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| 1 | Essential oils used in aromatherapy: A systemic review显示文摘Nowadays, use of alternative and complementary therapies with mainstream medicine has gained the momentum. Aromatherapy is one of the complementary therapies which use essential oils as the major therapeutic agents to treat several diseases. The essential or volatile oils are extracted from the flowers, barks, stem, leaves, roots, fruits and other parts of the plant by various methods. It came into existence after the scientists deciphered the antiseptic and skin permeability properties of essential oils. Inhalation, local application and baths are the major methods used in aromatherapy that utilize these oils to penetrate the human skin surface with marked aura. Once the oils are in the system, they remodulate themselves and work in a friendly manner at the site of malfunction or at the affected area. This type of therapy utilizes various permutation and combinations to get relief from numerous ailments like depression, indigestion, headache, insomnia, muscular pain, respiratory problems, skin ailments, swollen joints, urine associated complications etc. The essential oils are found to be more beneficial when other aspects of life and diet are given due consideration. This review explores the information available in the literature regarding therapeutic, medical, cosmetic, psychological, olfactory, massage aromatherapy, safety issues and different plants used in aromatherapy. All the available information was compiled from electronic databases such as Academic Journals, Ethnobotany, Google Scholar, PubM ed, Science Direct, Web of Science, and library search. | Babar Ali Naser Ali Al-Wabel Saiba Shams Aftab Ahamad Shah Alam Khan Firoz Anwar | 2015 | Asian Pacific Journal of Tropical Biomedicine2015，5，8： | 20 |
| 2 | TiO_2在Al_2O_3表面上分散状态的AEM研究显示文摘本文运用AEM方法考察了制备技术对TiO_2在Al_2O_3表面分散状态的影响.发现嫁接法可使TiO_2非常均匀地分散在Al_2O_3表面上,浸渍法也能得到较为均匀的TiO_2分布,而沉淀法所得到的TiO_2分散度较差.TiO_3只聚集在Al_20_3表面上的局部区域。 | 魏昭彬 辛勤 Sham E.L. Grange P. Delwon B. | 1990 | 物理化学学报1990，6，4： | 18 |
| 3 | Comparison of neurological clinical manifestation in patients with hemorrhagic and ischemic stroke显示文摘BACKGROUND: Cerebrovascular accident(CVA) is the third leading cause of death and disability in developed countries. Anyone suspected of having a stroke should be taken immediately to a medical facility for diagnosis and treatment. The symptoms that follow a stroke aren't signi? cant and depend on the area of the brain that has been affected and the amount of tissue damaged. Parameters for predicting long-term outcome in such patients have not been clearly delineated, therefore the aim of this study was to investigate this possibility and to test a system that might practicably be used routinely to aid management and predict outcomes of individual stroke patients.METHODS: A descriptive hospital-based study of the neurological symptoms and signs of 503 patients with ischemic stroke, including severe headache, seizure, eye movement disorder, pupil size, Glasgow Coma Scale(GCS), agitation were analyzed in this study.RESULTS: In the current study, dilated pupils, agitation, acute onset headache, lower GCS score, seizure, and eye gaze impairment had signi? cantly higher prevalence in hemorrhagic stroke patients(P<0.001). However, the rate of gradual progressive headache is significantly higher in ischemic stroke patients(P<0.001).CONCLUSION: Although this result provides reliable indicators for discrimination of stroke types, imaging studies are still the gold standard modality for diagnosis. | Seyedhossein Ojaghihaghighi Samad Shams Vahdati Akram Mikaeilpour Ali Ranlouz | 2017 | World Journal of Emergency Medicine2017，8，1： | 17 |
