|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Chronic intermittent hypoxia induces cardiac inflammation and dysfunction in a rat obstructive sleep apnea model显示文摘Chronic intermittent hypoxia is considered to play an important role in cardiovascular pathogenesis during the development of obstructive sleep apnea(OSA).We used a well-described OSA rat model induced with simultaneous intermittent hypoxia.Male Sprague Dawley rats were individually placed into plexiglass chambers with air pressure and components were electronically controlled.The rats were exposed to intermittent hypoxia 8 hours daily for 5weeks.The changes of cardiac structure and function were examined by ultrasound.The cardiac pathology,apoptosis,and fibrosis were analyzed by H&E staining,TUNNEL assay,and picosirius staining,respectively.The expression of inflammation and fibrosis marker genes was analyzed by quantitative real-time PCR and Western blot.Chronic intermittent hypoxia/low pressure resulted in significant increase of left ventricular internal diameters(LVIDs),endsystolic volume(ESV),end-diastolic volume(EDV),and blood lactate level and marked reduction in ejection fraction and fractional shortening.Chronic intermittent hypoxia increased TUNNEL-positive myocytes,disrupted normal arrangement of cardiac fibers,and increased Sirius stained collagen fibers.The expression levels of hypoxia induced factor(HIF)-l α,NF-κB,IL-6,and matrix metallopeptidase 2(MMP-2) were significantly increased in the heart of rats exposed to chronic intermittent hypoxia.In conclusion,the left ventricular function was adversely affected by chronic intermittent hypoxia,which is associated with increased expression of HIF-lα and NF-κB signaling molecules and development of cardiac inflammation,apoptosis and fibrosis. | Qin Wei Yeping Bian Fuchao Yu Qiang Zhang Guanghao Zhang Yang Li Songsong Song Xiaomei Ren Jiayi Tong | 2016 | The Journal of Biomedical Research2016，30，6： | 15 |
| 2 | Crystal structure of the swine-origin A (H1N1)- 2009 influenza A virus hemagglutinin (HA) reveals similar antigenicity to that of the 1918 pandemic virus显示文摘Influenza virus is the causative agent of the seasonal and occasional pandemic flu.The current H1N1 influenza pandemic,announced by the WHO in June 2009,is highly contagious and responsible for global economic losses and fatalities.Although the H1N1 gene segments have three origins in terms of host species,the virus has been named swine-origin influenza virus(S-OIV)due to a predominant swine origin.2009 S-OIV has been shown to highly resemble the 1918 pandemic virus in many aspects.Hemagglutinin is responsible for the host range and receptor binding of the virus and is therefore a primary indicator for the potential of infection.Primary sequence analysis of the 2009 S-OIV hemagglutinin(HA)reveals its closest relationship to that of the 1918 pandemic influenza virus,however,analysis at the structural level is necessary to critically assess the functional significance.In this report,we report the crystal structure of soluble hemagglutinin H1(09H1)at 2.9Å,illustrating that the 09H1 is very similar to the 1918 pandemic HA(18H1)in overall structure and the structural modules,including the five defined antiboby(Ab)-binding epitopes.Our results provide an explanation as to why sera from the survivors of the 1918 pandemics can neutralize the 2009 S-OIV,and people born around the 1918 are resistant to the current pandemic,yet younger generations are more susceptible to the 2009 pandemic. | Wei Zhang Jianxun Qi Yi Shi Qing Li Feng Gao Yeping Sun Xishan Lu Qiong Lu Christopher J.Vavricka Di Liu Jinghua Yan George F.Gao | 2010 | Protein & Cell2010，1，5： | 10 |
| 3 | POWER FLOW ANALYSIS FOR A NEW ISOLATION SYSTEM-FLEXIBLE FLOATING RAFT显示文摘POWERFLOWANALYSISFORANEWISOLATIONSYSTEM-FLEXIBLEFLOATINGRAFTPOWERFLOWANALYSISFORANEWISOLATIONSYSTEM-FLEXIBLEFLOATINGRAFTXiong... | Xiong Yeping Song Kongjie Wang Chun Han Yuchang( Shandong University of Technology) | 1996 | Chinese Journal of Mechanical Engineering1996，9，3： | 10 |
| 4 | Age-related decrease in expression of peroxisome proliferator-activated receptor α and its effects on development of dyslipidemia显示文摘Background Ageing is associated with increased incidence of dyslipidemia. To investigate potential molecular mechanisms, the effects of age and fibrate administration on peroxisome proliferator-activated receptor α(PPARα) expression in livers of young and old rats were studied.Methods A total of 16 young (2-month-old) and 16 old rats (24-month-old) were randomly assigned to a control group and fenofibrate group (fenofibrate in a total therapeutic dosage of 0.5% in ratio to each treated rat weight in 14 days). RT-PCR was applied to evaluate hepatic mRNA expression of PPARα and its target genes. Western blotting was used to determine PPARα protein level in liver tissue. Results When compared with 2-month-old rats, the liver tissue from 24-month-old rats showed reduced expression of PPARα mRNA (52%, P <0.05) and protein (109%, P <0.01). Consequently, the mRNA levels of PPAR