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| 1 | Impact of concomitant use of proton pump inhibitors and clopidogrel or ticagrelor on clinical outcomes in patients with acute coronary syndrome显示文摘BackgroundThere 是在质子泵禁止者(PPI ) 和 clopidogrel 之间的可能的不利相互作用上的大争论。另外, PPI 的使用是否少些影响 ticagrelor 遗体的临床的功效,知道。在经皮的冠的干预(一种总线标准) .MethodsWe 回顾地从 “ 分析了数据以后,我们试图与急性冠的症候群(交流)在病人在临床的结果上决定 PPI 和 clopidogrel 或 ticagrelor 的伴随物管理的影响;真实 world” ;,国际,在 2003 和 2014 之间的多中心登记( n = 15,401 )并且在1年的合成主要端点上估计了 PPI 和 clopidogrel 或 ticagrelor 的伴随物管理的影响(所有原因死亡收到 PPI 的病人更老,更经常女性,并且是更可能的有 comorbidities。没有协会为收到 clopidogrel 的病人在 PPI 使用和主要端点之间被观察(调整 HR:1.036;95% CI:0.903-1.189 ) 或 ticagrelor (调整 HR:2.320;95% CI:0.875-6.151 )(P 相互作用 = 0.2004 ) 。同样, PPI 的使用没与所有原因死亡,重新梗塞,或与交流后面的一种总线标准的为与任何一个 clopidogrel 对待的病人或 ticagrelor.ConclusionsIn 病人的严重流血的减少的风险的增加的风险被联系, PPI 的伴随物使用没在收到 clopidogrel 或 ticagrelor 的病人与不利结果的增加的风险被联系。我们的调查结果显示与 clopidogrel 或 ticagrelor 在联合使用 PPI 是合理的,特别在有胃肠的流血的更高的风险的病人。 | Yan YAN Xiao WANG Jing-Yao FAN Shao-Ping NIE Sergio Raposeiras-Roubin Emad Abu-Assi Jose P Simao Henriques Fabrizio D'Ascenzo Jorge Saucedo Jose R Gonzfilez-Juanatey Stephen B Wilton Wouter J Kikkert Ivlin Nufiez-Gil Albert Ariza-Sole Xian-Tao SONG Dimitrios Alexopoulos Christoph Liebetrau Tetsuma Kawaji Claudio Moretti Zenon Huczek Toshiharu Fujii Luis C Correia Masa-aki Kawashiril Sasko Kedev | 2016 | Journal of Geriatric Cardiology2016,13,3: | 12 |
| 2 | Genetic variants involved in gallstone formation and capsaicin metabolism,and the risk of gallbladder cancer in Chilean women显示文摘AIM:To determine the effects of genetic variants associated with gallstone formation and capsaicin (a pungent component of chili pepper) metabolism on the risk of gallbladder cancer (GBC).METHODS: A total of 57 patients with GBC, 119 patients with gallstones, and 70 controls were enrolled in this study. DNA was extracted from their blood or paraffi n block sample using standard commercial kits. The statuses of the genetic variants were assayed using Taqman SNP Genotyping Assays or Custom Taqman SNP Genotyping Assays.RESULTS:The non-ancestral T/T genotype of apolipoprotein B rs693 polymorphism was associated with a decreased risk of GBC (OR:0.14,95% CI:0.03-0.63). The T/T genotype of cholesteryl ester transfer protein (CETP) rs708272 polymorphism was associated with an increased risk of GBC (OR:5.04,95% CI:1.43-17.8).CONCLUSION: Genetic variants involved in gallstone formation such as the apolipoprotein B rs693 and CETP rs 708272 polymorphisms may be related to the risk of developing GBC in Chilean women. | Sergio Báez Yasuo Tsuchiya Alfonso Calvo Martha Pruyas Kazutoshi Nakamura Chikako Kiyohara Mari Oyama Masaharu Yamamoto | 2010 | World Journal of Gastroenterology2010,16,3: | 8 |
