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| 1 | bFGF and TGFβ expression in rat kidneys after ischemic/reperfusional gut injury and its relationship with tissue repair显示文摘INTRODUCTION Intestinal isehemia/rePerfusion(I/R)oeeureommonly in eritieally 111 Patients.It 15 wellreeognized that gutl/R may eause tissue damageand dysfunetion of intestine,and induee | Yang YH Fu XB Sun TZ Jiang LX Gu XM | 2000 | World Journal of Gastroenterology2000，6，1： | 13 |
| 2 | Effects of HBV gene variations on disease development and antiviral therapy for patients with chronic hepatitis B显示文摘Viral variation may change pathogenicity, escape immunity, lead to persistence infection, and cause drug resistance against antiviral therapy. This study was undertaken to investigate the effects of HBV gene variation on the progression of disease and on the efficacy of antiviral therapy for patients with chronic hepatitis B(CHB). METHODS:Hepatitis B virus (HBV) gene mutational sites were detected using gene chip in selected hepatitis B patients. RESULTS:In the patients HBeAg did not show serologic conversion or HBeAg(-)/anti-HBe(+), but their HBV DNA remained positive 24 weeks after α-interferon therapy, which was associated with mutations of nt1896, nt1814, nt1762 and nt1764. In the patients, that HBV DNA levels decreased or were undetectable, but rebounded later after antiviral therapy by lamivudine was associated with mutations of aa528 and(or) aa552(i.e.YMDD mutation), which resulted in lamivudine-resistance. YMDD mutation was prone to occur 52 weeks after lamivudine therapy in some chronic hepatitis B patients (26.4%). Nt1896 mutation was common in most chronic hepatitis B patients (68.5%). Chronic severe hepatitis, cirrhosis, and primary liver carcinoma were related to the mutations of nt1896, nt1762 and nt1764. CONCLUSIONS:HBV gene mutations could aggravate patient’s condition and affect the efficacy of antiviral therapy. The regular detection of HBV gene mutation is helpful for identification of disease prognosis and adjustment of therapeutic strategy. | Shenzhen Eastlake Hospital, Shenzhen 518020, China (Chen JY) and National Key Laboratory of Virology (Wuhan University) Department of Infectious Diseases, Renmin Hospital, Wuhan University, Wuhan 430060, China(Wang LW, Sun XM and Gong ZJ) | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 8 |
| 3 | Antisense inhibition of acetylcholinesterase gene expression for treating cognition deficit in Alzheimer's disease model mice显示文摘 | Fu AL Zhang XM Sun MJ | 2006 | 中国生物学文摘2006，20，10： | 2 |
| 4 | Sudies on inducing ap-optosis effects and mechanism of CIK cells for MGC-p gastric cancer cell lines显示文摘 | Sun S Li XM Yang WS | | 0，，02： | 1 |
| 5 | Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis显示文摘 | Sun XM MacFarlane M Zhuang J | 1999 | J Biol Chem1999，274，8： | 1 |
| 6 | Studies on inducing apoptosis effects and mechanism of CIK cells for MGC-803 gastric cancer cell lines显示文摘 | Sun S Li XM Li XD | | 0，，02： | 1 |
| 7 | Bcl - 2 and Bcl - xL inhibitor CD95 - mediated apoptosis by preventing mitochondrial release of Smac/DIABLO and subsequen inactivation of X - lin Red inhibitor of apoptosis protein 显示文摘 | Sun XM Bratton SB Butterworth M | 2002 | Biol Chem2002，277，11： | 1 |
| 8 | The relationship between endothelialdysfunction and oxidative stress in diabetes and prediabetes显示文摘 | Su Y Liu XM Sun YM | 2008 | IntJ Clin Pract2008，62，6： | 1 |
| 9 | The relationship between endothelial dysfunction oxidative stress in diabetes andprediabetes显示文摘 | Su Y Liu XM Sun YM | 2008 | International J Clinical Practice2008，62，6： | 1 |
| 10 | Next-generation sequencing identifies a novel compound heterozygous mutation in MYO7A in a Chinese patient with Usher Syndrome 1B显示文摘 | Wei XM Sun YY Yi X | 2012 | Clinica Chmiea Acta2012，413，： | 1 |
| 11 | Karyotype and DNA-methylation responses in myelodysplastic syndromes following treatment with traditional Chinese formula containing arsenic 显示文摘 | Sun SZ Ma R Hu XM | 2012 | Evid Based Complement Alternat Med2012，，： | 1 |
| 12 | Effect of different fertilizer application on the soil fertility of paddy soils in red soil region of southern China显示文摘 | Dong WY Zhang XY Wang HM Dai XQ Sun XM Qiu WW Yang FT | 2012 | Plos one2012，7，44： | 1 |
| 13 | BCL2/BCL-X(L) inhi- bition induces apoptosis, disrupts cellular calcium homeostasis, ant prevents platelet activation 显示文摘 | Vogler M Hamali HA Sun XM | 2011 | Blood2011，117，26： | 1 |
| 14 | Purification and Characterization of Polyphenol Oxidase from Rape Flower显示文摘 | Sun HJ Wang J Tao XM | 2012 | Journal of Agricultural and Food Chemistry2012，60，3： | 1 |
| 15 | Comparison of ginsenosides Rg1 and Rb1 for their effects on improving scopolamine- induced learning and memory impairment in mice显示文摘 | Wang Q Sun LH Liu XM | 2010 | Phytother Res2010，24，12： | 1 |
| 16 | Evidence for the involve ment of carbon centered radicals in the induction of apoptotic cel death by artemisinin compounds显示文摘 | Mercer AE Maggs JL Sun XM | 2007 | J Biol Chem2007，282，13： | 1 |
| 17 | Appearance of mosaic en-terovirus 71 in the 2008 outbreak of China显示文摘 | Ding NZ Wang XM Sun SW | 2009 | Virus Res2009，145，1： | 1 |
| 18 | Sffects of botulinum toxin A on the dystonia byvariou sdosage of injection显示文摘 | Sun XM WuXL Zhao HQ | 2002 | Zhongguo Linchuang Kangfu (ChinJClinRehabil)2002，6，18： | 1 |
| 19 | Key morphological features of apoptosis may occur in the absence of internucleosoreal DNA fragmentation 显示文摘 | COHEN GM SUN XM SNOWDEN RT | 1992 | Biochem J1992，286，2： | 1 |
| 20 | Evidence for the involvement of carbon-centered radicals in the induction of apoptotic cell death by artemisinin compounds显示文摘 | Mercer AE Maggs JL Sun XM | 2007 | J Biol Chem2007，282，13： | 1 |
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