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| 1 | Identifying paleoflood deposits archived in Zhongba Site,the Three Gorges reservoir region of the YangtzeRiver,China显示文摘Based on the principle that the present is the key to the past , detailed analyses, such as AMS 14C dating, grain size, component and morphology of heavy minerals, micro-morphology of zircon, Rb/Sr, magnetic susceptibility and total organic carbon (TOC), were conducted to identify paleoflood sediments archived in Zhongba Site. The results indicate that the plaeoflood sediments bear great similarities with modern flood sediments in the following aspects: (1) probability cumulative curves mainly show a pattern of 3―4 segments; (2) grain-size distribution of suspended matter ranges between 3 and 10Ф; (3) the sediments are well-sorted, most of which are suspended matter (>50%); (4) the same species, quantity and morphology of heavy minerals; (5) scanning electronic microscope images show that shapes of zircon are mainly oval and nearly spheral, rounded due to long-distance transport; (6) higher Rb/Sr values (0.55―0.66)than those of sediments from cultural layers (0.03―0.26); (7) magnetic susceptibility values (133.73―433.05 10-6m3/kg) are lower than those of sediments from cultural layers (959.25―2442.44 10?6 m3/kg); (8) TOC (0.14%―0.33%) are lower than those of sediments from cultural lay-ers (1.13%―2.95%). Our results demonstrate that, except for the 1981 flood, there are at least six paleoflood events that occurred during the Qing Dynasty, the middle of Song Dy-nasty, the early Warring States (400BC―350BC), the West Zhou Dynasty (920BC―900BC), the Xia Dynasty (2070BC―1600BC), and the late Neolithic Age (3000BC―2300BC), respectively . | ZHU Chen ZHENG Chaogui MA Chunmei SUN Zhibin ZHU Guangyao WANG Huilin GAO Huazhong WANG Pengling HUANG Run | 2005 | Chinese Science Bulletin2005，50，21： | 28 |
| 2 | Parainfluenza Virus Types 1, 2, and 3 in Pediatric Patients with Acute Respiratory Infections in Beijing During 2004 to 2012显示文摘 | Fang Wang Lin-Qing Zhao Ru-Nan Zhu Jie Deng Yu Sun Ya-Xin Ding Run Tian Yuan Qian | 2015 | Chinese Medical Journal2015，，20： | 8 |
| 3 | Screening and degrading characteristics and community structure of a high molecular weight polycyclic aromatic hydrocarbon-degrading bacterial consortium from contaminated soil显示文摘Inoculation with effcient microbes had been proved to be the most important way for the bioremediation of polluted environments. For the treatment of abandoned site of Beijing Coking Chemical Plant contaminated with high level of high-molecular-weight polycyclic aromatic hydrocarbons(HMW-PAHs) ,a bacterial consortium capable of degrading HMW-PAHs,designated 1-18-1,was enriched and screened from HMW-PAHs contaminated soil.Its degrading ability was analyzed by high performance liquid chromatography(HPLC) ,and the community structure was investigated by construction and analyses of the 16S rRNA gene clone libraries(A,B and F) at different transfers.The results indicated that 1-18-1 was able to utilize pyrene,fluoranthene and benzoapyrene as sole carbon and energy source for growth.The degradation rate of pyrene and fluoranthene reached 82.8%and 96.2%after incubation for 8 days at 30°C,respectively;while the degradation rate of benzoapyrene was only 65.1%after incubation for 28 days at 30°C. Totally,108,100 and 100 valid clones were randomly selected and sequenced from the libraries A,B,and F.Phylogenetic analyses showed that all the clones could be divided into 5 groups,Bacteroidetes,α-Proteobacteria,Actinobacteria,β-Proteobacteria andγ-Proteobacteria.Sequence similarity analyses showed total 39 operational taxonomic units(OTUs) in the libraries.The predominant bacterial groups wereα-Proteobacteria(19 OTUs,48.7%) ,γ-Proteobacteria(9 OTUs,23.1%) andβ-Proteobacteria(8 OTUs,20.5%) . During the transfer process,the proportions ofα-Proteobacteria andβ-Proteobacteria increased greatly(from 47%to 93%) ,while γ-Proteobacteria decreased from 32%(library A) to 6%(library F) ;and Bacteroidetes group disappeared in libraries B and F. | Run Sun Jinghua Jin Guangdong Sun Ying Liu Zhipei Liu | 2010 | Journal of Environmental Sciences2010，22，10： | 8 |
