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| 1 | Comparative clinical trial of S-pantoprazole versus racemic pantoprazole in the treatment of gastro-esophageal reflux disease显示文摘AIM: To compare the effi cacy and tolerability of S-pan- toprazole (20 mg once a day) versus racemic Panto- prazole (40 mg once a day) in the treatment of gastro- esophageal reflux disease (GERD). METHODS: This multi-centre, randomized, double-blind clinical trial consisted of 369 patients of either sex suf- fering from GERD. Patients were randomly assigned to receive either one tablet (20 mg) of S-pantoprazole once a day (test group) or 40 mg racemic pantoprazole once a day (reference group) for 28 d. Patients were evaluated for reduction in baseline on d 0, GERD symptom score on d 14 and 28, occurrence of any adverse effect during the course of therapy. Gastrointestinal (GI) endoscopy was performed in 54 patients enrolled at one of the study centers at baseline and on d 28. RESULTS: Signifi cant reduction in the scores (mean and median) for heart burn (P < 0.0001), acid regurgitation (P < 0.0001), bloating (P < 0.0001), nausea (P < 0.0001) and dysphagia (P < 0.001) was achieved in both groups on d 14 with further reduction on continuing the therapy till 28 d. There was a statistically signifi cant difference in the proportion of patients showing improvement in acid regurgitation and bloating on d 14 and 28 (P = 0.004 for acid regurgitation; P = 0.03 for bloating) and heart burn on d 28 (P = 0.01) between the two groups, with a higher proportion in the test group than in the refer- ence group. Absolute risk reductions for heartburn/acid regurgitation/bloating were approximately 15% on d 14 and 10% on d 28. The relative risk reductions were 26%-33% on d 14 and 15% on d 28. GI endoscopy showed no signifi cant difference in healing of esophagitis (P = 1) and gastric erosions (P = 0.27) between the two groups. None of the patients in either group reported any adverse effect during the course of therapy.CONCLUSION: In GERD, S-pantoprazole (20 mg) is more effective than racemic pantoprazole (40 mg) in improving symptoms of heartburn, acid regurgitation, bloating and equally effective in healing esophagitis and gastric erosions. The relative risk reduction is 15%-33%. Both drugs are safe and well tolerated. | Vikas G Pai Nitin V Pai Hemant P Thacker Jaisingh K Shinde Vijay P Mandora Subhash S Erram | 2006 | World Journal of Gastroenterology2006，12，37： | 19 |
| 2 | Detection of macrolide resistance in Mycoplasma pneumoniae by real - time PCR and high - resolution melt analysis 显示文摘 | Wolff B J Thacker W L Schwartz S B | 2008 | Antimicrob AgentsChemother2008，52，10： | 1 |
| 3 | Probabilistic engineering analysis using the NESSUS software显示文摘 | BenH Thacker David S Riha | | 0，，1： | 1 |
| 4 | The ART of success under Heathrow显示文摘 | WILLIAMS I THACKER S | | 0，，09： | 1 |
| 5 | Do Neoliberal Policies Deter Politi- cal Corruption? 显示文摘 | Anoruo E S Thacker | 2005 | International Organization2005，59，1： | 1 |
| 6 | An examination of relationship between upward influence tactics and assessments of pro- motability 显示文摘 | Thacker R A Wayne S J | 1995 | Journal of Management1995，21，： | 1 |
| 7 | Partial maxillectomy in the dog显示文摘 | Salisbury S K Thacker H L Pantzer E E | 1985 | Vet Surg1985，14，： | 1 |
| 8 | The partialpositive allosteric GABA(A) receptor modulatorEVT 201 is efficacious and safe in the treatment ofadult primary insomnia patients 显示文摘 | Walsh JK Thacker S Knowles LJ | 2009 | Sleep Med2009，10，： | 1 |
| 9 | Evaluation of omeprazole and lansoprazole as inhibitors of cytochrome P450 isoforms显示文摘 | Ko JW Nadia S Thacker D | 1997 | Drug Metab Dispos1997，25，7： | 1 |
| 10 | Experimental reproduction of postweaning multisystemic wasting syndrome in pigs by dual infection with Mycoplasma hyopneumoniae and porcine circovirus type 2显示文摘 | Opriessnig T Thacker E L Yu S | | 0，，06： | 1 |
| 11 | Use of the mobile nylon bag technique to determine the digestible energy con- tent of traditional and non-traditional feeds for swine显示文摘 | QIAO S Y THACKER P A | 2004 | Archives of Animal Nutrition2004，58，4： | 1 |
| 12 | Radiographic evaluation of the maxillary sinus prior to dental implant therapy: A comparison between two-dimensional and three-dimensional radiographic imaging 显示文摘 | Tadinada A Fung K Thacker S | 2015 | Imaging Sci Dent2015，45，3： | 1 |
| 13 | Interferon-alpha promotes abnormal vasculogenesis in lupus: a potential pathway for premature atherosclerosis显示文摘 | Denny MF Thacker S Mehta H | 2007 | Blood2007，110，8： | 1 |
| 14 | Effect of porcine parvovirus vaccination on the development of PMWS in segregated early weaned pigs coinfected with type 2 porcine circovirus and porcine parvovirus显示文摘 | T Opriessnig M Fenaux S Yu R.B Evans D Cavanaugh J.M Gallup F.J Pallares E.L Thacker K.M Lager X.J Meng P.G Halbur | 2003 | Veterinary Microbiology2003，，3： | 1 |
| 15 | Effects of feeding brown midrib corn silage with a high dietary concentration of alfalfa hay on lactational performance of Holstein dairy cows for the first 180 days of lactation显示文摘 | HOLT M EUNJ S THACKER C | 2012 | Journal of Dairy Science2012，96，1： | 1 |
| 16 | Experimental reproduction of postweaning multisystemic wasting syndrome in pigs by dual infection with Mycoplasma hyopneumonlae and porcine circovirus type 2显示文摘 | Opriessnig T Thacker E L Yu S | 2004 | Vet Pathol2004，41，6： | 1 |
| 17 | Transcriptome changes in Mycoplasma hyopneumoniae during infection 显示文摘 | MADSEM M L PUTTAMREDDY S THACKER E L | 2008 | Infect Immun2008，76，2： | 1 |
| 18 | Effects of suppress- ing the 3D separation on the rear slant on the {low structures around an Ahmed body显示文摘 | THACKER A AUBRUN S LEROY A | 2012 | J Wind Eng Ind Aerodyn2012，，： | 1 |
| 19 | Experimental reproduction of postweaning multisystemic wasting syndrome in pigs by dual-infection with Mycoplasma hyopneumoniae and porcine cireovirus type 2显示文摘 | Opriessnig T Thacker E L Yu S | 2004 | Vet Pathol2004，41，： | 1 |
| 20 | Puhic health surveillance in the united states显示文摘 | Thacker S B and Berkelman R L | 1988 | Epidemiologic reviews1988，10，： | 1 |
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