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| 1 | Central line-associated bloodstream infection among children with biliary atresia listed for liver transplantation显示文摘BACKGROUND Pre-transplant nutrition is a key driver of outcomes following liver transplantation in children.Patients with biliary atresia(BA) may have difficulty achieving satisfactory weight gain with enteral nutrition alone,and parenteral nutrition(PN) may be indicated.While PN has been shown to improve anthropometric parameters of children with BA listed for liver transplantation,less is known about the risks,particularly infectious,associated with this therapy among this specific group of patients.AIM To describe the incidence,microbiology,and risk factors of central line-associated bloodstream infection(CLABSI) among children with BA listed for liver transplantation.METHODS Retrospective review of children aged ≤ 2-years of age with BA who were listed for primary liver transplantation at Texas Children's Hospital from 2008 through2015(n = 96).Patients with a central line for administration of PN(n = 63) were identified and details of each CLABSI event were abstracted.We compared the group of patients who experienced CLABSI to the group who did not,to determine whether demographic,clinical,or laboratory factors correlated with development of CLABSI.RESULTS Nineteen of 63 patients(30%,95%CI:19,43) experienced 29 episodes of CLABSI during 4800 line days(6.04 CLABSI per 1000 line days).CLABSI was predominantly associated with Gram-negative organisms(14/29 episodes,48%)including Klebsiella spp.,Enterobacter spp.,and Escherichia coli.The sole polymicrobial infection grew Enterobacter cloacae and Klebsiella pneumoniae.Grampositive organisms(all Staphylococcus spp.) and fungus(all Candida spp.)comprised 9/29(31%) and 6/29(21%) episodes,respectively.No demographic,clinical,or laboratory factors were significantly associated with an increased risk for the first CLABSI event in Cox proportional hazards regression analysis CONCLUSION There is substantial risk for CLABSI among children with BA listed for liver transplantation.No clinical,demographic,or laboratory factor we tested emerged as an independent predictor of CLABSI.While our data did not show an impact of CLABSI on the short-term clinical outcome,it would seem prudent to implement CLABSI reduction strategies in this population to the extent that each CLABSI event represents potentially preventable hospitalization,unnecessary healthcare dollar expenditures,and may exact an opportunity cost,in terms of missed allograft offers. | Nicole D Triggs Stacey Beer Sonam Mokha Kat Hosek Danielle Guffey Charles G Minard Flor M Munoz Ryan W Himes | 2019 | World Journal of Hepatology2019，11，2： | 2 |
| 2 | Legume nodule organogenesis 显示文摘 | Cohn J Bradley D Stacey G | 1998 | Trends in Plant Science1998，3，： | 1 |
| 3 | Compositional constraints on the equation of state and the thermal properties of the lower mantle 显示文摘 | STACEY F ISAAK D G | 2001 | Geophys J Int2001，146，： | 1 |
| 4 | Mining subsidence and its effect on the environment: some differing examples显示文摘 | Bell F G Stacey T R Genske D D | 2000 | Environmental Geology2000，40，2： | 1 |
| 5 | An integrated transcriptome atlas of the crop model Glycine max and its use in comparative analyses in plants显示文摘 | Libault M Farmer A Joshi T Takahashi K Langley R.J Franklin L.D He J Xu D May G and Stacey G | | 0，，01： | 1 |
| 6 | The toxoplasma homolog of plasmodium apical membrane antigen-1 (AMA-1) is a microneme protein secreted in response to elerated intracellular calcium levels显示文摘 | CAROLYN G D VERN B C STACEY D G | 2000 | Mol Biochem Parasitol2000，111，1： | 1 |
| 7 | Mining subsidence and its effect on the environment:Some differing examples 显示文摘 | Bell F G Stacey T R Genske D D | 2000 | Envi- ronmental Geology2000，40，12： | 1 |
| 8 | Mining subsidence and its effect on the environment:Some differing examples显示文摘 | Bell F G Stacey T R Genske D D | 2000 | Environ Geol2000，40，2： | 1 |
| 9 | Vires NS1 Protein Induces Apoptosis in Cultured Cells 显示文摘 | Stacey S C Naomi D S Neumann G | 2001 | J Virol2001，75，： | 1 |
| 10 | Calcium-dependent phosphorylation of symbiosome membrane proteins from nitrogenfixing soybean nodules显示文摘 | WEAVER C D CROMBIE B STACEY G | 1991 | Plant Physiology1991，95，： | 1 |
| 11 | Calcium-dependent phosphorylation of symbiosome membrane proteins from nitrogen-fixing soybean nodules: Evidence for phosphory-lation of nodulin-26显示文摘 | Weaver C D Crombie B Stacey G | 1991 | Plant Physiology1991，95，1： | 1 |
| 12 | Thermomagnetic properties,natural magnetic moments,and magnetic anisotropies of some chondritic meteorites显示文摘 | Stacey F D Lovering J F Parry L G | 1961 | Journal of Geophysical Research1961，，66： | 1 |
| 13 | Calcium-dependent phosphorylation of symbiosome membrane proteins from nitrogen-fixing soybean nodules: Evidence for phosphorylation of Nodulin-26显示文摘 | WEAVER C D CROMBIE B STACEY G | 1991 | Plant Physiol1991，95，： | 1 |
| 14 | Impact of patient decision aids on appropriate and timely access to hip or knee arthroplasty for osteoarthritis: a randomized con- trolled trial显示文摘 | Stacey D Taljaard M Dervin G | 2015 | Osteoarthr Cartil2015，24，1： | 1 |
| 15 | Mining subsidence and its ffect on the environment:some differing examples显示文摘 | Bell F G Stacey T R Genske D D | 2000 | Environmental Geology2000，40，12： | 1 |
| 16 | Virus NS1 protein induces apoptosis in cultured cells 显示文摘 | Stacey S C Naomi D S Neumann G | 2001 | J Virol2001，75，： | 1 |
| 17 | Priorities, barri- ers and facilitators for remote support of cancer symp- toms:A survey of Canadian oncology nurses显示文摘 | Macartney G Stacey D Carley M | 2012 | Can On- col Nurs J2012，22，4： | 1 |
| 18 | The regulation of S phase initiation by p27Kipl in NIH3T3 cell显示文摘 | Sa G Guo Y Stacey D W | 2005 | Cell Cycle2005，4，4： | 1 |
| 19 | Moving SDM forward in Canada: milestones, public involvement, and barriers that remain显示文摘 | Legare F Stacey D Forest P G | 2011 | Zeitschrift fur Evidenz Fortbildung und Qualitat im Gesundheitswesen2011，105，4： | 1 |
| 20 | The International Stem Cell Banking Initiative (ISCBI):raising standards to bank on显示文摘 | Crook JM Hei D Stacey G | | 0，，3： | 1 |
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