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| 1 | High-performance distributed feedback quantum dot lasers with laterally coupled dielectric gratings显示文摘The combination of grating-based frequency-selective optical feedback mechanisms,such as distributed feedback(DFB)or distributed Bragg reflector(DBR)structures,with quantum dot(QD)gain materials is a main approach towards ultrahigh-performance semiconductor lasers for many key novel applications,as either stand-alone sources or on-chip sources in photonic integrated circuits.However,the fabrication of conventional buried Bragg grating structures on GaAs,GaAs/Si,GaSb,and other material platforms has been met with major material regrowth difficulties.We report a novel and universal approach of introducing laterally coupled dielectric Bragg gratings to semiconductor lasers that allows highly controllable,reliable,and strong coupling between the grating and the optical mode.We implement such a grating structure in a low-loss amorphous silicon material alongside GaAs lasers with InAs/GaAs QD gain layers.The resulting DFB laser arrays emit at pre-designed 0.8 THz local area network wavelength division multiplexing frequency intervals in the 1300 nm band with record performance parameters,including sidemode suppression ratios as high as 52.7 dB,continuous-wave output power of 26.6 mW(room temperature)and 6 mW(at 55℃),and ultralow relative intensity noise(RIN)of<-165 dB/Hz(2.5-20 GHz).The devices are also capable of isolator-free operating under very high external reflection levels of up to-12.3 dB while maintaining high spectral purity and ultralow RIN qualities.These results validate the novel laterally coupled dielectric grating as a technologically superior and potentially cost-effective approach for fabricating DFB and DBR lasers free of their semiconductor material constraints,which are thus universally applicable across different material platforms and wavelength bands. | ZHUOHUI YANG ZHENGQING DING LIN LIU HANCHENG ZHONG SHENG CAO XINZHONG ZHANG SHIZHE LIN XIAOYING HUANG HUADI DENG YING YU SIYUAN YU | 2022 | Photonics Research2022，10，5： | 3 |
| 2 | Regulation of mTORC1 by amino acids in mammalian cells: A general picture of recent advances显示文摘The mechanistic target of rapamycin complex 1(mTORC1)integrates various types of signal inputs,such as energy,growth factors,and amino acids to regulate cell growth and proliferation mainly through the 2 direct downstream targets,eukaryotic translation initiation factor 4 E-binding protein 1(4 EBP1)and ribosomal protein S6 kinase 1(S6 K1).Most of the signal arms upstream of mTORCl including energy status,stress signals,and growth factors converge on the tuberous sclerosis complex(TSC)-Ras homologue enriched in brain(Rheb)axis.Amino acids,however,are distinct from other signals and modulate mTORCl using a unique pathway.In recent years,the transmission mechanism of amino acid signals upstream of mTORCl has been gradually elucidated,and some sensors or signal transmission pathways for individual amino acids have also been discovered.With the help of these findings,we propose a general picture of recent advances,which demonstrates that various amino acids from lysosomes,cytoplasm,and Golgi are sensed by their respective sensors.These signals converge on mTORCl and form a huge and complicated signal network with multiple synergies,antagonisms,and feedback mechanisms. | Shizhe Zhang Xueyan Lin Qiuling Hou Zhiyong Hu Yun Wang Zhonghua Wang | 2021 | Animal Nutrition2021，，4： | 2 |
