992，，2： | 1 |
| 7 | Bacteriologic Features and Antimicrobial Susceptibility in Isolates from Orofacial Odontogenic Infections显示文摘 | Kuriyama T Karasawa T Nakagawa K | 2000 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2000，90，5： | 1 |
| 8 | Force fields, structures, and properties of poly ( vinylidene fluoride ) crystals显示文摘 | KARASAWA N GODDARD W A | 1992 | Macromolecules1992，25，26： | 1 |
| 9 | Detection of myocardial contractile reserve by low-dose dobutamin quantitative Gated singlephoton emission computed tomography in patients with Kawasaki disease and severe coronary artery lesions 显示文摘 | Karasawa K Miyashita M Taniguehi K | 2003 | Am J Cardiol2003，92，7： | 1 |
| 10 | Maintenance of stable cuff pressure in the Brandt tracheal tube during anesthesia with nitrous oxide 显示文摘 | Karasawa F Okuda T Mori T | 2002 | Sr J Anaesth2002，89，2： | 1 |
| 11 | Efficacy of novel hypoxic cell sensitiser doranidazole in the treatment of locally advanced pancreatic cancer:long-term results of a placebo-conrolled randomised study显示文摘 | KARASAWA K SUNAMURA M OKAMOTO A | | 0，，02： | 1 |
| 12 | Low-temperature formation of photocatalytic Pt-anatase film by magnetron sputtering 显示文摘 | J Sheng L Shivalingappa J Karasawa | 1999 | J Mat Sci1999，34，10： | 1 |
| 13 | Non-invasive measurement of coronary flow reserve in children with Kawasaki diserase显示文摘 | Noto N Karasawa K Kanamaru H | 2002 | Heart2002，87，6： | 1 |
| 14 | Gentic hetercgeneity in the precore refion of hepatitis B virus in hepatitis B antigennefative chronic hepatitis B patients: spontaneous seroconversion and interferon- induced seroconversion显示文摘 | Karasawa T Aizawa Y | 1995 | J Med Virol1995，45，： | 1 |
| 15 | The effect on intracuff pressure of various nitrous oxide concentrations used for inflating an endotracheal tube cuff显示文摘 | Karasawa F Ohshima T Takamatsu I | 2000 | Anesth Analg2000，91，3： | 1 |
| 16 | Study of the posterior circulation in moyamoya disease显示文摘 | Kikuchi H Karasawa J | 1984 | J Neurosurg1984，61，： | 1 |
| 17 | Differential subcellular location of mitochondria in rat serotonergic neurons depends on the presence and the absence of monoamine oxidase type B显示文摘 | Arai R Karasawa N Kurokawa K | 2002 | Neuroscience2002，114，： | 1 |
| 18 | Analysis of availability improvement in LMSS by means of satellite diversity based on three-state propagation channel mobile显示文摘 | KARASAWA Yoshio KIMURA Kazuhiro MINAMISONO Kenichi | 1997 | IEEE Trans on Veh Technol1997，46，4： | 1 |
| 19 | Clinical aspects of plasma platelet-activating factor acetylhydrolase 显示文摘 | Karasawa K | 2006 | Biochim Biophys Acta2006，1761，11： | 1 |
| 20 | Force fields, structures and proper?ties of poly( vinyl idene fluoride) crystals显示文摘 | Karasawa N Goddard W A | 1992 | Macromolecules1992，25，26： | 1 |
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