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| 1 | Neurocognitive Graphs of First-Episode Schizophrenia and Major Depression Based on Cognitive Features显示文摘Neurocognitive deficits are frequently observed in patients with schizophrenia and major depressive disorder(MDD). The relations between cognitive features may be represented by neurocognitive graphs based on cognitive features, modeled as Gaussian Markov random fields. However, it is unclear whether it is possible to differentiate between phenotypic patterns associated with the differential diagnosis of schizophrenia and depression using this neurocognitive graph approach. In this study, we enrolled 215 first-episode patients with schizophrenia(FES), 125 with MDD, and 237 demographically-matched healthy controls(HCs). The cognitive performance of all participants was evaluated using a battery of neurocognitive tests. The graphical LASSO model was trained with aone-vs-one scenario to learn the conditional independent structure of neurocognitive features of each group. Participants in the holdout dataset were classified into different groups with the highest likelihood. A partial correlation matrix was transformed from the graphical model to further explore the neurocognitive graph for each group. The classification approach identified the diagnostic class for individuals with an average accuracy of 73.41% for FES vs HC, 67.07% for MDD vs HC, and 59.48% for FES vs MDD. Both of the neurocognitive graphs for FES and MDD had more connections and higher node centrality than those for HC. The neurocognitive graph for FES was less sparse and had more connections than that for MDD.Thus, neurocognitive graphs based on cognitive features are promising for describing endophenotypes that may discriminate schizophrenia from depression. | Sugai Liang Roberto Vega Xiangzhen Kong Wei Deng Qiang Wang Xiaohong Ma Mingli Li Xun Hu Andrew J.Greenshaw Russell Greiner Tao Li | 2018 | Neuroscience Bulletin2018，34，2： | 6 |
| 2 | Gastric food retention at endoscopy is associated with severity of liver cirrhosis显示文摘BACKGROUND Gastrointestinal symptoms are prevalent in patients with cirrhosis.Cirrhotic patients have a known predilection to delayed gastric emptying compared to those without cirrhosis.However,the contributing factors have not been fully elucidated.Retained gastric food on esophagogastroduodenoscopy(EGD)has been used as a surrogate marker for delayed gastric emptying with reasonably high specificity.Therefore,we hypothesize that the frequency of retained gastric food contents at EGD will be higher in a cirrhotic population compared to a control population without liver disease.Additionally,we hypothesize that increased frequency of gastric food contents will be associated with increased severity of cirrhosis.AIM To determine the relative frequency of delayed gastric emptying among cirrhotics as compared to non-cirrhotics and to identify associated factors.METHODSWe performed a retrospective case-control study of cirrhotic subjects whounderwent EGD at an academic medical center between 2000 and 2015. Threehundred sixty-four patients with confirmed cirrhosis, who underwent a total of1044 EGDs for the indication of esophageal variceal screening or surveillance,were identified. During the same period, 519 control patients without liverdisease, who underwent a total of 881 EGDs for the indication of anemia, wereidentified. The presence of retained food on EGD was used as a surrogate fordelayed gastric emptying. The relative frequency of delayed gastric emptyingamong cirrhotics was compared to non-cirrhotics. Characteristics of patients withand without retained food on EGD were compared using univariable andmultivariable logistic regression analysis to identify associated factors.RESULTSOverall, 40 (4.5%) patients had evidence of retained food on EGD. Cirrhotics weremore likely to have retained food on EGD than non-cirrhotics (9.1% vs 1.4%, P <0.001). Characteristics associated with retained food on univariable analysisincluded age less than 60 years (12.6% vs 5.2%, P = 0.015), opioid use (P = 0.004),Child-Pugh class C (24.1% Child-Pugh class C vs 6.4% Child-Pugh class A, P =0.007), and lower platelet count (P = 0.027). On multivariate logistic regressionanalysis, in addition to the presence of cirrhosis (adjusted OR = 5.83;95%CI: 2.32-14.7, P < 0.001), diabetes mellitus (types 1 and 2 combined) (OR = 2.34;95%CI:1.08-5.06, P = 0.031), opioid use (OR = 3.08;95%CI: 1.29-7.34, P = 0.011), andChild-Pugh class C (OR = 4.29;95%CI: 1.43-12.9, P = 0.01) were also associatedwith a higher likelihood of food retention on EGD.CONCLUSIONCirrhotics have a higher frequency of retained food at EGD than non-cirrhotics.Decompensated cirrhosis, defined by Child-Pugh class C, is associated with ahigher likelihood of delayed gastric emptying. | David B Snell Shirley Cohen-Mekelburg Russell Weg Gaurav Ghosh Adam P Buckholz Amit Mehta Xiaoyue Ma Paul J Christos Arun B Jesudian | 2019 | World Journal of Hepatology2019，11，11： | 2 |
