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| 1 | Structural basis of SARS-CoV-2 3CL^pro and anti-COVID-19 drug discovery from medicinal plants显示文摘The recent pandemic of coronavirus disease 2019(COVID-19)caused by SARS-CoV-2 has raised global health concerns.The viral 3-chymotrypsin-like cysteine protease(3CL^pro)enzyme controls coronavirus replication and is essential for its life cycle.3CL^pro is a proven drug discovery target in the case of severe acute respiratory syndrome coronavirus(SARS-CoV)and Middle East respiratory syndrome coronavirus(MERS-CoV).Recent studies revealed that the genome sequence of SARS-CoV-2 is very similar to that of SARS-CoV.Therefore,herein,we analysed the 3CL^pro sequence,constructed its 3D homology model,and screened it against a medicinal plant library containing 32,297 potential anti-viral phytochemicals/traditional Chinese medicinal compounds.Our analyses revealed that the top nine hits might serve as potential anti-SARS-CoV-2 lead molecules for further optimisation and drug development process to combat COVID-19. | Muhammad Tahir ul Qamar Safar MAlqahtani Mubarak AAlamri Ling-Ling Chen | 2020 | Journal of Pharmaceutical Analysis2020，10，4： | 29 |
| 2 | Relationship between fatigue life of asphalt concrete and polypropylene/polyester fibers using artificial neural network and genetic algorithm显示文摘While various kinds of fibers are used to improve the hot mix asphalt(HMA) performance, a few works have been undertaken on the hybrid fiber-reinforced HMA. Therefore, the fatigue life of modified HMA samples using polypropylene and polyester fibers was evaluated and two models namely regression and artificial neural network(ANN) were used to predict the fatigue life based on the fibers parameters. As ANN contains many parameters such as the number of hidden layers which directly influence the prediction accuracy, genetic algorithm(GA) was used to solve optimization problem for ANN. Moreover, the trial and error method was used to optimize the GA parameters such as the population size. The comparison of the results obtained from regression and optimized ANN with GA shows that the two-hidden-layer ANN with two and five neurons in the first and second hidden layers, respectively, can predict the fatigue life of fiber-reinforced HMA with high accuracy(correlation coefficient of 0.96). | Morteza Vadood Majid Safar Johari Ali Reza Rahai | 2015 | Journal of Central South University2015，22，5： | 6 |
| 3 | 平均动脉压、脉压与全因死亡率的纵向变化:来自71629名未经治疗的正常高值血压参与者的数据显示文摘血压通常包括平稳成分[平均动脉压(mean arterial pressure,MAP)]和波动成分,都可独立预测死亡率。目前还没有针对中心脉压(central pulse pressure,cPP)、肱动脉脉压(brachial pulse pressure,bPP)、MAP的纵向变化与死亡率之间关系的调查。方法:对年龄16~95岁未接受高血压治疗的71 629例参与者进行2次常规检查. | Protogerou AD Vlachopoulos C Thomas F Zhang Y Pannier B Blacher J Safar ME 陈云 | 2018 | 中华高血压杂志2018，26，8： | 4 |
| 4 | The liver diseases of lipodystrophy: The long-term effect of leptin treatment显示文摘 | Elika Safar Zadeh Andreea O. Lungu Elaine K. Cochran Rebecca J. Brown Marc G. Ghany Theo Heller David E. Kleiner Phillip Gorden | 2013 | Journal of Hepatology2013，，1： | 3 |
| 5 | Pulse pressure and aortic pulse wave are markers of cardiovascular risk in hypertensive populations显示文摘 | Roland Asmar Annie Rudnichi Jacques Blacher Gérard M London Michel E Safar | 2001 | American Journal of Hypertension2001，，2： | 3 |
| 6 | pulse pressure:a predictor of long-term cardiovascular mortality in a French male population显示文摘 | Benetos A Safar M Rudinichi A | 1997 | Hypertens1997，30，6： | 2 |
| 7 | Cerebral resuscitation potentials for cardiac arrest显示文摘 | Safar P Behringer W Bottiger B W | 2002 | Crit Care Mad2002，30，4： | 2 |
| 8 | Imoroved outcome with fluid rest fiction in treatment of uncontrolled hemorrhagic shock 显示文摘 | Capone AC Safar P Stezol ski W | 1995 | J Am Coll Surg1995，180，1： | 1 |
| 9 | Pulse pressure and cardiovascular mortality in normotensive and hypertensive subjects显示文摘 | BENETOS A RUDNICHI A SAFAR M | 1998 | Hypertension1998，32，： | 1 |
| 10 | Pulse pressure:Appredictor of long-term cardiovascular mor-tality in a french male population 显示文摘 | BENETOS A SAFAR M E RUDINICHI A | 1997 | Hypertens1997，8，： | 1 |
| 11 | Pulse pressure, arterial stiffness, and drug treatment of hypertension显示文摘 | Van Bortel M Struijker - Boudier HA Safar ME | 2001 | Hypertension2001，38，4： | 1 |
| 12 | Pulse pressure, arterial stiffness and wave reflections ( augmentation index) as cardiovascular risk factors in hypertension 显示文摘 | Safar ME | 2008 | Ther Adv Cardiovase Dis2008，2，1： | 1 |
| 13 | Cardiac hypertrophy and arterial distensibility in essential hypertension显示文摘 | Bouthier JD Deluca N Safar ME | 1985 | Am Heart J1985，109，6： | 1 |
| 14 | Large-artery stiffness,hypertension and cardiovascular risk in order patients显示文摘 | Blacher J Safar ME | 2005 | Nat Clin Pract Cardiovasc Med2005，2，： | 1 |
| 15 | Resistance and conduit arteries following coverting enzyme inhibition in hypertension显示文摘 | Safar ME van Bortel LM Struijker-Boudier HA | 1997 | J Vasc Res1997，34，2： | 1 |
| 16 | Epidemiological aspects of pulse pressure and arterial stiffness显示文摘 | Safar ME | 1999 | J Hypertens1999，17，5： | 1 |
| 17 | Pulse pressure and cardiovascular mortality in normotensive and hypertension subjects显示文摘 | Benetos A Rudnichi A Safar M | 1998 | Hypertension1998，32，： | 1 |
| 18 | Prevention of aortic and cardiac fibrosis by spironolactone in old normotensive rats显示文摘 | LACOLLEY P SAFAR M E LUCET B | 2001 | J Am Coll Cardiol2001，37，： | 1 |
| 19 | Pulse pressure and cardiovascular mortality in normotensive and hypertensive subjects显示文摘 | Benetos A Rudnichi A Safar M | 1998 | Hypertension1998，32，3： | 1 |
| 20 | Systemic hypothermia , but not regimal gut hypothermia, improves survival from prolonged hemorrhagic shock in rats 显示文摘 | Wu X Stezoski J Safar P | 2002 | J Trauma2002，53，4： | 1 |
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