|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A very strong summer monsoon event during 30-40 kaBP in the Qinghai-Xizang (Tibet) Plateau and its relation to precessional cycle显示文摘Guliya ice core records, high lake-level records in the Qinghai-Xizang Plateau and at its north side as well as vegetation succession records indicated that during the period of 30-40 kaBP, namely the later age of the megainterstadial of last glacial period, or the marine oxygen isotope stage 3, the climate of the Qinghai-Xizang Plateau was exceptionally warm and humid, the temperature was 2-4℃ higher than today and the precipitation was 40% to over 100% | Shi, YF Liu, XD Li, BY Yao, TD | 1999 | Chinese Science Bulletin1999，44，20： | 40 |
| 2 | Impact of postoperative omega-3 fatty acid-supplemented parenteral nutrition on clinical outcomes and immunomodulations in colorectal cancer patients显示文摘AIM: To investigate the effect of omega-3 fatty acid parenteral supplementation postoperatively on clinical outcomes and immunomodulation in colorectal cancer patients. METHODS: Forty-two patients undergoing radical colorectal cancer resection with an indication for total parenteral nutrition postoperatively were enrolled in this prospective, double-blind, randomized, controlled study. Patients received total parenteral nutrition supplemented with either soybean oil (LCT; Intralipid, Fresenius-Kabi, SO group, n = 21) or a combination of omega-3 fish oil and soybean oil (LCT:fish oil = 5:1, fish oil; Omegaven, Fresenius-Kabi, FO group, n = 21), up to a total of 1.2 g lipid/kg per day for 7 d postoperatively. A same volume calorie and nitrogen was administrated. Routine blood test, biochemistry, systemic levels of IL-6 and TNF-α, percentage of CD3+, CD4+, and CD8+ lymphocytes were evaluated preoperatively and on postoperative d 1 and 8. Patient outcome was evaluated considering mortality during the hospital stay, length of postoperative hospital stay, and occurrence of infectious complications. RESULTS: Both lipid regimens were well tolerated. No differences between the two groups were noticed in demographics, baseline blood test, biochemistry, serum levels of IL-6 and TNF-α, percentage of CD4+, CD8+ lymphocytes, and ratios of CD4+/CD8+. Compared with those on postoperative d 1, serum IL-6 levels onpostoperative d 8 were significantly depressed in the FO group than in the reference group (-44.43 ± 30.53 vs -8.39 ± 69.08, P = 0.039). Simultaneously, the ratios of CD4+/CD8+ were significantly increased in the FO group (0.92 ± 0.62 vs 0.25 ± 1.22, P = 0.035). In addition, depression of serum TNF-α levels (-0.82 ± 2.71 vs 0.27 ± 1.67, P = 0.125) and elevation of CD3+ and CD4+ lymphocyte percentage (12.85 ± 11.61 vs 3.84 ± 19.62, P = 0.081, 17.80 ± 10.86 vs 9.66 ± 17.55, P = 0.084, respectively) were higher in the FO group than in the reference group. Patients in the FO group trended to need a shorter postoperative hospital stay (17.45 ± 4.80 d vs 19.62 ± 5.59 d, P = 0.19). No statistically significant difference was found when stratified to mortality and occurrence of infectious complications. CONCLUSION: Postoperative supplementation of omega-3 fatty acids may have a favorable effect on the outcomes in colorectal cancer patients undergoing radical resection by lowering the magnitude of inflammatory responses and modulating the immune response. | Bin Liang, Shan Wang, Ying-Jiang Ye, Xiao-Dong Yang, You-Li Wang, Jun Qu, Qi-Wei Xie, Mu-Jun Yin, Division of Surgical Oncology and Division of Gastroenterological Surgery, Peking University People’s Hospital, Beijing 100044, China Author contributions: Liang B and Wang S contributed equally to this work Liang B and Wang S designed the research Liang B, Ye YJ, Yang XD, Wang YL, Qu J, Xie QW, Yin MJ performed the research and collected the data Wang S and Ye YJ supervised the research Liang B and Ye YJ analyzed the data Liang B wrote the paper and revised the manuscript. | 2008 | World Journal of Gastroenterology2008，14，15： | 31 |
| 3 | 高脂饮食诱导的肠道微生物代谢障碍对精子发生和精子运动的损害显示文摘1973至2011年间西方国家男性精子密度快速下降50%以上,且当前无有效治疗方法减缓其下降趋势。越来越多的临床研究及动物实验表明,高脂饮食介导的肥胖、代谢综合征可以重塑肠道菌群,继而影响能量代谢、肠道黏膜屏障、宿主免疫、预防病原菌等生理功能。为了解高脂饮食是否通过肠道菌群影响男性生殖,该研究分别将正常饮食喂养的小鼠肠道菌群移植入6只正常饮食小鼠(组1),高脂饮食喂养的小鼠肠道菌群移植入另外6只正常饮食小鼠(组2)体内,15周后,检测到组2小鼠的精子生成、精子运动、曲细精管内精原干细胞数量、精母细胞数量均显著下降,血液内毒素升高近2倍,但组1小鼠的上述指标无明显改变。 | Ding N Zhang X Zhang XD 季文(编译) | 2020 | 中华医学杂志2020，100，26： | 25 |
