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| 1 | Spatial Variability of Nutrient Properties in Black Soil of Northeast China显示文摘A total of 1400 soil samples from the plow layer (0-20 cm) at an approximate interval of 5 km were collected in the autumn of 2002 over the entire black soil arable crops region to determine the spatial variability of seven variables, such as total organic matter content (OMC), total N, total P, total K, alkali-dissolvable N (AN), available P (AP) and available K (AK), with classical statistics and geostatistical analysis across the entire black soil area in Northeast China. In nonsampled areas ordinary kriging was utilized for interpolation of estimated nutrient determinations. Classical statistics revealed highly significant (P≤0.01) correlations with all seven of the soil properties, except for OMC with AP and total K with AK. In addition, using coefficients of variation, all soil properties, except for total K, were moderately variable. A geostatistical analysis indicated that structural factors, such as parent material, terrain, and water table, were the main causes of the spatial correlations. Strong spatial correlations were noted with OMC, total N, total P, AN, and AP, while they were moderate for total K and AK. The effective spatial autocorrelation of OMC, total N, total P, and AN ranged from 1 037 to 1 353 km, whereas the ranges of total K, AP, and AK were only from 6 to 138 km. The fit of the experimental semi-variograms to the theoretical models indicated that except for AN, kriging could successfully interpolate other six variables. Thus, the geostatistical method used on a large scale could accurately evaluate the spatial variability of most black soil nutrient properties in Northeast China. | ZHANG Xing-Yi SUI Yue-Yu ZHANG Xu-Dong MENG Kai S. J. HERBERT | 2007 | Pedosphere2007，17，1： | 118 |
| 2 | Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells显示文摘人的 pluripotent 干细胞代表功能的胰腺的内分泌的系房间的潜在地无限的来源。这里,我们报导一条高度有效的途径导致人的胚胎的茎(ES ) 细胞和导致的 pluripotent 茎(iPS ) 在一个定义化学药品的文化系统区分进成熟生产胰岛素的细胞的细胞。这条途径获得的区分的人的 ES 房间由流动 cytometry 分析作为 assayed 包括了将近 25% 胰岛素积极的房间,它以比得上成年人的小岛的一种方式响应葡萄糖刺激释放了 insulin/C-peptide。大多数这些生产胰岛素的房间共同表示成熟尾房间特定的标记象 NKX6-1 和 PDX1 那样,在 vivo 显示一个类似的基因表示模式到成年小岛尾房间。在这研究,我们也证明 EGF 便于 PDX1 积极的胰腺的祖先的扩大。而且,我们的协议也成功了高效地导致人的 iPS 房间区分进生产胰岛素的房间。因此,这个工作不仅提供一个新模型在 vitro 学习人的胰腺的专门化和成熟的机制,而且提高为糖尿病的处理利用病人特定的 iPS 房间的可能性。 | Donghui Zhang Wei Jiang Meng Liu Xin Sui Xiaolei Yin Song Chen Yan Shi Hongkui Deng | 2009 | Cell Research2009，19，4： | 90 |
| 3 | Erianin,a novel dibenzyl compound in Dendrobium extract,inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis显示文摘Ferroptosis,a novel form of programmed cell death,is characterized by iron-dependent lipid peroxidation and has been shown to be involved in multiple diseases,including cancer.Stimulating ferroptosis in cancer cells may be a potential strategy for cancer therapy.Therefore,ferroptosis-inducing drugs are attracting more attention for cancer treatment.Here,we showed that erianin,a natural product isolated from Dendrobium chrysotoxum Lindl,exerted its anticancer activity by inducing cell death and inhibiting cell migration in lung cancer cells.Subsequently,we demonstrated for the first time that erianin induced ferroptotic cell death in lung cancer cells,which was accompanied by ROS accumulation,lipid peroxidation,and GSH depletion.The ferroptosis inhibitors Fer-1 and Lip-1 but not Z-VAD-FMK,CQ,or necrostatin-1 rescued erianin-induced cell death,indicating that ferroptosis contributed to erianin-induced cell death.Furthermore,we demonstrated that Ca^(2+)/CaM signaling was a critical mediator of erianin-induced ferroptosis and that blockade of this