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| 1 | A hybrid invisibility cloak based on integration of transparent metasurfaces and zero-index materials显示文摘The invisibility cloak,a long-standing fantastic dream for humans,has become more tangible with the development of metamaterials.Recently,metasurface-based invisibility cloaks have been proposed and realized with significantly reduced thickness and complexity of the cloaking shell.However,the previous scheme is based on reflection-type metasurfaces and is thus limited to reflection geometry.In this work,by integrating the wavefront tailoring functionality of transparent metasurfaces and the wave tunneling functionality of zero-index materials,we have realized a unique type of hybrid invisibility cloak that functions in transmission geometry.The principle is general and applicable to arbitrary shapes.For experimental demonstration,we constructed a rhombic double-layer cloaking shell composed of a highly transparent metasurface and a double-zero medium consisting of dielectric photonic crystals with Dirac cone dispersions.The cloaking effect is verified by both full-wave simulations and microwave experimental results.The principle also reveals exciting possibilities for realizing skin-thick ultrathin cloaking shells in transmission geometry,which can eliminate the need for spatially varying extreme parameters.Our work paves a path for novel optical and electromagnetic devices based on the integration of metasurfaces and metamaterials. | Hongchen Chu Qi Li Bingbing Liu Jie Luo Shulin Sun Zhi Hong Hang Lei Zhou Yun Lai | 2018 | Light(Science & Applications)2018，7，1： | 13 |
| 2 | Co-occurrence of nitrite-dependent anaerobic methane oxidizing and anaerobic ammonia oxidizing bacteria in two Qinghai-Tibetan saline lakes显示文摘亚硝酸根依赖者厌氧氧化甲烷(n-damo ) 氧化的细菌和厌氧的氨(anammox ) 细菌是涉及全球碳并且氮骑车的二组微生物。为了测试 n-damo 和 anammox 细菌是否在自然盐的环境, DNA 和 cDNA 共同发生,样品从二个盐的湖的地表的沉积获得了(与 32 和 84 g/L 的咸度,分别地)与 anammox-damo-specific 和 n-damo-specific 教材集合的使用在西藏的高原上是 放大PCR 的,由克隆图书馆建设和种系发生的分析列在后面。DNA 和基于 cDNA 的克隆与 n-damo 结盟了, anammox 细菌成功地从二件样品被检索,显示这些二组细菌能象 84 g/L 一样高在有咸度的自然盐的环境共同发生。我们发现在自然为我们全球碳和氮周期的理解有大含意[出版摘要] | Jian YANG Hongchen JIANG Geng WU Weiguo HOU Yongjuan SUN Zhongping LAI Hailiang DONG | 2012 | Frontiers of Earth Science2012，6，4： | 12 |
| 3 | Regulation of FN1 degradation by the p62/SQSTM1-dependent autophagy-lysosome pathway in HNSCC显示文摘Epithelial–mesenchymal transition(EMT)is involved in both physiological and pathological processes.EMT plays an essential role in the invasion,migration and metastasis of tumours.Autophagy has been shown to regulate EMT in a variety of cancers but not in head and neck squamous cell carcinoma(HNSCC).Herein,we investigated whether autophagy also regulates EMT in HNSCC.Analyses of clinical data from three public databases revealed that higher expression of fibronectin-1(FN1)correlated with poorer prognosis and higher tumour pathological grade in HNSCC.Data from SCC-25 cells demonstrated that rapamycin and Earle’s balanced salt solution(EBSS)promoted autophagy,leading to increased FN1 degradation,while 3-methyladenine(3-MA),bafilomycin A1(Baf A1)and chloroquine(CQ)inhibited autophagy,leading to decreased FN1 degradation.On the other hand,autophagic flux was blocked in BECN1 mutant HNSCC Cal-27 cells,and rapamycin did not promote autophagy in Cal-27 cells;also in addition,FN1 degradation was inhibited.Further,we identified FN1 degradation through the lysosome-dependent degradation pathway using the proteasome inhibitor MG132.Data from immunoprecipitation assays also showed that p62/SQSTM1 participated as an autophagy adapter in the autophagy–lysosome pathway of FN1 degradation.Finally,data from immunoprecipitation assays demonstrated that the interaction between p62 and FN1 was abolished in p62 mutant MCF-7 and A2780 cell lines.These results indicate that autophagy significantly promotes the degradation of FN1.Collectively,our findings clearly suggest that FN1,as a marker of EMT,has adverse effects on HNSCC and elucidate the autophagy–lysosome degradation mechanism of FN1. | Xinchen Liu Lin Meng Xing Li Daowei Li Qilin Liu Yumeng Chen Xiangwei Li Wenhuan Bu Hongchen Sun | 2020 | International Journal of Oral Science2020，12，4： | 7 |
