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| 1 | 磺胺类药物化学研究新进展显示文摘磺胺是应用最早的一类化学合成抗菌药,在治疗感染性疾病中起着重要作用,因此许多研究致力于磺胺类化合物的深入开发.母体结构对氨基苯磺酰胺经化学结构修饰后呈现广泛的生物活性,显示出巨大的药用潜力和开发价值,相关研究异常活跃.结合本课题组研究,参考国内外近5年文献,本文系统地综述了磺胺母体结构不同部位的化学结构修饰及其衍生物,包括其金属超分子络合物在抗微生物、抗癌、抗寄生虫、消炎镇痛、抗惊厥、抗青光眼、抗糖尿病、抗癫痫及相关神经性疾病和利尿药等药用研发新情况,并展望了其发展趋势.希望为广谱性、高活性和低毒性磺胺类新药分子的合理设计提供指导,为开拓磺胺类化合物的用途提供新思路. | 何世超 Ponmani Jeyakkumar Avula Srinivasa Rao 王宪龙 张慧珍 周成合 | 2016 | 中国科学:化学2016，46，9： | 41 |
| 2 | Pancreatic cancer and its stroma: A conspiracy theory显示文摘Pancreatic cancer is characterised by a prominent desmoplastic/stromal reaction that has received little attention until recent times. Given that treatments focusing on pancreatic cancer cells alone have failed to significantly improve patient outcome over many decades, research efforts have now moved to understanding the pathophysiology of the stromal reaction and its role in cancer progression. In this regard, our Group was the first to identify the cells(pancreatic stellate cells, PSCs) that produced the collagenous stroma of pancreatic cancer and to demonstrate that these cells interacted closely with cancer cells to facilitate local tumour growth and distant metastasis. Evidence is accumulating to indicate that stromal PSCs may also mediate angiogenesis, immune evasion and the well known resistance of pancreatic cancer to chemotherapy and radiotherapy. This review will summarise current knowledge regarding the critical role of pancreatic stellate cells and the stroma in pancreatic cancer biologyand the therapeutic approaches being developed to target the stroma in a bid to improve the outcome of this devastating disease. | Zhihong Xu Srinivasa P Pothula Jeremy S Wilson Minoti V Apte | 2014 | World Journal of Gastroenterology2014，20，32： | 10 |
| 3 | Effect of technical parameters on transjugular intrahepatic portosystemic shunts utilizing stent grafts显示文摘AIM: To assess the effect of technical parameters on outcomes of transjugular intrahepatic portosystemic shunt(TIPS) created using a stent graft.METHODS: The medical records of 68 patients who underwent TIPS placement with a stent graft from 2008 to 2014 were reviewed by two radiologists blinded to the patient outcomes.Digital Subtraction Angiographic images with a measuring catheter in two orthogonal planes was used to determine the TIPS stent-to-inferior vena cava distance(SIVCD),hepatic vein to parenchymal tract angle(HVTA),portal vein to parenchymal tract angle(PVTA),and the accessed portal vein.The length and diameter of the TIPS stent and the use of concurrent variceal embolization were recorded by review of the patient's procedure note.Data on re-intervention within 30 d of TIPS placement,recurrence of symptoms,and survival were collected through the patient's chart.Cox proportional regression analysis was performed to assess the effect of these technical parameters on primary patency of TIPS,time to recurrence of symptoms,and all-cause mortality.RESULTS: There was no significant associationbetween the SIVCD and primary patency(P = 0.23),time to recurrence of symptoms(P = 0.83),or allcause mortality(P = 0.18).The 3,6,and 12-mo primary patency rates for a SIVCD ≥ 1.5 cm were 82.4%,64.7%,and 50.3% compared to 89.3%,83.8%,and 60.6% for a SIVCD of < 1.5 cm(P = 0.29).The median time to stenosis for a SIVCD of ≥ 1.5 cm was 19.1 mo vs 15.1 mo for a SIVCD of < 1.5 cm(P = 0.48).There was no significant association between the following factors and primary patency: HVTA(P = 0.99),PVTA(P = 0.65),accessed portal vein(P = 0.35),TIPS stent diameter(P = 0.93),TIPS stent length(P = 0.48),concurrent variceal embolization(P = 0.13) and reinterventions within 30 d(P = 0.24).Furthermore,there was no correlation between these technical parameters and time to recurrence of symptoms or all-cause mortality.Recurrence of symptoms was associated with stent graft stenosis(P = 0.03).CONCLUSION: TIPS stent-to-caval distance and other parameters have no significant effect on primary patency,time to recurrence of symptoms,or all-cause mortality following TIPS with a stent-graft. | Brice Andring Sanjeeva P Kalva Patrick Sutphin Rajiv Srinivasa Alvin Anene Marc Burrell Yin Xi Anil K Pillai | 2015 | World Journal of Gastroenterology2015，21，26： | 7 |
