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| 1 | Noncontrast-enhanced MRI-based Noninvasive Score for Portal Hypertension(CHESS1802):An International Multicenter Study显示文摘Background and Aims:This study aimed to determine the performance of the non-invasive score using noncontrastenhanced MRI(CHESS-DIS score)for detecting portal hy-pertension in cirrhosis.Methods:In this international multicenter,diagnostic study(ClinicalTrials.gov,NCT03766880),patients with cirrhosis who had hepatic venous pressure gradient(HVPG)measurement and noncontrast-enhanced MRI were prospectively recruited from four university hospitals in China(n=4)and Turkey(n=1)between December 2018 and April 2019.A cohort of patients was retrospectively recruited from a university hospital in Italy between March 2015 and November 2017.After segmentation of the liver on fat-suppressed T1-weighted MRI maps,CHESS-DIS score was calculated automatically by an in-house developed code based on the quantification of liver surface nodularity.Results:A total of 149 patients were included,of which 124 were from four Chinese hospitals(training cohort)and 25 were from two international hospitals(validation cohort).A positive correlation between CHESS-DIS score and HVPG was found with the correlation coefficients of 0.36(p<0.0001)and 0.55(p<0.01)for the training and validation cohorts,respectively.The area under the receiver operating characteristic curve of CHESS-DIS score in detection of clinically significant portal hypertension(CSPH)was 0.81 and 0.9 in the training and validation cohorts,respectively.The intra-class correlation coefficients for assessing the inter-and intra-observer agreement were 0.846 and 0.841,respectively.Conclusions:A non-invasive score using noncontrast-enhanced MRI was developed and proved to be significantly correlated with invasive HVPG.Besides,this score could be used to detect CSPH in patients with cirrhosis. | Yanna Liu Tianyu Tang NecatiÖrmeci Yifei Huang Jitao Wang Xiaoguo Li Zhiwei Li Weimin An Dengxiang Liu Chunqing Zhang Changchun Liu Jinqiang Liu Chuan Liu Guangchuan Wang Cristina Mosconi Alberta Cappelli Antonio Bruno Seray Akçalar EmrecanÇelebioğlu EvrenÜstüner Sadık Bilgiç Zeynep Ellik ÖzgünÖmer Asiller Lei Li Haijun Zhang Ning Kang Dan Xu Ruiling He Yan Wang Yang Bu Ye Gu Shenghong Ju Rita Golfieri Xiaolong Qi | 2021 | Journal of Clinical and Translational Hepatology2021，9，6： | 3 |
| 2 | Phylogeny and species differentiation of Mollitrichosiphum spp. (Aphididae, Greenideinae) based on mitochondrial CO1 and Cyt b genes显示文摘 | Ruiling ZHANG Xiaolei HUANG Liyun JIANG Gexia QIAO | 2011 | Current Zoology2011，57，6： | 2 |
| 3 | The Role of Income Structure Improvement in Helping Broaden the Rural Consumer Market显示文摘Too large urban-rural gap and weak rural consumption is the most significant problem in rural areas,and also an insurmountable barrier to the process of China's economic development.At the same time,the modernization of agriculture is proposed as the major policy for China to actively solve issues concerning agriculture,countryside and farmers.Using panel data model and taking into account the regional characteristics and time effects of the sample data,we conduct analysis of the farmers'income structure in the five provinces and one city of East China at the upper reaches of economy,and estimate the effects of farmers'income on farmers'consumer spending,in order to find the main channel for improving farmers'consumption.This paper emphasizes the great significance of farmers'consumption improvement to China's economic restructuring and solving the future economic development in the context of current financial crisis. | Wei CAI Yuntao HE Ruiling HUANG | 2013 | Asian Agricultural Research2013，5，10： | 1 |
| 4 | Environmental flows and its evaluation of restoration effect based on LEDESS model in Yellow River Delta wetlands显示文摘 | Xingong Wang Yu Lian Chong Huang Xiaojun Wang Ruiling Wang Kai Shan Bas Pedroli Michiel Eupen Amgad ElMahdi Mahtab Ali | 2012 | Mitigation and Adaptation Strategies for Global C2012，，4： | 1 |
| 5 | Theoretical analysis and applications of Y-Inversion Ventilation System in a mine fire zone显示文摘Based on mine fire fighting practices at the 1110 working face of the Brapukuria Coal Mine,Bangladesh,we introduce and discuss the Y-Inversion Ventilation System,the latest technology used both in mine fire zone management and the unsealing process.This ventilation system can ensure that all miners breathed fresh air,providing protection for them during fire fighting and unsealing the fire zone.On the other hand,adjusting the amount of air at the working face and forming a CO leakage path controlled the state of the fire and as well ensured that the different fire extinguishing measures could be applied successfully.These are all fundamental techniques which ensured successful fire extinguishing and unsealing of the fire zone.We also analyzed the main reasons for the spontaneous coal combustion that occurred at the 1110 working face.Successful application of advanced composite polymer colloidal perfusion techniques,polymer foam MEA perfusion and fire-prevention technology by infusing nitrogen,used in mine fire zone management and unsealing,are presented.We value the experience with these techniques very highly and are of the opinion that these techniques could be widely used in mine fire fighting practices under similar spontaneous coal combustion conditions elsewhere. | YANG Shengqlang PANG Weidong WEN Hu YU Baohua MA Zhihe HUANG Ruiling | 2010 | Mining Science and Technology2010，20，5： | 1 |