| 4 | Pyogenic liver abscess: Changing patterns in approach显示文摘AIM: To define optimum management of the pyogenic liver abscess and assess new trends in treatment. METHODS: One hundred and sixty nine patients with pyogenic liver abscess managed at Sher-i-Kashmir In- stitute of Medical Sciences, Srinagar, Kashmir (India) from July 2001 to August 2006 were studied to evaluate and define the optimum treatment. RESULTS: Mortality in the surgically treated group of patients was 9.4% (12/119), while those treated non-surgically had a fatality rate of 16.66% (7/42). Multiple liver abscesses treated surgically had a surprisingly low mortality of 30%. The biliary tract (64.97%) was the most common cause of liver abscess. Multiple abscesses, mixed organisms and abscess complications are all associated with a significantly increased mortality. However, the lethality of the primary disease process was the most important factor in determining survival.CONCLUSION: Transperitoneal surgical drainage and antibiotics are the mainstay of treatment. Percutaneous drainage is recommended for high risk patients only. | Ajaz A Malik Shams UL Bari Khawaja Abdul Rouf Khurshid Alam Wani | 2010 | World Journal of Gastrointestinal Surgery2010，2，12： | 15 |
| 5 | CYP2D6的多态性与文拉法辛的临床效应显示文摘 | Shams ME Arneth B Hiemke C 王小艳 | 2006 | 中国处方药2006，5，10： | 12 |
| 6 | Cdx1和Cdx2基因表达异常与先天性结肠性肠炎的关系显示文摘目的 结肠炎是先天性巨结肠患儿常见的并发症,组织学研究表明巨结肠性肠炎患儿肠粘膜内的内分泌细胞减少和粘膜内分泌型 IgA不足。而Cdx1和Cdx2基因调控结肠粘膜上皮细胞的分化和增殖,本研究的目的是明确Cdx1和Cdx2基因表达与先天性巨结肠性肠炎之间的关系。方法 采用半定量RT-PCR反应和原位杂交方法,11例先天性巨结肠患儿(年龄1~30个月,4例合并结肠炎)的无神经节细胞段、移行段和扩张段的手术切除标本为病例组,12例年龄相符(1~30个月)的非巨结肠患儿的远端结肠标本为对照组,观察Cdx1和Cdx2基因在其中的表达情况。结果Cdx1和Cdx2基因在对比组和先天性巨结肠的结肠粘膜上皮细胞均有表达,但是此二基因在先天性巨结肠性肠炎患儿的标本中表达明显减弱。结论 本研究结果表明Cdx1和Cdx2基因表达减弱与先天性巨结肠性肠炎的病因密切相关。 | 李龙 Vincent Lui Mai Har Sham 谭广 | 2003 | 中华小儿外科杂志2003，24，5： | 9 |
| 7 | Potent antitumor efficacy of an E1B 55kDa-deficient adenovirus carrying murine endostatin in hepatocellular carcinoma显示文摘 | Li G Sham J Yang J Su C Xue H Chua D Sun L Zhang Q Cui Z Wu M Qian Q | 2005 | 第二军医大学学报2005，26，11： | 9 |
| 8 | 基因-病毒治疗系统CNHK200-hA对肺癌治疗的研究显示文摘目的 构建抗肿瘤新生血管生成的基因治疗与病毒治疗相结合的基因 病毒治疗系统CNHK2 0 0 hA ,并对其肺癌的体内外治疗作用进行初步研究。方法 通过Westernblot分析 ,观察携带抗肿瘤新生血管生成基因angiostatink1 5 (hA)的基因 病毒治疗系统CNHK2 0 0 hA和非增殖型腺病毒对介导k1 5蛋白表达的影响 ;通过细胞病理作用及动物试验 ,比较CNHK2 0 0 hA和非增殖型腺病毒对人肺癌细胞株A5 4 9的杀伤作用及对肺癌裸鼠移植瘤的治疗作用。结果 基因 病毒治疗系统CNHK2 0 0 hA能够介导hA基因在肺癌细胞内高效表达k1 5蛋白 ,其表达量高于非增殖型腺病毒Ad hA。细胞病理效应显示 ,CNHK2 0 0 hA对A5 4 9的杀伤作用明显优于Ad hA ,CNHK2 0 0 hA在感染复数 (MOI)值为 1时可完全杀伤A5 4 9细胞 ,而达到相同杀伤效应的Ad hA的MOI值为 1 0 0。动物试验显示 ,CNHK2 0 0 hA对肺癌的疗效明显好于Ad hA及肿瘤增殖型病毒ONYX 0 1 5。结论 插入了抗肿瘤新生血管生成基因hA的基因 病毒治疗系统CNHK2 0 0 hA ,可明显提高hA基因的表达量 ,其在体内外的抗肺癌作用较非增殖型腺病毒Ad hA及肿瘤增殖型病毒ONYX 0 1 5进一步提高。 | 王伟国 薛惠斌 苏长青 崔贞福 聂明明 Jonathan Sham 吴孟超 钱其军 | 2005 | 中华肿瘤杂志2005，27，2： | 9 |
