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| 1 | Alcoholic liver disease and the gut-liver axis显示文摘Alcoholic liver disease (ALD) is one of the leading causes of liver diseases and liver-related death worldwide. Of the many factors that contribute to the pathogenesis of ALD, gut-derived lipopolysaccharide (LPS) plays a central role in induction of steatosis, inflammation, and fi brosis in the liver. In this review, we discuss the mechanisms by which alcohol contributes to increased gut permeability, the activation of Kupffer cells, and the infl ammatory cascade by LPS. The role of the Toll-like receptor 4 (TLR4) complex in LPS recognition and the importance of the TLR4-induced signaling pathways are evaluated in ALD. | Gyongyi Szabo Shashi Bala | 2010 | World Journal of Gastroenterology2010，16，11： | 50 |
| 2 | Emerging role of microRNAs in liver diseases显示文摘MicroRNAs are a class of small non-coding RNAs that are found in plants, animals, and some viruses. They modulate the gene function at the post-transcriptional level and act as a fine tuner of various processes, such as development, proliferation, cell signaling, and apopto-sis. They are associated with different types and stages of cancer. Recent studies have shown the involvement of microRNAs in liver diseases caused by various factors, such as Hepatitis C, Hepatitis B, metabolic disorders, and by drug abuse. This review highlights the role of microRNAs in liver diseases and their potential use as therapeutic molecules. | Shashi Bala Miguel Marcos Gyongyi Szabo | 2009 | World Journal of Gastroenterology2009，15，45： | 25 |
| 3 | Dynamic hip screw with locking side plate: a viable treatment option for intertrochanteric fracture显示文摘ObjectiveDynamic 新潮的螺丝钉(DHS ) 为稳定的 intertrochanteric 破裂的固定被推荐。它的手术后的开口率从 1% ~ 6%。在 osteoporotic 骨头,在 DHS 片的正常螺丝钉与锁螺丝钉相比提供更少的抛锚。这研究试图把 DHS 与锁方面板和常规方面 plate.MethodsFifty 作比较有 intertrochanteric 破裂的连续病人随机与标准 DHS (组 A ) 和锁住的 DHS 为固定被分配(Combi 板,组 B ) 。我们在 intertrochanteric 破裂为常规 DHS 和锁住的 DHS 比较了临床、放射学的结果。功能的结果用 score.ResultsCoxa valga 比在组 B 在组 A 更经常被发现的帕克活动性被评估(12% 对 0% , P = 0.42 ) 。臀部 vara 显示出一样的趋势(12% 对 8% , P = 0.81 ) 。在健全方面的 20 °
以内的手术后的颈柄角度的恢复的率比在组 A 在组 B (8% 盒子) 是更高的(4% 盒子, P = 0.98 ) 。在健全方面的 10 °
以内的子宫前倾角度恢复的率在组 B 也是更高的(100% 对 88% , s = 0.85 ) 。一般水准落后在组 A 和组 B 的螺丝钉滑动是 3.2 公里和 4.2 公里,平均破裂联合持续时间是 17.1 个星期, 16.4 个星期,和吝啬的帕克得分分别地是 5.6 和 5.8。螺丝钉开口在组 A 在一个病人被看见。没有开口在组 B 在任何病人被看见。没有耐心的发达深感染, avascular 坏死,深静脉血栓或任何东西学习表明了的在场的另外的重要 complications.ConclusionThe 有锁住的 DHS 的那对待的 intertrochanteric 破裂允许健全骨头愈合并且是没与任何主要复杂并发症联系。尽管这份报告是有希望的,因为仅仅有一种大样品尺寸的未来的研究将允许权威的结论,它应该小心地被解释。 | Nilesh Barwar Sanjay Meena Shashi Kant Aggarwal Prashant Garhwal | 2014 | Chinese Journal of Traumatology2014，17，2： | 23 |
| 4 | Intracranial pressure monitoring:Gold standard and recent innovations显示文摘Intracranial pressure monitoring (ICP) is based on the doctrine proposed by Monroe and Kellie centuries ago. With the advancement of technology and science, various invasive and non-invasive modalities of monitoring ICP continue to be developed. An ideal monitor to track ICP should be easy to use, accurate, reliable, reproducible, inexpensive and should not be associated with infection or haemorrhagic complications. Although the transducers connected to the extra ventricular drainage continue to be Gold Standard, its association with the likelihood of infection and haemorrhage