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| 1 | Protective effect of hydroxychloroquine on rheumatoid arthritis-associated atherosclerosis显示文摘Background: Patients with rheumatoid arthritis (RA) have an increased risk for cardiovascular disease. We examined the effect of gut microbiota in a mouse model of RA that develops atherosclerosis. Methods: We created three groups of K/BxN female mice that were positive for the anti‐glucose‐6‐phosphate isomerase (GPI) antibody: control diet (CD), high fat diet (HFD), and HFD with hydroxychloroquine (HFD + HCQ). Serological tests were used to detect the serum levels of total cholesterol (TCHO), low‐density lipoprotein cholesterol (LDL‐C), triglyceride (TG), high‐density lipoprotein cholesterol (HDL‐C), anti‐ GPI antibody titers, and serum cytokines. Atherosclerotic plaque was determined by histological analysis, and gut microbiota were determined by 16sV4 sequencing. Results: Relative to mice given the CD, those receiving the HFD had increased serum levels of LDL‐C, TCHO, and TG, decreased serum levels of HDL‐C, increased atherosclerotic lesions in the aortic root, and altered gut microbiota. Addition of HCQ to HFD decreased the serum levels of LDL‐C, TCHO, and TG, increased serum levels of HDL‐C, and decreased the atherosclerotic lesions in the aortic root. Mice receiving HFD + HCQ also had the greatest bacterial diversity among the three experimental groups. Moreover, HCQ treatment significantly increased the abundance of Akkermansia and Parabacteroides, and decreased the abundance of Clostridium sensu stricto cluster 1, and therefore may be responsible for the reduced RA‐associated atherosclerosis and dyslipidemia. Conclusion: Our mouse model of RA indicated that HFD increased ankle width and aggravated a therosclerosis a nd d yslipidemia, a nd t hat H CQ a lleviated t he d yslipidemia and atherosclerosis, but had no effect on ankle width. | Na Shi Shuangyue Zhang Gregg Silverman Mengtao Li Jun Cai Haitao Niu | 2019 | Animal Models and Experimental Medicine2019，2，2： | 6 |
| 2 | 教学设计和体育教师教育在体育素养教育中的应用(英文)显示文摘在培养具有体育素养的个体所必备的运动技能方面,体育教师起到重要作用。研究表明,教师教学设计的制订可提高学生运动技能的学习水平。本文展示了一个基于实证研究的模型,提供了可帮助教师计划和开展课程以提高学生运动技能的相关信息,讨论了在体育教育中影响运动技能学习的变量,包括时间、练习类型、内容、呈现方式和组织策略,以及学生的技术水平。此外,简要讨论了学生态度与运动技能学习和体育素养之间的关系。为了享受终生体育活动,具有体育素养的个体需要掌握各项运动技能。对学生的学习如何以及能否达到体育素养的目标,体育教师及其决定都有一定作用。 | Stephen Silverman Kevin Mercier | 2015 | Journal of Sport and Health Science2015，4，2： | 6 |
| 3 | 进化心理学概览(英文)显示文摘该文认为处于萌芽状态的进化心理学作为一个新的心理学分支学科对人类心理运行机制提出了一些基本的解释与预测。该文也讨论了进化心理学研究遭受到的两种批评,其一是文化的重要性没有得到重视;其二是进化历史是“假想的故事”。同时作者认为完整地理解心理学研究课题需要进行最终水平的因果分析,只有掌握与运用自然选择理论才能从最终水平上理解研究课题。 | Irwin Silverman | 2007 | 心理学报2007，39，3： | 3 |
| 4 | Optical force-induced nonlinearity and self-guiding of light in human red blood cell suspensions显示文摘Osmotic conditions play an important role in the cell properties of human red blood cells(RBCs),which are crucial for the pathological analysis of some blood diseases such as malaria.Over the past decades,numerous efforts have mainly focused on the study of the RBC biomechanical properties that arise from the unique deformability of erythrocytes.Here,we demonstrate nonlinear optical effects from human RBCs suspended in different osmotic solutions.Specifically,we observe self-trapping and scattering-resistant nonlinear propagation of a laser beam through RBC suspensions under all three osmotic conditions,where the strength of the optical nonlinearity increases with osmotic pressure on the cells.This tunable nonlinearity is attributed to optical forces,particularly the forward-scattering and gradient forces.Interestingly,in aged blood samples(with lysed cells),a notably different nonlinear behavior is observed due to the presence of free hemoglobin.We use a theoretical model with an optical force-mediated nonlocal nonlinearity to explain the experimental observations.Our work on light self-guiding through scattering biosoft-matter may introduce new photonic tools for noninvasive biomedical imaging and medical diagnosis. | Rekha Gautam Yinxiao Xiang Josh Lamstein Yi Liang Anna Bezryadina Guo Liang Tobias Hansson Benjamin Wetzel Daryl Preece Adam White Matthew Silverman Susan Kazarian Jingjun Xu Roberto Morandotti Zhigang Chen | 2019 | Light(Science & Applications)2019，8，1： | 3 |