| 9 | Parsley: a review of ethnopharmacology, phytochemistry and biological activities显示文摘OBJECTIVE:To summarize comprehensive information concerning ethnomedicinal uses, phytochemistry, and pharmacological activities of parsley. METHODS: Databases including PubMed, Scopus, Google Scholar, and Web of Science were searched for studies focusing on the ethnomedicinal use, phytochemical compounds and biological and pharmacological activities of parsley. Data were collected from 1966 to 2013. The search terms were: 'Parsley' or 'Petroselinum crispum' or 'Petroseli-num hortence '. RESULTS: Parsley has been used as carminative, gastro tonic, diuretic, antiseptic of urinary tract, anti-urolithiasis, anti-dote and anti-inflammatory and for the treatment of amenorrhea, dysmenorrhea, gastrointestinal disorder, hypertension, cardiac disease, urinary disease, otitis, sniffle, diabetes and also various dermal disease in traditional and folklore medicines. Phenolic compounds and flavonoids particularly apigenin, apiin and 6'-Acetylapiin; essential oil mainly myristicin and apiol; and also coumarins are the active compounds identified in Petroselinum crispum. Wide range of pharmacological activity including antioxidant, hepatoprotective, brain protective, anti-diabetic, analgesic, spasmolytic, immunosuppressant, anti-platelet, gastroprotective, cytoprotective, laxative, estrogenic, diuretic, hypotensive, antibacterial and antifungal activities have been exhibited for this plant in modern medicine. CONCLUSION: It is expectant that this study resulted in improvement the tendencies toward Petroselinum crispum as a useful and important medicinal plant with wide range of proven medicinal activity. | Mohammad Hosein Farzaei Zahra Abbasabadi Mohammad Reza Shams Ardekani Roja Rahimi Fatemeh Farzaei | 2013 | Journal of Traditional Chinese Medicine2013，33，6： | 9 |
| 10 | Serological diagnosis of nasopharyngeal carcinoma by enzyme linked immunosorbant assay:optimization,standardization and diagnostic criteria显示文摘Serologicaldiagnosisofnasopharyngealcarcinomabyenzymelinkedimmunosorbantasay:optimization,standardizationanddiagnosticcriteri... | M.H. Ng, H.L. Chen, R.X. Luo, K.H. Chan, P.C.Y. Woo, J.S.T. Sham, J. Huang, W.H.Seto P. Smith and B.E. Griffin | 1998 | Chinese Medical Journal1998，，6： | 8 |
| 11 | 在良性的胆汁的阻塞的 choledochoduodenostomy 的长期的结果显示文摘 AIM:To determine the long-term results of choledochodudenostomy in patients with benign billiary obstruction.METHODS:This prospective study was conducted at Sheri Kashmir Institute of Medical Sciences Srinagar Kashmir,India over a period of 10 years from January 1997 to December 2007.The total number of patients who underwent choledochoduodenostomy during this period was 270.On the basis of etiology of biliary tract obstruction,patients were divided into a calculus group,an oriental cholangiohepatitis group,a benign biliary stricture group and others.Patients were followed for a variable period of 13 mo to 15 years.RESULTS:Choledochoduodenostomy(CDD) with duodenotomy was performend in four patients.CDD with removal of T-tube,CDD with left hepatic lobectomy and CDD with removal of intra biliary ruptured hydatid was performed in three patients each.In the remaining patients only CDD was performed.Immediate post operative complications were seen in 63(23%) patients,while long-term complications were seen in 28(11%) patients,which were statistically significant.Three patients died during hospitalization while four patients died in the late post-operative period.CONCLUSION:Our conclusion is that CDD is safe and produces good long term results when a permanent biliary drainage procedure is required. | Ajaz A Malik Shiraz A Rather Shams UL Bari Khursheed Alam Wani | 2012 | World Journal of Gastrointestinal Surgery2012，4，2： | 7 |