| 4 | Vasculogenic mimicry is a prognostic factor for postoperative survival in patients with glioblastoma显示文摘A previous report has confirmed the existence and clinical significance of vasculogenic mimicry(VM)in glioma.However,its conclusions about the negative clinical significance of VM in glioblastoma are based on a small group of patients and,thus,might be unconvincing.The aim of the present study was to reevaluate the clinical significance of VM in glioblastoma.Patients were classified as VM-positive or | Wang SY Ke YQ Lu GH Song ZH Yu L Xiao S Sun XL Jiang XD Yang ZL Hu CC | 2013 | 中国神经肿瘤杂志2013，11，3： | 22 |
| 5 | Chemoprevention of tea on colorectal cancer induced by dimethylhydrazine in Wistar rats显示文摘AIM To investigate the chemopreventiveeffects of green tea and tea pigment on 1,2-dimethylhydrazine(DMH)-induced rat colorectalcarcinogenesis.METHODS Male weaning Wistar rats wererandomly allocated into four groups.Rats in thepositive control group were given s.c.injectionof DMH,once a week for ten weeks;rats in tea-treated groups,with the same DMH treatment asin the positive group,received 2% green tea and0.1% tea pigments;rats in the negative controlgroup were given s.c.injection of the samevolume of saline as well as DMH in the positivegroup.Animals were sacrified and necropsied atthe end of week 16 and week 32.RESULTS Aberrant cryptic foci(ACF)wereformed in animals in DMH-treated groups at theend of week 16.Compared to the DMH group,green tea and tea pigments groups had less ACF(148.25 and 204.25,respectively,P<0.01).Atthe end of week 32,all rats in DMH groupdeveloped large intestinal tumors.The resultsalso showed that DMH increased labeling index(LI)of proliferating cell nuclear antigen(PCNA)of intestinal mucosa and the expression of ras-p21.However,in the tea-treated groups,PCNA-LI was significantly reduced as compared withthe positive control group(36.63 and 40.36 inthe green tea group and tea pigment group,respectively,at the end of the experiment,P<0.01).ras-p21 expression was alsosignificantly reduced(2.07 and 2.36 in the colontumors of rats in the green tea group and teapigments group,respectively at the end of theexperiment,P<0.01).Furthermore,green tea and tea pigment inhibited the expression of Bcl-2protein(2,5,1,0 and 2,4,1,0,respectively,at the end of the experiment P<0.01),andinduced expression of Bax protein(0,1,3,4and 0,1,4,3,respectively,P<0.01).CONCLUSION Chinese green tea drinkinginhibited ACF and colonic tumors formation inrats,which showed that tea had a significantchemopreventive effect on DMH-inducedcolorectal carcinogenesis.Such effects may bedue to suppression of cell proliferation andinduction of apoptosis in the intestinal crypts. | Jia XD Han C | 2000 | World Journal of Gastroenterology2000，6，5： | 21 |
| 6 | Orthotopic liver transplantation for fulminant hepatitis B显示文摘INTRODUCTION When fulminant hepatitis progress to deep encephalopathy,with stage Ⅲ or Ⅳ coma,it is commonly irreversible with a high mortality rate(80%-100%).Liver transplantation may be | He XS Huang JF Chen GH Fu Q Zhu XF Lu MQ Wang GD Guan XD | 2000 | World Journal of Gastroenterology2000，6，3： | 14 |
| 7 | 肝内胆管细胞癌患者肠道菌群、胆汁酸代谢及细胞因子特征性互作图谱显示文摘【据《Hepatology》2020年3月报道】题:肝内胆管细胞癌患者肠道菌群、胆汁酸代谢及细胞因子特征性互作图谱(作者Jia XD等)肝内胆管细胞癌(ICC)是原发性肝癌的一种,死亡率极高。ICC患者肠道微生物、胆汁酸代谢和细胞因子变化特点及其相互关系还有待明确,对建立ICC无创诊断新方法意义重大。本研究旨在分析ICC患者肠道微生物、胆汁酸代谢和细胞因子变化特点及与疾病预后的关系。 | 卢姗姗 刘哲睿 JIA XD ZENG Z | 2020 | 临床肝胆病杂志2020，36，5： | 12 |
| 8 | Effects of continuous cucumber cropping and alternative rotations under protected cultivation on soil microbial community diversity显示文摘 | Yao HY Jiao XD Wu FZ | 2007 | 中国生物学文摘2007，21，8： | 10 |
| 9 | Microarray-based analysis of changes in diversity of microbial genes involved in organic carbon decomposition following land use/cover changes显示文摘 | Zhang YG Zhang XQ Liu XD Xiao Y Qu L J Wu LY Zhou JZ | 2007 | 中国生物学文摘2007，21，8： | 10 |