| 3 | P2Y12受体抑制剂联合质子泵抑制剂对急性冠脉综合征患者缺血事件影响的临床分析显示文摘目的本研究旨在分析P2Y12受体抑制剂联合质子泵抑制剂(PPI)治疗对经皮冠状动脉介入(PCI)术后的急性冠脉综合征患者缺血事件的影响。方法基于国际多中心回顾性注册登记研究,纳入2003至2014年因急性冠脉综合征人院行PCI术的患者,分为PPI组及非PPI组并随访1年,主要临床终点为全因死亡/再发心肌梗死的复合终点。根据P2Y12受体抑制剂种类,将入组患者分为氯吡格雷组及替格瑞洛组,并比较不同药物与PPI联用发生临床终点事件的风险。结果研究入选9429例患者,PPI组占54.8%,具有更多高危因素。Cox回归结果提示PPI组较非PPI组全因死亡/再发心肌梗死复合事件的发生差异无统计学意义(HR1.00,95%CI 0.86—1.18)。根据P2Y12抑制剂种类不同分为氯吡格雷组和替格瑞洛组,不同P2Y12受体抑制剂联用PPI较未联用PPI患者的临床终点无差异,联用PPI的氯吡格雷组与替格瑞洛组的临床终点差异也无统计学意义。结论急性冠脉综合征患者PPI与P2Y12受体抑制剂联用不增加全因死亡和再发心肌梗死风险,尤其PPI联用氯吡格雷在患者的缺血事件上与替格瑞洛比较差异无统计学意义。 | 冯斯婷 严妍 范婧尧 王晓 郑文 聂绍平 Sergio Raposeiras-Roubin Emad Abu-Assi Jose P Simao Henriques Fabrizio D' Ascenzo Jorge Saucedo Jose R Conzalez-Juanatey Stephen B Wilton Wouter J Kikkert Ivan Nunez-Gil Albert Ariza-Sole Dimitrios Alexopoulos Christoph Liebetrau Tetsuma Kawaji Claudio Moretti Zenon Huczek Toshiharu Fujii Luis C Correia Masa-aki Kawashiri Sasko Kedev | 2016 | 中华医学杂志2016,96,33: | 6 |
| 4 | Impact of triple antithrombotic therapy in patients with acute coronary syndrome undergoing percutaneous coronary intervention in real-world practice显示文摘为在急性冠的症候群(交流) 和经皮的冠的干预(一种总线标准) 以后的口头的 anticoagulation (OAC ) 上的病人的 ObjectiveThe 最佳的 antithrombotic 政体仍然保持辩论。寻求回顾地在真实世界的 setting.MethodsWe 评估 OAC 正 clopidogrel 的功效和安全与或没有阿司匹林的这研究分析了数据从一国际,在 2003 和 2014 之间的多中心登记(n = 15,401 ) 。有在一种总线标准以后的交流和收到的 OAC 的病人被屏蔽。合成主要端点是 1 年的所有原因死亡,重新梗塞,或分析注册了 642 个病人包括的严重 bleeding.ResultsThe 期末考试有 OAC 和 clopidogrel (双治疗) 的 62 个病人(9.7%) ,和有阿司匹林, OAC 和 clopidogrel (三倍的治疗) 的联合的 580 个病人(90.3%) 。三倍的治疗上的病人更经常是女性的并且是更可能的有 comorbidities。关于在与三倍的治疗病人一起的双治疗之间的主要结束点没有重要差别[17.74% 对 17.24% ;unadjusted 危险比率(HR ) :1.035;95% 信心间隔(CI ) :0.556-1.929;调整 HR:1.026;95% CI:0.544-1.937 ] 。然而,重新梗塞率比三倍的治疗病人在双治疗是显著地更高的(14.52% 对 5.34% ;unadjusted HR:2.807;95% CI:1.329-5.928;调整 HR:2.333;95% CI:1.078-5.047 ) 。另外,在所有原因死亡和严重 bleeding.ConclusionsIn 的二政体之间没有差别有交流后面的一种总线标准并且与 OAC 的一个指示的真实病人,三倍的治疗没与双治疗相比与不利结果的增加的率被联系。而且,它减少了重新梗塞冒险并且没增加严重流血的风险。 | Yan YAN Xiao WANG Jing-Yao FAN Shao-Ping NIE SerGio Raooseiras-Roubin Emad Abu-Assi Jose P Simao Henriques: Fabrizio D'Ascenzo Jorge Saucedo Jose R Gonzalez-Juanate Stephen B Wilton Wouter J Kikkert Ivan Nunez-Gil Albert Ariza-Sole Xian-Tao SONG Dimitrios Alexopoulos Christoph Liebetrau Tetsuma Kawaji Claudio Morettil Zenon Huczek Toshiharu Fujii Luis cL Correia Masa-aki Kawashiri Sasko Kedev | 2017 | Journal of Geriatric Cardiology2017,14,11: | 6 |
| 5 | Heme oxygenase-1 expression in the left atrial myocardium of patients with chronic atrial fibrillation related to mitral valve disease: its regional relationship with structural remodeling 显示文摘 | DOMENICO C M D SERGIO C M D ROBERTA M B | 2008 | Human Pathology2008,39,: | 1 |
| 6 | Changes on cortisol level and digestive enzyme activity in juveniles of Japanese flounder, Paralichthys olivaceus, exposed to different salinity regimes 显示文摘 | SERGIO N B MASATOMO TAGAWA YOH YAMASHITA | 2007 | Aquaculture2007,266,14: | 1 |
| 7 | Life cycle assessment (LCA) of waste management strategies:landfilling,sorting plant and incineration显示文摘 | Francesco C Silvia B Sergio U | 2008 | Energy2008,23,8: | 1 |
| 8 | R&R blends as refrigerants显示文摘 | Sergio B Roberto C Laura F | 2004 | International Refrigeration and Air Conditioning Conference2004,,: | 1 |