| 4 | 高端口服固体仿制药的设计及其产品关键质量属性的控制——以FDA批准的琥珀酸美托洛尔缓释片为例显示文摘高端制剂难以仿制的主要原因是产品的设计要求比较复杂,如果对产品的理解和控制不足,产品质量和生物等效性则难以符合要求。目前,我国医药市场上高端制剂的可及性较低。国家鼓励创新的大环境为制药行业提高这类仿制药的可及性提供了一个好机会。琥珀酸美托洛尔缓释片是一个较难开发和生产的高端仿制药物制剂。以南通联亚药业被美国FDA批准的琥珀酸美托洛尔缓释片为例,对此产品的制剂特点、研发技术难点、审评要求及最终产品测试结果进行介绍,以期为国内高端仿制药物制剂的开发及审评提供参考。 | 龚健 徐彦 赖鹏 陈义生 房杏春 胡成松 CHINTA Srinivasa Reddy 张国华 | 2018 | 药学进展2018，42，9： | 7 |
| 5 | Influence of bio-inspired flow channel designs on the performance of a PEM fuel cell显示文摘Performance of the proton exchange membrane fuel cell(PEMFC)is appreciably affected by the channel geometry.The branching structure of a plant leaf and human lung is an efficient network to distribute the nutrients in the respective systems.The same nutrient transport system can be mimicked in the flow channel design of a PEMFC,to aid even reactant distribution and better water management.In this work,the effect of bio-inspired flow field designs such as lung and leaf channel design bipolar plates,on the performance of a PEMFC was examined experimentally at various operating conditions.A PEMFC of 49 cm2 area,with a Nafion 212 membrane with a 40%catalyst loading of 0.4 mg·cm-2 on the anode side and also 0.6 mg·cm-2 on the cathode side is assembled by incorporating the bio-inspired channel bipolar plate,and was tested on a programmable fuel-cell test station.The impact of the working parameters like reactants’relative humidity(RH),back pressure and fuel cell temperature on the performance of the fuel cell was examined;the operating pressure remains constant at 0.1 MPa.It was observed that the best performance was attained at a back pressure of 0.3 MPa,75°C operating temperature and 100%RH.The three flow channels were also compared at different operating pressures ranging from 0.1 MPa to 0.3 MPa,and the other parameters such as operating temperature,RH and back pressure were set as 75°C,100%and 0.3 MPa.The experimental outcomes of the PEMFC with bio-inspired channels were compared with the experimental results of a conventional triple serpentine flow field.It was observed that among the different flow channel designs considered,the leaf channel design gives the best output in terms of power density.Further,the experimental results of the leaf channel design were compared with those of the interdigitated leaf channel design.The PEMFC with the interdigitated leaf channel design was found to generate 6.72%more power density than the non-interdigitated leaf channel design.The fuel cell with interdigitated leaf channel design generated5.58%more net power density than the fuel cell with non-interdigitated leaf channel design after considering the parasitic losses. | Srinivasa Reddy Badduri G.Naga Srinivasulu S.Srinivasa Rao | 2020 | Chinese Journal of Chemical Engineering2020，28，3： | 6 |
| 6 | Condition Monitoring of CNC Machining Using Adaptive Control显示文摘In this work, an adaptive control constraint system has been developed for computer numerical control (CNC) turning based on the feedback control and adaptive control/self-tuning control. In an adaptive controlled system, the signals from the online measurement have to be processed and fed back to the machine tool controller to adjust the cutting parameters so that the machining can be stopped once a certain threshold is crossed. The main focus of the present work is to develop a reliable adaptive control system, and the objective of the control system is to control the cutting parameters and maintain the displacement and tool flank wear under constraint valves for a particular workpiece and tool combination as per ISO standard. Using Matlab Simulink, the digital adaption of the cutting parameters for experiment has confirmed the efficiency of the adaptively controlled condition monitoring system, which is reflected in different machining processes at varying machining conditions. This work describes the state of the art of the adaptive control constraint (ACC) machining systems for