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| 1 | Differentiation of Mesenchymal Stem Cells Into Dopaminergic Neuron-like Cells in vitro显示文摘To explore the way to induce mesenchymal stem cells (MSCs) to differentiate into dopaminergic neurons in vitro. Methods MSCs were obtained from rat bone marrow, cultured and passaged. MSCs used in this experiment had multipotency, which was indirectly proved by being induced to differentiate into chondrocytes and adipocytes. MSCs were cultured in medium containing 0.5 mmol/L IBMX for 2 days. Then the medium was replaced with induction medium, which contained GDNF, IL-1β, mesencephalic glial-cell-conditioned medium and flash-frozen mesencephalic membrane fragments. The surface markers of the differentiated neurons, such as NSE, nestin, MAP-2a, b and TH were detected by immunocytochemistry and Western blot after MSCs were cultured in induction medium for 7 days and 15 days. Results MSCs differentiated into neural progenitors and expressed nestin after MSCs were incubated with medium containing IBMX for 2 d. After the medium was replaced with induction medium containing many inducing agents, MSCs differentiated into neuron-like cells and dopaminergic neuron-like cells and expressed NSE, MAP-2a, b and TH. The percentage of NSE-positive cells, MAP-2a, b-positive cells and TH-positive cells was 30.032±2.489%, 41.580±5.101% and 34.958±5.534%, respectively after MSCs were induced in medium containing GDNF, IL-1β, mesencephalic glial-cell-conditioned medium and flash-frozen mesencephalic membrane fragments for 15 days. Conclusion MSCs can differentiate into dopaminergic neuron-like cells and are a new cell source for the treatment of neurodegeneration diseases and have a great potential for wide | L1GUO FEIYIN HONG-QIMENG LINGLING TA-NAHU-HE PENGLI CHUN-XIAZHANG SHUNYU DE-SHENGDUAN HONG-XUEFAN | 2005 | Biomedical and Environmental Sciences2005，18，1： | 31 |
| 2 | Diffusion-tensor imaging as an adjunct to dynamic contrastenhanced MRI for improved accuracy of differential diagnosis between breast ductal carcinoma in situ and invasive breast carcinoma显示文摘Objective:To determine the value of diffusion-tensor imaging(DTI) as an adjunct to dynamic contrastenhanced magnetic resonance imaging(DCE-MRI) for improved accuracy of differential diagnosis between breast ductal carcinoma in situ(DCIS) and invasive breast carcinoma(IBC).Methods:The MRI data of 63 patients pathologically confirmed as breast cancer were analyzed.The conventional MRI analysis metrics included enhancement style,initial enhancement characteristic,maximum slope of increase,time to peak,time signal intensity curve(TIC) pattern,and signal intensity on FST2 WI.The values of apparent diffusion coefficient(ADC),directionally-averaged mean diffusivity(D_(avg)),exponential attenuation(EA),fractional anisotropy(FA),volume ratio(VR) and relative anisotropy(RA)were calculated and compared between DCIS and IBC.Multivariate logistic regression was used to identify independent factors for distinguishing IBC and DCIS.The diagnostic performance of the diagnosis equation was evaluated using the receiver operating characteristic(ROC) curve.The diagnostic efficacies of DCEMRI,DWI and DTI were compared independendy or combined.Results:EA value,lesion enhancement style and TIC pattern were identified as independent factor for differential diagnosis of IBC and DCIS.The combination diagnosis showed higher diagnostic efficacy than a single use of DCE-MRI(P=0.02),and the area of the curve was improved from 0.84(95%CI,0.67-0.99) to0.94(95%CI,0.85-1.00).Conclusions:Quantitative DTI measurement as an adjunct to DCE-MRI could improve the diagnostic performance of differential diagnosis between DCIS and IBC compared to a single use of DCE-MRI. | Yuan Wang Xiaopeng Zhang Kun Cao Yanling Li Xiaoting Li Liping Qi Lei Tang Zhilong Wang Shunyu Gao | 2015 | Chinese Journal of Cancer Research2015，27，2： | 12 |
