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| 1 | A cohort study of adolescents with depression in China:tracking multidimensional outcomes and early biomarkers for intervention显示文摘Background Depression in adolescents is recognised as a global public health concern,but little is known about the trajectory of its clinical symptoms and pathogenesis.Understanding the nature of adolescents with depression and identifying earlybiomarkers can facilitatepersonalised intervention andreducediseaseburden.Aims To track multidimensional outcomes of adolescents with depression and develop objective biomarkers for diagnosis,as well as response to treatment,prognosis and guidance for early identification and intervention.Methods This is a multidimensional cohort study on the Symptomatic trajectory and Biomarkers of Early Adolescent Depression(sBEAD).We planned to recruit more than 1000 adolescents with depression and 300 healthy controls within 5 years.Multidimensional clinical presentations and objective indicators are collected at baseline,weeks 4,8,12 and 24,and years 1,2,3,4 and 5.Conclusions To the best of our knowledge,this is the first longitudinal cohort study that examines multidimensional clinical manifestations and multilevel objective markers in Chinese adolescents with depression.This study aims at providing early individualised interventions for young,depressed patients to reduce the burden of disease. | Xiaofei Zhang Yanling Zhou Jiaqi Sun Ruilan Yang Jianshan Chen Xiaofang Cheng Zezhi Li Xinlei Chen Chanjuan Yang Xinhong Zhu Liping Cao | 2022 | General Psychiatry2022，35，4： | 2 |
| 2 | Amperometric determination of NADH at a Nile blue/ordered mesoporous carbon composite electrode显示文摘 | Liande Zhu Ruilan Yang Xiaoyan Jiang Dongxu Yang | 2008 | Electrochemistry Communications2008，，3： | 1 |
| 3 | Bienzymatic glucose biosensor based on co-immobilization of peroxidase and glu-cose oxidase on a carbon nanotubes electrode显示文摘 | Zhu Liande Yang Ruilan Zhai Jiangli | 2007 | Biosens Bioelectron2007，23，4： | 1 |
| 4 | The codimension-two bifurcation for the recent proposed SD oscillator显示文摘 | Ruilan Tian Qingjie Cao Shaopu Yang | 2010 | Nonlinear Dynamics2010，，1： | 1 |
| 5 | Bifurcations and chaotic thresholds for the spring-pendulum oscillator with irrational and fractional nonlinear restoring forces显示文摘 | Ruilan Tian Qiliang Wu Yeping Xiong Xinwei Yang Wenjie Feng | 2014 | The European Physical Journal Plus2014，，5： | 1 |
| 6 | The codimension-two bifurcation for the recent proposed SD?oscillator显示文摘 | Ruilan Tian Qingjie Cao Shaopu Yang | 2010 | Nonlinear Dynamics (-)2010，，1： | 1 |
| 7 | Periodic-phase-diagram similarity method for weak signal detection显示文摘The periodic-phase-diagram similarity method is proposed to identify the frequency of weak harmonic signals.The key technology is to find a set of optimal coefficients for Duffing system,which leads to the periodic motion under the influence of weak signal and strong noise.Introducing the phase diagram similarity,the influences of strong noise on the similarity of periodic phase diagram are discussed.The principle of highest similarity of periodic phase diagram with the same frequency is detected by discussing the persistence of similarity of periodic motion phase diagram under the strong noise and the periodic-phase-diagram similarity method is constructed.The weak signals of early fault and strong noise are input into Duffing system to obtain the identified system.The stochastic subharmonic Melnikov method is extended to obtain the conditions of the optimal coefficients for the identified system.Based on the results,the constructed frequency conversion harmonic weak signals are considered to form a datum periodic system.With the change of frequency in the datum periodic system,the phase diagram similarity of the two constructed systems can be calculated.Based on the periodic-phase-diagram similarity method,the frequency of weak harmonic signals can be identified by the principle of highest similarity of periodic phase diagram with the same frequency.The results of numerical simulation and the early fault diagnosis results of actual bearings verify the feasibility of the periodic-phase-diagram similarity method.The accuracy of the detection effect is 97%,and the minimum signal-to-noise ratio is−80.71 dB. | Ruilan Tian Yangkun Zhang Shaopu Yang Kai Yuan Qiang Xue Quanrong Ren | 2021 | International Journal of Mechanical System Dynamics2021，1，2： | 0 |
