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| 1 | Alpha-1 antitrypsin deficiency and the risk of hepatocellular carcinoma in end-stage liver disease显示文摘AIM:To evaluate the association between alpha-1 antitrypsin deficiency(A1ATD) and hepatocellular carcinoma(HCC) in patients with end-stage liver disease(ESLD).METHODS:Patients with cirrhosis and ESLD referred to the Cleveland Clinic Foundation for liver transplantation between 2003 and 2014 were included in the study(N = 675). ESLD was defined as having histological features of cirrhosis and/or radiological evidence of cirrhosis in the context of portal hypertension(ascites,variceal bleeding,thrombocytopenia,or hepatic encephalopathy). A1 ATD was diagnosed using phenotype characterization(MZ or ZZ),liver biopsy detection of PAS-positive diastaseresistant(PAS+) globules,or both. Patients with other causes of liver diseases such as hepatitis C virus(HCV),alcoholic liver disease and non-alcoholic steatohepatitis(NASH) or NASH were also included in the study. HCC was diagnosed by using imaging modalities,biopsy findings,or explanted liver inspection. Follow-up time was defined as the number of years from the diagnosis of cirrhosis to the diagnosis of hepatocellular carcinoma,or from the diagnosis of cirrhosis to the last follow up visit. The rate of HCC was assessed using time-tointerval analysis for interval censored data.RESULTS:This study included 675 patients. 7% of subjects had A1ATD(n = 47). Out of all subjects who did not have A1 ATD,46% had HCV,17% had alcoholic liver disease,19% had NASH and 18% had another primary diagnosis. Of the 47 subjects with A1 ATD,15 had a primary diagnosis of A1ATD(PI*ZZ phenotype and PAS+ globules),8 had a PI*MZ phenotype alone,14 had PAS+ alone,and 10 had both the PI*MZ phenotype and PAS+. Median follow-up time was 3.4(25th,75 th percentiles:1,5.2) years. The overall rate of hepatocellular carcinoma in all subjects was 29%(n = 199). In the A1 ATD group,the incidence rate of HCC was 8.5% compared to 31% in the group of patients with other causes of cirrhosis(P = 0.001). Patients with ESLD due to A1 ATD had the lowest yearly cumulative rate of hepatocellular carcinoma at 0.88% per year compared to 2.7% for those with HCV cirrhosis,1.5% in patients with NASH and 0.9% in alcohol-induced liver disease(P < 0.001).CONCLUSION:Within this group of patients with ESLD,there was no significant association between A1 ATD and increased risk of HCC. | Clara Antoury Rocio Lopez Nizar Zein James K Stoller Naim Alkhouri | 2015 | World Journal of Hepatology2015，7，10： | 3 |
| 2 | Mechanism for 2, 4-D safening of nicosulfuron/terbufos interaction com 显示文摘 | Simpson D M Diehl K E Stoller E W | 1993 | Abstr Weed Sci Soc Amer1993，33，： | 2 |
| 3 | Outcomes with FOLFIRINOX for borderline resectable and locally unresectable pancreatic cancer显示文摘 | Brian A. Boone Jennifer Steve Alyssa M. Krasinskas Amer H. Zureikat Barry C. Lembersky Michael K. Gibson Ronald G. Stoller Herbert J. Zeh Nathan Bahary | 2013 | J Surg Oncol2013，，4： | 2 |
| 4 | 高分辨率能谱测井——识别复杂矿物(二)显示文摘中子诱发俘获能谱测井仪能够测量井下岩石中特定元素的含量。岩石物理师可根据这些测量数据得出矿物、岩性和地层骨架等性质。早期能谱测井仪的能谱灵敏度不足以获取总有机碳数据,而总有机碳是认识非常规资源远景区的重要测量数据。一种新的测井仪器可提供总碳测量,据此可确定有机碳含量。该仪器在识别复杂岩性方面有着前所未有的精度。 | Manuel Aboud Rob Badry Jim Grau Susan Herron FaridHamichi Jack Horkowitz James Hemingway Robin MacDonald Pablo Saldungaray Don Stachiw Northern Cross Christian Stoller Princeston Junction Richard E.Williams | 2015 | 国外测井技术2015，0，1： | 2 |
| 5 | Estimated blood loss and transfusion rate sassociated with percutaneous nephrotithotomy显示文摘 | Stoller ML Wolf JSJr St Lezin MA | 1994 | J Urol1994，152，： | 1 |
| 6 | A decade of ARL collection development:a look at the data 显示文摘 | Michael Stoller | 2006 | Collection Building2006，25，2： | 1 |
| 7 | Clinical standardization of horizontal tooth mobility显示文摘 | Stoller NH Laudenbach KW | 1980 | J Clin Periodontol1980，7，3： | 1 |
| 8 | Learnthe Language of the plant显示文摘 | Jerry Stoller | 1995 | Fertilizer International1995，，347： | 1 |
| 9 | The vesical calculi 显示文摘 | Bradley F Schwartz Marshall L Stoller | 2000 | Urol Clin North Am2000，2，3： | 1 |
| 10 | Pyonephrosis: diagno- sis and treatment显示文摘 | St LM Hofmann R Stoller ML | 1992 | Br J Urol1992，70，： | 1 |
| 11 | Symbolic reachability analysis for parameterized administrative role-based access con- trol显示文摘 | Stoller S D Yang Ping Gofman M I | 2011 | Computers & Security2011，30，2： | 1 |
| 12 | A comparison of displacement cascades in copper and iron by molecular dynamics and its application to microstructural evolution显示文摘 | PHYTHIAN W J STOLLER R E FOREMAN A J E | | 0，，03： | 1 |
| 13 | Meniscal tears:pathologic correlation with MR imaging显示文摘 | Stoller DW Martin C CruesJV Ⅲ | | 0，，03： | 1 |
| 14 | Comorbidities, Patient Knowledge, and Disease Management in a National Sample of Patients with COPD显示文摘 | R. Graham Barr Bartolome R. Celli David M. Mannino Thomas Petty Stephen I. Rennard Frank C. Sciurba James K. Stoller Byron M. Thomashow Gerard M. Turino | 2009 | The American Journal of Medicine2009，，4： | 1 |
| 15 | Donorgifled allograft urolithiasis:early percutaneous management显示文摘 | Lu HF Shekarriz B Stoller ML | 2002 | Urology2002，59，： | 1 |
| 16 | Influence of long-term aging on the microstructual evolution of nuclear reactor pressure vessel material: an atom probe study 显示文摘 | PAREIGE P RUSSELL K F STOLLER R E | 1997 | J Nucl Mater1997，250，： | 1 |
| 17 | Meniscal tears: pathologic correlation with MR imaging 显示文摘 | Stoller D W Martin C Crues J V 3rd | 1987 | Radiology1987，163，3： | 1 |
| 18 | Weekly versus daily chan- ges of in - line suction catheters : impacton rates of ventilator - associatde pneumonia and associated costs 显示文摘 | Stoller JK Orens DK Fatica C | 2003 | Respir Care2003，48，5： | 1 |
| 19 | Carbon-based supercapcitors produced by activation of grapheme显示文摘 | ZHU Y W SHANTHI M STOLLER M D | 2011 | Science2011，332，： | 1 |
| 20 | Pulmonary involvement in Niemann-Pick disease: case report and literature review显示文摘 | Minai OA Sullivan EJ Stoller JK | 2000 | Respir Med2000，94，12： | 1 |
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