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| 1 | Molecular mechanism and functional consequences of lansoprazole-mediated heme oxygenase-1 induction显示文摘AIM:To investigate the molecular mechanism and functional consequences of heme oxygenase-1(HO-1) activation by lansoprazole in endothelial cells and macrophages. METHODS:Expression of HO-1 mRNA was analyzed by Northern blotting.Western blotting was used to determine the HO-1 and ferritin protein levels. NADPH-dependent reactive oxygen species(ROS) formation was measured with lucigenin-enhanced chemiluminescence.HO-1 promoter activity in mouse fibroblasts,stably transfected with a 15-kb HO-1 gene that drives expression of the reporter gene luciferase, was assessed using in vivo bioluminescence imaging. RESULTS:Lansoprazole increased HO-1 mRNA levels in endothelial cells and HO-1 protein levelsin macrophages.In addition,lansoprazole-induced ferritin protein levels in both cell systems.Moreover, induction of the antioxidant proteins HO-1 and ferritin by lansoprazole was followed by a decrease in NADPH- mediated ROS formation.The radical scavenging properties of lansoprazole were diminished in the presence of the HO inhibitor,chromium mesoporphyrin IX.Induction of HO-1 gene expression by lansoprazole was not related to oxidative stress or to the activation of the mitogen-activated protein kinase pathway. However,the phosphatidylinositol 3-kinase inhibitor LY294002 showed a concentration-dependent inhibition of HO-1 mRNA and promoter activity. CONCLUSION:Activation of HO-1 and ferritin may account for the gastric protection of lansoprazole and is dependent on a pathway blocked by LY294002. | Stephanie Schulz-Geske Kati Erdmann Ronald J Wong David K Stevenson Henning Schrder Nina Grosser | 2009 | World Journal of Gastroenterology2009，15，35： | 7 |
| 2 | 高吸水聚合物(SAP):新型多功能混凝土外加剂 | Viktor Mechtcherine Lukasz Dudziak Arnd-Eike Brüdern Simone Hempel Christof Schrfl 俞琳 | 2012 | 商品混凝土2012，0，5： | 6 |
| 3 | Chronic intestinal failure and short bowel syndrome in Crohn’s disease显示文摘Chronic intestinal failure(CIF)is a rare but feared complication of Crohn’s disease.Depending on the remaining length of the small intestine,the affected intestinal segment,and the residual bowel function,CIF can result in a wide spectrum of symptoms,from single micronutrient malabsorption to complete intestinal failure.Management of CIF has improved significantly in recent years.Advances in home-based parenteral nutrition,in particular,have translated into increased survival and improved quality of life.Nevertheless,60%of patients are permanently reliant on parenteral nutrition.Encouraging results with new drugs such as teduglutide have added a new dimension to CIF therapy.The outcomes of patients with CIF could be greatly improved by more effective prevention,understanding,and treatment.In complex cases,the care of patients with CIF requires a multidisciplinary approach involving not only physicians but also dietitians and nurses to provide optimal intestinal rehabilitation,nutritional support,and an improved quality of life.Here,we summarize current literature on CIF and short bowel syndrome,encompassing epidemiology,pathophysiology,and advances in surgical and medical management,and elucidate advances in the understanding and therapy of CIF-related complications such as catheter-related bloodstream infections and intestinal failure-associated liver disease. | Aysegül Aksan Karima Farrag Irina Blumenstein Oliver Schröder Axel U Dignass Jürgen Stein | 2021 | World Journal of Gastroenterology2021，27，24： | 4 |
| 4 | Keratinocytes costimulate naive human T cells via CD2: a potential target to prevent the development of proinflammatory Th1 cells in the skin显示文摘The interplay between keratinocytes and immune cells,especially T cells,plays an important role in the pathogenesis of chronic inflammatory skin diseases.During psoriasis,keratinocytes attract T cells by releasing chemokines,while skin-infiltrating selfreactive T cells secrete proinflammatory cytokines,e.g.,IFN γand IL-17A,that cause epidermal hyperplasia.Similarly,in chronic graftversus-host disease,allogenic IFN γ-producing Th1/Tc1 and IL-17-producing Th17/Tc17 cells are recruited by keratinocyte-derived chemokines and accumulate in the skin.However,whether keratinocytes act as nonprofessional antigen-presenting cells to directly activate naive human T cells in the epidermis remains unknown.Here,we demonstrate that under proinflammatory conditions,primary human keratinocytes indeed activate naive human T cells.This activation required cell contact and costimulatory signaling via CD58/CD2 and CD54/LFA-1.Naive T cells costimulated by keratinocytes selectively differentiated into Th1 and Th17 cells.In particular,keratinocyte-initiated Th1 differentiation was dependent