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| 1 | Peripheral CD4^(+) T cell signatures in predicting the responses to anti-PD-1/PD-L1 monotherapy for Chinese advanced non-small cell lung cancer显示文摘Limited benefit population of immune checkpoint inhibitors makes it urgent to screen predictive biomarkers for stratifying the patients.Herein,we have investigated peripheral CD4^(+) T cell signatures in advanced non-small cell lung cancer(NSCLC)patients receiving anti-PD-1/PD-L1 treatments.It was found that the percentages of IFN-γand IL-17A secreting naïve CD4^(+) T cells(Tn),and memory CD4^(+) T cells(Tm)expressing PD-1,PD-L1 and CTLA-4 were significantly higher in responder(R)than non-responder(NonR)NSCLC patients associated with a longer progression free survival(PFS).Logistic regression analysis revealed that the baseline IFN-γ-producing CD4^(+) Tn cells and PD-1^(+)CD4^(+) Tm cells were the most significant signatures with the area under curve(AUC)value reaching 0.849.This was further validated in another anti-PD-1 monotherapy cohort.Conversely,high percentage of CTLA-4^(+)CD4^(+) Tm cells was associated with a shorter PFS in patients receiving anti-PD-L1 monotherapy.Our study therefore elucidates the significance of functional CD4^(+) Tn and Tm subpopulations before the treatment in predicting the responses to anti-PD-1 treatment in Chinese NSCLC patients.The fact that there display distinct CD4^(+) T cell signatures in the prediction to anti-PD-1 and anti-PD-L1 monotherapy from our study provides preliminary evidence on the feasibility of anti-PD-1 and anti-PD-L1 combination therapy for advanced NSCLC patients. | Liliang Xia Hui Wang Mingjiao Sun Yi Yang Chengcheng Yao Sheng He Huangqi Duan Weimin Xia Ruiming Sun Yaxian Yao Zhiwei Chen Qiong Zhao Hong Li Shun Lu Ying Wang | 2021 | Science China(Life Sciences)2021，64，10： | 7 |
| 2 | Indiscriminate ssDNA cleavage activity of CRISPR-Cas12a induces no detectable off-target effects in mouse embryos显示文摘Dear Editor,Newly discovered characteristics like'collateral effect'or trans-cleavage in CRISPR-Cas13 and CRISPR-Cas12 systems have enabled their usage in nucleic acid detection(Gootenberg et al.2017,2018;Chen et al.2018).The collateral RNA cleavage of Cas13a has been reported to be harmful for cell development(Wang et al.2019;Buchman et al.2020).As a representative gene editor of CRISPR-Cas12 system,CRISPR-Cas12a(Cpf1)holds great potential for therapeutic applications in the future(Zetsche et al.2015;Koo et al.2018;Campa et al.2019). | Yu Wei Yingsi Zhou Yajing Liu Wenqin Ying Ruiming Lv Qimeng Zhao Haibo Zhou Erwei Zuo Yidi Sun Hui Yang Changyang Zhou | 2021 | Protein & Cell2021，12，9： | 2 |
| 3 | Rice gene OsNAC19 encodes a novel NAC-domain transcription factor and responds to infection by Magnaporthe grisea显示文摘 | Ruiming Lin Wensheng Zhao Xiangbing Meng Min Wang Youliang Peng | 2006 | Plant Science2006，，1： | 1 |
| 4 | Erythropoietin Ameliorates Renal Ischemia and Reperfusion Injury via Inhibiting Tubulointerstitial Inflammation显示文摘 | Linkun Hu Cheng Yang Tian Zhao Ming Xu Qunye Tang Bin Yang Ruiming Rong Tongyu Zhu | 2012 | Journal of Surgical Research2012，，1： | 1 |
| 5 | Occurrence and investigation of enteric viral infections in pigs with diarrhea in China显示文摘 | Qian Zhang Ruiming Hu Xibiao Tang Chenglong Wu Qigai He Zhanqin Zhao Huanchun Chen Bin Wu | 2013 | Archives of Virology2013，，： | 1 |
| 6 | Occurrence and investigation of enteric viral infections in pigs with diarrhea in China显示文摘 | Qian Zhang Ruiming Hu Xibiao Tang Chenglong Wu Qigai He Zhanqin Zhao Huanchun Chen Bin Wu | 2013 | Archives of Virology2013，，8： | 1 |
| 7 | Twinned substructure in lath martensite of water quenched Fe-0.2%C and Fe-0.8%C steels显示文摘In the present investigation,twinned substructures within lath martensite of two water quenched steels(0.2 wt.%C and 0.8 wt.%C)were studied.The lath martensite has typical hierarchical packet-block-lath with dislocation substructure.Besides,laths that are misoriented by<011>/70.5°or<111>/60° and bordered by{011}plane,namely twinned laths,are observed,of which the density increases and the scale decreases as more carbons were presented.Such twinned laths have body centered cubic(bcc)crystal structure,belonging to twinned variants following the classical Kurdjumov-Sachs(K-S)orientation relationship with respect to the parent austenite.Unlike bcc{112}<111>twins,twinned variants produce strong double diffraction and in turn the extra diffraction spots that are commonly observed in the martensite in steels with wide range of carbon contents. | Haidong Sun Yuhui Wang Zuohua Wang Ning Liu Yan Peng Xiujuan Zhao Ruiming Ren Hongwang Zhang | 2020 | Journal of Materials Science & Technology2020，47，14： | 1 |
| 8 | Strain gradient induced grain refinement far below the size limit in a low carbon hypoeutectoid steel(0.19 wt%C)via pipe inner surface grinding treatment显示文摘A low carbon hypoeutectoid steel(0.19 wt%C)with proeutectoid ferrite and pearlite dual-components was subjected to surface plastic deformation via pipe inner surface grinding(PISG)at room temperature.The deformation microstructures for each component were systematically characterized along depth,and the patterns of structural evolution toward nanometer regime as well as the governing parameters were addressed.Proeutectoid ferrite grains were refined down to 17 nm,and the pattern covering a length scale of 4–5 orders of magnitude from micron-to nanometer-scale follows:formation of cellular dislocation structure(CDS),elongated dislocation structure(EDS),ultrafine lamellar structure(UFL)and finally the nanolaminated structure(NL).The