| 6 | A genetically engineered Escherichia coli that senses and degrades tetracycline antibiotic residue显示文摘Due to the abuse of antibiotics,antibiotic residues can be detected in both natural environment and various industrial products,posing threat to the environment and human health.Here we describe the design and implementation of an engineered Escherichia coli capable of degrading tetracycline(Tc)-one of the commonly used antibiotics once on humans and now on poultry,cattle and fisheries.A Tcdegrading enzyme,TetX,from the obligate anaerobe Bacteroides fragilis was cloned and recombinantly expressed in E.coli and fully characterized,including its Km and kcat value.We quantitatively evaluated its activity both in vitro and in vivo by UVeVis spectrometer and LC-MS.Moreover,we used a tetracycline inducible amplification circuit including T7 RNA polymerase and its specific promoter PT7 to enhance the expression level of TetX,and studied the dose-response of TetX under different inducer concentrations.Since the deployment of genetically modified organisms(GMOs)outside laboratory brings about safety concerns,it is necessary to explore the possibility of integrating a kill-switch.Toxin-Antitoxin(TA)systems were used to construct a mutually dependent host-plasmid platform and biocontainment systems in various academic and industrious situations.We selected nine TA systems from various bacteria strains and measured the toxicity of toxins(T)and the detoxifying activity of cognate antitoxins(A)to validate their potential to be used to build a kill-switch.These results prove the possibility of using engineered microorganisms to tackle antibiotic residues in environment efficiently and safely. | Zepeng Mu Zhuoning Zou Ye Yang Wenbo Wang Yue Xu Jianyi Huang Ruiling Cai Ye Liu Yajin Mo Boyi Wang Yiqun Dang Yongming Li Yushan Liu Yueren Jiang Qingyang Tan Xiaohong Liu Cheng Hu Hua Li Sha Wei Chunbo Lou Yang Yu Jiangyun Wang | 2018 | Synthetic and Systems Biotechnology2018，3，3： | 0 |
| 7 | In situ rapid versatile method for the preparation of zirconium metal-organic framework filters显示文摘The development of the rapid preparation of highly stable metal-organic framework(MOF)-based devices provides the possibility of meeting the increasing demands of MOF in industrial applications.However,MOFs experience poor processability and stable high-valence-metal(Ⅳ)-based MOFs favor forming either thermodynamically stable metal hydroxides or oxides during their growth and nucleation,which hinders their practical applications.Herein,we present a versatile deep eutectic solvent(DES)-assisted hot pressing method to in situ rapidly prepare six distinct zirconium-based MOF nanocrystals on fibers(denoted as Zr-MOFilters)within 20 min.A small amount of DES promotes MOF precursor contact and accelerates Zr-MOF growth.Temperature and pressure facilitate the formation of Zr-MOFs onto desired substrates.In situ1H nuclear magnetic resonance spectra and time-dependent Fourier-transform infrared spectra were conducted to elucidate the growth of Zr-MOF nanocrystals.As a proof-of-concept,the abilities of Zr-MOFilters for Cr_(2)O_(7)^(2−) and micro(nano)plastics removal have been demonstrated.This strategy paves the way for the rapid fabrication of highly stable MOF-based devices and brings MOFs a step closer to practical application. | Hang Wang Xingmao Zhang Ruxin Yao Shuang Zhao Pengfei Zhao Ruile Yang Lin Wang Yichao Huang Tong Wei Xiang Li Zhuangjun Fan Bo Wang | 2022 | Science China Chemistry2022，65，12： | 0 |
| 8 | Deep Learning for Medication Recommendation:A Systematic Survey显示文摘Making medication prescriptions in response to the patient's diagnosis is a challenging task.The number of pharmaceutical companies,their inventory of medicines,and the recommended dosage confront a doctor with the well-known problem of information and cognitive overload.To assist a medical practitioner in making informed decisions regarding a medical prescription to a patient,researchers have exploited electronic health records(EHRs)in automatically recommending medication.In recent years,medication recommendation using EHRs has been a salient research direction,which has attracted researchers to apply various deep learning(DL)models to the EHRs of patients in recommending prescriptions.Yet,in the absence of a holistic survey article,it needs a lot of effort and time to study these publications in order to understand the current state of research and identify the best-performing models along with the trends and challenges.To fill this research gap,this survey reports on state-of-the-art DL-based medication recommendation methods.It reviews the classification of DL-based medication recommendation(MR)models,compares their performance,and the unavoidable issues they face.It reports on the most common datasets and metrics used in evaluating MR models.The findings of this study have implications for researchers interested in MR models. | Zafar Ali Yi Huang Irfan Ullah Junlan Feng Chao Deng Nimbeshaho Thierry Asad Khan Asim Ullah Jan Xiaoli Shen Wu Ruil Guilin Qi | 2023 | Data Intelligence2023，5，2： | 0 |
| 9 | Characteristics and significance of peripheral blood T-cell receptor repertoire features in patients with indeterminate lung nodules显示文摘Dear Editor,Dear Editor,Lung cancer is one of the most common cancers and a leading cause of cancer-related deaths.T cells are known to play a significant role in the destruction of cancer cells.T cells have therefore become the focus of lung cancer immunotherapy.T-cell receptors(TCRs)can recognize antigenic peptides presented by HLA proteins.TCRs are distinct individually and vary with pathophysiological condition,so T cells can respond to a wide range of antigens.TCR repertoire diversity reflects the potential for cellular immunity,and several studies have demonstrated that complementarity determining region 3(CDR3β)diversity is important in cancer therapy and prognosis.1 Liu et al.have reported that the CDR3βdiversity of patients with advanced lung cancer differs significantly from that of healthy individuals. | Huaichao Luo Ruiling Zu Ziru Huang Yingqiang Li Yulin Liao Wenxin Luo Peng Zhou Dongsheng Wang Shifu Chen Weimin Li Jian Huang | 2022 | Signal Transduction and Targeted Therapy2022，7，11： | 0 |
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