| 4 | Annexin A2-S100A10 heterotetramer is upregulated by PML/RARα fusion protein and promotes plasminogen-dependent fibrinolysis and matrix invasion in acute promyelocytic leukemia显示文摘 | Dan Huang Yan Yang Jian Sun Xiaorong Dong Jiao Wang Hongchen Liu Chengquan Lu Xueyu Chen Jing Shao Jinsong Yan | 2017 | Frontiers of Medicine2017，11，3： | 4 |
| 5 | Extraction, detection, and profiling of serum biomarkers using designed Fe3O4@SiO2@HA core-shell particles显示文摘 | Chandrababu Rejeeth Xuechao Pang Ru Zhang Wei Xu Xuming Sun Bin Liu Jiatao Lou Jingjing Wan Hongchen Gu Wei Yan Kun Qian | 2018 | Nano Research2018，11，1： | 2 |
| 6 | Ultra-small nanodots coated with oligopeptides providing highly negative charges to enhance osteogenic differentiation of hBMSCs better than osteogenic induction medium显示文摘For bone regenerative engineering,it is a promising method to form skeletal tissues differentiating from human bone morrow mesenchyme stem cells(hBMSCs).However,it is still a critical challenge to efficiently control ostogenesis and clearly reveal the influence factor.To this end,the fluorescent gold nanodots(Au NDs) with highly negative charges as osteogenic induction reagent are successfully synthesized,which display better than commercial osteogenic induction medium through the investigations of ALP activity(2.5 folds) and cytoskeleton staining(1.5 folds).Two kinds of oligopeptides with different bio-structures(cysteine,Cys and glutathione,GSH) are selected for providing surficial charges on Au NDs.It is revealed that Au-Cys with more negative charges(-51 mV) play better role than Au-GSH(-19 mV) in osteogenic differentiation,when both of them have same size(~2 nm),sphere shape and show similar cell uptake amount.To explore deeply,osteogenesis related signaling pathways are monitored,revealing that the enhancement of osteogenic differentiation was through autophagy signaling pathway triggered by Au-Cys.And the promotion of highly negative charges in osteogenic diffe rentiation was further proved via sliver nanodots(Ag NDs,Ag-Cys and Ag-GSH) and carbon nanodots(CDs,Cys-CDs and GSH-CDs).This work indicates part of insights during hBMSCs differentiation and provides a novel strategy in osteogenic differentiation process. | Yueqi Zhao Lin Meng Kai Zhang Yuanqing Sun Yue Zhao Zhe Yang Yangliu Lin Xinrui Liu Hongchen Sun Bai Yang Quan Lin | 2021 | Chinese Chemical Letters2021，32，1： | 1 |
| 7 | Research on processing technique of hawthorn fruit and blackcurrant compound functional beverage显示文摘 | SUN Hongchen LIU Dongyue AN Shuai | 2013 | Advanced Materials Research2013，807，： | 1 |
| 8 | Highly Photoluminescent Carbon Dots for Multicolor Patterning, Sensors, and Bioimaging显示文摘 | Shoujun Zhu Qingnan Meng Lei Wang Junhu Zhang Yubin Song Han Jin Kai Zhang Hongchen Sun Haiyu Wang Bai Yang | 2013 | Angew. Chem. Int. Ed2013，，14： | 1 |
| 9 | Polycation-functionalized gold nanodots with tunable near-infrared fluorescence for simultaneous gene delivery and cell imaging显示文摘 | Yuanqing Sun Dandan Wang Yueqi Zhao Tianxin Zhao Hongchen Sun Xiangwei Li Chuanxi Wang Bai Yang Quan Lin | 2018 | Nano Research2018，11，5： | 1 |