signaling significantly rescued cell death induced by erianin treatment by suppressing ferroptosis.Taken together,our data suggest that the natural product erianin exerts its anticancer effects by inducing Ca^(2+)/CaMdependent ferroptosis and inhibiting cell migration,and erianin will hopefully serve as a prospective compound for lung cancer treatment. | Peng Chen Qibiao Wu Jiao Feng Lili Yan Yitian Sun Shuiping Liu Yu Xiang Mingming Zhang Ting Pan Xiaying Chen Ting Duan Lijuan Zhai Bingtao Zhai Wengang Wang Ruonan Zhang Bi Chen Xuemeng Han Yicong Li Liuxi Chen Ying Liu Xingxing Huang Ting Jin Wenzheng Zhang Hong Luo Xiaohui Chen Yongqiang Li Qiujie Li Guohua Li Qin Zhang Lvjia Zhuo Zuyi Yang Huifen Tang Tian Xie Xiaoping Ouyang Xinbing Sui | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 42 |
| 4 | Effect of oxidization on enrichment behavior of TiO_2 in titanium-bearing slag显示文摘Due to the dispersed distribution of the titanium component in various mineral phases and very fine grain size, it is difficult to recover the titanium component from the slag. In order to utilize titanium resources, selective enriching and selective growing of the titanium component from the molten slag is expected. In this paper, the selection of the best tita- nium enrichment phase and the effect of oxidization on the enrichment of titanium by blowing air into the molten slag were studied. The results showed that through oxidizing the slag, the content of the perovskite phase increases while that of the other titanium-bearing mineral phases decreases until they disappear. Most titania resources were enriched into the perovskite phase and increase in size. The process of enrichment and growth is easily carried out. | WANG Mingyu LI Liaosha ZHANG Li ZHANG Linnan TU Ganfeng SUI Zhitong | 2006 | Rare Metals2006，25，2： | 23 |
| 5 | Effect of Low Light on the Characteristics of Photosynthesis and Chlorophyll a Fluorescence During Leaf Development of Sweet Pepper显示文摘Low light stress is one of the main limiting factors which influence the production of sweet pepper under protected cultivation in China. In this experiment, two genotypes of sweet pepper, ShY (low light-tolerant genotype) and 20078 (low light-sensitive genotype), were used to study the effects of low light (photosynthetic photon flux density, PPFD was 75- 100 μmol m-2 s-1, control 450-500 μmol m-2 s-1) on photosynthesis during leaf development. The result indicated that under low light chlorophyll content, net photosynthetic rate (PN), photosynthetic apparent quantum efficiency (i) and carboxylation efficiency (CE) of sweet pepper leaves increased gradually and decreased after reaching the maximum levels. The time to reach the peak values for all the above parameters was delayed, whereas the light compensation point (LCP) decreased gradually along with leaf expansion. The decrease in maximum quantum yield of PS II (Fv/Fm) was not observed at any stages of the leaf development under low light condition, but the actual PS II efficiency under irradiance ( PS II) was lower accompanied by an increased non-photochemical quenching (NPQ) in young and/or old leaves compared with mature leaves. The antenna thermal dissipation (D) was a main way of heat dissipation when young leaves received excessive light energy, while the decline in photosynthetic function in senescence leaf was mostly owing to the decrease in carbon assimilation capacity, followed by a significantly increased allocation of excessive energy (Ex). Compared with 20078, ShY could maintain higher P N , PS II and lower Q A reduction state for a longer time during leaf development. Thus, in ShY photosynthetic efficiency and the activity of electron transport of PS II were not significantly affected due to low light stress. | SUI Xiao-lei MAO Sheng-li WANG Li-hao ZHANG Bao-xi ZHANG Zhen-xian | 2012 | Journal of Integrative Agriculture2012，11，10： | 22 |