have led to the search for alternate noninvasive methods of monitoring ICP. While Camino transducers, Strain gauge micro transducer based ICP monitoring devices and the Spiegelberg ICP monitor are the emerging technology in invasive ICP monitoring, optic nerve sheath diameter measurement, venous opthalmodynamometry, tympanic membrane displacement, tissue resonance analysis, tonometry, acoustoelasticity, distortionproduct oto-acoustic emissions, trans cranial doppler, electro encephalogram, near infra-red spectroscopy, pupillometry, anterior fontanelle pressure monitoring, skull elasticity, jugular bulb monitoring, visual evoked response and radiological based assessment of ICP are the non-invasive methods which are assessed against the gold standard. | Deb Sanjay Nag Seelora Sahu Amlan Swain Shashi Kant | 2019 | World Journal of Clinical Cases2019，7，13： | 16 |
| 5 | Compartmentalized Metabolic Engineering for Artemisinin Biosynthesis and Effective Malaria Treatment by Oral Delivery of Plant Cells显示文摘Artemisinin 对药抵抗的疟疾的寄生虫是高度有效的,它将近影响全球人口和杀死的一半 > 500 000 个人每年。artemisinin 的主要费用是过去常从 Artemisia annua 提取并且净化这药的昂贵的过程。这显然不必要的步的消除将在地方性的区域使这有势力抗疟药药买得起到全球人口生活。这里,我们报导了非蛋白质药 artemisinin biosynthesized 的口头的交货(0.8 mg/g 干燥重量) 在在由设计二的烟草的临床上有意义的层次,新陈代谢的小径指向了到三不同细胞的分隔空间(叶绿体,原子核,和线粒体) 。二倍地转基因的线显示出 isopentenyl 焦磷酸盐的三方面的改进,并且指向 AACPR, DBR2,和 CYP71AV1 到叶绿体导致了更高的表示和 dihydroartemisinic 酸的有效相片氧化到 artemisinin。从转基因的烟草植物的叶子的部分净化的摘录在变形体感染 falciparum 的红血房间的 vitro 生长前进禁止了。artemisinin 减少了的整个未经触动的植物房间 bioencapsulating 的口头的喂在与商业药比较的质问老鼠的 parasitemia 层次。如此的新奇 synergistic 途径应该通过可食的植物的新陈代谢的工程便于 artemisinin 和另外的药的便宜生产和交货。 | Karan Malhotra Mayavan Subramaniyan Khushboo Rawat Md. Kalamuddin M. Irfan Qureshi Pawan Malhotra Asif Mohmmed Katrina Cornish Henry Daniell Shashi Kumar1 | 2016 | Molecular Plant2016，9，11： | 14 |
| 6 | Functional properties, phenolic constituents and antioxidant potential of industrial apple pomace for utilization as active food ingredient显示文摘Apple pomace is a waste biomass generated after apple fruit processing.In present investigation,efforts were made to comprehend influence of differently dried pomace on cell wall properties and phenolic profile.Different drying techniques were employed to remove moisture content from fresh apple pomace.Total dietary fiber yield(74%)and array of functional properties such as density,water and oil holding capacity,swelling capacity and glucose dialysis retardation index(36.91%)was found better in freeze dried fraction.The higher total phenolics(5.78±0.08 mg GAE/g dry weight)content was also recorded in freeze dried fraction followed by oven and sun drying.The 50%aqueous acetone was found as more efficient solvent for extraction of phenolic constituents.RP-HPLC analysis has revealed presence of quercetin,phloridzin and phloretin as major phenolics.Thus,it is evident from the results that pomace generated at industrial scale can be utilized as a source of dietary food ingredient. | Shalika Ranaa Sakshi Gupta Ajay Rana Shashi Bhushan | 2015 | Food Science and Human Wellness2015，4，4： | 8 |