| 10 | Expression of gap junction genes connexin 32,connexin 43 and their proteins in hepatocellular carcinoma and normal liver tissues显示文摘AIM To investigate the significance andmechanism of cx32 mRNA,cx43 mRNA and theirproteins in hepatocarcinogenesis.METHODS Sixty-one cases of HCC and 14cases of normal liver tissues were detected byimmunohistochemical and in situ hybridization(ISH)methods.RESULTS In HCC grades Ⅰ,Ⅱ,Ⅲ and normalliver tissues,the positive rates of Cx32 proteinwere 55.6%,42.1%,18.2% and 92.9%,respectively.The detection rates of Cx43 proteinwere 44.4%,26.3%,12.1% and 78.6%,respectively.There was significant difference inCx32 and Cx43 protein between HCC and normalliver tissues(P<0.01).ISH the positive rates ofcx32 mRNA shown by ISH in HCC grades Ⅰ,Ⅱ,Ⅲ and normal liver tissues were 88.9%,84.2%,87.9% and 92.9%,respectively.Those of cx43mRNA were 77.8%,78.6%,78.8% and 85.7%,respectively.There was no statistical differencein the positive rates of cx32 mRNA and cx43mRNA between HCC and normal liver tissue(P>0.05).CONCLUSION The aberrant location of Cx32and Cx43 proteins could be responsible forprogression of hepatocarcinogenesis,and thedefect of cx genes in post-translationalprocessing might be the possible mechanism. | Ma XD Sui YF Wang WL | 2000 | World Journal of Gastroenterology2000，6，1： | 9 |
| 11 | Application of carbazole compounds in study of hydrocarbon migration显示文摘IN recent years, studies on nitrogen compounds have been widely carried out by overseas schol-are, and achievements have been obtained spec1ally in the application of carbazoles to thestudy of hydrocarbon migration. But in China, few people work on this research area. | Liu, LF Xu, XD Mao, DF Yu, HJ | 1997 | Chinese Science Bulletin1997，42，23： | 6 |
| 12 | Carbide Behavior during High Temperature Creep in DZ40M Co-base Superalloy显示文摘The carbide behavior of a directionalIy solidified Co-base superalloy DZ40M has been investigatedafter creep at 700° and 900°. During the high temperature creep, a great amount of secondary carbide, M3C6 precipitated in alloy matrix. At 700℃, the M23C6 precipitation occurred in slip bands, indicating that it was stress-induced, while at 900℃, M23C6 formed surrounding the primary carbides, which is a characteristic of thermally aged alloy. The M23C6 particles pinned up dislocations and subgrain boundaries, strengthening the alloy matrix effectively. The creep crack initiation of DZ40M alloy was exclusively related to the primary carbides. The fracture of the primary carbide and the crack at the interface between them and matrix resulted in the crack formation. Furthermore, it was found that at 900℃, the surface of specimens was oxidized severely and the preferentially oxidized primary carbides acted as crack initiation sites. | Jiang, WH Yao, XD Guan, HR Hu, ZQ | 1999 | Journal of Materials Science & Technology1999，15，6： | 6 |
| 13 | 三维隧通开挖模拟中的平面应变分析显示文摘 | Pan.,XD 李彰明 | 1991 | 隧道译丛1991，，3： | 6 |
| 14 | A New Ursene Type Triterpenoid from Crepis napifera显示文摘A new triterpenoid, urs-20-en-3β-acetoxy-22α-ol, and three known compounds 3β- acetoxy-amyrin, 3β-acetoxy-lupeol, lupeol were isolated from the leaves of Crepis napifera (Franch.) Babc. Their structures were determined by means of spectroscopic studies. | Wu, SH Luo, XD Ma, YB Wu, DG | 2000 | Chinese Chemical Letters2000，11，8： | 3 |
| 15 | Ductile Phase Toughened Brittle Materials显示文摘Toughening of brittle materials by the inclusion of ductile phases is governed by several important factors which include ceramic-ductile phase interfacial bond strength, physical and chemical compatibility between ceramic and ductile phase, geometry and mechanical properties of ductile phase. The present understanding of the effect of these factors on toughening is reviewed and clarified. Continuous ductile phases (network, fibre or plate) are found to be more efficient for the toughening of brittle materials than discrete ductile particles. However, ductile particle toughened brittle materials have the advantages of material homogeneity isotropy and particularly better high temperature properties. It has been demonstrated that the influence of interfacial bond strength is determined by the geometry of the ductile phase in the composites. For the comparatively continuous ductile phase, such as ductile network, fibre or