target genes, LPL, ACO, ACS and CPT-1 were markedly lowered by 19%, 8%, 13% and 9% respectively, and apoCIII increased by 24% in livers from 24-month-old rats, compared with values obtained from 2-month-old rats ( P <0.05). Fenofibrate therapy significantly lowered plasma triglyceride and total cholesterol levels in old rats, accompanied with improvement in hepatic expression of genes, including LPL, ACO, ACS, CPT-1 and apoCIII, but no change was found in PPARα expression in livers from either 24-month or 2-month-old rats. Conclusions The decrease in the hepatic PPARα expression is probably directly related to the lipid metabolic disturbances observed in old animals. The beneficial effects of fenofibrate administration in old rats suggests that fibrates may be useful for treating lipid disturbances in old people. | YEPing WANGZhao-jun ZHANGXiu-jin ZHAOYa-li | 2005 | Chinese Medical Journal2005，，13： | 9 |
| 5 | Complete fuzzy scheduling and fuzzy earned value management in construction projects显示文摘This paper aims to present a comprehensive proposal for project scheduling and control by applying fuzzy earned value.It goes a step further than the existing literature:in the formulation of the fuzzy earned value we consider not only its duration,but also cost and production,and alternatives in the scheduling between the earliest and latest times.The mathematical model is implemented in a prototypical construction project with all the estimated values taken as fuzzy numbers.Our findings suggest that different possible schedules and the fuzzy arithmetic provide more objective results in uncertain environments than the traditional methodology.The proposed model allows for controlling the vagueness of the environment through the adjustment of the α-cut,adapting it to the specific circumstances of the project. | José Luís PONZ-TIENDA Eugenio PELLICER Víctor YEPES | 2012 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2012，13，1： | 9 |
| 6 | Urokinase-type plasminogen activator is a modulator of synaptic plasticity in the central nervous system:implications for neurorepair in the ischemic brain显示文摘The last two decades have witnessed a rapid decrease in mortality due to acute cerebral ischemia that paradoxically has led to a rapid increase in the number of patients that survive an acute ischemic stroke with various degrees of disability.Unfortunately,the lack of an effective therapeutic strategy to promote neurological recovery among stroke survivors has led to a rapidly growing population of disabled patients.Thus,understanding the mechanisms of neurorepair in the ischemic brain is a priority with wide scientific,social and economic implications.Cerebral ischemia has a harmful effect on synaptic structure associated with the development of functional impairment.In agreement with these observations,experimental evidence indicates that synaptic repair underlies the recovery of neurological function following an ischemic stroke.Furthermore,it has become evident that synaptic plasticity is crucial not only during development and learning,but also for synaptic repair after an ischemic insult.The plasminogen activating system is assembled by a cascade of enzymes and their inhibitors initially thought to be solely involved in the generation of plasmin.However,recent work has shown that in the brain this system has an important function regulating the development of synaptic plasticity via mechanisms that not always require plasmin generation.Urokinase-type plasminogen activator(uPA)is a serine proteinase and one of the plasminogen activators,that upon binding to its receptor(uPAR)not only catalyzes the conversion of plasminogen into plasmin on the cell surface,but also activates cell signaling pathways that promote cell migration,proliferation and survival.The role of uPA is the brain is not fully understood.However,it has been reported while uPA and uPAR are abundantly found in the developing central nervous system,in the mature brain their expression is restricted to a limited group of cells.Remarkably,following an ischemic injury to the mature brain the expression of uPA and uPAR increases to levels comparable to those observed during development.More specifically,neurons release uPA during the recovery phase from an ischemic injury,and astrocytes,axonal boutons and dendritic spines recruit uPAR to their plasma membrane.Here we will review recent evidence indicating that binding of uPA to uPAR promotes the repair of synapses damaged by an ischemic injury,with the resultant recovery of neurological function.Furthermore,we will discuss data indicating that treatment with recombinant uPA is a potential therapeutic strategy to promote neurological recovery among ischemic stroke survivors. | Manuel Yepes | 2020 | Neural Regeneration Research2020，15，4： | 8 |