| 9 | Is There Room For Local Development in a Globalized World显示文摘 | Sergio B | | 0,,: | 1 |
| 10 | Comparison of the usefulness of cardiac resynchronization therapy in three age-groups (<65, 65-74 and ≥75 Years) (from the InSync/InSync ICD Italian Registry)显示文摘 | Stefano F Sergio V Giuseppe B | 2011 | Am J Cardiol2011,107,10: | 1 |
| 11 | In vitro studies of the effects of aflatoxin B~ and fumonisin B1 on trypsin -like and collagenase -like activity from the hepatopan- creas of white shrimp (Litopenaeus vannamei) 显示文摘 | Armando B Sergio I F Wilfrido T | 2005 | Aq- uaculture2005,250,: | 1 |
| 12 | On the design of an ECOC-compliant genetic algorithm显示文摘 | MIGUEL A B SERGIO E XAVIER B | 2014 | PatternRecognition2014,47,2: | 1 |
| 13 | LUCCHESIMn-tourmaline from island of Elba (Italy): Crystal chemistry显示文摘 | Ferdinando B Giovanna A Sergio F | 2005 | American Mineralogist2005,90,: | 1 |
| 14 | Induction of unstable alleles at the temperature-sensitiveVirescent-1 gene of maize using the transposable element Dissociation 显示文摘 | Sergio C E Stefania B A | 1995 | Genetical Research1995,66,: | 1 |
| 15 | Integrins显示文摘 | Malgorzata B Sergio C Donald G | 2010 | Cell Tissue Res2010,339,: | 1 |
| 16 | Mitochondrial DNA mutation at the D310(displacement loop)mononucleotide sequence in the pathogenesis of gallbladder carcinoma显示文摘 | MOYING T SERGIO B MARTHA P | 2004 | Clin Cancer Res2004,10,3: | 1 |
| 17 | Involvement of primary mesenchymal precursors and hematopoietic bone marrow cells from chronic myeloid leukemia patients by BCR‐ABL1 fusion gene显示文摘 | Mauricio Chandia José-María Sayagués María-Laura Gutiérrez María-Carmen Chillón José-Alejandro Aristizábal Alejandro Corrales Marta Castellanos Alberto Melón María-Luz Sánchez Paloma Bárcena Sergio Matarraz María González‐González Susana Barrena Antonio L | 2014 | Hematol2014,,3: | 1 |
| 18 | 临床怀疑深静脉血栓形成病人的压迫超声诊断:前瞻性队列研究显示文摘目的:评价临床上怀疑为深静脉血栓形成但压迫超声显像所见正常病人不给予肝素治疗的安全性。设计:根据一种简化的程序来做压迫超声显像,超声显像的部位限于3处,即腹股沟部的股总静脉、腘静脉及胭静脉远端小腿静脉的分叉部位。初诊时超声显像为正常的病人1周后再重复检查1次。评价结果的标准:对于临床上怀疑为深静脉血栓形成的病人,凡是间隔1周两次超声显像均正常者则不予以肝素治疗,随访6个月,统计在这段时间内静脉血栓栓塞合并症的发生率。参加单位:四所大学附属医院的研究中心。结果:本研究共包括1702名病人,第一次检查发现400名血栓形成者,第二次检查又发现12名,因此用超声诊断方法在该1702名临床上怀疑为深静脉血栓形成的病人中确诊了412例,占24%。全组病人均获得随访,在两次 B 超检查之间,有1例发生了静脉血栓性栓塞的合并症,在6个月随访期间又有8例,所以累计发生率为0.7%(95%可信限为0.3%~1.2%),登门随访及补做检查的次数为平均每例0.8次。结论:对于临床上怀疑为深静脉血栓形成的病人,若连续两次压迫超声检查均为正常者,不给予肝素治疗是安全的。 | Alberto Cogo Anthonie W A Lensing Maria M W Koopman Franco Piovella Sergio Siragusa Philip S Wells Sabina Villalta Harry R Bller Alexander G G Turpie Paolo Prandoni 冷希圣 | 1998 | 英国医学杂志中文版1998,0,1: | 1 |
| 19 | Response ofpseudomonasputida F1 cultures to fluctuating toluene loads and operational failures in suspended growth bioreaetors显示文摘 | Luis F D Sergio B | 2008 | Biodegradation2008,19,: | 1 |
| 20 | Lipolysis and lipid oxidation in fermented sausages depending on different processing conditions and different antioxidants显示文摘 | Emanuela Z Sergio G Alessandra B | 2004 | Meat Science2004,66,: | 1 |