| 6 | Baicalin induces ferroptosis in bladder cancer cells by downregulating FTH1显示文摘Ferroptosis is a non-apoptotic regulated cell death caused by iron accumulation and subsequent lipid peroxidation.Currently,the therapeutic role of ferroptosis on cancer is gaining increasing interest.Baicalin an active component in Scutellaria baicalensis Georgi with anticancer potential various cancer types;however,the effects of baicalein on bladder cancer and the underlying molecular mechanisms remain largely unknown.In the study,we investigated the effect of baicalin on bladder cancer cells5637 and KU-19-19.As a result,we show baicalin exerted its anticancer activity by inducing apoptosis and cell death in bladder cancer cells.Subsequently,we for the first time demonstrate baicalin-induced ferroptotic cell death in vitro and in vivo,accompanied by reactive oxygen species(ROS) accumulation and intracellular chelate iron enrichment.The ferroptosis inhibitor deferoxamine but not necrostatin-1,chloroquine(CQ),N-acetyl-L-cysteine,L-glutathione reduced,or carbobenzoxy-valyl-alanyl-aspartyl-[O-methyl]-fluoromethylketone(Z-VAD-FMK) rescued baicalin-induced cell death,indicating ferroptosis contributed to baicalin-induced cell death.Mechanistically,we show that ferritin heavy chain1(FTH1) was a key determinant for baicalin-induced ferroptosis.Overexpression of FTH1 abrogated the anticancer effects of baicalin in both 5637 and KU19-19 cells.Taken together,our data for the first time suggest that the natural product baicalin exerts its anticancer activity by inducing FTH1-dependent ferroptosis,which will hopefully provide a prospective compound for bladder cancer treatment. | Na Kong Xiaying Chen Jiao Feng Ting Duan Shuiping Liu Xueni Sun Peng Chen Ting Pan Lili Yan Ting Jin Yu Xiang Quan Gao Chengyong Wen Weirui Ma Wencheng Liu Mingming Zhang Zuyi Yang Wengang Wang Ruonan Zhang Bi Chen Tian Xie Xinbing Sui Wei Tao | 2021 | Acta Pharmaceutica Sinica B2021，11，12： | 23 |
| 7 | Magma underplating and Hannuoba present crust-mantle transitional zone composition: Xenolith petrological and geochemical evidence显示文摘On the basis of mineral assemblage, mineralogy, petrology, and major, trace ele-mental and isotopic geochemistry of the underplated granulite- and eclogite-facies accumulate, peridotite and pyroxenite xenoliths entrained in Hannuoba Cenozoic basalts, this work con-strained the petrological constituents for the crust-mantle transitional zone, which is supported by the results of high-temperature and pressure velocity experiments on rocks and geophysics deep survey. Present lower part of lower crust is mainly composed of granulite-facies mafic accumu-lates (dominantly plagioclase websterite) and crust-mantle transitional zone dominantly com-posed of eclogite-facies pyroxenites with or without garnet and spinel lherzolites; Archaean ter-rain granulite is only nominally early lower crust. Magma underplating in the crust-mantle boundary led to the crustal vertical accretion and the formation of the crust-mantle transitional zone, which is a significant mechanism for the chemical adjustment of the crust-mantle boundary since the Phanerozoic. | FAN Qicheng1,2, ZHANG Hongfu1, SUI Jianli1, ZHAI Mingguo1, SUN Qian2 & LI Ni2 1. Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100029, China 2. Institute of Geology, China Seismological Bureau, Beijing 100029, China | 2005 | Science China Earth Sciences2005，48，8： | 20 |