| 4 | Prospective study of scoring system in selective intraoperative cholangiography during laparoscopic cholecystectomy显示文摘AIM: To evaluate of scoring system in predicting choledocholithiasis in selective intraoperative cholangiography (IOC) during laparoscopic cholecystectomy (LC).METHODS: The scoring system of predicting choledocholithiasis was developed during the retrospective study in 264 cases, and was tested in 184 to evaluate its predictive value in choledocholithiasis.RESULTS: The scoring system was developed in a retrospective study of 264 cases, the statistical analyses showed the predictive factors included sex, transaminase levels, alkaline phosphatase level, bilirubin level, and common bile duct diameter on ultrasonography. The scoring system was used in 184 cases prospectively, of which, 3 of 162 (1.9%) cases scoring <3 had choledocholithiasis, 17 of 22 (77.3 %) cases scores≥3 had choledocholithiasis. A case of scores≥3 or more prospectively should be considered highly intraoperative cholangiography during laparoscopic cholecystectomy.CONCLUSION: The scoring system can predict choledocholithiasis and is helpful in selection patietns for intraoperative cholangiography. | Xiao-Dong Sun Xiao-Yan Cai Jun-Da Li Xiu-Jun Cai Yi-Ping Mu Jin-Min Wu Department of General Surgery,The Affiliated Sir Run Run Shaw Hospital,Zhejiang University Medical College,Hangzhou 310016,Zhejiang Province,China | 2003 | World Journal of Gastroenterology2003，9，4： | 7 |
| 5 | Pre-operative radiochemotherapy of locally advanced rectal cancer显示文摘AIM: To evaluate results of pre-operative radiochemotherapy followed by surgery for 15 patients with locally advanced un-resectable rectal cancer.METHODS: 15 patients with advanced non-resectable rectal cancer were treated with pre-operative irriadiation of 40-46 Gy plus concomitant chemotherapy (5-FU+LV and 5′-DFuR) (RCS group). For comparison, 27 similar patients,treated by preoperative radiotherapy (40-50 Gy) plus surgery were served as control (RS group).RESULTS: No radiochemotherapy or radiotherapy was interrupted and then was delayed because of toxicities in both groups. The radical resectability rate was 73.3% in the RCS group and 37.0% (P=0.024) in RS group. Sphincter preservation rates were 26.6% and 3.7% respectively (P=0.028). Sphincter preservation rates of lower rectal cancer were 27.3 % and 0.0 % respectively (P=0.014). Response rates of RCS and RS groups were 46.7 % and 18.5 %(P=0.053). The tumor downstage rates were 8 (53.3%)and 9 (33.3%) in these groups (P=0.206). The 3-year overall survival rates were 66.7 % and 55.6% (P=0.485), and the disease free survival rates were 40.1% and 33.2%(P=0.663). The 3-year local recurrent rates were 26.7%and 48.1% (P=0.174). No obvious late effects were found in either groups.CONCLUSION: High resectability is possible following preoperative radiochemotherapy and can have more sphincters preserved. It is important to improve the quality of the patients′ life even without increasing the survival or local control rates. Preoperative radiotherapy with concomitant full course chemotherapy (5-Fu+LV and 5′-DFuR) is effective and safe. | Xiao-Nan Sun Qi-Chu Yang Jian-Bin Hu Department of Radiation Oncology,Sir Run Run Shaw Hospital,College of Medicine,Zhejiang University,Hangzhou 310016,Zhejiang Province,China | 2003 | World Journal of Gastroenterology2003，9，4： | 6 |
| 6 | A review:Synthesis,modification and photocatalytic applications of ZnIn_(2)S_(4)显示文摘Solar energy is an ideal energy source for solving energy shortages and serious environmental problems.In the past few decades,photocatalytic technology which uses solar energy to deal with the above problems has caused great interest.ZnIn_(2)S_(4),as a layered ternary metal chalcogenide compound,has a series of advantages such as the wide light absorption range and adjustable bandgap.It has been applied in the different fields of photocatalysis in recent years.This review introduced the crystal structures and growth mechanism of ZnIn_(2)S_(4)and summarized the preparation methods of ZnIn_(2)S_(4).Also,the promoted strategies of ZnIn_(2)S_(4)based photocatalytic system and their applications in the pollutant removal,hydrogen evolution,reduction of CO_(2),nitrogen fixation,and chemical synthesis was summarized.Furthermore,the challenges and development directions of the current ZnIn_(2)S_(4)based photocatalytic system were proposed.It is hoped that this review will help researchers design a better ZnIn_(2)S_(4)based photocatalytic system. | Jie Wang Sijia Sun Run Zhou Yangzi Li Zetian He Hao Ding Daimei Chen Weihua Ao | 2021 | Journal of Materials Science & Technology2021，，19： | 6 |
