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| 1 | Proton pump inhibitors therapy and risk of Clostridium difficile infection: Systematic review and meta-analysis显示文摘AIM To perform a systematic review and meta-analysis on proton pump inhibitors(PPIs) therapy and the risk of Clostridium difficile infection(CDI). METHODS We conducted a systematic search of MEDLINE/Pub Med and seven other databases through January 1990 to March 2017 for published studies that evaluated the association between PPIs and CDI. Adult case-control and cohort studies providing information on the association between PPI therapy and the development of CDI were included. Pooled odds ratios(ORs) estimates with 95% confidence intervals(CIs) were calculated using the random effect. Heterogeneity was assessed by I^2 test and Cochran's Q statistic.Potential publication bias was evaluated via funnel plot, and quality of studies by the Newcastle-Otawa Quality Assessment Scale(NOS). RESULTS Fifty-six studies(40 case-control and 16 cohort) involving 356683 patients met the inclusion criteria and were analyzed. Both the overall pooled estimates and subgroup analyses showed increased risk for CDI despite substantial statistical heterogeneity among studies. Meta-analysis of all studies combined showed a significant association between PPI users and the risk of CDI(pooled OR = 1.99, CI: 1.73-2.30, P < 0.001) as compared with non-users. The association remained significant in subgroup analyses: by design-case-control(OR = 2.00, CI: 1.68-2.38, P < 0.0001), and cohort(OR = 1.98, CI: 1.51-2.59, P < 0.0001); adjusted(OR = 1.95, CI: 1.67-2.27, P < 0.0001) and unadjusted(OR = 2.02, CI: 1.41-2.91, P < 0.0001); unicenter(OR = 2.18, CI: 1.72-2.75, P < 0.0001) and multicenter(OR = 1.82, CI: 1.51-2.19, P < 0.0001); age ≥ 65 years(OR = 1.93, CI: 1.40-2.68, P < 0.0001) and < 65 years(OR = 2.06, CI: 1.11-3.81, P < 0.01). No significant differences were found in subgroup analyses(test for heterogeneity): P = 0.93 for case-control vs cohort, P = 0.85 for adjusted vs unadjusted, P = 0.24 for unicenter vs multicenter, P = 0.86 for age ≥ 65 years and < 65 years. There was significant heterogeneity across studies(I^2 = 85.4%, P < 0.001) as well as evidence of publication bias(funnel plot asymmetry test, P = 0.002). CONCLUSION This meta-analysis provides further evidence that PPI use is associated with an increased risk for development of CDI. Further high-quality, prospective studies are needed to assess whether this association is causal. | Anca Trifan Carol Stanciu Irina Girleanu Oana Cristina Stoica Ana Maria Singeap Roxana Maxim Stefan Andrei Chiriac Alin Ciobica Lucian Boiculese | 2017 | World Journal of Gastroenterology2017，23，35： | 15 |
| 2 | A view of cloud computing显示文摘 | Michael Armbrust Armando Fox Rean Griffith Anthony D. Joseph Randy Katz Andy Konwinski Gunho Lee David Patterson Ariel Rabkin Ion Stoica Matei Zaharia | 2010 | Communications of the ACM2010，，4： | 13 |
| 3 | Impact of Clostridium difficile infection on inflammatory bowel disease outcome: A review显示文摘Although a considerable number of studies support a substantial increase in incidence, severity, and healthcare costs for Clostridium difficile infection(CDI) in inflammatory bowel disease(IBD), only few evaluate its impact on IBD outcome. Medline and several other electronic databases from January 1993 to October 2013 were searched in order to identify potentially relevant literature. Most of the studies showed that IBD patients with CDI present a greater proportion of worse outcomes than those without CDI. These patients have longer length of hospital stay, higher rates of colectomies, and increased mortality. Patients with ulcerative colitis are more susceptible to CDI and have more severe outcomes than those with Crohn's disease. However, studies reported variable results in both short-and long-term