| 10 | Rational design of hydrogels for immunomodulation显示文摘The immune system protects organisms against endogenous and exogenous harm and plays a key role in tissue development,repair and regeneration.Traditional immunomodulatory biologics exhibit limitations including degradation by enzymes,short half-life and lack of targeting ability.Encapsulating or binding these biologics within biomaterials is an effective way to address these problems.Hydrogels are promising immunomodulatory materials because of their prominent biocompatibility,tuneability and versatility.However,to take advantage of these opportunities and optimize material performance,it is important to more specifically elucidate,and leverage on,how hydrogels affect and control the immune response.Here,we summarize how key physical and chemical properties of hydrogels affect the immune response.We first provide an overview of underlying steps of the host immune response upon exposure to biomaterials.Then,we discuss recent advances in immunomodulatory strategies where hydrogels play a key role through(i)physical properties including dimensionality,stiffness,porosity and topography;(ii)chemical properties including wettability,electric property and molecular presentation;and(iii)the delivery of bioactive molecules via chemical or physical cues.Thus,this review aims to build a conceptual and practical toolkit for the design of immune-instructive hydrogels capable of modulating the host immune response. | Wenhuan Bu Yuanhao Wu Amir M.Ghaemmaghami Hongchen Sun Alvaro Mata | 2022 | Regenerative Biomaterials2022，9，1： | 1 |
| 11 | Highly Photoluminescent Carbon Dots for Multicolor Patterning, Sensors, and Bioimaging显示文摘 | Shoujun Zhu Qingnan Meng Lei Wang Junhu Zhang Yubin Song Han Jin Kai Zhang Hongchen Sun Haiyu Wang Bai Yang | 2013 | Angew Chem Int Ed2013，，14： | 1 |
| 12 | Immunomodulatory effects and mechanisms of distraction osteogenesis显示文摘Distraction osteogenesis(DO) is widely used for bone tissue engineering technology. Immune regulations play important roles in the process of DO like other bone regeneration mechanisms. Compared with others, the immune regulation processes of DO have their distinct features. In this review, we summarized the immune-related events including changes in and effects of immune cells, immune-related cytokines, and signaling pathways at different periods in the process of DO. We aim to elucidated our understanding and unknowns about the immunomodulatory role of DO. The goal of this is to use the known knowledge to further modify existing methods of DO, and to develop novel DO strategies in our unknown areas through more detailed studies of the work we have done. | Shude Yang Ning Wang Yutong Ma Shuaichen Guo Shu Guo Hongchen Sun | 2022 | International Journal of Oral Science2022，14，1： | 1 |
| 13 | Brasenia-inspired hydrogel with sustained and sequential release of BMP and WNT activators for improved bone regeneration显示文摘Although bone morphogenetic protein(BMP) and WNT signaling play pivotal roles in bone development,homeostasis, and regeneration, the applications of proteins to stimulate corresponding signaling pathways showed limited outcomes in the repair and regeneration of bone defects that might be attributed to the reciprocal interventions of these pathways. In order to satisfy the combinational and sequential activation of BMP and WNT pathways, inspired by the heterogeneous hydrogel-liked structures of Brasenia, heterogeneous alginate/chitosan hydrogels were fabricated and spatially loaded with FK506 and BIO to achieve sustained and sequential release of the activators. Alkaline phosphatase staining, alizarin red staining and q RT-PCR results suggested that FK506 and BIO enhanced osteoblastic differentiation in vitro when used separately. Besides, by mixing and matching the activators and the hydrogel layers, a superior releasing mode that a combination of early FK506 release and following BIO release was identified via both in vitro and in vivo explorations for most efficient bone regeneration. These results suggested that drug-loaded heterogeneous hydrogels possess great potentials in treating bone loss defects for future clinical practice. | Xinqing Hao Xuewei Zhang Yue Hu Chunxia Ren Cangwei Liu Lu Wang Yijun Zhou Shuangshuang Wang Huanyu Luo Guangxing Yan Xiao Wang Xiaomeng Wang Feilong Ren Ce Shi, Wenlong Song Hongchen Sun | 2023 | Chinese Chemical Letters2023，34，7： | 0 |