| 7 | Human rhinovirus C infection is associated with asthma in children determined by x TAG respiratory viral panel FAST显示文摘Dear Editor,Cumulative evidence supports the role of early-life viral infections,especially respiratory syncytial virus(RSV)and human rhinovirus(HRV),as major antecedents of childhood asthma(Lemanske,2002;Jackson et al.,2008).In this study,the x TAG respiratory viral panel FAST(RVP FAST)assay,a multiplex polymerase chain reaction(PCR)-based method(Arens et al.,2010;BaladaLlasat et al.,2011;Gharabaghi et al.,2011;Selvaraju,2012),was used to investigate the association of infec- | Dongmei Chen Qinwei Song Runan Zhu Yuan Qian Yu Sun Jie Deng Fang Wang Yaxin Ding Run Tian Chuanhe Liu Wenjing Zhu Linqing Zhao | 2017 | Virologica Sinica2017，32，2： | 5 |
| 8 | The genetics of tiger pelage color variations显示文摘 | Xiao XU Gui-Xin Dong Anne Schmidt-Kuntzel Xue-Li Zhang Yan Zhuang Run Fang Xin Sun Xue-Song Hu Tian-You Zhang Han-Dong Yang De-Lu Zhang Laurie Marker Zheng-Fan Jiang Ruiqiang Li Shu-Jin Luo | 2017 | Cell Research2017，27，7： | 5 |
| 9 | Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection显示文摘Structural principles underlying the composition and synergistic mechanisms of protective monoclonal antibody cocktails are poorly defined.Here,we exploited antibody cooperativity to develop a therapeutic antibody cocktail against SARS-CoV-2.On the basis of our previously identified humanized cross-neutralizing antibody H014,we systematically an a lyzed a fully human n aive antibody library and rationally identified a potent neutralizing antibody partner,P17,which confers effective protection in animal model.Cryo-EM studies dissected the nature of the P17 epitope,which is SARS-CoV-2 specific and distinctly different from that of HOI4.High-resolution structure of the SARS-CoV-2 spike in complex with HOM and P17,together with functional investigations revealed that in a two-antibody cocktail,synergistic neutralization was achieved by S1 shielding and conformational locking,thereby blocking receptor attachment and viral membrane fusion,conferring high potency as well as robustness against viral mutation escape.Furthermore,cluster analysis identified a hypothetical 3rd antibody partner for further reinforcing the cocktail as pan-SARS-CoVs therapeutics. | Hangping Yao Yao Sun Yong-Qiang Deng Nan Wang Yongcong Tan Na-Na Zhang Xiao-Feng Li Chao Kong Yan-Peng Xuc Qi Chen Tian-Shu Cao Hui Zhao Xintian Yan Lei Cao Zhe Lv Dandan Zhu Rui Feng Nanping Wu Wenhai Zhang Yuhao Hu Keda Chen Rong-Rong Zhang Qingyu Lv Shihui Sun Yunhua Zhou Run Yan Guan Yang Xinglu Chanjuan Liu Xiangyun Lu Linfang Cheng Hongying Qiu Xing-Yao Huang Tianhao Weng Danrong Shi Weidong Jiang Junbin Shao Lei Wang Jie Zhang Tao Jiang Guojun Lang Cheng-Feng Qinc Lanjuan Li Xiangxi Wang | 2021 | Cell Research2021，31，1： | 5 |
| 10 | Biodiesel preparation from transesterification of glycerol trioleate catalyzed by basic ionic liquids显示文摘In the present study,the transesterification of glycerol trioleate was carried out over a basic ionic liquid,1-butyl-3- methylimidazolium hydroxide([Bmim]OH) and an 87.2%yield of methyl ester was achieved.The product was isolated through simple decantation from the biphasic system due to the immiscibility of[BmimJOH with ester.[Bmim]OH can be easily recovered and reused six times without dramatic decrease in ester yield. | Shuai Zhou Lu Liu Bo Wang Feng Xu Run Cang Sun | 2012 | Chinese Chemical Letters2012，23，4： | 5 |