| 8 | Comparisons of multiple characteristics between young and old lung cancer patients显示文摘 | JIANG Wei KANG Yue SHI Guang-yue ZHANG Hai-yu CAI Li SUN Xiu-wei SUN Li-chun SUI Guang-jie | 2012 | Chinese Medical Journal2012，，1： | 13 |
| 9 | Association of TNF-α-238G/A and 308 G/A Gene Polymorphisms with Pulmonary Tuberculosis among Patients with Coal Worker’s Pneumoconiosis显示文摘Objectives Tumor necrosis factor-α (TNF-α) may play an important role in host’s immune response to mycobacterium tuberculosis (M. tuberculosis) infection. This study was to investigate the association of TNF-α gene polymorphism with pulmonary tuberculosis (TB) among patients with coal worker’s pneumoconiosis (CWP). Methods A case-control study was conducted in 113 patients with confirmed CWP complicated with pulmonary TB and 113 non-TB controls with CWP. They were matched in gender, age, job, and stage of pneumoconiosis. All participants were interviewed with questionnaires and their blood specimens were collected for genetic determination with informed consent. The TNF-α gene polymorphism was determined with polymerase chain reaction of restriction fragment length polymorphism (PCR-RFLP). Frequency of genotypes was assessed for Hardy-Weinberg equilibrium by chi-square test or Fisher’s exact probability. Factors influencing the association of individual susceptibility with pulmonary TB were evaluated with logistic regression analysis. Gene-environment interaction was evaluated by a multiplicative model with combined OR. All data were analyzed using SAS version 8.2 software. Results No significant difference in frequency of the TNF-α-308 genotype was found between CWP complicated with pulmonary TB and non-TB controls (χ2=5.44, P=0.07). But difference in frequency of the TNF-α-308 A allele was identified between them (χ2=5.14, P=0.02). No significant difference in frequencies of the TNF-α-238 genotype and allele (P=0.23 and P=0.09, respectively) was found between cases and controls either, with combined (GG and AA) OR of 3.96 (95% confidence interval of 1.30~12.09) at the-308 locus of the TNF-α gene, as compared to combination of the TNF-α-238 GG and TNF-α-308 GG genotypes. Multivariate-adjusted odds ratio of the TNF-α-238 GG and TNF-α-308 GA genotypes was 1.98 (95% CI of 1.06~3.71) for risk for pulmonary TB in patients with CWP. There was a synergic interaction between the TNF-α-308 GG genotype and body mass index (OR=4.92), as well as an interaction between the TNF-α-308 GG genotype and history of BCG immunization or history of TB exposure. And, the interaction of the TNF-α-238 GG genotype and history of BCG immunization or TB exposure with risk for pulmonary TB in them was also indicated. Conclusions TNF-α-308 A allele is associated with an elevated risk for pulmonary TB, whereas TNF-α-238 A allele was otherwise. | HONG-MIN FAN ZHUO WANG FU-MIN FENG KONG-LAI ZHANG JU-XIANG YUAN HONG SUI HONG-YAN QIU LI-HUA LIU XIAO-JUAN DENG JING-XUE REN | 2010 | Biomedical and Environmental Sciences2010，23，2： | 12 |
| 10 | Affinity peptide developed by phage display selection for targeting gastric cancer显示文摘AIM:To develop an affinity peptide that binds to gastric cancer used for the detection of early gastric cancer.METHODS:A peptide screen was performed by biopanning the PhD-12 phage display library,clearing non-specific binders against tumor-adjacent normal appearing gastric mucosa and obtaining selective binding against freshly harvested gastric cancer tissues.Tumortargeted binding of selected peptides was confirmed by bound phage counts,enzyme-linked immunosorbent assay,competitive inhibition,fluorescence microscopy and semi-quantitative analysis on immunohistochemistry using different types of cancer tissues.RESULTS:Approximately 