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| 1 | Endoscopic ultrasound-guided vs endoscopic retrograde cholangiopancreatography biliary drainage for obstructed distal malignant biliary strictures: A systematic review and meta-analysis显示文摘BACKGROUND For palliation of malignant biliary obstruction(MBO), the gold-standard method of biliary drainage is endoscopic retrograde cholangiopancreatography(ERCP)with the placement of metallic stents. Endoscopic ultrasound(EUS)-guided drainage is an alternative that is typically reserved for cases of ERCP failure.Recently, however, there have been robust randomized clinical trials(RCTs)comparing EUS-guided drainage and ERCP as primary approaches to MBO.AIM To compare EUS guidance and ERCP in terms of their effectiveness and safety in palliative biliary drainage for MBO.METHODS This was a systematic review and meta-analysis, in which we searched the MEDLINE, Excerpta Medica, and Cochrane Central Register of Controlled Trials databases. Only RCTs comparing EUS and ERCP for primary drainage of MBO were eligible. All of the studies selected provided data regarding the rates of technical and clinical success, as well as the duration of the procedure, adverse events, and stent patency. We assessed the risk of biases using the Jadad score and the quality of evidence using the Grading of Recommendations Assessment,Development and Evaluation criteria.RESULTS The database searches yielded 5920 records, from which we selected 3 RCTs involving a total of 222 patients(112 submitted to EUS and 110 submitted to ERCP). In the EUS and ERCP groups, the rate of technical success was 91.96%n and 91.81%, respectively, with a risk difference(RD) of 0.00%(95%CI:-0.07, 0.07;P = 0.97; I^2 = 0%). The clinical success was 84.81% and 85.53% in the EUS and ERCP groups, respectively, with an RD of-0.01%(95%CI:-0.12, 0.10; P = 0.90; I^2 =0%). The mean difference(MD) for the duration of the procedure was-0.12%(95%CI:-8.20, 7.97; P = 0.98; I^2 = 84%). In the EUS and ERCP groups, there were14 and 25 adverse events, respectively, with an RD of-0.06%(95%CI:-0.23, 0.12; P= 0.54; I^2 = 77%). The MD for stent patency was 9.32%(95%CI:-4.53, 23.18; P =0.19; I^2 = 44%). The stent dysfunction rate was significantly lower in the EUS t group(MD =-0.22%; 95 CI:-0.35,-0.08; P = 0.001; I^2 = 0%).CONCLUSION EUS represents an interesting alternative to ERCP for MBO drainage,demonstrating lower stent dysfunction rates compared with ERCP. Technical and clinical success, duration, adverse events and patency rates were similar. | Fernanda P Logiudice Wanderlei M Bernardo Facundo Galetti Vitor M Sagae Carolina O Matsubayashi Antonio C Madruga Neto Vitor O Brunaldi Diogo T H de Moura Tomazo Franzini Spencer Cheng Sergio E Matuguma Eduardo G H de Moura | 2019 | World Journal of Gastrointestinal Endoscopy2019，11，4： | 6 |
| 2 | Factor analysis identifies subgroups of constipation显示文摘AIM:To determine whether distinct symptom groupings exist in a constipated population and whether such grouping might correlate with quantifiable pathophysiological measures of colonic dysfunction.METHODS:One hundred and ninety-one patients presenting to a Gastroenterology clinic with constipation and 32 constipated patients responding to a newspaper advertisement completed a 53-item,wide-ranging selfreport questionnaire.One hundred of these patients had colonic transit measured scintigraphically.Factor analysis determined whether constipation-related symptoms grouped into distinct aspects of symptomatology.Cluster analysis was used to determine whether indi-vidual patients naturally group into distinct subtypes.RESULTS:Cluster analysis yielded a 4 cluster solution with the presence or absence of pain and laxative unresponsiveness providing the main descriptors.Amongst all clusters there was a considerable proportion of patients with demonstrable delayed colon transit,irritable bowel syndrome positive criteria and regular stool frequency.The majority of patients with these characteristics also reported regular laxative use.CONCLUSION:Factor analysis identified four constipation subgroups,based on severity and laxative unresponsiveness,in a constipated population.However,clear stratification into clinically identifiable groups remains imprecise. | Philip G Dinning Mike Jones Linda Hunt Sergio E Fuentealba Jamshid Kalanter Denis W King David Z Lubowski Nicholas J Talley Ian J Cook | 2011 | World Journal of Gastroenterology2011，17，11： | 3 |
| 3 | Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial显示文摘 | Robert J Motzer Bernard Escudier Stéphane Oudard Thomas E Hutson Camillo Porta Sergio Bracarda Viktor Grünwald John A Thompson Robert A Figlin Norbert Hollaender Gladys Urbanowitz William J Berg Andrea Kay David Lebwohl Alain Ravaud | 2008 | The Lancet2008，，9637： | 2 |
| 4 | Online error correcting output codes显示文摘 | SERGIO E DAVID M ELOI P | 2011 | Pattern Recognition Letters2011，32，3： | 1 |
| 5 | Comparison of accuracy between compression and injection-molded complete dentures显示文摘 | Sergio S Robert E Elmne L | | 0，，03： | 1 |