| 12 | Relationship between Temperaments of Medicinal Plants and Their Major Chemical Compounds显示文摘Objective: To determine any relationship between temperaments of medicinal plants referred to traditional Iranian manuscripts and their major chemical compounds. Methods: Plants used in traditional Iranian medicine were categorized based on their major chemical compounds including alkaloids, phenolic compounds, and essential oils. Their temperaments were extracted from traditional herbal pharmacopeias of Iran. The possible relationship between major chemical compounds and temperaments of each group were evaluated. Results: Plants containing phenolic compounds as their major constituents are hot and dry temperaments except those contain tannins with cold and dry temperaments. Plants containing essential oils have hot and dry temperaments except those whose major essential oils with alcoholic structure which have cold and dry temperaments. Alkaloid-containing plants have cold and dry or hot and dry temperaments based on their alkaloidal structures. Conclusions: There is a close relationship between major chemical compounds of medicinal plants and their temperaments mentioned in traditional Iranian manuscripts. | Mohammad Reza Shams Ardekani Roja Rahimi Behjat Javadi Leila Abdi Mahnaz Khanavi | 2011 | Journal of Traditional Chinese Medicine2011，31，1： | 7 |
| 13 | PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage Analyses显示文摘 | Shaun Purcell Benjamin Neale Kathe Todd-Brown Lori Thomas Manuel A.R. Ferreira David Bender Julian Maller Pamela Sklar Paul I.W. de Bakker Mark J. Daly Pak C. Sham | 2007 | The American Journal of Human Genetics2007，，3： | 5 |
| 14 | Complementary and alternative medicine use in Iranian patients with diabetes mellitus显示文摘OBJECTIVE: There is increasing interest in complementary and alternative medicine generally, and especially by those affected by chronic diseases, such as diabetes mellitus. We aimed to determine the prevalence and pattern of complementary and alternative medicine use among patients suffering from diabetes mellitus in Shiraz, southern Iran. Another objective was to explore associated factors for use of complementary and alternative medicine among patients with diabetes mellitus.METHODS: A 19-item semi-structured questionnaire(open- and close-ended) was administered to 239 patients with diabetes mellitus in this cross-sectional study. It was carried out in two outpatient diabetes clinics affiliated with the Shiraz University of Medical Sciences, Shiraz, Iran.RESULTS: One hundred and eighty patients(75.3%) used at least one type of complementary and alternative medicine in the last year prior to the interview. Patients with diabetes mellitus who were living in a large family(≥ 5 members), not taking insulin, and believed that complementary and alternative medicine have synergistic effects with conventional medicine, were independently and significantly(P values: 0.02, 0.04, and 0.01, respectively) more likely to use complementary and alternative medicine. Most of the