92.8% of the non-specific phage clones were subtracted from the original phage library after two rounds of biopanning against normal-appearing gastric mucosa.After the third round of positive screening,the peptide sequence AADNAKTKSFPV(AAD) appeared in 25%(12/48) of the analyzed phages.For the control peptide,these values were 6.8 ± 2.3,5.1 ± 1.7,3.5 ± 2.1,4.6 ± 1.9 and 1.1 ± 0.5,respectively.The values for AAD peptide were statistically signif icant(P < 0.01) for gastric cancer as compared with other histological classif ications and control peptide.CONCLUSION:A novel peptide is discovered to have a specific binding activity to gastric cancer,and can be used to distinguish neoplastic from normal gastric mucosa,demonstrating the potential for early cancer detection on endoscopy. | Wen-Jie Zhang Yan-Xia Sui Arun Budha Jian-Bao Zheng Xue-Jun Sun Ying-Chun Hou Thomas D Wang Shao-Ying Lu | 2012 | World Journal of Gastroenterology2012，18，17： | 12 |
| 11 | Risk factors for combined hepatocellular-cholangiocarcinoma:A hospital-based case-control study显示文摘AIM:To identify risk factors contributing to the development of combined hepatocellular-cholangiocarcinoma(CHC) in China.METHODS:One hundred and twenty-six patients with CHC and 4:1 matched healthy controls were interviewed during the period from February 2000 to October 2012.Logistic regression analysis was used to calculate odds ratios(OR)and 95%confidence intervals(CI)for each risk factor.RESULTS:Univariate analysis showed that the significant risk factors for CHC development were hepatitis B virus(HBV)infection,heavy alcohol consumption,a family history of liver cancer,and diabetes mellitus.Multivariate stepwise logistic regression analysis showed that HBV infection(OR=19.245,95%CI:13.260-27.931)and heavy alcohol consumption(OR=2.186,95%CI:1.070-4.466)were independent factors contributing to the development of CHC.CONCLUSION:HBV infection and heavy alcohol consumption may play a role in the development of CHC in China. | Yan-Ming Zhou Xiao-Feng Zhang Lu-Peng Wu Cheng-Jun Sui Jia-Mei Yang | 2014 | World Journal of Gastroenterology2014，20，35： | 11 |
| 12 | Early versus late percutaneous dilational tracheostomy in critically ill patients anticipated requiring prolonged mechanical ventilation显示文摘 | ZHENG Yue SUI Feng CHEN Xiu-kai ZHANG Gui-chen WANG Xiao-wen ZHAO Song SONG Yang LIU Wei XIN Xin LI Wen-xiong | 2012 | Chinese Medical Journal2012，，11： | 11 |
| 13 | Origin of Baotoudong syenites in North China Craton:Petrological, mineralogical and geochemical evidence显示文摘Baotoudong 正长岩 pluton 被定位到 Baotou 城市的东方,内部蒙古,沿着北方中国 Craton (NCC ) 的北边缘的三叠纪的碱的 magmatic 带的最西的部分。锆石 U-Pb 年龄, petrological,矿物学并且 pluton 的 geochemical 数据在这份报纸被获得,抑制它的起源和披风来源特征。pluton 由 nepheline-clinopyroxene 正长岩和碱长石正长岩组成,与 214.7 ? 的锆石 U-Pb 年龄 ?????????? 潡潴摵湯 ????? 甠瑬慲潰慴獳捩 ???????????????????? | NIU Xiao Lu YANG Jing Sui LIU Fei ZHANG Hong Yu YANG Ming Chun | 2016 | Science China Earth Sciences2016，59，1： | 10 |
| 14 | Results and Analyses of BDS Precise Orbit Determination with the Enhancement of Fengyun-3C显示文摘Global navigation satellite system occultation sounder (GNOS) Fengyun-3C was launched successfully on September 23, 2013, which carried GPS/BDS receiver for the first time. This provides the convenience to study the enhancement results of low earth orbiter satellite (LEO) to BDS precise orbit determination (POD). First the data characteristic and code observation noise of GNOS are analyzed. Then the enhancement experiments in the case of global and regional ground observation stations layout are processed with four POD schemes: BDS single system, GPS/BDS double system, BDS single system with GNOS observations, GPS/BDS