|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Analysis of inborn errors of metabolism: disease spectrum for expanded newborn screening in Hong Kong显示文摘氨基酸,器官的酸和丰满的酸氧化的新陈代谢(IEM ) 的古典先天的错误的背景数据大部分正在缺乏香港,在集体基于 spectrometry 的扩展新生儿为 IEM 屏蔽没被开始的地方。瞄准在香港评估近似发生,光谱和古典 IEM 的另外的特征的当前的学习,将在开发为实验室血浆氨基酸记录的本地 area.Methods 屏蔽节目的一个扩展新生儿重要,血浆 acylcarnitines 和尿从年 2005~2009 的器官的酸分析在为 IEM 提供生物化学、基因的诊断服务的三个地区性的化学病理实验室包括回顾地 reviewed.Resu 在香港的古典 IEM 的发生粗略地被估计每 1000live 出生每 4122 生活出生,或 0.243 个盒子是至少 1 个盒子。这发生类似于全球报导的那些,包括中国的大陆。hyperphenylalaninemia 的估计的发生在 29 542 实时 births.Conclusions 是 1 我们的数据显示它为在香港的扩展新生的屏蔽节目的介绍是无可争辩的。因为香港是一个大城市的城市,一个全面扩展新生的屏蔽程序和工作分派系统应该是可得到的服务在区域出生的出生不满一月的婴儿。 | Han-Chih Hencher Lee Chloe Miu Mak Ching-Wan Lam Yuet-Ping Yuen, Angel On-Kei Chan Chi-Chung Shek Tak-Shing Siu Chi-Kong Lai Chor-Kwan Ching Wai-Kwan Siu Sammy Pak-Lam Chen Chun-Yiu Law Morris Hok-Leung Tai Sidney Tam Albert Yan-Wo Chan | 2011 | Chinese Medical Journal2011，，7： | 12 |
| 2 | Leptin Signaling Protects NK Cells from Apoptosis During Development in Mouse Bone Marrow显示文摘增加的证据在有免疫力的反应显示 leptin 的一个角色,但是发信号的 leptin 是否涉及在骨头髓(BM ) 调整 NK 房间开发,仍然保持大部分不清楚。在这研究,我们在在 prediabetic 的缺乏的 db/db 老鼠上演的 leptin 受体的 BM 描绘了 NK 房间区别和成熟。尽管 BM 细胞质类似于控制值, NK 房间的全部的数字严重地在变异的鼠标被减少。db/db BM 房间的流动 cytometric 分析揭示了在区别的各种各样的阶段开发 NK 房间的显著地减少的频率。显著地显示的 BM db/db NK 房间增加了 apoptosis,但是维持了正常房间骑车地位和 proliferative 能力。而且, recombinant leptin 能显著地在文化从野类型的老鼠提高 NK 房间的幸存。NK 房间上的进一步的检查功能的活动证明 db/db NK 房间与显著地增加的 IL-10 展出了正常内在的 cytotoxicity 生产。一起拿,我们的调查结果建议发信号的 leptin 经由在老鼠 BM 提高不成熟的 NK 房间的幸存调整 NK 房间开发。 | Cherry Kam Chun Lo Queenie Lai Kwan Lam Min Yang King-Hung Ko Lingyun Sun Rui Ma Shengjun Wang Huaxi Xu Sidney Tam Chang-You Wu Bo-Jiang Zheng Liwei Lu | 2009 | Cellular & Molecular Immunology2009，6，5： | 2 |
| 3 | Applicability of Intraoperative Parathyroid Hormone Assay During Thyroidectomy显示文摘 | Chung Yau Lo John M. Luk Sidney C. Tam | 2002 | Annals of Surgery2002，，5： | 1 |
| 4 | Vitamin D Deficiency Is Associated with Depletion of Circulating Endothelial Progenitor Cells and Endothelial Dysfunction in Patients with Type 2 Diabetes显示文摘 | Yuen-Fung Yiu Yap-Hang Chan Kai-Hang Yiu Chung-Wah Siu Sheung-Wai Li Lai-Yung Wong Stephen W. L. Lee Sidney Tam Eric W. K. Wong Bernard M. Y. Cheung Hung-Fat Tse | 2011 | The Journal of Clinical Endocrinology & Metabolism2011，，5： | 1 |
| 5 | Pluronic L-81 ameliorates diabetic symptoms in db/db mice through transcriptional regulation of microsomal triglyceride transfer protein显示文摘AIM: To test whether oral L-81 treatment could im-prove the condition of mice with diabetes and to investigate how L-81 regulates microsomal triglyceride transfer protein (MTP) activity in the liver. METHODS: Genetically diabetic (db/db) mice were fed on chow supplemented with or without L-81 for 4 wk. The body weight, plasma glucose level, plasma lipid profile, and adipocyte volume of the db/db mice were assessed after treatment. Toxicity of L-81 was also evaluated. To understand the molecular mecha-nism, HepG2 cells were treated with L-81 and the effects on apolipoprotein B (apoB) secretion and mRNA