| 3 | Pattern formation in 2-μm Tm Mamyshev oscillators associated with the dissipative Faraday instability显示文摘We investigate numerically the pattern formation in 2-μm thulium-doped Mamyshev fiber oscillators, associated with the dissipative Faraday instability. The dispersion-managed fiber ring oscillator is designed with commercial fibers, allowing the dynamics for a wide range of average dispersion regimes to be studied, from normal to nearzero cavity dispersion where the Benjamin–Feir instability remains inhibited. For the first time in the 2-μm spectral window, the formation of highly coherent periodic patterns is demonstrated numerically with rates up to ~100 GHz. In addition, irregular patterns are also investigated, revealing the generation of rogue waves via nonlinear collision processes. Our investigations have potential applications for the generation of multigigahertz frequency combs. They also shed new light on the dissipative Faraday instability mechanisms in the area of nonlinear optical cavity dynamics. | Pan Wang Shunyu Yao Philippe Grelu Xiaosheng Xiao Changxi Yang | 2019 | Photonics Research2019，7，11： | 4 |
| 4 | Research on the Production Process of Apple Clear Juice Beverage显示文摘[Objective] The study aimed to determine the formula and production process of apple clear juice beverage. [Method] Concentrated apple juice was used as the raw material in this experiment, apple clear juice beverage was produced through dilution, blending, color protection, sterilization and other key processes. By using orthogonal test, the best formula of the apple clear juice beverage was determined, and then the color protection effects of three color protection agents Cys, NaHSO3 and VC on the apple clear juice beverage were compared. [Result] The best formula of the apple clear juice beverage was composed of 0.15% citric acid, 0.20% sodium citrate, 0.06% tannic acid, 6% white sugar and 16% concentrated apple juice. Besides, there was a big difference among the three kinds of color protection agents (Cys, NaHSO3 and VC) in the color protection effects on the apple clear juice beverage. Considering the quality safety of the product, 0.60% VC was chosen as the best color protection agent. [Conclusion] The research could provide theoretical references for using concentrated apple juice to produce apple clear juice beverage. | ZHU Xia HAN Shunyu YANG Xueshan WANG Jin SHENG Wenjun ZHANG Bo | 2012 | Chinese Food Science2012，1，4： | 3 |
| 5 | Utility of CT in differentiating liver metastases of well-differentiated gastroenteropancreatic neuroendocrine neoplasms from poorly-differentiated neuroendocrine neoplasms显示文摘Objective: To determine the capability of dynamic enhanced computed tomography(CT) to differentiate liver metastases(LMs) of well-differentiated from poorly-differentiated gastroenteropancreatic neuroendocrine neoplasms(GEP-NENs).Methods: Patients with LMs of GEP-NENs who underwent dynamic enhanced CT examination in Peking University Cancer Hospital from January 2009 to October 2015 were included and data were retrospectively analyzed. We assessed the qualitative and quantitative CT features to identify the significant differentiating CT features of LMs of poorly-differentiated GEP-NENs from those of well-differentiated GEP-NENs using univariate analysis and a multivariate logistic regression model.Results: The study included 22 patients with LMs of well-differentiated GEP-NENs and 32 patients with LMs of poorly-differentiated GEP-NENs. Univariate analysis revealed statistically significant differences between the LMs of well-and poorly-differentiated GEP-NENs in terms of feeding arteries(36.4% vs. 75.0%, χ2=8.061,P=0.005), intratumoral neovascularity(18.2% vs. 59.4%, χ2=9.047, P=0.003), lymphadenopathy(27.3% vs. 81.2%,χ2=15.733, P<0.001), tumor-to-aortic ratio in the hepatic arterial and portal