double system with GNOS observations. The precision of BDS orbits and clocks are compared via overlapping arcs. Results show that in the case of global station layout the along directional precision of GEO satellite has the biggest improvement, with the improvement percentage 60%. Then the precision of cross direction and the along direction of remaining satellites shows the second biggest improvement. The orbit precision of BDS-only POD in part of observation arcs some satellite even suffers a slight decline. The root mean square (RMS) of overlapping clock difference of visible arcs in GPS/BDS POD experiments improves by 0.1 ns level. As to the experiments of regional station layout with 7 ground stations, the orbit and clock overlapping precision and orbit predicting precision are analyzed. Results show that the predicting precision of BDS GEO satellites in the along direction improves by 85%. The remaining also has a substantial improvement, with the average percentage 21.7%. RMS of overlapping clock difference of visible arcs improves by 0.5 ns level. | Tian ZENG Lifen SUI Xiaolin JIA Guofeng JI Qinghua ZHANG | 2019 | Journal of Geodesy and Geoinformation Science2019，2，3： | 9 |
| 15 | The biological role of the CXCL12/CXCR4 axis in esophageal squamous cell carcinoma显示文摘Esophageal cancer is the eighth most common malignant tumor and the sixth leading cause of cancer-related death worldwide.Esophageal squamous cell carcinoma(ESCC)is the main histological type of esophageal cancer,and accounts for 90%of all cancer cases.Despite the progress made in surgery,chemotherapy,and radiotherapy,the mortality rate from esophageal cancer remains high,and the overall 5-year survival rate is less than 20%,even in developed countries.The C-X-C motif chemokine ligand 12(CXCL12)is a member of the CXC chemokine subgroup,which is widely expressed in a variety of tissues and cells.CXCL12 participates in the regulation of many physiological and pathological processes by binding to its specific receptor,C-X-C motif chemokine receptor type 4(CXCR4),where it causes embryonic development,immune response,and angiogenesis.In addition,increasing evidence indicates that the CXCL12/CXCR4 axis plays an important role in the biological processes of tumor cells.Studies have shown that CXCL12 and its receptor,CXCR4,are highly expressed in ESCC.This abnormal expression contributes to tumor proliferation,lymph node and distant metastases,and worsening prognosis.At present,antagonists and imaging agents against CXCL12 or CXCR4 have been developed to interfere with the malignant process and monitor metastasis of tumors.This article summarizes the structure,function,and regulatory mechanism of CXCL12/CXCR4 and its role in the malignancy of ESCC.Current results from preclinical research targeting CXCL12/CXCR4 are also summarized to provide a reference for the clinical diagnosis and treatment of ESCC. | Xianxian Wu Hongdian Zhang Zhilin Sui Yang Wang Zhentao Yu | 2021 | Cancer Biology & Medicine2021，18，2： | 9 |
| 16 | Degradation of bisphenol-A using ultrasonic irradiation assisted by low-concentration hydrogen peroxide显示文摘This study investigated the degradation of bisphenol-A (BPA) by ultrasonic irradiation in the presence of different additives (H2O2,air bubbles and humic acid) under various operating conditions,i.e.,ultrasonic frequency,power intensity and power density.The results demonstrated that the BPA degradation followed pseudo first-order kinetics under different experimental conditions.The optimum power intensities were 0.9,1.8,and 3.0W/cm 2 at the frequencies of 400,670,and 800 kHz,respectively.At the fixed frequency (800 kHz),the degradation rate of BPA was shown