| 7 | Review of evolution of tunnel position in anterior cruciate ligament reconstruction显示文摘Anterior cruciate ligament(ACL) rupture is one of the commonest knee sport injuries. The annual incidence of the ACL injury is between 100000-200000 in the United States. Worldwide around 400000 ACL reconstructions are performed in a year. The goal of ACL reconstruction is to restore the normal knee anatomy and kinesiology. The tibial and femoral tunnel placements are of primordial importance in achieving this outcome. Otherfactors that influence successful reconstruction are types of grafts, surgical techniques and rehabilitation programmes. A comprehensive understanding of ACL anatomy has led to the development of newer techniques supplemented by more robust biological and mechanical concepts. In this review we are mainly focussing on the evolution of tunnel placement in ACL reconstruction, focusing on three main categories, i.e., anatomical, biological and clinical outcomes. The importance of tunnel placement in the success of ACL reconstruction is well researched. Definite clinical and functional data is lacking to establish the superiority of the single or double bundle reconstruction technique. While there is a trend towards the use of anteromedial portals for femoral tunnel placement, their clinical superiority over trans-tibial tunnels is yet to be established. | Faizal Rayan Shashi Kumar Nanjayan Conal Quah Darryl Ramoutar Sujith Konan Fares S Haddad | 2015 | World Journal of Orthopedics2015，6，2： | 7 |
| 8 | Plasma microRNA profiles distinguish lethal injury in acetaminophen toxicity: A research study显示文摘AIM: To investigate plasma microRNA (miRNA) profiles indicative of hepatotoxicity in the setting of lethal acetaminophen (APAP) toxicity in mice. METHODS: Using plasma from APAP poisoned mice, either lethally (500 mg/kg) or sublethally (150 mg/kg) dosed, we screened commercially available murine microRNA libraries (SABiosciences, Qiagen Sciences, MD) to evaluate for unique miRNA profiles between these two dosing parameters. RESULTS: We distinguished numerous, unique plasma miRNAs both up- and downregulated in lethally compared to sublethally dosed mice. Of note, many of the greatest up- and downregulated miRNAs, namely 574-5p, 466g, 466f-3p, 375, 29c, and 148a, have been shown to be associated with asthma in prior studies. Interestingly, a relationship between APAP and asthma has been previously well described in the literature, with an as yet unknown mechanism of pathology. There was a statistically significant increase in alanine aminotransferase levels in the lethal compared to sublethal APAP dosing groups at the 12 h time point (P < 0.001). There was 90% mortality in the lethally compared to sublethally dosed mice at the 48 h time point (P = 0.011). CONCLUSION: We identified unique plasma miRNAs both up- and downregulated in APAP poisoning which are correlated to asthma development. | Jeanine Ward Shashi Bala Jan Petrasek Gyongyi Szabo | 2012 | World Journal of Gastroenterology2012，18，22： | 6 |
| 9 | Comparative analysis of APACHE-Ⅱ and P-POSSUM scoring systems in predicting postoperative mortality in patients undergoing emergency laparotomy显示文摘BACKGROUND Laparotomy remains one of the commonest emergency surgical procedures.Early prognostic evaluation would aid in selecting the high-risk patients for an aggressive treatment.Awareness about risks could potentially contribute to the quality of perioperative care and optimum utilization of resources.Portsmouth modification of Physiological and operative severity for the enumeration of mortality and morbidity (P-POSSUM) and the acute physiology and chronic health evaluation