| 14 | Resistive Switching Properties and Failure Behaviors of(Pt, Cu)/Amorphous ZrO_(2)/Pt Sandwich Structures显示文摘The effect of Pt and Cu electrodes on the resistive switching properties and failure behaviors of amorphous ZrO_2 ?lms were investigated. Compared with Cu/ZrO_2/Pt structures, the Pt/ZrO_2/Pt structures exhibit better resistive switching properties such as the higher resistance ratio of OFF/ON states, the longer switching cycles and narrow distribution of OFF state resistance(Roff). The switching mechanism in the Pt/ZrO_2/Pt structure can be attributed to the formation and rupture of oxygen vacancy ?laments; while in the Cu/Zr O2/Pt structure, there exist both oxygen vacancy ?laments and Cu ?laments. The formation of Cu?laments is related to the redox reaction of Cu electrode under the applied voltage. The inhomogeneous dispersive injection of Cu ions results in the dispersive Roff and signi?cant decrease of operate voltage.Schematic diagrams of the formation of conductive ?laments and the failure mechanism in the Cu/ZrO_2/Pt structures are also proposed. | Haifa Zhai Jizhou Kong Jien Yang Jing Xu Qingran Xu Hongchen Sun Aidong Li Di Wu | 2016 | Journal of Materials Science & Technology2016，32，7： | 0 |
| 15 | Bifunctional Mo-doped FeCo–Se aerogels catalysts with excellent OER and ORR activities for electro-Fenton process显示文摘Antibiotic pollution in aqueous solutions seriously endangers the natural environment and public health.In this work,Mo-doped transition metal FeCo–Se metal aerogels(MAs)were investigated as bifunctional catalysts for the removal of sulfamethazine(SMT)in solution.The optimal Mo_(0.3)Fe_(1)Co_(3)–Se catalyst can remove 97.7% of SMT within 60 min(SMT content:10 mg/L,current intensity:10 mA/cm 2).The unique porous cross-linked structure of aerogel confered the catalyst sufficient active sites and efficient mass transfer channels.For the anode,Mo_(0.3)Fe_(1)Co_(3)–Se MAs exhibits superior oxygen evolution reaction(OER)property,with an overpotential of only 235 mV(10 mA/cm 2).Compared with Fe_(1)Co_(3) MAs or Mo_(0.3)Fe_(1)Co_(3) MAs,density functional theory(DFT)demonstrated that the better catalytic capacity of Mo_(0.3)Fe_(1)Co_(3)–Se MAs is attributed to the doping of Mo species and selenization lowers the energy barrier for the*OOH to O_(2) step in the OER process.Excellent OER perfor-mance ensures the self-oxygenation in this system,avoiding the addition of air or oxygen in the traditional electro-Fenton process.For the cathode,Mo doping can lead to the lattice contraction and metallic character of CoSe_(2),which is beneficial to accelerate electron transfer.The adjacent Co active sites effectively adsorb*OOH and inhibit the breakage of the O–O bond.Rotating ring disk electrode(RRDE)test indicated that Mo_(0.3)Fe_(1)Co_(3)–Se MAs has an excellent 2e^(-)ORR activity with H_(2)O_(2) selectivity up to 88%,and the generated H_(2)O_(2) is activated by the adjacent Fe site through heterogeneous Fenton process to generate⋅OH. | Fengjiang Chen Fan Yang Sai Che Hongchen Liu Chong Xu Neng Chen Yankun Sun Chunhui Yu Zhijie Wu Yongfeng Li | 2023 | Green Chemical Engineering2023，4，3： | 0 |
| 16 | Construction of hollow polydopamine nanoparticle based drug sustainable release system and its application in bone regeneration显示文摘Nanomaterial-based drug sustainable release systems have been tentatively applied to bone regeneration.They,however,still face disadvantages of high toxicity,low biocompatibility,and low drug-load capacity.In view of the low toxicity and high biocompatibility of polymer nanomaterials and the excellent load capacity of hollow nanomaterials with high specific surface area,we evaluated the hollow polydopamine nanoparticles(HPDA NPs),in order to find an optimal system to effectively deliver the osteogenic drugs to improve treatment of bone defect.Data demonstrated that the HPDA NPs