venous phase(T-A/AP: 0.297±0.080 vs.0.251±0.059, t=2.437, P=0.018; T-A/PVP: 0.639±0.138 vs. 0.529±0.117, t=3.163, P=0.003) and tumor-to-liver ratio in the hepatic arterial phase(T-L/AP: 1.108±0.267 vs. 0.907±0.240, t=2.882, P=0.006). The LMs of poorlydifferentiated GEP-NENs showed more feeding arteries, more intratumoral neovascularity, more lymphadenopathy and a lower tumor-to-aortic ratio. Multivariate analysis suggested that intratumoral neovascularity [P=0.015, OR=0.108, 95% confidence interval(95% CI), 0.018–0.646], lymphadenopathy(P=0.001,OR=0.055, 95% CI, 0.009–0.323) and T-A/PVP(P=0.004, OR=5.3 E–5, 95% CI, 0.000–0.044) were independent factors for differentiating LMs of poorly-differentiated from well-differentiated GEP-NENs.Conclusions: Dynamic enhanced CT features(intratumoral neovascularity, lymphadenopathy and T-A/PVP)are useful in the pathological classification of LMs of GEP-NENs. | Yong Cui Xiaoting Li Shunyu Gao Zhongwu Li Yanling Li Ming Lu Yingshi Sun | 2018 | Chinese Journal of Cancer Research2018，30，1： | 3 |
| 6 | Investigation of suitable precursors for manganese oxide catalysts in ethyl acetate oxidation显示文摘The control of ethyl acetate emissions from fermentation and extraction processes in the pharmaceutical industry is of great importance to the environment.We have developed three Mn_(2)O_(3)catalysts by using different Mn precursors(MnCl_(2),Mn(CH_(3)COO)_(2),MnSO_(4)),named as Mn_(2)O_(3)-Cl,-Ac,-SO_(4).The tested catalytic activity results showed a sequence with Mn precursors as:Mn_(2)O_(3)-Cl>Mn_(2)O_(3)-Ac>Mn_(2)O_(3)-SO_(4).The Mn_(2)O_(3)-Cl catalyst reached a complete ethyl acetate conversion at 212℃(75℃lower than that of Mn_(2)O_(3)-SO_(4)),and this high activity 100%could be maintained high at 212℃for at least 100 hr.The characterization data about the physical properties of catalysts did not show an obvious correlation between the structure and morphology of Mn_(2)O_(3)catalysts and catalytic performance,neither was the surface area the determining factor for catalytic activity in the ethyl acetate oxidation.Here we firstly found there is a close linear relationship between the catalytic activity and the amount of lattice oxygen species in the ethyl acetate oxidation,indicating that lattice oxygen species were essential for excellent catalytic activity.Through H_(2)temperature-programmed reduction(H_(2)-TPR)results,we found that the lowest initial reduction temperature over the Mn_(2)O_(3)-Cl had stronger oxygen mobility,thus more oxygen species participated in the oxidation reaction,resulting in the highest catalytic performance.With convenient preparation,high efficiency,and stability,Mn_(2)O_(3)prepared with MnCl_(2)will be a promising catalyst for removing ethyl acetate in practical application. | Yan Zhang Meng Wang Shunyu Kang Tingting Pan Hua Deng Wenpo Shan Hong He | 2021 | Journal of Environmental Sciences2021，33，6： | 2 |
| 7 | Significant enhancement in water resistance of Pd/Al2O3 catalyst for benzene oxidation by Na addition显示文摘A series of Na-doped 1 wt% Pd/Al2O3 catalysts with different Na loadings were prepared by wet impregnation and tested for the catalytic oxidation of benzene. Suitable addition of Na had a remarkable promotion effect on water resistance and enhancement of low temperature activity of Pd/Al2O3 catalysts. The optimal mole ratio between Na and Pd was 1:1. The properties of the prepared catalysts were characterized by X-ray diffraction (XRD), Brunauer Emmett Teller (BET), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), O2-temperature-programmed desorption (O2-TPD), and in situ DRIFTS. Results indicated that the addition of Na not only decreased the content of adsorbed water species but also increased the amount of liable surface oxygen species, which are likely the key factors for the excellent water resistance of the catalyst. Na addition also improved the mobility of the lattice oxygen species, which was favorable for catalytic activity. Moreover, the well-dispersed negatively charged Pd particles and suitable redox properties derived from Na addition also contributed to the improved performance and water resistance of the Na1Pd1/Al2O3 catalyst. In situ DRIFTS results revealed that benzene was oxidized to maleate and acetate species via intermediate o-benzoquinone species, which finally turned into harmless CO2 and H2O. | Shunyu Kang Meng Wang Na Zhu Chunying Wang Hua Deng Hong He | 2019 | Chinese Chemical Letters2019，30，7： | 2 |