turning. AISI4140 steel of 150 BHN hardness is used as the workpiece material, and carbide inserts are used as cutting tool material throughout the experiment. With the developed approach, it is possible to predict the tool condition pretty accurately, if the feed and surface roughness are measured at identical conditions. As part of the present research work, the relationship between displacement due to vibration, cutting force, flank wear, and surface roughness has been examined. | B. Srinivasa Prasad D. Siva Prasad A. Sandeep G. Veeraiah | 2013 | International Journal of Automation and computing2013，10，3： | 5 |
| 7 | High performance liquid chromatography mass spectrometric method for the simultaneous quantification of pravastatin and aspirin in human plasma:Pharmacokinetic application显示文摘A rapid and sensitive liquid chromatography-tandem mass spectrometric(LC-MS/MS) assay method has been developed and fully validated for the simultaneous quantification of pravastatin and aspirin in human plasma.Furosemide was used as an internal standard.Analytes and the internal standard were extracted from human plasma by liquid-liquid extraction technique using methyl tertiary butyl ether.The reconstituted samples were chromatographed on a Zorbax SB-C_18 column by using a mixture of 5 mM ammonium acetate buffer and acetonitrile(20:80,v/v) as the mobile phase at a flow rate of 0.8 mL/min.The calibration curve obtained was linear(r≥0.99) over the concentration range of 0.50-600.29 ng/mL for pravastatin and 20.07-2012.00 ng/mL for aspirin.Method validation was performed as per FDA guidelines and the results met the acceptance criteria.A run time of 2.0 min for each sample made it possible to analyze more than 400 human plasma samples per day.The proposed method was found to be applicable to clinical studies. | Srinivasa Rao Polagani Nageswara Rao Pilli Venkateswarlu Gandu | 2012 | Journal of Pharmaceutical Analysis2012，2，3： | 5 |
| 8 | Effect of pulsed current micro plasma arc welding process parameters on fusion zone grain size and ultimate tensile strength of Inconel 625 sheets显示文摘The paper focuses on developing mathematical models to predict grain size and ultimate tensile strength of pulsed current micro plasma arc welded Inconel 625 nickel alloy. Four factors, five levels, central composite rotatable design matrix is used to optimize the number of experiments. The mathematical models have been developed by response surface method. The adequacy of the models is checked by analysis of variance technique. By using the developed mathematical models, grain size and ultimate tensile strength of the joints can be predicted with 99% confidence level. Contour plots are drawn to study the interaction effect of pulsed current micro plasma arc welding parameters on fusion zone grain size and ultimate tensile strength of Inconel 625 weld joints. | Kondapalli Siva Prasad Chalamalasetti Srinivasa Rao Damera Nageswara Rao | 2012 | Acta Metallurgica Sinica(English Letters)2012，25，3： | 4 |
| 9 | Biomechanics of knee joint-- A review显示文摘现在的纸是知道工作怎么在膝的 biomechanics 的领域里被执行。各种各样的模型明确的表达被讨论并且进一步分类进数学模型,二维的模型和三维的模型。膝几何学是人的身体运动,膝看怎么各种各样,在不同飞机在并且怎么被看的关键部分胫骨和腿节上的力量行为被学习。它导致知道对膝关节起作用的力量。对各种各样的研究人员显示出的膝起作用的膝几何学和力量的试验性的研究被讨论了,并且结果的比较被做。另外,膝的静态、动态的分析也分别地被讨论了到某程度。 | Bhaskar Kumar MADETI Srinivasa Rao CHALAMALASETTI S. K. Sundara siva rao BOLLA PRAGADA | 2015 | Frontiers of Mechanical Engineering2015，10，2： | 4 |
| 10 | )plication of geo-microbial prospecting method for finding oil and gas reservoirs显示文摘 | M. A. Rasheed Syed Zaheer Hasan P. L. Srinivasa Rao Annapurna Boruah V.Sudarshan B. Kumar T. Harinarayana | 2015 | Frontiers of Earth Science2015，9，1： | 3 |
| 11 | Short-term financing in a cash-constrained supply chain显示文摘 | N.R. Srinivasa Raghavan Vinit Kumar Mishra | 2009 | International Journal of Production Economics2009，，2： | 3 |
| 12 | A Study of Mechanization of Cotton Harvesting in India and Its Implications显示文摘 | Srinivasa Konduru Fumiko Yamazaki Mechel Paggi | 2013 | Journal of Agricultural Science and Technology(B)2013，3，11： | 3 |