users(97.7%) reported use of herbal preparations, and 89.4% of users did not change their medication, neither in medication schedule nor its dosage.CONCLUSION: The use of complementary and alternative medicine, especially herbal remedies, is popular among diabetes patients in Shiraz, Iran. This use is associated with patients' family size, type of conventional medications and their view about concomitant use of complementary and conventional medicine. | Mohammad Hashem Hashempur Mojtaba Heydari Seyed Hamdollah Mosavat Seyyed Taghi Heydari Mesbah Shams | 2015 | Journal of Integrative Medicine2015，13，5： | 5 |
| 15 | Rational use of mesenchymal stem cells in the treatment of autism spectrum disorders显示文摘Autism and autism spectrum disorders(ASD) refer to a range of conditions characterized by impaired social and communication skills and repetitive behaviors caused by different combinations of genetic and environmental influences. Although the pathophysiology underlying ASD is still unclear, recent evidence suggests that immune dysregulation and neuroinflammation play a role in the etiology of ASD. In particular, there is direct evidence supporting a role for maternal immune activation during prenatal life in neurodevelopmental conditions. Currently, the available options of behavioral therapies and pharmacological and supportive nutritional treatments in ASD are only symptomatic. Given the disturbing rise in the incidence of ASD, and the fact that there is no effective pharmacological therapy for ASD, there is an urgent need for new therapeutic options. Mesenchymal stem cells(MSCs) possess immunomodulatory properties that make them relevant to several diseases associated with inflammation and tissue damage. The paracrine regenerative mechanisms of MSCs are also suggested to be therapeutically beneficial for ASD.Thus the underlying pathology in ASD, including immune system dysregulation and inflammation, represent potential targets for MSC therapy. This review willfocus on immune dysfunction in the pathogenesis of ASD and will further discuss the therapeutic potential for MSCs in mediating ASD-related immunological disorders. | Qiang Liu Mo-Xian Chen Lin Sun Chloe U Wallis Jian-Song Zhou Li-Juan Ao Qi Li Pak C Sham | 2019 | World Journal of Stem Cells2019，11，2： | 5 |
| 16 | 基因-病毒治疗系统CNHK300-murine endostatin治疗肝癌的实验研究显示文摘目的 探讨一种新的基因 病毒治疗系统CNHK30 0 murineendostatin(简称CNHK30 0 mE)对肝癌的治疗作用。方法 利用基因重组技术构建一种用人端粒酶逆转录酶 (hTERT)启动子控制腺病毒E1A基因表达并携带内皮抑素基因的基因 病毒治疗系统 ;通过 5 0 %组织培养感染剂量 (TCID5 0 )方法和细胞活性检测法四氮唑盐比色试验 (MTT法 )观察CNHK30 0 mE在 2种肝癌细胞株 (HepGII及Hep3B)及 1株正常的成纤维细胞株 (MRC 5 )中的病毒增殖能力和对细胞的杀灭能力 ;通过肝癌SMMC772 1细胞裸鼠皮下移植瘤模型观察该病毒对肝癌生长和对肿瘤血管生成的抑制作用 ;利用Western印迹法和酶联免疫吸附实验 (ELISA)法检测内皮抑素基因在体内和体外的表达。结果分别感染肝癌细胞株和正常细胞株 96h后病毒的增殖倍数相差 32 96倍 ,其达到半数杀伤量 (ED50 )时的感染复数 (MOI)值相差 2 5倍 ,差异有显著意义 ,且两者均明显优于ONYX 0 15 ;CNHK30 0 mE能明显抑制肝癌皮下移植瘤内血管的生成 ,对肿瘤生长的抑制作用与携带同一治疗基因的非增殖型腺病毒和不携带治疗基因的增殖型腺病毒ONYX 0 15相比均增强 (P均 <0 0 1) ;其所介导的内皮抑素基因在体内和体外的表达量均与携带该基因的非增殖型腺病毒载体相比均增高 (P <0 0 | 李根丛 聂明明 杨甲梅 苏长青 孙立臣 钱炎珍 Jonathan Sham 方国恩 吴孟超 钱其军 | 2004 | 中华医学杂志2004，84，11： | 5 |
| 17 | 影像组学在胰腺疾病中的应用进展显示文摘影像组学是指从横断面影像学资料中获取定量特征并分析这些数据以支持临床决策。近10年来,影像学在疾病诊断与治疗过程中的地位极大提高,与此相关的研究数据也呈指数增长,可供临床医师进行更有意义的探索。胰腺疾病,包括胰腺癌、胰腺囊性肿瘤和胰腺神经内分泌肿瘤等,需要复杂的临床决策,这一直是影像组学研究的热点和难点。随着胰腺疾病影像组学的迅速发展,患者和临床医师有望在短期内受益。影像组学已在判断肿瘤表型、疾病生物学和患者预后方面崭露头角,即将成为胰腺疾病患者诊断与治疗的有力工具。 | Jonathan Sham He Jin | 2019 | 中华消化外科杂志2019，18，7： | 5 |
