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| 1 | Multiphase computed tomography radiomics of pancreatic intraductal papillary mucinous neoplasms to predict malignancy显示文摘BACKGROUND Intraductal papillary mucinous neoplasms(IPMNs)are non-invasive pancreatic precursor lesions that can potentially develop into invasive pancreatic ductal adenocarcinoma.Currently,the International Consensus Guidelines(ICG)for IPMNs provides the basis for evaluating suspected IPMNs on computed tomography(CT)imaging.Despite using the ICG,it remains challenging to accurately predict whether IPMNs harbor high grade or invasive disease which would warrant surgical resection.A supplementary quantitative radiological tool,radiomics,may improve diagnostic accuracy of radiological evaluation of IPMNs.We hypothesized that using CT whole lesion radiomics features in conjunction with the ICG could improve the diagnostic accuracy of predicting IPMN histology.AIM To evaluate whole lesion CT radiomic analysis of IPMNs for predicting malignant histology compared to International Consensus Guidelines.METHODS Fifty-one subjects who had pancreatic surgical resection at our institution with histology demonstrating IPMN and available preoperative CT imaging were included in this retrospective cohort.Whole lesion semi-automated segmentation was performed on each preoperative CT using Healthmyne software(Healthmyne,Madison,WI).Thirty-nine relevant radiomic features were extracted from each lesion on each available contrast phase.Univariate analysis of the 39 radiomics features was performed for each contrast phase and values were compared between malignant and benign IPMN groups using logistic regression.Conventional quantitative and qualitative CT measurements were also compared between groups,viaχ2(categorical)and Mann Whitney U(continuous)variables.RESULTS Twenty-nine subjects(15 males,age 71±9 years)with high grade or invasive tumor histology comprised the'malignant'cohort,while 22 subjects(11 males,age 70±7 years)with low grade tumor histology were included in the'benign'cohort.Radiomic analysis showed 18/39 precontrast,19/39 arterial phase,and 21/39 venous phase features differentiated malignant from benign IPMNs(P<0.05).Multivariate analysis including only ICG criteria yielded two significant variables:thickened and enhancing cyst wall and enhancing mural nodule<5 mm with an AUC(95%CI)of 0.817(0.709-0.926).Multivariable post contrast radiomics achieved an AUC(95%CI)of 0.87(0.767-0.974)for a model including arterial phase radiomics features and 0.834(0.716-0.953)for a model including venous phase radiomics features.Combined multivariable model including conventional variables and arterial phase radiomics features achieved an AUC(95%CI)of 0.93(0.85-1.0)with a 5-fold cross validation AUC of 0.90.CONCLUSION Multi-phase CT radiomics evaluation could play a role in improving predictive capability in diagnosing malignancy in IPMNs.Future larger studies may help determine the clinical significance of our findings. | Stuart L Polk Jung W Choi Melissa J McGettigan Trevor Rose Abraham Ahmed Jongphil Kim Kun Jiang Yoganand Balagurunathan Jin Qi Paola T Farah Alisha Rathi Jennifer B Permuth Daniel Jeong | 2020 | World Journal of Gastroenterology2020，26，24： | 5 |
| 2 | Aging, obsolescence and or- ganizational innovation 显示文摘 | Sorensen J B Stuart T E | 2000 | Administrative Science Quarterly2000，45，： | 1 |
| 3 | Aging, obsolescence and organizational innovation显示文摘 | Srensen J B Stuart T E | 2000 | Administrative Science Quarterly2000，45，1： | 1 |
| 4 | Wormlike micellar and vesicular phases in aqueous solutions of single-tailed surfac- rants with aromatic counterions 显示文摘 | Buwalda T R Stuart M C A Engberts J B F N | 2000 | Langmuir2000，16，： | 1 |
| 5 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 6 | Femtosecond pulsed laser ablation of metal alloy and semiconductor largets显示文摘 | TRELENBERG T W DINH L N STUART B C | 2004 | Applied Surjace Science2004，229，： | 1 |
| 7 | Aging,obsolescence,and organizational innovation显示文摘 | Sorensen J B Stuart T E | 2000 | Administrative Science Quarterly2000，45，1： | 1 |
| 8 | Local search and the evolution of technological capabilities 显示文摘 | Stuart T B Podoly J M | 1996 | Strategic Management Journal1996，17，1： | 1 |
| 9 | Aging, obsolescence and organiza- tional innovation显示文摘 | Sorensen J B Stuart T E | 2000 | Administrative Science Quarterly2000，4，1： | 1 |
| 10 | Wormlike micellar and vesicular phases in aqueous solutions of single - tailed surfactants with aromatic counterions 显示文摘 | BUWALDA T R STUART M C A ENGBERTS J B F N | 2000 | Langmuir2000，16，： | 1 |
| 11 | Withdrawal-related adverse events from clinical trials of clobazam in Lennox-Gastaut syndxmle 显示文摘 | Dwain T Stuart IH Ihor B | 2014 | Epilep-syBehav2014，37，： | 1 |
| 12 | Aging, obsolescence, and organizational innovation 显示文摘 | SORENSEN J B STUART T E | 2000 | Administrative Science Quarterly2000，45，1： | 1 |
| 13 | The relationship between subtypes of depression and cardiovascular disease : a systematic review of biological models 显示文摘 | Baune B T Stuart M Gilmour A | 2012 | Transl Psychiatry2012，2，92： | 1 |
| 14 | Local search and the evolution of technological capabilities 显示文摘 | STUART T B POLODY J M | 1996 | Strategic Management Journal1996，，17： | 1 |
| 15 | Aging, obsolescence and 0rganizational innovation 显示文摘 | Sorensen J B Stuart T E | 2000 | Administrative Science Quarterly2000，45，1： | 1 |
| 16 | Effects of participation in a martial arts-based antibullying program in elementary schools 显示文摘 | Stuart W T Bridget K B Timothy D N Eric M V Peter F Stephen W T | 2008 | Psychology in the School2008，45，10： | 1 |
| 17 | Aging, Obsoles cence, and Organizational Innovation显示文摘 | SORENSEN J B STUART T E | 2000 | Adminis trative Science Quarterly2000，45，1： | 1 |
| 18 | Self-phase modulation in chirped-pulse amplification显示文摘 | Perry M D Ditmtre T Stuart B C | 1994 | Opt Lett1994，19，24： | 1 |
| 19 | Coke Formation dur- ing Thermal Cracking of n-Octane 显示文摘 | Shah Y T Stuart E B Sheth K D | 1976 | Industrial & Engi- neering Chemistry Process Design and Development1976，15，4： | 1 |
| 20 | An antibiotic-altered microbiota provides fuel for the enteric foe显示文摘 | Leah T Stiemsma Stuart E Turvey Brett B Finlay | 2014 | Cell Research2014，24，1： | 1 |
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