level of the MTP gene were assessed.RESULTS: Treatment of db/db mice with L-81 sig-nificantly reduced and nearly normalized their body weight, hyperphagia and polydipsia. L-81 also markedly decreased the fasting plasma glucose level, improved glucose tolerance, and attenuated the elevated levels of plasma cholesterol and triglyceride. At the effective dosage, little toxicity was observed. Treatment of HepG2 cells with L-81 not only inhibited apoB secretion, but also signif icantly decreased the mRNA level of the MTP gene. Similar to the action of insulin, L-81 exerted its effect on the MTP promoter. CONCLUSION: L-81 represents a promising candidate in the development of a selective insulin-mimetic mol-ecule and an anti-diabetic agent. | Wo-Shing Au Li-Wei Lu Sidney Tam Otis King Hung Ko Billy KC Chow Ming-Liang He Samuel S Ng Chung-Man Yeung Ching-Chiu Liu Hsiang-Fu Kung Marie C Lin | 2009 | World Journal of Gastroenterology2009，15，24： | 1 |
| 6 | Association between acute-phase reactants and advanced glycation end products in type 2 diabetes 显示文摘 | KATHRYN CB CHOW WS SIDNEY TAM | 2004 | Diabetes Care2004，27，： | 1 |
| 7 | Hypoadiponectinemia as a Predictor for the Development of Hypertension: A 5-Year Prospective Study显示文摘 | Wing-Sun Chow Bernard M.Y. Cheung Annette W.K. Tso Aimin Xu Nelson M.S. Wat Carol H.Y. Fong Liza H.Y. Ong Sidney Tam Kathryn C.B. Tan Edward D. Janus Tai-Hing Lam Karen S.L. Lam | 2007 | Hypertension2007，，6： | 1 |
| 8 | Adeno-associated virus-mediated pancreatic and duodenal homeobox gene-1 expression enhanced differentiation of hepatic oval stem cells to insulin-producing cells in diabetic rats显示文摘 | Hua Li Xinyan Li Karen S. L. Lam Sidney Tam Weidong Xiao Ruian Xu | 2008 | Journal of Biomedical Science2008，，4： | 1 |
| 9 | Development and validation of a high-throughput double solid phase extraction–liquid chromatography–tandem mass spectrometry method for the determination of tetrodotoxin in human urine and plasma显示文摘 | Bonnie Mei-Wah Fong Sidney Tam Sik-Hon Tsui Kelvin Sze-Yin Leung | 2010 | Talanta2010，，3： | 1 |
| 10 | Randomized controlled trial of vitamin D supplement on endothelial function in patients with type 2 diabetes显示文摘 | Yuen-Fung Yiu Kai-Hang Yiu Chung-Wah Siu Yap-Hang Chan Sheung-Wai Li Lai-Yung Wong Stephen W.L. Lee Sidney Tam Eric W.K. Wong Chu-Pak Lau Bernard M.Y. Cheung Hung-Fat Tse | 2012 | Atherosclerosis2012，，： | 1 |
| 11 | Circulating Levels of Adipocyte and Epidermal Fatty Acid-Binding Proteins in Relation to Nephropathy Staging and Macrovascular Complications in Type 2 Diabetic Patients显示文摘 | Yeung Dennis C Y Xu Aimin Tso Annette W K Chow W S Wat Nelson M S Fong Carol H Y Tam Sidney Sham Pak C Lam Karen S L | 2009 | Diabetes Care2009，，1： | 1 |
| 12 | Adeno-associated virus-mediated pancreatic and duodenal homeobox gene-1 expression enhanced differentiation of hepatic oval stem cells to insulin-producing cells in diabetic rats显示文摘 | Hua Li Xinyan Li Karen S. L. Lam Sidney Tam Weidong Xiao Ruian Xu | 2008 | Journal of Biomedical Science2008，，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员