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| 1 | 2010年世界胃肠病学组织关于炎症性肠病诊断和治疗的实践指南显示文摘炎症性肠病(IBD)是一组特发性、慢性、炎症性肠道疾病状态,包括两种主要类型:克罗恩病(CD)和溃疡性结肠炎(UC),两者的临床和病理特征既有重叠又有区别。IBD过去常见于发达国家,近几十年,发展中国家的患病率逐步上升。本指南就IBD诊断和治疗方面提出的独特议题在当前的文献和指南中几乎从未被提及。由于各地区的IBD临床特点差异较大,因此根据患者的主诉诊断IBD或评估疾病活动度需随地区的变化而变化。同样,治疗亦应根据疾病的分类和当地医疗资源进行调整。世界胃肠病学组织根据世界各国医疗资源的差异,采用级联方法制订了IBD的诊疗指南。 | Charles N.Bernstein Michael Fried J.H.Krabshuis Henry Cohen R.Eliakim Suleiman Fedail Richard Gearry K.L.Goh Saheed Hamid Aamir Ghafor Khan A.W.LeMair Malfertheiner Qin Ouyang J.F.Rey Ajit Sood Flavio Steinwurz Ole O.Thomsen Alan Thomson Gillian Watermeyer 杨钊斌 杨川华 钱本余 | 2010 | 胃肠病学2010，15，9： | 101 |
| 2 | Effects of K and N Nutrition on Function and Production of Ranunculus asiaticus显示文摘Potassium (K) aflects a range of physiological processes in the plant and is a key factor controlling crop productivity and yield quality. Little information is available concerning effects of K nutrition on function of cut flower plants. The present study was carried out to investigate the interaction between K and N nutrition, on flower quantity and quality of Ranunculus asiaticus L. The plants were supplied with three levels of K fertigation (60, 120, or 180 mg K L-1) under 50 mg N L-1 application, and at the intermediate level of 120 mg K L-1, to three levels of N applications (50, 100, or 150 mg N L-1). The two lowest K treatments and the lowest N treatment excelled in flower production due to the lower incidence of stem-toppling, a disorder associated with localized Ca deficiencies in rapidly expanding tissues of the flower stem. Detrimental effects in terms of yield quality were apparent already under supply of 180 mg K L-1 and 50 mg N L?1, and were not associated with changes in osmotic potential, relative water content or membrane stability of the plant tissue, or with changes in mineral contents of the leaves other than reduced Ca under high N application. Our results suggest a low nutritional requirement of R. asiaticus L. for K and N, a lack of involvement of tissue water relations in the reduced flower quality under the application of high concentrations of K and N, and an induction of stem toppling under high application of N and K by reduced availability of Ca to the expanding tissue of the flower stem. | N.BERNSTEIN M.IOFFE G.LURIA M.BRUNER Y.NISHRI S.PHILOSOPH-HADAS S.SALIM I.DORI E.MATAN | 2011 | Pedosphere2011，21，3： | 7 |
| 3 | World Gastroenterology Organization Practice Guidelines for the Diagnosis and Management of IBD in 2010显示文摘 | Charles N.Bernstein MichaelFried J.H.Krabshuis HenryCohen R.Eliakim SuleimanFedail RichardGearry K.L.Goh SaheedHamid Aamir GhaforKhan A.W.LeMair Malfertheiner QinOuyang J.F.Rey AjitSood FlavioSteinwurz Ole O.Thomsen AlanThomson GillianWatermeyer | 2009 | Inflamm Bowel Dis2009，，1： | 3 |
| 4 | Cancer risk in patients with inflammatory bowel disease显示文摘 | Charles N.Bernstein James F.Blanchard ErichKliewer AndreWajda | 2001 | Cancer2001，，4： | 2 |
| 5 | Cancer risk in patients with inflammatory bowel disease显示文摘 | Charles N.Bernstein James F.Blanchard ErichKliewer AndreWajda | 2001 | Cancer2001，，4： | 2 |