synthesized herein could efficiently load four types of osteogenic drugs and the drugs can effectively release from the HPDA NPs for a relatively longer time in vitro and in vivo with low toxicity and high biocompatibility.Results of qRT-PCR,ALP,and alizarin red S staining showed that drugs released from the HPDA NPs could promote osteogenic differentiation and proliferation of rat bone marrow mesenchymal stem cells(rBMSCs)in vitro.Image data from micro-CT and H&E staining showed that all four osteogenic drugs released from the HPDA NPs effectively promoted bone regeneration in the defect of tooth extraction fossa in vivo,especially tacrolimus.These results suggest that the HPDA NPs,the biodegradable hollow polymer nanoparticles with high drug load rate and sustainable release ability,have good prospect to treat the bone defect in future clinical practice. | Lu Wang Shuwei Liu Chunxia Ren Siyuan Xiang Daowei Li Xinqing Hao Shilei Ni Yixin Chen Kai Zhang Hongchen Sun | 2021 | International Journal of Oral Science2021，13，3： | 0 |
| 17 | Expert consensus on odontogenic maxillary sinusitis multi-disciplinary treatment显示文摘Odontogenic maxillary sinusitis (OMS) is a subtype of maxillary sinusitis (MS). It is actually inflammation of the maxillary sinus that secondary to adjacent infectious maxillary dental lesion. Due to the lack of unique clinical features, OMS is difficult to distinguish from other types of rhinosinusitis. Besides, the characteristic infectious pathogeny of OMS makes it is resistant to conventional therapies of rhinosinusitis. Its current diagnosis and treatment are thus facing great difficulties. The multi-disciplinary cooperation between otolaryngologists and dentists is absolutely urgent to settle these questions and to acquire standardized diagnostic and treatment regimen for OMS. However, this disease has actually received little attention and has been underrepresented by relatively low publication volume and quality. Based on systematically reviewed literature and practical experiences of expert members, our consensus focuses on characteristics, symptoms, classification and diagnosis of OMS, and further put forward multidisciplinary treatment decisions for OMS, as well as the common treatment complications and relative managements. This consensus aims to increase attention to OMS, and optimize the clinical diagnosis and decision-making of OMS, which finally provides evidence-based options for OMS clinical management. | Jiang Lin Chengshuo Wang Xiangdong Wang Faming Chen Wei Zhang Hongchen Sun Fuhua Yan Yaping Pan Dongdong Zhu Qintai Yang Shaohua Ge Yao Sun Kuiji Wang Yuan Zhang Mu Xian Ming Zheng Anchun Mo Xin Xu Hanguo Wang Xuedong Zhou Luo Zhang | 2024 | International Journal of Oral Science2024，16，1： | 0 |
| 18 | Characterization of liquid–liquid phase separation using super-resolution and single-molecule imaging显示文摘Liquid – liquid phase separation (LLPS) is an emerging phenomenon involved in various biological processes. The formation of phase-separated condensates is crucial for many intrinsically disordered proteins to fulfill their biological functions. Using the recombinant protein to reconstitute the formation of condensates in vitro has become the standard method to investigate the behavior and function of LLPS. Meanwhile, there is an urgent need to characterize the LLPS in living cells. Importantly, condensates formed through LLPS at physical relevant concentrations are often smaller than the optical diffraction limit, which makes precise characterization and quantification inaccurate due to the scatter of light. The booming development of super-resolution optical microscopy enables the visualization of multiple obscured subcellular components and processes, which is also suitable for the LLPS research. In this protocol, we provide step-by-step instructions to help users take advantage of super-resolution imaging to depict the morphology