| 8 | Transarterial chemoembolization in combination with programmed death-1/programmed cell death-ligand 1 immunotherapy for hepatocellular显示文摘Hepatocellular carcinoma(HCC)is one of the most common malignancies worldwide.With the development of systemic therapies,several studies are currently underway,especially those related to the use of programmed death-1/programmed cell death-ligand 1(PD-1/PD-L1)immunotherapy.Moreover,studies on transarterial che-moembolization(TACE)and PD-1/PD-L1 immunotherapy have demonstrated some interesting outcomes.This article reviewed the current clinical evidence on the combination of TACE and PD-1/PD-L1 immunotherapy.Overall,our review summarized that a favorable survival time could be achieved using this combination in most patients.However,complications such as hyperprogression should be taken seriously,and the underlying mechanisms need to be explored. | Jingxin Yan Manjun Deng Shunyu Kong Ting Li Zhenwu Lei Lushun Zhang Yutong Zhuang Xin He Huanwei Wang Haining Fan Yingxing Guo | 2022 | iLIVER2022，1，4： | 2 |
| 9 | NiO nanosheet assembles for supercapacitor electrode materials显示文摘In this paper, large scale hierarchically assembled Ni O nanosheets have been favorably fabricated through a facile hydrothermal route. The as-prepared Ni O nanosheet assembles were characterized in detail by various analytical techniques. The results showed these nanosheets present the thickness of about 30 nm and the surface area is 116.9 m^2 g^(-1). These NiO nanosheet assembles were used as the working electrode materials in electrochemical tests, which demonstrated a specific capacitance value of 81.67 Fg ^(-1)at the current density of 0.5 Ag^(-1)and excellent long cycle-life stability with 78.5% of its discharge specific capacitance retention after 3000 cycles at the current density of 0.5 Ag^(-1), revealing the as-synthesized NiO nanosheet assembles might be a promising electrode material for supercapacitor applications. | Huanhao Xiao Shunyu Yao Hongda Liu Fengyu Qu Xu Zhang Xiang Wu | 2016 | Progress in Natural Science:Materials International2016，26，3： | 2 |
| 10 | Effects of an Algicidal Bacterium Pseudomonas mendocina on the Growth and Antioxidant System of Aphanizomenon flos-aquae显示文摘 | Shunyu Shi Dongshan Tang Yongding Liu | 2009 | Current Microbiology2009，，2： | 1 |
| 11 | Efficacy and complications of transarterial chemoembolization alone or in combination with different protocols for hepatocellular carcinoma: A Bayesian network meta-analysis of randomized controlled trials显示文摘Background and aims:Transarterial chemoembolization(TACE)is the standard treatment for most intermediate-toadvanced stage hepatocellular carcinoma.With the ongoing development of interventional therapies,TACE in combination with different protocols is being explored.A network meta-analysis to collect recent evidence in this field is required.Methods:We searched PubMed,Web of Science,Cochrane Central Register of Controlled Trials,Embase,Chinese National Knowledge Infrastructure database,Cochrane Library,and Wanfang database from their inception to May 2022 for randomized controlled trials(RCTs)that reported TACE in combination with different protocols for hepatocellular carcinoma.Results:In total,67 RCTs assessing eight combination treatments were included.The quality of