| 3 | Application of fluorescence in situ hybridization in the detection of bladder transitional-cell carcinoma: A multi-center clinical study based on Chinese population显示文摘Objective:To evaluate the diagnostic value of fluorescence in situ hybridization(FISH)in bladder cancer.Methods:We enrolled healthy volunteers and patients who were clinically suspected to have bladder cancer and conducted FISH tests and cytology examinations from August 2007 to December 2008.Receiver operating characteristic(ROC)curve analysis was performed and the area under curve(AUC)values were calculated for both the FISH and urine cytology tests.Results:A cohort of 988 healthy volunteers was enrolled to establish a reference range for the normal population.A total of 4807 patients with hematuria were prospectively,randomly enrolled for the simultaneous analysis of urine cytology,FISH testing,and a final diagnosis as determined by the pathologic findings of a biopsy or a surgically-excised specimen.Overall,the sensitivity of FISH in detecting transitional-cell carcinoma was 82.7%,while that of cytology was 33.4%(p<0.001).The sensitivity values of FISH for non-muscle invasive and muscle invasive bladder transitional-cell carcinoma were 81.7%and 89.6%,respectively(p=0.004).The sensitivity values of FISH for low and high grade bladder cancer were 82.6%and 90.1%,respectively(p=0.002).Conclusion:FISH is significantly more sensitive than voided urine cytology for detecting bladder cancer in patients evaluated for gross hematuria at all cancer grades and stages.Higher sensitivity using FISH was obtained in high grade and muscle invasive tumors. | Liqun Zhou Kaiwei Yang Xuesong Li Yi Ding Dawei Mu Hanzhong Li Yong Yan Jinyi Li Dongwen Wang Wei Li Yulong Cong Jiangping Gao Kewei Ma Yajun Xiao Sheng Zhang Hongyi Jiang Weilie Hu Qiang Wei Xunbo Jin Zhichen Guan Qingyong Liu Danfeng Xu Xin Gao Yongguang Jiang Weimin Gan Guang Sun Qing Wang Yanhui Liu Jianquan Hou Liping Xie Xishuang Song Fengshuo Jin Jiafu Feng Ming Cai Zhaozhao Liang Jie Zhang Dingwei Ye Lin Qi Lulin Ma Jianzhong Shou Yuping Dai Jianyong Shao Ye Tian Shizhe Hong Tao Xu Chuize Kong Zefeng Kang Yuexin Liu Xun Qu Benkang Shi Shaobin Zheng Yi Lin Shujie Xia Dong Wei Jianbo Wu Weiling Fu Zhiping Wang Jianbo Liang | 2019 | Asian Journal of Urology2019，6，1： | 2 |
| 4 | Microstructure and rolling capability of modified AZ31–Ce–Gd alloys显示文摘 | Wenping Li Hong Zhou Pengyu Lin Shizhe Zhao | 2009 | Materials Characterization2009，，11： | 1 |
| 5 | HIRFL-CSR Control System Progress显示文摘The control system architecture is divided into several parts and three levels. Level I: CPCI architecture for special control processing.Level II: Industrial computer, (PC and SUN SPARC). PCI Modules for general control processing. Level III: Micro-gateway + 31 application modules. The Gateway connects Ethernet to RS-485 and CANBUS or other field-Level II System Progress bus. Run real-time LINUX (NUT) for general control processing. | Qiao Weimin, Jing Lan, Ma Yunhai, Gou Shizhe, Lin Jie, Liang Yihai, Liu Ning, Zhang Chunxia Wang Dan, Zhang Shuocheng, Meng Jian, Liu Junke and Zhang Changshuan | 2002 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2002，，1： | 0 |
| 6 | A 0.1–1.5 GHz multi-octave quadruple-stacked CMOS power amplifier显示文摘In this letter,we design and analyze 0.1–1.5 GHz multi-octave quadruple-stacked CMOS power amplifier(PA)in 0.18μm CMOS technology.By using two-stage quadruple-stacked topology and feedback technology,the proposed PA realizes an ultra-wideband CMOS PA in a small chip area.Wideband impedance matching is achieved with smaller chip dimension.The effects of feedback resistors on the RF performance are also discussed for this stacked-FET PA.The PA shows measured input return loss(<–10.8 dB)and output return loss(<–9.6 dB)in the entire bandwidth.A saturated output power of 22 dBm with maximum 20%power added efficiency(PAE)is also measured with the drain voltage at 5 V.The chip size is 0.44 mm^2 including all pads. | Shizhe Wei Haifeng Wu Qian Lin Mingzhe Zhang | 2020 | Journal of Semiconductors2020，41，6： | 0 |
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