and quantify the molecule number of endogenous condensates in living cells using RNA Pol II as an example. This streamlined workflow offers exceptional robustness, sensitivity, and precision, which could be easily implemented in any laboratory with an inverted total internal reflection microscope. We expect that super-resolution microscopy will contribute to the investigation of both large and tiny condensates under physiological and pathological conditions and lead our understanding of the mechanism of LLPS to a higher and deeper layer. | Hongchen Zhang Shipeng Shao Yujie Sun | 2022 | Biophysics Reports2022，8，1： | 0 |
| 19 | Polyurethane foam-supported three-dimensional interconnected graphene nanosheets network encapsulated in polydimethylsiloxane to achieve significant thermal conductivity enhancement显示文摘Polyurethane(PU)foams are widely used in thermal management materials due to their good flexibility.However,their low thermal conductivity limits the efficiency.To address this issue,we developed a new method to produce tannic acid(TA)-modified graphene nanosheets(GTs)-encapsulated PU(PU@GT)foams using the soft template microstructure and a facile layer-by-layer(L-B-L)assembly method.The resulting PU@GT scaffolds have ordered and tightly stacked GTs layers that act as three-dimensional(3D)highly interconnected thermal networks.These networks are further infiltrated with polydimethylsiloxane(PDMS).The through-plane thermal conductivity of the polymer composite reaches 1.58 W·m^(−1)·K^(−1) at a low filler loading of 7.9 wt.%,which is 1115%higher than that of the polymer matrix.Moreover,the mechanical property of the composite is~2 times higher than that of the polymer matrix while preserving good flexibility of the polymer matrix owing to the retention of the PU foam template and the construction of a stable 3D graphene network.This work presents a facile and scalable production approach to fabricate lightweight PU@GT/PDMS polymer composites with excellent thermal and mechanical performance,which implies a promising future in thermal management systems of electronic devices. | Wenjing Li Ni Wu Sai Che Li Sun Hongchen Liu Guang Ma Ye Wang Chong Xu Yongfeng Li | 2023 | Frontiers of Materials Science2023，17，3： | 0 |
| 20 | Preparation and Characterization of CaO/ZnO Core-shell Structured Nanoparticles显示文摘Residual bacteria and microleakage in a complicated root canal can often result in reinfection of the periapical tissues.To promote the antibacterial and sealing eftects of a root canal filling,core-shell structured CaO/ZnO nanospheres were synthesized using a precipitation method based on a traditional root canal sealer,zinc oxide-eugenol(ZOE).The obtained CaO/ZnO particles had a size of 80—90 nm and a core-shell structure.The film thickness,flow rate,pH,and calcium ion release of the core-shell structured CaO/ZnO nanospheres-eugenol paste were tested.The pH and calcium ion release results showed a slight increase in the prepared nanospheres,with a flow rate of 24.22 mm and a formed film thickness of 30 pm,which are basically consistent with ISO 6876:2001 standards(regarding dental root canal sealing materials).Cytotoxicity tests showed that the cytocompatibility of the CaO/ZnO nanospheres-eugenol paste was much higher than that of the ZOE or iRoot SP groups(P<0.05).A comparison of the sealing ability and antibacterial activity showed that the core-shell structured CaO/ZnO nano spheres-eugenol paste had significantly better effects than the ZOE and iRoot SP sealers(P<0.05).The core-shell structured CaO/ZnO nano sphere paste displayed excellent sealing and antibacterial properties,and it has promising application potential in endodontics. | WANG Lili LIU Yanan PENG Xiaoxing SUN Yuanqing LIU Xiaohua LIU Huimin LIN Quan SUN Hongchen YANG Bai LI Xiangwei | 2020 | Chemical Research in Chinese Universities2020，36，5： | 0 |
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