on costimulation through CD58/CD2.The latter molecule initiated STAT1 signaling and IFN γproduction in T cells.Costimulation of T cells by keratinocytes resulting in Th1 and Th17 differentiation represents a new explanation for the local enrichment of Th1 and Th17 cells in the skin of patients with a chronic inflammatory skin disease.Consequently,local interference with T cell–keratinocyte interactions may represent a novel strategy for the treatment of Th1 and Th17 cell-driven skin diseases. | Christian Orlik Daniel Deibel Johanna Küblbeck Emre Balta Sabina Ganskih Jüri Habicht Beate Niesler Jutta Schröder-Braunstein Knut Schäkel Guido Wabnitz Yvonne Samstag | 2020 | Cellular & Molecular Immunology2020，17，4： | 4 |
| 5 | 海绵动物的演化意义及其生物硅的仿生应用显示文摘海绵动物是地球上最古老、最简单的动物,但对它在生物进化中的定位却经历了一个漫长而复杂的认识过程.作为“活化石”,海绵动物为生物演化研究提供了最好的证据;而对海绵动物研究更令人入胜的是近年来人们发现硅质海绵动物骨针的独特结构和良好光纤特性,从而开辟了利用纳米生物技术进行仿生合成的广泛研究领域.综述了海绵动物的发现及新的分子生物学进化证据,骨针硅蛋白催化合成生物硅的研究进展及仿生合成在纳米生物技术和医学领域的潜在应用. | Werner E G Müller 王晓红 曾令森 Heinz C Schrder | 2007 | 科学通报2007，52，12： | 4 |
| 6 | Requirements Engineering for Cloud Computing显示文摘 | Holger Schrǒdl Stefan Wind | 2011 | 通讯和计算机(中英文版)2011，8，9： | 3 |
| 7 | Analysis of pattern–process interactions based on landscape models—Overview, general concepts, and methodological issues显示文摘 | B. Schr?der R. Seppelt | 2006 | Ecological Modelling2006，，4： | 2 |
| 8 | Antioxidant, antimicrobial and cytotoxic activities of selected medicinal plants from Yemen显示文摘 | Mohamed Al-Fatimi Martina Wurster Gudrun Schr?der Ulrike Lindequist | 2007 | Journal of Ethnopharmacology2007，，3： | 2 |
| 9 | Transthoracic En-bloc Esophagectomy显示文摘In patients with esophageal carcinoma surgical resection remains the standard of curative treatment. For locally advanced tumors (pT1sm–pT3) transthoracic esophagectomy with extended lym- phadenectomy is the standard surgical procedure since it o?ers a complete removal of the primary tumor and possible lymph node metastases. This surgical resection is appropriate for squamous cell but also adenocarcinoma of the esophagus because both histological entities demonstrate a lymphatic spread to the abdominal compartment and the upper mediastinum. In-hospital mortality rates are between 6% and 9%; anastomotic leakage and pulmonary complications mainly contribute to postoperative morbidity. In terms of 5-year survival the transthoracic procedure o?ers a better prognosis compared to the transhiatal resection. | W. Schrder P. M. Schneider A. H. Hlscher | 2004 | The Chinese-German Journal of Clinical Oncology2004，3，4： | 2 |
| 10 | Biophilic design in architecture and its contributions to health,well-being,and sustainability:A critical review显示文摘In the last ten years,‘nature’and biophilic design have received widespread attention in architecture,especially in response to growing environmental challenges.However,open questions and controversies remain regarding conceptualizing and addressing‘nature’in practice and research.This study conducts a literature review to discuss biophilic design as a theoretical framework to interpret‘nature’in architecture.The following questions are answered:(1)How has the concept of biophilic design emerged,and how can it be defined?(2)In what ways can biophilic design contribute to the goals of sustainable architecture?(3)What are the key design strategies in biophilic design?This review identifies and compares the key frameworks of biophilic design and explains their major elements.We then analyse the benefits(e.g.,enhance health,well-being,productivity,biodiversity,and circularity)of biophilic design in achieving sustainability,as framed through the UN Sustainable Development Goals.The results indicate that biophilic design is more complex and richer than the mere application of vegetation in buildings;it broadens the variety through encompassing different types of nature from physical,sensory,metaphorical,morphological,material to spiritual.Moreover,knowledge gaps are identified to motivate future research and critical reflections on biophilic design practices. | Weijie Zhong Torsten Schröder Juliette Bekkering | 2022 | Frontiers of Architectural Research2022，11，1： | 2 |
| 11 | A spatially explicit and quantitative vulnerability assessment of ecosystem service change in Europe显示文摘 | Marc J. Metzger Dagmar Schr?ter Rik Leemans Wolfgang Cramer | 2008 | Regional Environmental Change2008，，3： | 2 |