Ⅱ(APACHE-Ⅱ) have been the most widely used scoring systems for emergency laparotomies.It is always better to have a single scoring system to predict outcomes and audit healthcare organizations.AIM To compare the ability of APACHE-II and P-POSSUM to predict postoperative morbidity and mortality in patients undergoing emergency laparotomy.METHODS All patients undergoing emergency laparotomy at the Tata Main Hospital,Jamshedpur between December 2013 and November 2014 were included in the study.In this observational study,P-POSSUM and APACHE-Ⅱ scoring were done,and the outcome analysis evaluated with mortality being the primary outcome.RESULTS For P-POSSUM,at a cut off value of 63 to predict mortality using receiver operating characteristics curve analysis,the area under the curve was 0.989;and for APACHE-Ⅱ,at the cut off value of 24,the area under the curve was 0.965.CONCLUSION Because the ability of APACHE-Ⅱ to predict mortality was similar to P-POSSUM and APACHE-Ⅱ does not need scoring for intra-operative findings and histopathology reports,APACHE-Ⅱ can be used pre-operatively to assess the risk in patients undergoing emergency laparotomy.However,for audit purposes,either of the two scoring systems can be used. | Deb Sanjay Nag Ankur Dembla Pratap Rudra Mahanty Shashi Kant Abhishek Chatterjee Devi Prasad Samaddar Parul Chugh | 2019 | World Journal of Clinical Cases2019，7，16： | 5 |
| 10 | 培养角膜缘上皮移植后穿透性角膜移植术的早期结果显示文摘目的:描述曾行培养角膜缘上皮移植的患者再行穿透性角膜移植(PKP)的早期结果。
方法:对因化学烧伤造成角膜缘干细胞缺乏而行培养的角膜缘上皮移植后又进行穿透性角膜移植术的患者有关人口统计学、原发病因、角膜缘移植类型、眼表稳定性、视力、移植片透明度和并发症方面的资料进行回顾和复习。对受体角膜片组织病理学特征进行研究,重点观察上皮状态。
结果:在患有角膜缘干细胞缺乏而进行培养的角膜缘上皮移植术的125例患者中,15例接受了穿透性角膜移植术(PKP)。角膜缘上皮移植术后(自体移植组n=11,同种异体移植组n=4)平均间隔时间为7个月(范围2—12个月)。同种异体移植组的4例患者均接受了免疫抑制疗法。15只眼中14只眼(93%)获得了含有稳定的角膜上皮的健全的角膜植片。15只眼中14只眼术前最佳矫正视力低于20/200。PKP后平均随访8.3±5.0个月,8只眼最佳矫正视力高于20/60,5只眼最佳矫正视力20/200至20/60。2只眼低于20/200。15只眼中3只眼发生异体角膜植片的排斥反应但被成功治疗。1只眼发生植片排斥的同时发生了青光眼。同种异体角膜缘上皮移植无一例显示排斥表现。
结论:培养的角膜缘上皮移植后,在形成稳定的眼表后行PKP的早期结果是良好的。为了避免排斥反应,培养的同种异体角膜缘上皮移植者行充分的免疫抑制治疗是必需的。角膜同种异体移植能够单独排斥同种异体角膜缘移植物。 | Virender S. Sangwan Himanshu P. Matalia Geeta K. Vemuganti Ghazala Ifihekar Anees Fatima Shashi Singh, Gullapalli N. Rao 董白霞(译) 马景学(校) | 2005 | 美国医学会眼科杂志(中文版)2005，17，4： | 5 |
| 11 | Comparisons of three data storage models in parametric temporal databases显示文摘The parametric temporal data model captures a real world entity in a single tuple, which reduces query language complexity. Such a data model, however, is difficult to be implemented on top of conventional databases because of its unfixed attribute sizes. XML is a matured technology and can be an elegant solution for such challenge. Representing data in XML trigger a question about storage efficiency. The goal of this work is to provide a straightforward answer to such a question. To this end, we compare three different storage models for the parametric temporal data model and show that XML is not worse than any other approaches. Furthermore, XML outperforms the other storages under certain conditions. Therefore, our simulation results provide a positive indication that the myth about XML is not true in the parametric temporal data model. | Seo-Young NOH Shashi K. GADIA Haengjin JANG | 2013 | Journal of Central South University2013，20，7： | 5 |