outcomes. Contrasting results were also found between studies using nationwide data and those reporting from single-center, or between some NorthAmerican and European studies. An important limitation of all studies analyzed was their retrospective design. Due to contrasting data often provided by retrospective studies, further prospective multi-center studies are necessary to evaluate CDI impact on IBD outcome. Until then, a rapid diagnosis and adequate therapy of infection are of paramount importance to improve IBD patients' outcome. The aim of this article is to provide up to date information regarding CDI impact on outcome in IBD patients. | Anca Trifan Carol Stanciu Oana Stoica Irina Girleanu Camelia Cojocariu | 2014 | World Journal of Gastroenterology2014，20，33： | 11 |
| 4 | A view of cloud computing显示文摘 | Michael Armbrust Armando Fox Rean Griffith Anthony D. Joseph Randy Katz Andy Konwinski Gunho Lee David Patterson Ariel Rabkin Ion Stoica Matei Zaharia | 2010 | Communications of the ACM2010，，4： | 5 |
| 5 | Subspace-based frequency estimation in the presence of moving-average noise using decimation显示文摘 | Stoica Petre Nordsjo Anders E | 1997 | SignalProcessing1997，63，： | 2 |
| 6 | Texture evolution of five wrought magnesium alloys during route A equal channel angular extrusion: Experiments and simulations显示文摘 | S.R. Agnew P. Mehrotra T.M. Lillo G.M. Stoica P.K. Liaw | 2005 | Acta Materialia2005，，11： | 2 |
| 7 | A data-oriented (and beyond) network architecture显示文摘 | Teemu Koponen Mohit Chawla Byung-Gon Chun Andrey Ermolinskiy Kye Hyun Kim Scott Shenker Ion Stoica | 2007 | ACM SIGCOMM Computer Communication Review2007，，4： | 2 |
| 8 | On parameter identifiability of MIMO radar 显示文摘 | Li J Stoica P Xu L Z Roberts W | 2007 | IEEE Signal Processing Letters2007，14，12： | 1 |
| 9 | On parame-ter identifiability of MIMO radar显示文摘 | Jian Li Petre Stoica Luzhou Xu William Roberts | 2007 | IEEE Signal ProcessingLetters2007，14，12： | 1 |
| 10 | Asymptotic performance of optimal gain-and-phase estimators of sensor arrays显示文摘 | CHENG Q HUA Y B STOICA P | 2000 | IEEE Transactions on Signal Processing2000，48，12： | 1 |
| 11 | Direction finding in the presence of an intermittent interference显示文摘 | Besson O Stoica P Kaniya Y | 2002 | IEEE Trans on SP2002，50，7： | 1 |
| 12 | Chord:a scalable peer-to-peer lookup protocol for Internet applications显示文摘 | STOICA I MORRIS R NOWELL D L | 2003 | IEEE/ACM Transactions on Networking2003，11，1： | 1 |
| 13 | MUSIC Maximum Likelihood,and Cramer-Rao Bound显示文摘 | Stoica P Nehorai A | 1989 | IEEE Trans ASSP1989，37，5： | 1 |
| 14 | Reduction in vaneomycin - resistant entorococcus and clostridium diffcile infections ther- mometer显示文摘 | Brook S Khan A Stoica 'D | 1998 | Infection Control and Hospital Epidemiology1998，19，： | 1 |
| 15 | Target Detection and Parameter Estimation for MIMO Radar Systems 显示文摘 | Xu L Z Li J Stoica P | 2008 | IEEE Transactions on Aerospace and Electronic Systems2008，44，3： | 1 |
| 16 | Fully automatic computation of diagonal loading levels for robust adaptive beamforming显示文摘 | Du Lin Li Jian Stoica P | 2010 | IEEE Transactions on Aerospace and Electronic Systems2010，46，1： | 1 |
| 17 | Optimal Designs for Space-time Linear Precoders and Decoders显示文摘 | Scaglione A Stoica P Barbarossa S | 2002 | IEEE Transactions on Signal Processing2002，50，5： | 1 |
| 18 | Generalized linear precoder and decoder design for MIMO channels using the weighted MMSE criterion显示文摘 | Sampath H Stoica P Paulraj A | | 0，，12： | 1 |
| 19 | Waveform synthesis for diversity-based transmit beampattern design显示文摘 | Stoica P Li J and Zhu X | 2008 | IEEE Transactions on Signal Processing2008，56，6： | 1 |
| 20 | Differential diagnosis of breast lesions using ultrasound elastography显示文摘 | Gheonea IA Stoica Z Bondari S | 2011 | Indian Radiol Imaging2011，21，4： | 1 |
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