| 12 | Efficient photon coupling from a diamond nitrogen vacancy center by integration with silica fiber显示文摘A central goal in quantum information science is to efficiently interface photons with single optical modes for quantum networking and distributed quantum computing.Here,we introduce and experimentally demonstrate a compact and efficient method for the low-loss coupling of a solid-state qubit,the nitrogen vacancy(NV)center in diamond,with a single-mode optical fiber.In this approach,single-mode tapered diamond waveguides containing exactly one high quality NV memory are selected and integrated on tapered silica fibers.Numerical optimization of an adiabatic coupler indicates that near-unity-efficiency photon transfer is possible between the two modes.Experimentally,we find an overall collection efficiency between 16%and 37%and estimate a single photon count rate at saturation above 700 kHz.This integrated system enables robust,alignment-free,and efficient interfacing of single-mode optical fibers with single photon emitters and quantum memories in solids. | Rishi N Patel Tim Schröder Noel Wan Luozhou Li Sara L Mouradian Edward H Chen Dirk R Englund | 2016 | Light(Science & Applications)2016，5，1： | 2 |
| 13 | 食管黏膜下鳞状细胞癌及腺癌的高淋巴结转移率显示文摘Background and study aims: The application of endoscopic mucosectomy in early esophageal cancer is limited by the presence of lymph-node metastasis. The aim of this prospective study was to analyze the rate of lymph-node involvement relative to the depth of mucosal or submucosal tumor penetration, comparing squamous-cell carcinomas and adenocarcinomas. Patients and methods: A total of 60 patients with pT1 esophageal cancer- 24 with squamous-cell carcinomas (SCCs) and 36 with adenocarcinomas- were treated with transthoracic enbloc esophagectomy with two-field lymphadenectomy (n = 50) or transhiatal esophageal resection (n = 10). An average of 30 lymph nodes were examined, and the following characteristics were evaluated: histology, mucosal infiltration, depth of submucosal wall infiltration in three thirds (sm1, sm2, sm3), grading, resection category, ratio of metastatic to resected lymph nodes, and locations of metastatic nodes. Results: The rates of lymph-node metastasis were 0% for the 16 mucosal carcinomas and 45% for the 44 submucosal carcinomas (P< 0.01). There were no significant differences in the extent of lymph-node involvement between submucosal adenocarcinomas (41% ) and submucosal SCCs (50% ). Sm1 carcinomas were associated with a lower rate of lymph-node metastasis (SCCs 33% , adenocarcinomas 22% ) than sm3 carcinomas (SCCs 69% , adenocarcinomas 78% ). Two patients (9% ) with submucosal SCCs and five patients (23% ) with submucosal adenocarcinomas were classified as having stage pM1 lymph. The average lymph-node ratio in patients with pN1 was 0.13 for adenocarcinomas and 0.1 for SCCs (difference not significant). In the multivariate analysis, the parameters mucosal vs. submucosal (P < 0.01) and G1/G2 vs. G3 (P < 0.05) showed a significant impact in relation to metastatic lymph nodes. Conclusions: The most important factor for predicting lymph-node metastasis in early esophageal cancer is the presence of submucosal infiltration. Early adenocarcinomas and SCCs do not differ with regard to their rate of lymphatic involvement. The rate of lymph-node metastasis increases with the depth of submucosal infiltration, but metastases can already occur in sm1 lesions. Submucosal infiltration is a contraindication for endoscopic mucosectomy. Limited surgical procedures without adequate lymphadenectomy do not appear to be appropriate in the treatment of patients with submucosal esophageal carcinomas. | Bollschweiler E. Baldus S.E. Schrder W. A.H. Hlscher 张红凯 | 2006 | 世界核心医学期刊文摘(胃肠病学分册)2006，2，8： | 2 |
| 14 | Resistograph and X-raydensity charts of wood:Comparative evaluation of drillresistance profiles and X-ray density charts of different woodspecies显示文摘 | Rinn F Schweingruber F H schr E | 1996 | Holzforschung(Internal Journal of Biology Chemistry Physics and Technology of Wood)1996，50，4： | 1 |
| 15 | NADPH oxidases in cardiovascular disease显示文摘 | Brandes RP Weissmann N Schr(o)der K | 2010 | Free Radic Biol Med2010，49，： | 1 |
| 16 | effect of proton pump inhibitors on clinical outcome in patients treated with clopidogrel:a systematic review and meta-analysis显示文摘 | Siller-Matula JM Jilma B Schr(o)r K | | 0，，12： | 1 |
| 17 | Metabolic pathway analysis for rational design of L-methionine production by Escherichia coli and Corynebacterium glutamicum显示文摘 | Kr(o)mer JO Wittmann C Schr(o)der H | | 0，，4： | 1 |
| 18 | Early detection of prostate cancer in 2007-part 1:PSA and PSA kinetics显示文摘 | Schrder FH Carter HB Wolters T | 2008 | European Urology2008，53，3： | 1 |
| 19 | Holocene environmental history of thermokarst lakes on Richards Island, Northwest Territories, Canada: Theocamoebians as paleolimnological indicators显示文摘 | Audrey Dallimore Claudia J. Schr?der-Adams Scott R. Dallimore | 2000 | Journal of Paleolimnology2000，，3： | 1 |
| 20 | The kinetic of calcium and magnesium entry onto mycorrhizal spruce root显示文摘 | Kuhn A J Schr? der WH Bauch J | 2000 | Planta2000，210，3： | 1 |
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