| 8 | HIF-1αpromotes virus replication and cytokine storm in H1N1 virus-induced severe pneumonia through cellular metabolic reprogramming显示文摘The mortality of patients with severe pneumonia caused by H1N1 infection is closely related to viral replication and cytokine storm.However,the specific mechanisms triggering virus replication and cytokine storm are still not fully elucidated.Here,we identified hypoxia inducible factor-1α(HIF-1α)as one of the major host molecules that facilitates H1N1 virus replication followed by cytokine storm in alveolar epithelial cells.Specifically,HIF-1αprotein expression is upregulated after H1N1 infection.Deficiency of HIF-1αattenuates pulmonary injury,viral replication and cytokine storm in vivo.In addition,viral replication and cytokine storm were inhibited after HIF-1αknockdown in vitro.Mechanistically,the invasion of H1N1 virus into alveolar epithelial cells leads to a shift in glucose metabolism to glycolysis,with rapid production of ATP and lactate.Inhibition of glycolysis significantly suppresses viral replication and inflammatory responses.Further analysis revealed that H1N1-induced HIF-1αcan promote the expression of hexokinase 2(HK2),the key enzyme of glycolysis,and then not only provide energy for the rapid replication of H1N1 virus but also produce lactate,which reduces the accumulation of the MAVS/RIG-I complex and inhibits IFN-α/βproduction.In conclusion,this study demonstrated that the upregulation of HIF-1αby H1N1 infection augments viral replication and cytokine storm by cellular metabolic reprogramming toward glycolysis mainly through upregulation of HK2,providing a theoretical basis for finding potential targets for the treatment of severe pneumonia caused by H1N1 infection. | Xiaoxiao Meng Yong Zhu Wenyu Yang Jiaxiang Zhang Wei Jin Rui Tian Zhengfeng Yang Ruilan Wang | 2024 | Virologica Sinica2024，39，1： | 0 |
| 9 | Correlation between clinical course and radiographic development on CT scan in patients with COVID-19显示文摘Background:To analyze the correlation between clinical course and radiographic development on computed tomography(CT)in patients with confirmed coronavirus disease 2019(COVID-19)and to provide more evidence for treatment.Methods:This retrospective,observational,cohort study enrolled 49 patients with Reverse transcription-polymerase chain reaction(RT-PCR)-confirmed COVID-19,which included 30 patients admitted to the intensive care unit(ICU)of Wuhan Third Hospital and 19 patients either admitted to or receiving telemedicine consultation from Shanghai General Hospital,Shanghai Xuhui Dahua Hospital,and hospitals in other provinces.CT scans were performed in all enrolled patients and the radiographic features including simple ground-glass opacities(GGOs),GGO with interlobular septal thickening,consolidations with GGO,and consolidations only were monitored by repeating the CT.The progression of these radiographic features was analyzed in combination with their clinical staging and the time interval between onset of symptoms to CT.Results:Based on illness severity,the 49 patients were classified into four stages:mild(n=6),moderate(n=12),severe(n=16),and critically ill(n=15).The CT findings were classified into three phases:early(n=5),progres-sion(n=39),and recovery(n=5).Among the 49 patients,9 had bilateral diffuse GGO or diffuse consolidations(white lungs)and were counted as 18 lesions.Three patients had no abnormal findings on initial CT,but their repeat CT showed new lesions.In all,we identified 892 lesions including simple GGO,GGO with interlobular septal thickening,consolidations with GGO,and consolidations only.Conclusions:Most patients had pulmonary lesions on the posterior,inferior,and peripheral lung fields on CT.The development of GGO with interlobular septal thickening,GGO with consolidations,and consolidations only happened mainly between day 8 and 14.The emergence of consolidations may suggest the progression to the severe phase of the illness,whereas simple consolidations or“white lung”may suggest a critically ill phase. | Yun Xie Luyu Yang Hui Dong Song Cao Wenkai Zhang Qiong Chen Baoliang Jin Zhiguo Zhou Jun Liu Zhiyan He Ruilan Wang | 2021 | Journal of Intensive Medicine2021，1，1： | 0 |
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