| 13 | Vibrational Spectroscopy of Stretching and Bending Modes of Nickel Tetraphenyl Porphyrin: an Algebraic Approach显示文摘我们由使用 U (2 ) 为 36 个震动的乐队计算镍 tetraphenyl 卟啉的震动的频率代数学的途径。在计算的代数学的参数与试验性的数据是精确的。 | Srinivasa Rao KARUMURI Joydeep CHOUDHURY Nirmal Kumar SARKAR Ramendu BHATTACHARJEE | 2009 | Chinese Physics Letters2009，26，9： | 3 |
| 14 | Simultaneous determination of atorvastatin,metformin and glimepiride in human plasma by LC-MS/MS and its application to a human pharmacokinetic study显示文摘A simple, rapid and sensitive liquid chromatography-tandem mass spectrometric (LC-MS/ MS) assay method has been developed and fully validated for the simultaneous quantification of atorvastatin, metformin and glimepiride in human plasma. Carbamazepine was used as internal standard (IS). The analytes were extracted from 200 mL aliquots of human plasma via protein precipitation using acetonitrile. The reconstituted samples were chromatographed on a Alltima HP C18 column by using a 60:40 (v/v) mixture of acetonitrile and 10 mM ammonium acetate (pH 3.0) as the mobile phase at a flow rate of 1.1 mL/min. The calibration curves obtained were linear (r 2 Z0.99) over the concentration range of 0.50-150.03 ng/mL for atorvastatin, 12.14-1207.50 ng/mL for metformin and 4.98-494.29 ng/mL for glimepiride. The API-4000 LC-MS/MS in multiple reaction monitoring (MRM) mode was used for detection. The results of the intra- and inter-day precision and accuracy studies were well within the acceptable limits. All the analytes were found to be stable in a battery of stability studies. The method is precise and sensitive enough for its intended purpose. A run time of 2.5 min for each sample made it possible to analyze more than 300 plasma samples per day. The developed assay method was successfully applied to a pharmacokinetic study in human male volunteers. | Srinivasa Rao Polagani Nageswara Rao Pilli Ramakrishna Gajula Venkateswarlu Gandu | 2013 | Journal of Pharmaceutical Analysis2013，3，1： | 3 |
| 15 | Optimization of green sand mould system using Taguchi based grey relational analysis显示文摘The strength of the mould cavity in sand casting is very much significant to attain high-quality castings. Optimization of green sand process parameters plays a vital role in minimizing casting defects. In the present research work, the effect of process parameters such as AFS grain fineness number, water, molasses, bentonite, fly ash, and ramming, and their levels on the resultant mould properties were investigated and optimized using Taguchi based grey relational analysis. The Taguchi L18 orthogonal array and analysis of variance(ANOVA) were used. The quality characteristics viz., green compression strength, permeability, bulk density, mould hardness and shatter index of green sand mould were optimized using grey relational grade, based on the experiments designed using Taguchi's Design of Experiments. ANOVA analysis indicated that water content is the most influential parameter followed by bentonite, and degree of ramming that contributes to the quality characteristics. The results are confirmed by calculating confidence intervals, which lies within the interval limits. Finally, microstructure observations and X-ray diffraction analysis have been performed for the optimal sand parametric combination. Results show that presence of maximum amount of SiO_2, which might be the reason for enhancement of the physical properties of the sand. | Srinivasa Rao Pulivarti Anil Kumar Birru | 2018 | China Foundry2018，15，2： | 3 |