| 18 | Surgical management of complicated hydatid cysts of the liver显示文摘AIM: To review the clinical presentation and surgical management of complicated hydatid cysts of the liver and to assess whether conservative surgery is adequate in the management of complicated hydatid cysts of liver.METHODS:The study was carried out at Sher-i-Kashmir Institute of Medical Science,Srinagar,Kashmir,India.Sixty nine patients with hydatid disease of the liver were surgically managed from April 2004 to October 2005 with a follow up period of three years.It included 27 men and 42 women with a median age of 35 years.An abdominal ultrasound,computed tomography and serology established diagnosis.Patients with jaundice and high suspicion of intrabiliary rupture were subjected to preoperative endoscopic retrograde cholangiography.Cysts with infection,rupture into the biliary tract and peritoneal cavity were categorized as complicated cysts.Eighteen patients(26%)had complicated cysts and formed the basis for this study.RESULTS:Common complications were infection(14%),intrabiliary rupture(9%)and intraperitoneal rupture(3%).All the patients with infected cysts presented with pain and fever.All the patients with intrabiliary rupture had jaundice,while only four with intrabiliary rupture had pain and only two had fever.Surgical procedures performed in complicated cysts were:infection-omentoplasty in three and external drainage in seven;intrabiliary rupture-omentoplasty in two and internal drainage in four patients.Two patients with intraperitoneal rupture underwent external drainage.There was no mortality.The postoperative morbidity was 50%in complicated cysts and 16%in uncomplicated cysts.CONCLUSION:Complicated hydatid cyst of the liver can be successfully managed surgically with good long term results. | Ajaz A Malik Shams UL Bari Ruquia Amin Masooda Jan | 2010 | World Journal of Gastrointestinal Surgery2010，2，3： | 4 |
| 19 | Attenuation of mitochondrial,but not cytosolic,Ca^(2+) overload reduces myocardial injury induced by ischemia and reperfusion显示文摘瞄准:mitochondrial Ca2+ 的变细([Ca2+] m ) ,然而并非 cytosolic Ca2+([Ca2+] c ) ,超载改进可收缩的恢复。我们假设了那变细[Ca2+] m,然而并非[Ca2+] c,超载对 ischemia/reperfusion-induced 损害授与 cardioprotection。方法:从孤立的酒的老鼠心,房间生存能力,和在孤立的老鼠短暂的电子上导致的 Ca2+ 的梗塞尺寸室的 myocytes 被测量。我们决定了 BAPTAAM 的效果,一座Ca2+螯岩山,在废除两个的超载的集中[Ca2+] c 并且[Ca2+] m ,和钌红,Ca2+的 mitochondrial uniporter 的一个禁止者搬运,在废除超载的集中[Ca2+] m ,然而并非[Ca2+] c ,在 ischemia/reperfusion 导致的心脏的损害上。结果:两个的变细[Ca2+] m 并且[Ca2+]由 BAPTAAM 的 c ,和变细[Ca2+] m ,然而并非[Ca2+] c ,由钌红的超载,减少了心脏的损害观察,显示重要性[Ca2+]在响应 ischemia/reperfusion 的 cardioprotection 和可收缩的恢复的 m 。结论:学习用一条原因效果途径提供了不含糊的证据那变细[Ca2+] m,然而并非[Ca2+] c,超载为对 ischemia/reperfusion-induced 损害的 cardioprotection 负责。我们也证实了以前的观察那变细[Ca2+] m,然而并非[Ca2+] c,旁边钌红改进可收缩的恢复追随者 ischemia/reperfusion。 | Chun-mei CAO Wing-yee YAN Jing LIU Kenneth WL KAM Shi-zhong ZHAN James SK SHAM Tak-ming WONG | 2006 | Acta Pharmacologica Sinica2006，27，7： | 4 |
| 20 | 用格子Boltzmann方法数值模拟三维空化现象显示文摘空化是一种微观、瞬时、随机、多相的复杂现象,其过程中所产生的极端条件以及伴随的一系列空化效应,将对液流系统产生破坏性和建设性两方面的作用.采用基于Shan-Chen模型的单组分多相流格子Boltzmann方法对水体中的三维空化现象进行了数值模拟,研究了低压下水体中气核半径与空化现象的相互关系,成功再现了低压下水体中微小气核发展成气泡的过程,并进一步研究了水体依次流经低压区、高压区时空化产生、发展、溃灭的全过程.数值模拟结果和理论预测结果符合良好. | 张新明 周超英 Islam Shams 刘家琦 | 2009 | 物理学报2009，58，12： | 3 |
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