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| 1 | Therapeutic Effect of Dimethyl Dimethoxy Biphenyl Dicarboxylate on Collagen-Induced Arthritis in Rats显示文摘Objective:To study the effect of oral administration of dimethyl dimethoxy biphenyl dicarboxylate(DDB) on adjusting angiogeneic/inflammatory mediators and ameliorating the pathology of bones in rats with collagen-induced arthritis(CIA).Methods:Wistar rat model of CIA was set up using bovine collagen type Ⅱ.Fifty rats were divided into five groups randomly:normal,CIA model,DDB treatment,methotrexate(MTX) treatment,and combined DDB+MTX treatment.Ankle joints of rats were imaged with digital X-ray machine to show the destruction of joints.Fore and hind paw and knee joints were removed above the ankle joint then processed for haematoxylin and eosin staining.Plasma levels of vascular endothelial growth factor(VEGF),platelet derived growth factor,interleukin-8(IL-8),IL-4,tumor necrosis factor α(TNF-α),and cyclooxygenase-2(COX-2) were quantified by enzyme-linked immunosorbent assay.Nitric oxide levels were detected by Griess reagent.Results:Compared with the CIA model group,a remarkable reduction in various angiogenic(VEGF and IL-8) and inflammatory mediators(TNF-α,IL-4 and COX-2) after treatment with DDB either alone or combined with MTX(P<0.05 or P<0.01).Histopathological and X-ray findings were confirmatory to the observed DDB anti-arthritic effect.The DDB-treated group showed amelioration in signs of arthritis which appeared essentially similar to normal.Conclusion:Our data shed light on the therapeutic efficacy of DDB in experimental rheumatoid arthritis(RA) compared with a choice drug(MTX) and it may be offered as a second-line drug in the treatment of RA. | Roba M Talaat Amira S Abo-EI-Atta Sabah M Farou Karima I EI-Dosoky | 2015 | Chinese Journal of Integrative Medicine2015，21，11： | 1 |
| 2 | Removal of phosphorus from vegetable oil by acid-activated sepiolite显示文摘 | SABAH E MAJDAN M | 2009 | Journal of Food Engineering2009，91，： | 1 |
| 3 | Adsorption mechanism of cationic surfactants onto acid- and heat-activated sepiolites 显示文摘 | Sabah E Turan M Celik MS | 2002 | Water Research2002，36，16： | 1 |
| 4 | Aysmmetric trans- mission of linearly polarized waves and dynamically wave ro- tation using chiral metamaterial显示文摘 | Dincer F Sabah C Karaaslan M | 2013 | Prog Electromagn Res2013，140，： | 1 |
| 5 | Cyclooxygenase-2 expression in stromal tumors of the gastrointestinal tract显示文摘 | Sabah M Cummins RJ | 2003 | Hum Pathol2003，34，： | 1 |
| 6 | Adsorption of anionic surfactants onto sepiolite 显示文摘 | Ozdemir O Cinar M Sabah E | 2007 | Journal of Hazardous Materials2007，147，12： | 1 |
| 7 | Principal component and multiple regression analysis in modelling of ground-level ozone and factors affecting its concentrations显示文摘 | Abdul-Wahab Sabah A Bakheit Charles S Al-Alawi Saleh M | 2005 | Environmental Modelling & Software2005，20，10： | 1 |
| 8 | The problem with KIT: clinical implications and practical difficulties with CDll7 immunostaining显示文摘 | Sabah M Leader M Kay E | 2003 | Appl Immunohistochem Mol Morphol2003，11，1： | 1 |
| 9 | The biochemical value of urinary metallopmteinases 3 and 9 in diagnosis and prog- nosis of bladder cancer in Egypt显示文摘 | E1-Sharkawy F E1 Sabah M Hassan Z eta| | 2014 | J Biomed Sci2014，21，1： | 1 |
| 10 | Adsorption of cobalt from aqueous solutions onto sepiolite显示文摘 | Karaa M Yuzera H Sabah E | 2003 | Water Res2003，37，： | 1 |
| 11 | Particle swarm optimization for task assignment problem 显示文摘 | Ayed S Imtiaz S Sabah A M | 2002 | Microprocessors and Microsystems2002，26，： | 1 |
| 12 | Adsorption of cobalt from aqueous solution onto sepiolite显示文摘 | Kara M Yuzer H Sabah E | 2003 | Water Research2003，37，： | 1 |
| 13 | Sepiolite: an effective bleaching adsorbent for the physical refining of degummed rapeseed oil 显示文摘 | SABAH E CELIK M S | 2005 | JAmOilChemSoc2005，82，12： | 1 |
| 14 | The problem with KIT:clinical implications and practical difficulties with CD117 immunostaining显示文摘 | SABAH M LEADER M KAY E | 2003 | Appl Immunohistochem Mol Morphol2003，11，1： | 1 |
| 15 | 显示文摘 | Sabah M Basir A | 2003 | Hydrometallurgy2003，69，： | 1 |
| 16 | Altered expression of cell cycle regulatory proteins in gastrointestinal stromal tumors:markers with potential prognostic implications显示文摘 | Sabah M Cummins R Leader M | 2006 | Hum Pathol2006，37，： | 1 |
| 17 | Design and Ex- perimental Investigation of Portable Solar Thermoelectric Refrigerator 显示文摘 | Sabah A A Elkamel A A1-Damkhi A M | 2009 | Renewable Energy2009，34，1： | 1 |
| 18 | Unexpected difference in phenol sorption on PTMA-and BTMA-bentonite显示文摘 | Majdan M Bujacka M Sabah E | | 0，，01： | 1 |
| 19 | 查看详情显示文摘 | Sabah E Turan M Celik M S | | 0，，16： | 1 |
| 20 | Adsorption of cobalt from aqueous solutions onto sepiolite显示文摘 | M Kara H Yuzer E Sabah M.S Celik | 2002 | Water Research2002，，1： | 1 |
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