| 11 | 1,5-dicaffeoylquinic acid protects primary neurons from amyloid β1-42-induced apoptosis via PI3K/Akt signaling pathway显示文摘背景最近, 1,5-dicaffeoylquinic 酸( 1,5-DQA ),从翠菊 scaber 孤立的 caffeoylquinic 酸衍生物,被发现有 neuroprotective effects.However , 1,5-DQA 的保护的机制还没清楚地是学习是在我们调查了的 neuronal culture.Methods 上探索 1,5-DQA 的保护的机制的这的 identified.The 目的对淀粉的 1-42 ( A42 )的 1,5-DQA 的 neuroprotective 效果在主要 neuronal culture.To 导致了 neurotoxicity 评估 neuroprotective | XIAO Hai-bing CAO Xu WANG Lei RUN Xiao-qin SU Ying TIAN Cheng SUN Sheng-gang LIANG Zhi-hou | 2011 | Chinese Medical Journal2011，，17： | 4 |
| 12 | Rapid Determination of Silicon Content in Rice显示文摘A method for rapid determination of silicon content in rice was introduced. The reliability of this method was verified byusing a recombinant inbred line (RIL) population of rice cross Zhenshan 97B / Milyang 46. Two hundred and forty-nine RILs weretransplanted in two replications. Simple correlation coefficients on the silicon content in the hull, flag leaf and stem in rice betweenduplicate samples of 498 rice materials were 0.97954, 0.97026 and 0.98848, respectively. Ten representative samples wereselected for measurement using the high-temperature alkaline fusion method. Simple correlation coefficient between the siliconcontents determined by the high-temperature alkaline fusion method and by the present method is 0.9993. | DAI Wei-min ZHANG Ke-qin DUAN Bin-wu SUN Cheng-xiao ZHENG Kang-le CAI Run ZHUANG Jie-yun | 2005 | Rice science2005，12，2： | 4 |
| 13 | Binding between Prion Protein and Aβ Oligomers Contributes to the Pathogenesis of Alzheimer’s Disease显示文摘A plethora of evidence suggests that protein misfolding and aggregation are underlying mechanisms of various neurodegenerative diseases,such as prion diseases and Alzheimer's disease(AD).Like prion diseases,AD has been considered as an infectious disease in the past decades as it shows strain specificity and transmission potential.Although it remains elusive how protein aggregation leads to AD,it is becoming clear that cellular prion protein(PrP^c)plays an important role in AD pathogenesis.Here,we briefly reviewed AD pathogenesis and focused on recent progresses how PrP^c contributed to AD development.In addition,we proposed a potential mechanism to explain why infectious agents,such as viruses,conduce AD pathogenesis.Microbe infections cause AD deposition and upregulation of PrP^c,which lead to high affinity binding between AD oligomers and PrP^c.The interaction between PrP^c and AP oligomers in turn activates the Fyn signaling cascade,resulting in neuron death in the central nervous system(CNS).Thus,silencing PrP^c expression may turn out be an effective treatment for PrP^c dependent AD. | Chang Kong Hao Xie Zhenxing Gao Ming Shao Huan Li Run Shi Lili Cai Shanshan Gao Taolei Sun Chaoyang Li | 2019 | Virologica Sinica2019，34，5： | 4 |
| 14 | OsGCD1,a novel player in rice intine construction显示文摘In angiosperms,pollen development is an intricate indispensable process for successful sexual reproduction,which involves accurately and tightly controlled regulations and requires numerous genes expressed in both sporophytic and gametophytic tissues of the anther(McCormick,2004).Understanding the molecular mechanism underlying pollen development is of great significance for the construction of male sterile lines and crop breeding.However,many critical issues concerning pollen development still need to be elucidated.Recently,targeted editing of pollen development-related genes mediated by CRISPR/Cas9 system has provided powerful tools to facilitate the relevant studies in crops to figure out these issues(Li et al., 2016,2017). | Xiaorong Huang Mengmeng Run Meng-Xiang Sun | 2019 | Journal of Genetics and Genomics2019，46，7： | 3 |
| 15 | Association of Different Human Rhinovirus Species with Asthma in Children: A Preliminary Study显示文摘 | Min Zhao Wen-Jing Zhu Yuan Qian Yu Sun Ru-Nan Zhu Jie Deng Fang Wang Ya-Xin Ding Run Tian Chuan-He Liu Ling-Hui Meng Lin-Qing Zhao | 2016 | Chinese Medical Journal2016，，13： | 3 |