| 12 | IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice显示文摘 | Petrasek Jan Bala Shashi Csak Timea Lippai Dora Kodys Karen Menashy Victoria Barrieau Matthew Min So-Yun Kurt-Jones Evelyn A Szabo Gyongyi | 2012 | EN2012，，10： | 4 |
| 13 | Optimality Conditions and Duality for Nondifferentiable Multiobjective Semi-Infinite Programming Problems with Generalized(C,α,ρ,d)-Convexity显示文摘This paper obtains sufficient optimality conditions for a nonlinear nondifferentiable multiobjective semi-infinite programming problem involving generalized(C,α,ρ,d)-convex functions.The authors formulate Mond-Weir-type dual model for the nonlinear nondifferentiable multiobjective semiinfinite programming problem and establish weak,strong and strict converse duality theorems relating the primal and the dual problems. | MISHRA Shashi Kant JAISWAL Monika HOAI AN Le Thi | 2015 | Journal of Systems Science & Complexity2015，28，1： | 4 |
| 14 | Synthesis and evaluation of novel analogues of mangiferin as potent antipyretic显示文摘Objective:To screen different analogues of mangiferin pharmacologically for antipyretic activity. Methods:The naturally occurring xanthone glycoside mangiferin was isolated by column chromatography from the elhanolic extract of stem bark of Mangifera indica.Mangiferin was further converted to 5-(N-phenylamino methyleno) mangiferin.5-(N-p-chlorophenylamino methyleno) mangiferin,5-(N-2-methyl phenylamino methyleno) mangiferin.5-(N-p-methoxy phenylamino methyleno) mangiferin.5-(N,N-diphenylamino methyleno) mangiferin,5-(N-α-napthylamino methyleno) mangiferin and 5-(N-4-methyl phenylamino methyleno) mangiferin analogues.The synthesized compounds were further screened for antipyretic activity along with mangiferin at a dose level of 100 and 200 tng/kg.Mangiferin and its analogues were characterized by melting point and R_f value determination and through spectral technique like UV,IR,and NMR spectral analysis.Results:The antipyretic activity of mangiferin as well as all analogues was found to be more significant in at higher dose ie.200 mg/kg which was depicted thmugh a decrease in rectal temperature up to 3 h.Conclusions:The antipyretic activity of mangiferin and its analogues may be attributed to inhibition in synthesis of TNF-αand anti-oxidant activity associated with amelioration of inflammatory actions of cytokines. | Shashi Kant Singh Saurabh K Sinha SK Prasad R Kumar Bhawani S Bithu S Sadish Kumar P Singh | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，11： | 4 |
| 15 | Herbal antioxidant in clinical practice:A review显示文摘Antioxidant-the word itself is magic.Using the antioxidant concept as a spearhead in proposed mechanisms for staving off so-called'free-radical'reactions,the rush is on to mine claims for the latest and most effective combination of free-radical scavenging compounds.We must acknowledge that such'radicals'have definitively been shown to damage all biochemical components such as DNA/HNA,carbohydrates,unsaturated lipids,proteins,and micronutrients such as carotenoids(alpha and beta carotene,lycopene),vitamins A,B_6,B_(12),and folate.Defense strategies against such aggressive radical species include enzymes,antioxidants that occur naturally in the body(glutathione,uric acid,ubiquinol-10,and others)and radical scavenging nutrients,such as vitamins A,C,and E,and carotenoids.This paper will present a brief discussion of some well-and little-known herbs that may add to the optimization of antioxidant status and therefore