primary outcomes was from moderate to low.The Bayesian network meta-analysis confirmed that TACE combined with iodine-125 seed implantation had the highest probability of 1-year survival rate and TACE combined with sorafenib had the highest probability of 2-year survival rate.TACE alone had the highest probability of incidence of fever,TACE combined with sorafenib had the highest probability of incidence of pain and TACE combined with percutaneous ethanol injection had the highest probability of incidence of nausea and vomiting.Conclusion:This Bayesian network meta-analysis found that TACE combined with iodine-125 seed and TACE combined with sorafenib may benefit patients in terms of 1-year survival and 2-year survival,respectively.To confirm this conclusion,high-quality and well-designed RCTs with a larger sample size are needed. | Jingxin Yan Manjun Deng Ting Li Changhao Dong Minglan Wang Shunyu Kong Yingxing Guo Haining Fan | 2023 | iLIVER2023，2，2： | 1 |
| 12 | Effects of an algicidal bacterium Pseudomomas mendocina on the growth and antioxidant system of Aphanizomenon flos-aquae 显示文摘 | Shi Shunyu Tang Dongshan Liu Yongding | 2009 | Current Microbiology2009，59，2： | 1 |
| 13 | Strain variation in the susceptibility and immune response to Clonorchis sinensis infection in mice显示文摘 | Md. Hafiz Uddin Shunyu Li Young Mee Bae Min-Ho Choi Sung-Tae Hong | 2011 | Parasitology International2011，，： | 1 |
| 14 | Machinable long PVP- stabilized silver nanowires显示文摘 | Peng Jiang Shunyu Li SishenXie | 2004 | ChemEur J2004，10，19： | 1 |
| 15 | Tuberculosis of nose and palae with vanishing uvula显示文摘 | Baruah B Goyal A Shunyu NB | 2011 | Indian J Med Microbiol2011，29，1： | 1 |
| 16 | Physiological and biochemical responses of Scytonema javanicum(cyanobacterium)to salt stress显示文摘 | Dongshan Tang Shunyu Shi Dunhai Li | 2007 | Journal of Arid Environments2007，71，： | 1 |
| 17 | Cut throat zone Ⅱ neck injury and advantage of a feeding jejunostomy显示文摘 | Laleng M Darlong Neizekhotuo B Shunyu etal | 2009 | J Emery Trauma Shock2009，2，3： | 1 |
| 18 | Lysis of Aphanizomen on flos-aquae (Cyonobacterium) by a bacterium Bacillus cereus显示文摘 | Shunyu S Yongding L Yinwu S | | 0，，03： | 1 |
| 19 | Research on the Production Process of Apple Cl ear Juice Beverage显示文摘 | ZHU Xia HAN Shunyu YANG Xueshan WANG Jin SHENG W enjun ZHANG Bo | | 0，，04： | 1 |
| 20 | Tip-Based Nanomachining on Thin Films:A Mini Review显示文摘As one of the most widely used nanofabrication methods,the atomic force microscopy(AFM)tip-based nanomachining technique offers important advantages,including nanoscale manipulation accuracy,low maintenance cost,and flexible experimental operation.This technique has been applied to one-,two-,and even three-dimensional nanomachining patterns on thin films made of polymers,metals,and two-dimensional materials.These structures are widely used in the fields of nanooptics,nanoelectronics,data storage,super lubrication,and so forth.Moreover,they are believed to have a wide application in other fields,and their possible industrialization may be realized in the future.In this work,the current state of the research into the use of the AFM tip-based nanomachining method in thin-film machining is presented.First,the state of the structures machined on thin films is reviewed according to the type of thin-film materials(i.e.,polymers,metals,and two-dimensional materials).Second,the related applications of tip-based nanomachining to film machining are presented.Finally,the current situation of this area and its potential development direction are discussed.This review is expected to enrich the understanding of the research status of the use of the tip-based nanomachining method in thin-film machining and ultimately broaden its application. | Shunyu Chang Yanquan Geng Yongda Yan | 2022 | Nanomanufacturing and Metrology2022，5，1： | 0 |
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