| 16 | Association of CDKN2B-AS1 Polymorphisms with Premature Triple-vessel Coronary Disease and Their Sex Specificity in the Chinese Population显示文摘Objective The aim of this study is to establish whether cyclin-dependent kinase inhibitor 2B antisense RNA 1(CDKN2 B-AS1) gene polymorphisms are associated with premature triple-vessel disease(PTVD). Methods Nine single-nucleotide polymorphisms(rs1063192, rs10757274, rs1333042, rs1333049, rs2285327, rs3217986, rs3217992, rs4977574, and rs9632884) were genotyped in 884 PTVD patients and 907 control subjects(males ≤ 50 years old and females ≤ 60 years old) using the improved multiplex ligase detection reaction method. Results The allele frequencies of rs10757274 G, rs1333049 C, rs4977574 G(all P < 0.001), and rs3217986 G(P = 0.040) were significantly higher in the PTVD group than in the control group, but those of rs1063192 A, rs1333042 G, and rs9632884 C(all P < 0.001) were significantly lower in the former than in the latter. Logistic regression analysis revealed that homozygote AA of rs1333042 is associated with decreased risk for PTVD(OR = 0.42, 95% CI: 0.22-0.82, P = 0.011). In addition, the allele frequencies observed differed between genders. The G allele of rs3217986 was associated with increased risk for PTVD in male patients only(OR = 2.94, 95% CI: 1.27-6.80, P = 0.012) in the dominant model, and no positively mutated allele was found in female patients. Conclusion Polymorphisms of the CDKN2 B-AS1 gene are associated with the incidence of PTVD in the Chinese population. Furthermore, the frequencies of mutated alleles differed between genders. | XU Jing Jing JIANG Lin XU Lian Jun GAO Zhan ZHAO Xue Yan ZHANG Yin SONG Ying LIU Ru SUN Kai GAO Run Lin XU Bo SONG Lei YUAN Jin Qing | 2018 | Biomedical and Environmental Sciences2018，31，11： | 3 |
| 17 | Multi-Objective Optimization for China's Power Carbon Emission Reduction by 2035显示文摘Low carbon transformation plays an important role in promoting the energy production and consumption revolution. Currently, the power sector of China still faces a series of challenges, such as the overcapacity of coal-fired power, the renewable energy consumption, the new constraints of carbon-emissions, and fragmented power planning. This study develops a multi-objective optimization model to predict the future trend of China power structure by 2035. The key factors such as network, power, load and storage are taken into account. Besides, the technical feasibility, economic rationality and social acceptable constraints are also fully considered. Through planning and optimization, the premise of low carbon transformation is to ensure the continuity of existing policies for removing inefficient assets, and the core is to develop and utilize non-fossil energy on a large scale. Specifically, the capacity of coal-fired power will be attained in the peak in 2025, and the factor will also transfer from main power supplier to main power and energy supplier. Before 2025, the clean replacement of incremental power installation will be completed. In 2035, 92% of new investment comes from non-fossil energy. The economy and competitiveness of wind power and PV(Photovoltaic) power generation are continuously increasing. By 2020, the coal-fired power and the wind power in eastern of China will be parity firstly. In 2025, the cost of PV and wind power will be the same. Furthermore, the evaluation dimension of modern power system with clean, low-carbon, safety and high efficiency are innovatively constructed, and the index system target of 2035 is quantitatively analyzed and prospected. | WU Jianjun TANG Guihua WANG Run SUN Yanwei | 2019 | Journal of Thermal Science2019，28，2： | 3 |
| 18 | Pterostilbene Ameliorates Glycemic Control,Dyslipidemia and Liver Injury in Type 2 Diabetes Rats显示文摘Type 2 diabetes mellitus(T2DM)is typified by the increment of chronic blood glucose levels that is caused by an absolute and/or a relative deficiency of insulin,accounts for 90%of diabetes and causes a range of complications[1]. | ZHANG Yu Jing SUN Hua Lei WANG Teng LIU Xin Xin LIU Chang SHEN Fang WANG Bing Ya DING Run Rong LIU Yi Ming HUANG Guo Yu LI Wen Jie LI Xing | 2020 | Biomedical and Environmental Sciences2020，33，5： | 3 |
| 19 | Delignification of rye straw using hydrogen peroxide显示文摘 | Run Cang Sun J.M. Fang J. Tomkinson | 2000 | Industrial Crops & Products2000，，2： | 1 |
| 20 | Reconstitution of cellulose and lignin after [C2mim][OAc] pretreatment and its relation to enzymatic hydrolysis显示文摘 | Tong‐Qi Yuan Wei Wang Li‐Ming Zhang Feng Xu Run‐Cang Sun | 2012 | Bioeng2012，，3： | 1 |
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