| 6 | Predicting smear negative pulmonary tuberculosis with classification trees and logistic regression: a cross-sectional study 显示文摘 | Fernanda Carvalho de Queiroz Mello Luiz Gustavo do Valle Bastos Sergio Luiz Machado Soares Valeria MC Rezende Marcus Barreto Conde Richard E Chaisson Afranio Lineu Kritski Antonio Ruffino Netto Guilherme Looreiro Wet neck | 2006 | BMC Public Health2006，23，6： | 1 |
| 7 | Separability of ternary error-correcting output codes显示文摘 | SERGIO E ORIOL P and PETIA R | 2009 | Pattern Recognition Letters2009，30，5： | 1 |
| 8 | Fast energyaware OLSR routing in VANETs by means of a parallel evolutionary algorithm显示文摘 | Jamal Toutouh Sergio Nesmachnow Alba E | 2013 | Cluster Computing2013，16，3： | 1 |
| 9 | Subclass problem-dependent design for error-correcting output codes 显示文摘 | SERGIO E DAVID M J T ORIOL P | 2008 | IEEE Transactions on Pattern Analysis and Machine Intelligence2008，30，6： | 1 |
| 10 | Re-coding ECOCs without Re-training显示文摘 | SERGIO E ORIOL P and PETIA R | 2010 | Pattern Recognition Letters2010，31，7： | 1 |
| 11 | On the design of an ECOC-compliant genetic algorithm显示文摘 | MIGUEL A B SERGIO E XAVIER B | 2014 | PatternRecognition2014，47，2： | 1 |
| 12 | Induction of unstable alleles at the temperature-sensitiveVirescent-1 gene of maize using the transposable element Dissociation 显示文摘 | Sergio C E Stefania B A | 1995 | Genetical Research1995，66，： | 1 |
| 13 | An Efficient Multi-camera,Multi-target Scheme for the Three-dimensional Control of Robots Using Uncalibrated Vision显示文摘 | Gonzalez-Galvan E J Cruz-Ramirez Sergio R | 2003 | Robotics and Computer-Integrated Manufacturing2003，19，5： | 1 |
| 14 | Revealing the genetic basis of multiple sclerosis: are we there yet?显示文摘 | Sergio E Baranzini | 2010 | Current Opinion in Genetics & Development2010，，3： | 1 |
| 15 | Wind erosion quantity and quality of an Entic Haplustoll of the semi-arid pampas of Argentina显示文摘 | BUSCHIAZZO Daniel E ZOBECK Ted M ABASCAL Sergio A | 2007 | Journal of Arid Environments2007，，： | 1 |
| 16 | Characterisation of electrochemically deposited Ni-Mo alloy coatings 显示文摘 | Luciana S Sanches Sergio H Domingues Claudia E B Marino Lucia H Mascaro | 2004 | Electrochemistry Communications2004，6，6： | 1 |
| 17 | Optical Correlation Based on the Fractional Fourier Transform显示文摘 | SERGIO GRANIERI RICARDO ARIZAGA ENRIQUE E SICRE | 1997 | APPLIED OPTICS1997，36，26： | 1 |
| 18 | Calculation of energy transaction allocation factors显示文摘 | Aniss Fradi Sergio Brignone and Bruce E Wollenberg | 2001 | IEEE Trans on Power Systems2001，16，2： | 1 |
| 19 | SARS-CoV-2 productively infects primary human immune system cells in vitro and in CoviD-19 patients显示文摘The severe acute respiratory syndrome coronavirus 2(SARS-CovV-2)infection is associated with a hyperinflammatory state and lymphocytopenia,a hallmark that appears as both signature and prognosis of disease severity outcome.Although cytokine storm and a sustained inflammatory state are commonly associated with immune cell depletion,it is still unclear whether direct SARS-Cov-2 infection of immune cells could also play a role in this scenario by harboring viral replication.We found that monocytes,as well as both B and T lymphocytes,were susceptible to SARS-Cov-2 infection in vitro,accumulating double-stranded RNA consistent with viral RNA replication and ultimately leading to expressive T cell apoptosis.In addition,flow cytometry and immunofluorescence analysis revealed that SARS-Cov-2 was frequently detected in monocytes and B lymphocytes from coronavirus disease 2019(CoVID-19)patients.The rates of SARS-Cov-2-infected monocytes in peripheral blood mononuclear cells from CoVID-19 patients increased over time from symptom onset,with SARS-CoV-2-positive monocytes,B cells,and CD4+T lymphocytes also detected in postmortem lung tissue.These results indicated that SARS-CoV-2 infection of blood-circulating leukocytes in covID-19 patients might have important implications for disease pathogenesis and progression,immune dysfunction,and virus spread within the host. | Marjorie C.Pontelli italo A.Castro Ronaldo B.Martins Leonardo La Serra Flavio P.Veras Daniele C.Nascimento Camila M.Silva Ricardo S.Cardoso Roberta Rosales Rogério Gomes Thais M.Lima Juliano P.Souza Brenda C.Vitti Diego B.Caetite Mikhael H.F.de Lima Spencer D.Stumpf Cassandra E.Thompson Louis-Marie Bloyet Juliana E Toller-Kawahisa Marcela C.Giannini Leticia P.Bonjorno Marial.F.Lopes Sabrina S.Batah Li Siyuan Rodrigo Luppino-Assad Sergio C.L.Almeida Fabiola R.Oliveira Maira N.Benatti Lorena L.F.Pontes Rodrigo C.Santana Fernando C.Vilar Maria Auxiliadora-Martins Pei-Yong Shi Thiago M.Cunha Rodrigo T.Calado JoséC.Alves-Filho Dario S.Zamboni Alexandre T.Fabro Paulo Louzada-Junior Rene D.R.Oliveira Sean P.J.Whelan Fernando Q.Cunha Eurico Arruda | 2022 | Journal of Molecular Cell Biology2022，14，4： | 1 |
| 20 | et al, Isomerization of propargylic alcohols into α,β-unsaturated carbonyl compounds catalyzed by the sixteen-electron allyl-ruthenium(Ⅱ) complex 显示文摘 | Cadierno V Garcia G Sergio E | 2006 | Advanced Synthesis & Catalysis2006，348，： | 1 |
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