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| 1 | Campylobacter concisus and other Campylobacter species in children with newly diagnosed Crohn’s disease显示文摘 | Si MingMan LiZhang Andrew S.Day Steven T.Leach Daniel A.Lemberg HazelMitchell | 2010 | Inflamm Bowel Dis2010,,6: | 2 |
| 2 | IBD Around the world: Comparing the epidemiology, diagnosis, and treatment: Proceedings of the World Digestive Health Day 2010 – Inflammatory bowel disease task force meeting显示文摘 | Daniel C.Baumgart Charles N.Bernstein ZaighamAbbas Jean F.Colombel Andrew S.Day GeertD’Haens IrisDotan Khean L.Goh ToshifumiHibi Richard A.Kozarek Eamonn M.M.Quigley WalterReinisch Bruce E.Sands Jose D.Sollano A. HillarySteinhart FlávioSteinwurz Morten H. | 2011 | Inflamm Bowel Dis2011,,2: | 2 |
| 3 | Systematic review: nutritional therapy in paediatric Crohn’s disease显示文摘 | A. S.DAY K. E.WHITTEN M.SIDLER D. A.LEMBERG | 2007 | Alimentary Pharmacology & Therapeutics2007,,4: | 1 |
| 4 | Systematic review: nutritional therapy in paediatric Crohn’s disease显示文摘 | A. S.DAY K. E.WHITTEN M.SIDLER D. A.LEMBERG | 2007 | Alimentary Pharmacology & Therapeutics2007,,4: | 1 |
| 5 | Inhibition of Wnt signaling by Frizzled7 antibody-coated nanoshells sensitizes triple-negative breast cancer cells to the autophagy regulator chloroquine显示文摘Nano Research volume 13,pages1693–1703(2020)Cite this article 137 Accesses 6 Altmetric Metrics details Abstract Despite improvements in our understanding of the biology behind triple-negative breast cancer(TNBC),it remains a devastating disease due to lack of an effective targeted therapy.Inhibiting Wnt signaling is a promising strategy to combat TNBC because Wnt signaling drives TNBC progression,chemoresistance,and stemness.However,Wnt inhibition can lead to upregulation of autophagy,which confers therapeutic resistance.This provides an opportunity for combination therapy,as autophagy inhibitors applied concurrently with Wnt inhibitors could increase treatment efficacy.Here,we applied the autophagy inhibitor chloroquine(CQ)to TNBC cells in combination with Frizzled7 antibody-coated nanoshells(FZD7-NS)that suppress Wnt signaling by blocking Wnt ligand/FZD7 receptor interactions,and evaluated this dual treatment in vitro.We found that FZD7-NS can inhibit Axin2 and CyclinD1,two targets of canonical Wnt signaling,and increase the expression of LC3,an autophagy marker.When FZD7-NS and CQ are applied together,they reduce the expression of several stemness genes in TNBC cells,leading to inhibition of TNBC cell migration and self-renewal.Notably,co-delivery of FZD7-NS and CQ is more effective than either therapy alone or the combination of CQ with free FZD7 antibodies.This demonstrates that the nanocarrier design is important to its therapeutic utility.Overall,these findings indicate that combined regulation of Wnt signaling and autophagy by FZD7-NS and CQ is a promising strategy to combat TNBC. | Jianxin Wang Megan N.Dang Emily S.Day | 2020 | Nano Research2020,13,6: | 1 |
| 6 | Sustained modulation of intestinal bacteria by exclusive enteral nutrition used to treat children with Crohn’s disease显示文摘 | S. T.LEACH H. M.MITCHELL W. R.ENG L.ZHANG A. S.DAY | 2008 | Alimentary Pharmacology & Therapeutics2008,,6: | 1 |
| 7 | 全球化下的混合品牌战略显示文摘1983年,哈佛商学院教授特德·莱维特(Ted Levitt)曾坚定地提出“市场全球化即将到来”,并预言,随着全球化的不断推进,以高度统一性运营的全球公司由于成本优势将占上风。这个预言意味着全球品牌主宰时代或将到来——产品在每个国家都有一致的名称、特点、定位和目标市场。 | George S.Day David J.Reibstein 吴海峰(翻译) | 2007 | 北大商业评论2007,,5: | 0 |
| 8 | 想要推荐信?你给我写显示文摘几年前,我请两位同事为我的经费申请书撰写推荐信。其中一位同事是自己写给我的,另一位则表示自己面临沉重的时间压力,问我能不能自己起草这封信。我对此表示谅解,但却对装作他人来评述我自己的工作感到不自在。为了安抚我的良心,我以自己的名义写了这封信:"我"代表我自己,"你"代表我的同事。这有些冒险。如果这位同事只是在这封信上签名并把它寄出去, | Roger S.Day 姜天海(译) | 2017 | 科学新闻2017,0,8: | 0 |
| 9 | 企业为什么成了近视眼?显示文摘早在2001年,就有很多迹象表明房地产泡沫正在扩大,金融衍生品被开发得过滥。但诺森罗克银行、美国国家金融服务公司、贝尔斯登公司等金融机构,对此几乎视而不见,直到最后危机突然降临。为什么那么多聪明人会忽视次贷市场崩盘的迹象? | Paul J.H.Schoemaker George S.Day | 2010 | 北大商业评论2010,,6: | 0 |
| 10 | 洞悉威胁并积极搜寻机会显示文摘许多管理者倾向于信息的消极获取,这样做可能会导致公司陷入困境,因此,必须探寻新的信息收集方式。 | George S.Day Paul J.H.Schoemaker 李悦(编译) | 2006 | 财经文摘2006,,6: | 0 |