offer added preventive values for overall health.It is important to state at the outset that antioxidants vary widely in their free-radical quenching effects and each may be individually attracted to specific cell sites.Further evidence of the specialized nature of the carotenoids is demonstrated by the appearance of two carotenoids in the macula region of the retina where beta-carotene is totally | Shashi Alok Sanjay Kumar Jain Amita Verma Mayank Kumar Alok Mahor Monika Sabharwal | 2014 | Asian Pacific Journal of Tropical Biomedicine2014，4，1： | 4 |
| 16 | Comparison of eigensensitivity and ANN based methods in model updating of an eight-story building显示文摘Analytical models prepared from field drawings do not generally provide results that match with experimental results.The error may be due to uncertainties in the property of materials,size of members and errors in the modelling process.It is important to improve analytical models using experimentally obtained data.For the past several years,data obtained from ambient vibration testing have been successfully used in many cases to update and match dynamic behaviors of analytical models with real structures.This paper presents a comparison between artificial neural network(ANN) and eigensensitivity based model updating of an existing multi-story building.A simple spring-mass analytical model,developed from the structural drawings of the building,is considered and the corresponding spring stiffness and lumped mass of all floors are chosen as updating parameters.The advantages and disadvantages of these updating methods are discussed.The advantage is that both methods ensure a physically meaningful model which canbe further employed in determining structural response and health monitoring. | Prabakaran K Ashok Kumar Shashi Kant Thakkar | 2015 | Earthquake Engineering and Engineering Vibration2015，14，3： | 3 |
| 17 | Primary access-related complications in laparoscopic cholecystectomy via the closed technique: experience of a single surgical team over more than 15 years显示文摘 | Prakash Kumar Sasmal Om Tantia Mayank Jain Shashi Khanna Bimalendu Sen | 2009 | Surgical Endoscopy2009，，11： | 3 |
| 18 | 氟化物对雄兔生殖器官脂质代谢的生化效应显示文摘在实验动物中,氟化物对其生殖器官可产生毒性作用。据报道,氟化物可引起鼠生殖器官结构和代谢的改变,还可导致其生殖力的降低。Tokar氏发现慢性氟中毒与性腺机能减退相关。 | A. Shashi 唐崇文 | 1993 | 地方病译丛1993，14，3： | 2 |
| 19 | Phenylboronic acids in crystal engineering:Utility of the energetically unfavorable syn,syn-conformation in co-crystal design显示文摘原则上, Phenylboronic 酸能在三不同 conformers 存在(syn, syn;syn,反和反,反) 与不同精力侧面。处于他们的本国的状态,这些混合物比较喜欢精力充沛地赞成的 syn,反符合构造。在分子的建筑群,然而,功能展出 conformational 差异。与 N 施主混合物,在我们报导的这份报纸,一系列合作水晶由基于 syn 包含 synthons 的设计策略准备了, boronic 酸功能的 syn 符合构造。为这个目的,我们与 1,2-diazo 碎片(alprazolam, 1H-tetrazole, acetazolamide 和 benzotriazole ) 采用了混合物,为共结晶的 1,10-phenanthroline 和 2,2-bipyridine 试验。然而,我们的学习证明在 coformer 的 1,2-diazo 碎片的仅仅的存在不与 syn 保证合作水晶的成功的形成, boronic 酸的 syn 符合构造。 | VARUGHESE Sunil SINHA Shashi Bhushan DESIRAJU Gautam R. | 2011 | Science China Chemistry2011，54，12： | 2 |
| 20 | Diagnostic and prognostic impact of six circulating microRNAs in acute coronary syndrome显示文摘 | Christian Widera Shashi K. Gupta Johan M. Lorenzen Claudia Bang Johann Bauersachs Kerstin Bethmann Tibor Kempf Kai C. Wollert Thomas Thum | 2011 | Journal of Molecular and Cellular Cardiology2011，，： | 2 |
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