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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | DNA repair gene XRCC1 polymorphisms, smoking, and bladder cancer risk 显示文摘 | Stern MC Umbach DM van Gils CH | 2001 | Cancer Epidemiol Biomarkers Prev2001，10，2： | 1 |
| 3 | XPD codon 751 polymorphism, metabolism genes, smoking, and bladder cancer risk显示文摘 | Stern MC Johnson LR Bell DA | 2002 | Cancer Epidemiol Biomarkers Prev2002，11，101： | 1 |
| 4 | DNA repair gene XRCC3 codon 241 polymorphism, its interaction with smoking and XRCC1 polymorphisms, and bladder cancer risk 显示文摘 | Stern MC Umbach DM Lunn RM | 2002 | Cancer Epidemiol Biomarkers Prev2002，11，9： | 1 |
| 5 | Sodium channel blockade reduces hypoxic sodium loading and sodium-dependent calcium loading显示文摘 | Haigney MC Lakatta EG Stern MD | 1994 | Circulation1994，90，1： | 1 |
| 6 | DNArepair gene XRCC1 polymorphisms, smoking, and bladder cancer risk 显示文摘 | Stern MC Umbach DM van Gils CH | 2001 | Cancer Epidemiol Biomark ers Prev2001，10，2： | 1 |
| 7 | CTNNB1 mutations and beta-catenin protein accumulation in human hepatocellular carcinomas associated with high exposure to aflatoxin B1显示文摘 | Devereux TR Stern MC Flake GP | 2001 | Mol Carcinog2001，31，2： | 1 |
| 8 | Associations with growth factor genes (FGF1,FGF2,PDGFB,FGFR2,NRG2,EGF,ERBB2) with breast cancer risk and survival: the breast cancer health disparities study显示文摘 | SLATTERY ML JOHN EM STERN MC | 2013 | Breast Cancer Res Treat2013，140，3： | 1 |
| 9 | Analysis of intra-uterine cytokine concentration and matrix-metalloproteinase activity in women with recurrent failed embryo transfer显示文摘 | Inagaki N Stern C Mc Bain J | 2003 | Hum Reprod2003，18，3： | 1 |
| 10 | Sodium channel blockade reduces hypoxic sodium loading and sodium-dependent calcium loading显示文摘 | Haigeny MC Lakatta EG Stern MD | 1994 | Circulation1994，90，1： | 1 |
| 11 | CTNNB1 mutations and beta-catenin protein accumulation in human hepatocellular carcinomas associated with high exposure to aflatoxin B1显示文摘 | Devereux TR Stern MC Flake GP | 2001 | Mol Carcinog2001，31，2： | 1 |
| 12 | 显示文摘 | Stern MC | 2001 | Cancer Epidemiol Biomarkers Prev2001，10，2： | 1 |
| 13 | Genetic ancestry modifies theassociation between genetic risk variants and breast cancer riskamong Hispanic and non-Hispanic white women显示文摘 | Fejerman L Stern MC Ziv E | 2013 | Carcinogenesis2013，34，8： | 1 |
| 14 | Sodiun channel blockade reduces hypoxie sodium loading and sodium-dependent calcium loading显示文摘 | Haigney MC Lakatta HS Stern MD | 1994 | Circulation1994，90，1： | 1 |
| 15 | Polyunsaturated fatty acids, DNA repair single nucleotide polymorphisms and colorectal cancer in the singapore chinese health study 显示文摘 | Stern MC Butler LM Corral R | 2009 | J Nutrigenet Nutrigenomics2009，2，6： | 1 |
| 16 | XPD eodon 751 polymorphism metabolism genes smoking and bladder cancer risk显示文摘 | Stern MC Johnson LR Bell DA | 2002 | Cancer Epidemiol Biomarkers Prey2002，11，101： | 1 |
| 17 | DNA repair single-nu- cleotide polymorphisms in colorectal cancer and their role as mod- ifiers of the effect of cigarette smoking and alcohol in the Singa- pore Chinese Health Study 显示文摘 | Stern MC Conti DV Siegmund KD | 2007 | Cancer Epidemiol Biomarkers Prey2007，16，11： | 1 |
| 18 | Angiogensis is an early event in the devlopment of chemically induced skintumors显示文摘 | Bolontrade MF Stern MC Binder RL | 1998 | Carcinogenesis1998，19，12： | 1 |
| 19 | Sodium channel blockade reduces hypoxic sodium loading and sodium-dependent calcium loading显示文摘 | Haigney MC Lakatta EG Stern MD Silverman HS | 1994 | Circulation1994，90，： | 1 |
| 20 | DNA repair gene XRCCI polymorphisms, smoking, and bladder cancer risk 显示文摘 | Stern MC Umbach DM Gils CH | 2001 | Cancer Epidemiol Biomark Prey2001，10，： | 1 |
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