| 3 | Open treatment of pelvic and acetabular fractures 显示文摘 | Gettys FK Russell GV Karunakar MA | 2011 | Orthop Clin North Am2011，42，1： | 1 |
| 4 | Early microbial translocation blockade reduces SIV-mediated inflammation and viral replication显示文摘 | Kristoff Jan Haret-Richter George Ma Dongzhu Ribeiro Ruy M Xu Cuiling Cornell Elaine Stock Jennifer L He Tianyu Mobley Adam D Ross Samantha Trichel Anita Wilson Cara Tracy Russell Landay Alan Apetrei Cristian Pandrea Ivona | 2014 | Journal of Clinical Investigation2014，，： | 1 |
| 5 | Manage- ment of dental unit waterline biofilms in the 21st eentu ry显示文摘 | O'Donnell MJ Boyle MA Russell RJ | 2011 | Future Mierobiol2011，6，10： | 1 |
| 6 | New York Heart Association functional class predicts exercise parameters in the current era显示文摘 | Russell SD Saval MA Robbins JL | 2009 | Am Heart J2009，158，4： | 1 |
| 7 | Neuroprotection by scatter factor/hepatocyte growth factor and HGF-1 in cerebellar granule neurons is phosphatidy linositol3-kinase/Akt-dependent and MAPK/CREB-inde-pendent显示文摘 | Russell JC Gomes R | 2002 | J Neurochem2002，81，： | 1 |
| 8 | Effect of peptides and amino acids on efficiency of rumen bacterial protein synthesis in continuous culture显示文摘 | Cotta MA Russell J B | 1982 | J Dairy Sci1982，65，： | 1 |
| 9 | Suggested exeisional margins for cutaueous malignant lesions based on mohs mierographic sur- gery显示文摘 | Sehell AE Russell MA Park SS | 2013 | JAMA Facial Plast Surg2013，15，5： | 1 |
| 10 | Complete Genome Sequence of the Probiotic Lactic Acid Bacterium Lactobacillus acidophilus NCFM 显示文摘 | Ahermann E Russell WM Azcarate Peril MA | 2005 | Proc Natl Acad Sci USA2005，102，11： | 1 |
| 11 | Management of dental unit waterline biofilms in the 21 -eentury显示文摘 | Or Donnell MJ Boyle MA Russell R J | 2011 | Future Microbiol2011，6，10： | 1 |
| 12 | Appendectomy and the risk of developing ulcerative colitis or Crohn’s disease: Results of a large case-control study. South Limburg Inflammatory Bowel Disease Study Group显示文摘 | MG Russel E Dorant RJ Brummer MA van de Kruijs JW Muris JM Bergers J Goedhard RW Stockbrugger | 1997 | Gastroenterology1997，，2： | 1 |
| 13 | Neuronal pentraxin 1: a novel mediator of hypoxic-ischemic injury in neonatal brain显示文摘 | HOSSAIN MA RUSSELL JC OBRIEN R | 2004 | J Neurosci2004，，24： | 1 |
| 14 | Distinct signaling pathways respond to arsenite and reactive oxygen species in Schiz osaceharomyces Pombe显示文摘 | Rodriguez-Gabriel MA Russell P | 2005 | Eukaryot Cell2005，4，： | 1 |
| 15 | Targeting heavy smokers in general practice:randomised controlled trial of trausdermal nicotine patches显示文摘 | Russell MA Stapleton JA Feyerabend C | 1993 | Br Med J1993，306，6888： | 1 |
| 16 | ING1 protein targefing to the nudeus by karyopherins is necessary for activation of p21显示文摘 | Russell MW Soliman MA Schriemer D | 2008 | Biochem Biophys Res Commun2008，374，3： | 1 |
| 17 | Transplantation from matched siblings using once-daily intravenous busulfan/fludarabine with thymoglobulin:a myeloablative regimen with low nonrelapse mortality in all but older patients with high-risk disease显示文摘 | Russell JA Duan Q Chaudhry MA | 2008 | Biol Blood Marrow Transplant2008，14，8： | 1 |
| 18 | Management of dental unit waterline biofilms in the 21st century显示文摘 | O Donnell MJ Boyle MA Russell RJ et a1 | 2011 | Future Microbiol2011，6，10： | 1 |
| 19 | Development of the falls risk for older people in the community (FROP-Com) screening tool 显示文摘 | Russell MA Hill KD Day LM | 2009 | Age Ageing2009，38，： | 1 |
| 20 | Synthesis of potent leukotriene A(4) hydrolase inhibitors identification of 3-(methyl (3-(4-(phenylmethyl) phenoxy) propyl) amino) propanoic acid 显示文摘 | Penning TD Russel MA Chen BB | 2002 | J Med Chem2002，45，： | 1 |
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