plate, comparatively weak inteffocial bond strength can promote partial debonding of the brittle matrix-ductile phase intedece during crack propagation and is beneficial for toughening. For discrete particulate ductile phase toughened brittle materials, the small gauge length of the ductile phase often results in the ductile phase pull-out during crack propagation which is the main limitation to toughening.Thus strong bond strength is required to ensure the bridging of the crack by the ductile phase.The coefficient of thermal expansion (CTE) mismatch between matrix and ductile phase has also been correlated with the geometry of the ductile phase. In most of the ceramic/metal systems,the CTE of the ductile metal phase is greater than that of the ceramic matrix. In the case of ductile network, fibre or plate, the residual stress created by the CTE mismatch can contribute to toughening through its influence on the initial crack opening stress while the bridging of the crack by the ductile phase is still ensured. However, for discrete ductile particles, the residual stress created by CTE mismatch is liable to cause cracks to by-pass the spherical particles, limiting the efficient use of the inherent toughness of the ductile phase. Low-modulus ductile inclusions are beneficial for the bridging of cracks by the ductile phase. Softer, more ductile inclusions are more effective for the toughening of brittle materials by particulate ductile | Sun, XD Yeomans, JA | 1996 | Journal of Materials Science & Technology1996，12，2： | 3 |
| 16 | Hepatic adenylate energy charge levels in patients with hepatoma after hepatic artery embolization显示文摘HepaticadenylateenergychargelevelsinpatientswithhepatomaafterhepaticarteryembolizationLILi1,YANLuNan1,CHENXiaoLi1,LUWuShe... | Li, L Yan, LN Chen, XL Lu, WS Xie, XD Wu, YT | 1998 | World Journal of Gastroenterology1998，4，2： | 2 |
| 17 | The Mechanism of the Initial Dark Oxidation of Ethers and the Ether-Oxygen Contact Charge Transfer Complex显示文摘The coan cbargr transfer (CCT) absorption spectra of isopropyl ether , phenyl isopropyl ether and benzyl isopropyl ether with oxygen were measured . The mechanism of the initial dark oxidation of different ethers via ether-O2 CCT was | Zhu, JM Cao, WX Feng, XD | 1997 | Chinese Chemical Letters1997，8，10： | 2 |
| 18 | Delayed cardioprotection of aged rat myocytes is associated with activation of mitogenactivated protein kinase 显示文摘 | Liu XH Wang SW Wu XD | 2000 | Chinese Medical Journal2000，113，1： | 2 |
| 19 | Imaging pancreatobiliary ductal system with optical coherence tomography: A review显示文摘An accurate, noninvasive and cost-effective method of in situ tissue evaluation during endoscopy would be highly advantageous for the detection of dysplasia or early cancer and for identifying different disease stages. Optical coherence tomography(OCT) is a noninvasive, high-resolution(1-10 μm) emerging optical imaging method with potential for identifying microscopic subsurface features in the pancreatic and biliary ductal system. Tissue microstructure of pancreaticobiliary ductal system has been successfully imaged by inserting an OCT probe through a standard endoscope operative channel. High-resolution OCT images and the technique's endoscopic compatibility have allowed for the microstructural diagnostic of thepancreatobiliary diseases. In this review, we discussed currently available pancreaticobiliary ductal imaging systems to assess the pancreatobiliary tissue microstructure and to evaluate varieties of pancreaticobiliary disorders and diseases. Results show that OCT can improve the quality of images of pancreatobiliary system during endoscopic retrograde cholangiopancheatography procedure, which may be important in distinguishing between the neoplastic and non-neoplastic lesions. | Mohammad S Mahmud Gray R May Mohammad M Kamal Ahmed S Khwaja Carry Sun Alex Vitkin Victor XD Yang | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，11： | 2 |
| 20 | The polymorphisms of GSTM 1, GSTF1, HYL 1 * 2, and XRCC 1, and aflatoxin B1-related hepato cellular carcinoma in Guangxi population, China 显示文摘 | Long XD Ma Y Wei YP | 2006 | Hepatol Res2006，36，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员