| 6 | IBD Around the world: Comparing the epidemiology, diagnosis, and treatment: Proceedings of the World Digestive Health Day 2010 – Inflammatory bowel disease task force meeting显示文摘 | Daniel C.Baumgart Charles N.Bernstein ZaighamAbbas Jean F.Colombel Andrew S.Day GeertD’Haens IrisDotan Khean L.Goh ToshifumiHibi Richard A.Kozarek Eamonn M.M.Quigley WalterReinisch Bruce E.Sands Jose D.Sollano A. HillarySteinhart FlávioSteinwurz Morten H. | 2011 | Inflamm Bowel Dis2011，，2： | 2 |
| 7 | Immunomodulators:still having a role?显示文摘Immunomodulators,particularly the thiopurines and to a lesser extent methotrexate,were standard of care for inflammatory bowel diseases,including Crohn’s disease and ulcerative colitis,for>40 years.While there has been a renaissance in available therapies with the advent of biologics and small molecules,an impetus remains for the ongoing use of thiopurines and methotrexate.This is particularly true for the maintenance of remission and when used in combination therapy with infliximab to suppress anti-biologic antibodies.This article summarizes the data behind immunomodulator use in Crohn’s disease,focusing on the beneficial role these drugs still have while acknowledging their clinical limitations. | Jeffery M.Venner Charles N.Bernstein | 2022 | Gastroenterology Report2022，10，1： | 2 |
| 8 | World Gastroenterology Organization Practice Guidelines for the Diagnosis and Management of IBD in 2010显示文摘 | Charles N.Bernstein MichaelFried J.H.Krabshuis HenryCohen R.Eliakim SuleimanFedail RichardGearry K.L.Goh SaheedHamid Aamir GhaforKhan A.W.LeMair Malfertheiner QinOuyang J.F.Rey AjitSood FlavioSteinwurz Ole O.Thomsen AlanThomson GillianWatermeyer | 2009 | Inflamm Bowel Dis2009，，1： | 1 |
| 9 | World Gastroenterology Organization Practice Guidelines for the Diagnosis and Management of IBD in 2010显示文摘 | Charles N.Bernstein MichaelFried J.H.Krabshuis HenryCohen R.Eliakim SuleimanFedail RichardGearry K.L.Goh SaheedHamid Aamir GhaforKhan A.W.LeMair Malfertheiner QinOuyang J.F.Rey AjitSood FlavioSteinwurz Ole O.Thomsen AlanThomson GillianWatermeyer | 2009 | Inflamm Bowel Dis2009，，1： | 1 |
| 10 | Homocysteinemia and B vitamin status among adult patients with inflammatory bowel disease: A one‐year prospective follow‐up study显示文摘 | KathyVagianos Charles N.Bernstein | 2012 | Inflamm Bowel Dis2012，，4： | 1 |
| 11 | A randomized, placebo‐controlled trial of calcium supplementation for decreased bone density in corticosteroid‐using patients with inflammatory bowel disease: a pilot study显示文摘 | C. N.BERNSTEIN L. L.SEEGER P. A.ANTON L.ARTINIAN S.GEFFREY W.GOODMAN T. R.BELIN F.SHANAHAN | 2003 | Alimentary Pharmacology & Therapeutics2003，，5： | 1 |
| 12 | World Gastroenterology Organization Practice Guidelines for the Diagnosis and Management of IBD in 2010显示文摘 | Charles N.Bernstein MichaelFried J.H.Krabshuis HenryCohen R.Eliakim SuleimanFedail RichardGearry K.L.Goh SaheedHamid Aamir GhaforKhan A.W.LeMair Malfertheiner QinOuyang J.F.Rey AjitSood FlavioSteinwurz Ole O.Thomsen AlanThomson GillianWatermeyer | 2009 | Inflamm Bowel Dis2009，，1： | 1 |
| 13 | World Gastroenterology Organization Practice Guidelines for the Diagnosis and Management of IBD in 2010显示文摘 | Charles N.Bernstein MichaelFried J.H.Krabshuis HenryCohen R.Eliakim SuleimanFedail RichardGearry K.L.Goh SaheedHamid Aamir GhaforKhan A.W.LeMair Malfertheiner QinOuyang J.F.Rey AjitSood FlavioSteinwurz Ole O.Thomsen AlanThomson GillianWatermeyer | 2009 | Inflamm Bowel Dis2009，，1： | 1 |
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