pearlite experiences the deformation and refinement,and finally the transforming the ultrafine pearlite(UFP)into nanolaminated pearlite(NLP)with the ferrite lamellae as thin as 20 nm.Refinement for both UFL(UFP)and NL(NLP)can be realized via forming novel extended boundaries within ferrite lamellae.A critical lattice curvature of~2.8°is required for forming such extended boundary,corresponding to a minimum strain gradient of 0.25μm^(-1)for a 100 nm-thick lamella.Refinement below size limit(expressed by lamellar thickness d_Tin nm)is correlated with the strain gradient(χ,inμm^(-1))by:d_T=12.5/x.Refinement contributions from strain gradient caused by PISG processing and material heterogeneity were discussed. | Wenqiang Li Yiming Zhao Ning Liu Changji Li Ruiming Ren Dayong Cai Hongwang Zhang | 2021 | Journal of Materials Science & Technology2021，，19： | 0 |
| 9 | Experimental Study on the Characteristics of Water Vapor Generation from Gas-washing Bottle and Injector显示文摘Gas-washing and water injection are two commonly used methods in generating certain moisture content in gas flow stream, but the control accuracy of these methods remains uncertain. The purpose of the study is to investigate the characteristic of water vapor generation of the two methods. The temperature and humidity recorder and FTIR gas analyzer have been adopted to monitor the moisture content in tests. It has been revealed that, in gas-washing process, the moisture content in gas stream is well below saturation, and long time is required before moisture content stabilized after water bath temperature or carrier gas flow rate changed. Water injection pump could directly control the amount of water injected into gas stream. However, the moisture content generated in this way is not stable but oscillates in cycles, whose frequency and magnitude are closely related to water injection amount. | WANG Zhipeng WANG Lang ZHAO Angran CHENG Shuhao YANG Ruiming ZHUOYuqun TONG Huiling | 2019 | Journal of Thermal Science2019，28，1： | 0 |
| 10 | Effect of Jianpi Bushen formula for colon cancer patients who underwent adjuvant chemotherapy:Statistical analysis plan for a multicenter trial显示文摘Background:Patients with colon cancer who receive chemotherapy usually experience various gastrointestinal adverse reactions,including nausea,vomiting,and diarrhea,which make it challenging for them to adhere to treatment.As an effective traditional Chinese medicine,the Jianpi Bushen formula has been widely used to alleviate the side effects of chemotherapy.Objective:To evaluate the efficacy and safety of Jianpi Bushen formulae for patients who undergo chemotherapy.This statistical analysis plan(SAP)is intended to enhance the transparency and research quality of our randomized controlled trial.Methods:Our study is a multicenter,double-blind,randomized controlled clinical trial.This trial aimed to compare the completion rate of chemotherapy in colon cancer patients who are using and not using Jianpi Bushen formula.To attenuate possible selection bias in the final report,we declared the overall trial design,outcome measures,subgroup analyses,and safety measures.Also,we described the data management and statistical analysis methods in detail.Conclusion:The SAP provides more detailed information than the trial protocol for data management and statistical analysis methods.Further post-hoc analyses can be performed by referring to the SAP,and possible selection bias can be attenuated. | Ruiming Zhao Huijuan Cao Lingyun Sun Tong Zhang Yun Xu Shaohua Yan Jun Mao Jianping Liu Yutong Fei Yufei Yang | 2023 | Journal of Traditional Chinese Medical Sciences2023，10，1： | 0 |
| 11 | Key elements that determine the efficacy of cupping therapy:A bibliometric analysis and review of clinical studies显示文摘Objective:The aim of this review was to identify the possible mechanisms behind cupping therapy by employing an evidence-based approach,and to explore its possible regional and systemic effects in the human body.Methods:We searched six electronic databases and four online trial registries for articles published up to January 1,2020.Clinical studies on the mechanisms of retained cupping,flashing cupping,moving cupping,and vacuum cupping were considered for this review.The methodological qualities of controlled studies were assessed using the National Institute for Clinical Excellence methodology checklist,the Newcastle-Ottawa Scale,and the Cochrane risk of bias tool.Characteristic statistical description and qualitative summary of results were used for data analysis.Results:Thirty-eight studies(37 full texts and one abstract)were included in this study.Due to the clinical heterogeneity among the studies,we could not conduct a meta-analysis.The results showed that the key factors that contribute to the efficacy of cupping therapy are negative pressure and temperature.Cupping therapy mainly causes local and systemic changes in hemodynamics,immune regulation,metabolism,and pain relief.Conclusion:We identified negative pressure as the key element behind cupping therapy.Cupping therapy may cause redistribution of oxygen at the cupping site and in neighboring tissues,thereby inducing a therapeutic effect by increasing regional blood flow.It may also induce metabolic change,immunomodulation,and neuromodulation.However,additional rigorous clinical research needs to be conducted to further clarify the mechanism behind cupping therapy. | Jiayin Tao Pei Zhao Tingting Mo Ruiming Zhao Nan Yang Myeong Soo Lee Jianping Liu Huijuan Cao | 2020 | Journal of Traditional Chinese Medical Sciences2020，7，4： | 0 |
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