| 16 | Spatial differences in soybean bioactive components across China and their influence by weather factors显示文摘Bioactive components are partially responsible for the nutritional and health benefits of soybeans. Four major bioactive components: isoflavones, oligosaccharides, phospholipids,and saponins, were quantified in 763 soybean samples collected from widely distributed regions across China from 2010 to 2013. A majority of the tested bioactive components showed generally declining trends from the north(high latitude) to the south(low latitude).A positive relationship between total oligosaccharides(TO) and altitude was observed. Total isoflavones(TI), phospholipids(TP) and TO were negatively correlated with cumulative temperature above or equal to 15 °C(AT15) and mean daily temperature(MDT), but positively correlated with diurnal temperature range(DTR) and hours of sunshine(HS).Total saponins(TS) were negatively correlated with MDT but positively correlated with rainfall(RF), whereas TO were negatively correlated with RF. Path-coefficient analysis showed that, besides genotype differences, temperature and HS during the reproductive period influenced TI and TP contents, while temperature and RF influenced TS and TO. The effects of weather factors on soybean bioactive components in diverse regions of China were characterized. These findings will be helpful in promoting soybean production for functional food purposes. | Wenwen Song Ruping Yang Xiushi Yang Shi Sun Srinivasa Rao Mentreddy Bingjun Jiang Tingting Wu Shiyan Tian Enoch Sapey Cunxiang Wu Wensheng Hou Guixing Ren Tianfu Han | 2018 | The Crop Journal2018，6，6： | 3 |
| 17 | Silica-bonded N-propyl sulfamic acid as an efficient recyclable catalyst for the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones/thiones under heterogeneous conditions显示文摘Silica-bonded N-propyl sulfamic acid(SBNPSA) catalyzed one-pot three component Biginelli condensation of different substituted aromatic aldehydes with ethyl acetoacetate and urea/thoiurea to the respective 3,4-dihydropyrimidin-2-(1H)-ones and thiones in environment friendly procedure is described. The facile reaction conditions, simple isolation and purification procedures of this method make it a good option for the synthesis of dihydropyrimidinones. | Srinivasa Rao Jetti Anjna Bhatewara Tanuja Kadre Shubha Jain | 2014 | Chinese Chemical Letters2014，25，3： | 3 |
| 18 | Mechanics of mechanically fastened joints in polymer–matrix composite structures – A review显示文摘 | Srinivasa D. Thoppul Joana Finegan Ronald F. Gibson | 2008 | Composites Science and Technology2008，，3： | 3 |
| 19 | Phoenix phylogeny, and analysis of genetic variation in a diverse collection of date palm(Phoenix dactylifera) and related species显示文摘Date palm(Phoenix dactylifera),one of the most ancient crops,is grown commercially in>30 countries.Using whole plastome assemblies,phylogenetic analyses revealed that cultivated date palm accessions share the same clade with Phoenix sylvestris,Phoenix pusilla and Phoenix acaulis,which are native to the Indian subcontinent,and Phoenix caespitosa that is native to the Arabian Peninsula and the deserts of Somalia.Analysis of genetic diversity and genetic relationships among date palm accessions from 13 producing countries involved 195 date palm accessions that were genotyped at 19 microsatellite loci.Extensive genetic diversity was observed,with many accessions heterozygous for most markers in this clonally propagated crop.The average number of alleles per locus(42.1),expected heterozygosity(0.8),observed heterozygosity(0.47)and fixation indices(FST=0.42)demonstrated substantial genetic diversity and population structure.Iraqi accessions were found to have the richest allelic diversity,and the most private alleles.The model-based Bayesian method indicated that these accessions could be broadly divided into two structure groups,one group with predominantly African accessions and another predominantly Asian.Some germplasm,especially from Tunisia and Iraq,deviated from this generalization.Many accessions in the STRUCTURE-derived groups were found to be genetic admixtures,with gene flow between Asian and African groups.Indian and Pakistani date palms were found to be most closely related to North African germplasm. | Srinivasa R.Chaluvadi Porter Young Kentrez Thompson Bochra Amina Bahri Bhavesh Gajera Subhash Narayanan Robert Krueger Jeffrey L.Bennetzen | 2019 | Plant Diversity2019，41，5： | 3 |
| 20 | A case study of geotextile-reinforced embankment on soft ground显示文摘 | Dennes T Bergado Pham V Long B.R Srinivasa Murthy | 2002 | Geotextiles and Geomembranes2002，，6： | 2 |
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