| 5 | An optimal algorithm for approximate nearest neighbor searching fixed dimensions显示文摘 | Sunil Arya David M. Mount Nathan S. Netanyahu Ruth Silverman Angela Y. Wu | 1998 | Journal of the ACM (JACM)1998，，6： | 2 |
| 6 | 肝脏肿瘤经皮冰冻消融术后生物化学和血液学的变化:48次治疗报告显示文摘目的回顾分析肝脏肿瘤经皮冰冻消融术后实验室化验值出现异常的频度和严重程度,估计实验室化验值与肿瘤及消融体积的相关性。方法这项符合HIPAA要求的研究得到了伦理委员会的批准,可免除知情同意书。对39例病人(男性18例,女性21例;年龄29—86岁)的65个肝脏肿瘤(62个转移瘤和3个肝细胞癌)进行了48次MRI引导下经皮冰冻消融术,回顾分析其生物化学和血液学方面的实验室检查数据。分析术前基础化验值与术后0-6h、1~2周化验值相对于肿瘤和消融带边界体积的变化。肿瘤与消融边界体积用一般性估计方程计算。 | R.T. Nair S.G. Silverman K. Tuncali N.A. Obuchowski E. van Sonnenberg S. Shankar. 叶锦棠(译) 唐光健(校) | 2008 | 国际医学放射学杂志2008，31，5： | 2 |
| 7 | Management of the Open Abdomen: From Initial Operation to Definitive Closure显示文摘 | Vargo Daniel Richardson J David Campbell Andre Chang Michael Fabian Timothy Franz Michael Kaplan Mark Moore Frederick Reed R Lawrence Scott Bradford Silverman Ronald | 2009 | The American Surgeon2009，，11： | 2 |
| 8 | 医患沟通技巧--Calgary-Cambridge指南沟通过程技巧显示文摘开始会谈
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1.把上一项任务搁在一边,注意让自己舒适、从容面对患者。
2.集中注意力准备这次接诊。
建立初始的融洽氛围
3.问候患者并获知患者姓名。
4.自我介绍,说明此次接诊的作用和性质,必要时征得对方的同意。 | 王雪花 Jonathan Silverman Suzanne Kurtz Juliet Draper 杨雪松 | 2018 | 中国医学人文2018，4，8： | 2 |
| 9 | The effect of endoscopic sphincterotomy on acute and chronic complications of biliary endoprostheses显示文摘 | Craig Margulies Eduardo Sampaio Siqueira William Bruce Silverman Xue Sen Lin John Anthony Martin Mordechai Rabinovitz Adam Slivka | 1999 | Gastrointestinal Endoscopy1999，，6： | 2 |
| 10 | Impact of metabolic indices on central artery stiffness: independent association of insulin resistance and glucose with aortic pulse wave velocity显示文摘 | D. R. Webb K. Khunti R. Silverman L. J. Gray B. Srinivasan P. S. Lacy B. Williams M. J. Davies | 2010 | Diabetologia2010，，6： | 2 |
| 11 | Cancer risk in patients with diabetes mellitus显示文摘 | Hans-Olov Adami Joseph McLaughlin Anders Ekbom Christian Berne Debra Silverman David Hacker Ingemar Persson | 1991 | Cancer Causes and Control1991，，5： | 2 |
| 12 | Point target detection in consecutive frame staring IR imagery with evolving cloud clutter 显示文摘 | CAEFER C E MOONEY J M SILVERMAN J | 1995 | SPIE1995，2561，： | 2 |
| 13 | Understanding marine mussel adhesion显示文摘 | Silverman H G Boberto F F | 2007 | Mar Bioteehnol ( NY)2007，9，6： | 1 |
| 14 | Strategic Alliances and Interfirm Knowledge Transfer显示文摘 | David C M Oxley E H Silverman S B | 1996 | Strategic Management Journal1996，，17： | 1 |
| 15 | Scintigraphic detection of hemobilia complicating angiodysplasia显示文摘 | Silverman E D Kistler A M | 1994 | J Nucl Med1994，35，5： | 1 |
| 16 | CT and ultrasound features of metanephric adenoma in adults with pathologic correlation显示文摘 | Visweswaran A Silverman SG | 1999 | J Comput Assist Tomogr1999，23，3： | 1 |
| 17 | Identification of genes and gene products necessary for bacterial bioluminescence显示文摘 | Silverman M | 1984 | Proc Natl Acad Sci1984，81，： | 1 |
| 18 | A smoothed EM approach to indirect estimation problems, with particular reference to stereology and emission tomography显示文摘 | Jones MC Wilson JD | 1990 | J Roy Stat Soc B1990，52，3： | 1 |
| 19 | Withdrawal syndrome after the double-blind cessation of caffeine consumption显示文摘 | SILVERMAN K EVANS SM STRAIN EC | 1992 | N Engl J Med1992，327，16： | 1 |
| 20 | Association between a GABRB3 polymorphism and autism 显示文摘 | Buxbaum J D Silverman J M Smith C J | 2002 | Mol Psychiatry2002，7，3： | 1 |
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