proportional to the increase of power density applied.With this manner,the BPA sonolysis could be facilitated at H2O2 dosage being lower than 0.1 mmol/L;while BPA degradation was hindered at H2O2 concentration in excess of 1 mmol/L.Additionally,BPA removal was shown to be inhibited by the presence of aeration and humic acid during ultrasonic irradiation.The present study suggested that the degradation rate of BPA assisted by ultrasonic irradiation was influenced by a variety of factors,and high BPA removal rate could be achieved under appropriate conditions. | Kejia Zhang Naiyun Gao Yang Deng Tsair Fuh Lin Yan Ma Lei Li Minghao Sui | 2011 | Journal of Environmental Sciences2011，23，1： | 9 |
| 17 | Sludge concentration dynamic distribution and its impact on the performance of UNITANK显示文摘UNITANK 是联合传统的激活的污泥过程和定序的批反应堆的 theadvantages 的一个生物废水处理过程,它是 UNITANKwere 的性能上的这研究,污泥分发和它的影响在广州的 Liede 废水植物( WWTP )执行了的 dividedinto 坦克 A , B 和 C.In , China.Results 证明在坦克 A 和在在坦克 A 的污泥集中 distribution.Theinitial 污泥集中的系统的 B 之间有 astrong 联营能介绍 | ZHANG Fa-gen LIU Jun-xin SUI Jun | 2007 | Journal of Environmental Sciences2007，19，2： | 9 |
| 18 | Synergistic effects of non-thermal plasma-assisted catalyst and ultrasound on toluene removal显示文摘A wire-mesh catalyst coated by La0.8Sr0.2MnO3 was combined with a dielectric barrier discharge (DBD) reactor for toluene removal at atmospheric pressure. It was found that toluene removal efficiency and carbon dioxide selectivity were enhanced in the catalytic packed-bed reactor. In addition, ozone and nitrogen monoxide from the gas effluent byproducts decreased. This is the first time that ultrasound combined with plasma has been used for toluene removal. A synergistic effect on toluene removal was observed in the plasma-assisted ultrasound system. At the same time, the system increased toluene conversion and reduced ozone emission. | Yongli Sun Libo Zhou Luhong Zhang Hong Sui | 2012 | Journal of Environmental Sciences2012，24，5： | 9 |
| 19 | Atorvastatin prevents amyloid-13 peptide oligomer- induced synaptotoxicity and memory dysfunction in rats through a p38 MAPK-dependent pathway显示文摘 | Ling-ling ZHANG Hai-juan SUI Bing LIANG Han-ming WANG Wen-hui QU Sheng-xue YU Ying JIN | 2014 | Acta Pharmacologica Sinica2014，35，6： | 9 |
| 20 | Dynamic expression of nerve growth factor and its receptor Trk A after subarachnoid hemorrhage in rat brain显示文摘Delayed ischemic neurologic deficit after subarachnoid hemorrhage results from loss of neural cells.Nerve growth factor and its receptor Trk A may promote regeneration of neural cells,but their expression after subarachnoid hemorrhage remains unclear.In the present study,a rat model of subarachnoid hemorrhage was established using two injections of autologous blood into the cistern magna.Immunohistochemical staining suggested that the expression of nerve growth factor and Trk A in the cerebral cortex and brainstem increased at 6 hours,peaked at 12 hours and decreased 1 day after induction of subarachnoid hemorrhage,whereas the expression in the hippocampus increased at 6 hours,peaked on day 1,and decreased 3 days later.Compared with those for the rats in the sham and saline groups,neurobehavioral scores decreased significantly 12 hours and 3 days after subarachnoid hemorrhage(P < 0.05).These results suggest that the expression of nerve growth factor and its receptor Trk A is dynamically changed in the rat brain and may thus participate in neuronal survival and nerve regeneration after subarachnoid hemorrhage. | Jin-ning Song Zun-wei Liu Long Sui Bin-fei Zhang Yong-lin Zhao Xu-dong Ma Hua Gu | 2016 | Neural Regeneration Research2016，11，8： | 9 |
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