| 7 | Resveratrol reduces intracellular reactive oxygen species levels by inducing autophagy through the AMPK-mTOR pathway显示文摘Oxidative stress induced by free fatty acid aggravates endothelial injury,which leads to diabeti cardiovascular complications.Reduction of intracellular oxidative stress may attenuate these pathogeni processes.The dietary polyphenol resveratrol reportedly exerts potential protective effects against endothelia injury.This study determined whether resveratrol can reduce the palmitic acid (PA)-induced generation o reactive oxygen species (ROS)and further explored the underlying molecular mechanisms.We found tha resveratrol significantly reduced the PA-induced endothelial ROS levels in human aortic endothelial cells Resveratrol also induced endothelial cell autophagy,which mediated the effect of resveratrol on ROS reduction Resveratrol stimulated autophagy via the AMP-activated protein kinase (AMPK)-mTOR pathway.Taketogether,these data suggest that resveratrol prevents PA-induced intracellular ROS by autophagy regulation via the AMPK-mTOR pathway.Thus,the induction of autophagy by resveratrol may provide a novel therapeuti candidate for cardioprotection in metabolic syndrome. | Jun Song Yeping Huang Wenjian Zheng Jing Yan Min Cheng Ruxing Zhao Li Chen Cheng Hu Weiping Jia | 2018 | Frontiers of Medicine2018，12，6： | 7 |
| 8 | A formal model for access control with supporting spatial context显示文摘There is an emerging recognition of the importance of utilizing contextual informa tion in authorization decisions. Controlling access to resources in the field of wireless and mobile networking require the definition of a formal model for access control with supporting spatial context. However, traditional RBAC model does not specify these spatial requirements. In this paper, we extend the existing RBAC model and propose the SC-RBAC model that utilizes spatial and location-based information in security policy definitions. The concept of spatial role is presented, and the role is assigned a logical location domain to specify the spatial boundary. Roles are activated based on the current physical position of the user which obtained from a specific mobile terminal. We then extend SC-RBAC to deal with hierarchies, modeling permission, user and activation inheritance, and prove that the hierarchical spatial roles are capable of constructing a lattice which is a means for articulate multi-level security policy and more suitable to control the information flow security for safety-critical location-aware information systems. Next, constrained SC-RBAC allows express various spatial separations of duty constraints, location-based cardinality and temporal constraints for specify fine-grained spatial semantics that are typical in location-aware systems. Finally, we introduce 9 invariants for the constrained SC-RBAC and its basic security theorem is proven. The constrained SC-RBAC provides the foundation for applications in need of the constrained spatial context aware access control. | ZHANG Hong HE YePing SHI ZhiGuo | 2007 | Science in China(Series F)2007，50，3： | 7 |
| 9 | Gastric mucosa-associated lymphoid tissue lymphomas and Helicobacter pylori infection:A Colombian perspective显示文摘AIM:To assess the significance of chromosome translocation t(11;18)(q21;q21),B-cell lymphoma 10 (BCL-10) protein and Helicobacter pylori (H.pylori) infection in gastric mucosa-associated lymphoid tissue (MALT) lymphoma in Colombia.METHODS:Fifty cases of gastric MALT lymphoma and their respective post-treatment follow-up biopsies were examined to assess the presence of the translocation t(11;18)(q21;q21) as identified by fluorescence in situ hybridization;to detect protein expression patterns of BCL10 using immunohistochemistry;and for evaluation of tumor histology to determine the correlation of these factors and resistance to H.pylori eradication.RESULTS:Infection with H.pylori was confirmed in all cases of gastric MALT lymphoma in association with chronic gastritis.Bacterial eradication led to tumor regression in 66% of cases.The translocation t(11;18)(q21;q21) was not present in any of these cases,nor was there evidence of tumor transformation to diffuse large B-cell lymphoma.Thirty-four percent of the patients showed resistance to tumor regression,and within this group,7 cases,representing 14% of all those analyzed,were considered to be t(11;18)(q21;q21)-positive gastric MALT lymphomas.Protein expression of BCL10 in the nucleus was associated with the presence of translocation and treatment resistance.Cases that were considered unresponsive to therapy were histologically characterized by the presence of homogeneous tumor cells and a lack of plasmacytic differentiation.Responder cases exhibited higher cellular heterogeneity and a greater frequency of plasma cells.CONCLUSION:Both t(11;18)(q21;q21)-positive MALT lymphoma cases and those with nuclear BCL10 expression are considered resistant to H.pylori eradication.It is suggested that chronic antigenic stimulation is not a dominant event in resistant cases. | Sally Yepes Maria Mercedes Torres Carlos Saavedra Rafael Andrade | 2012 | World Journal of Gastroenterology2012，18，7： | 6 |
| 10 | Simultaneous desulfurization and denitrification of flue gas by pre-ozonation combined with ammonia absorption显示文摘A process of simultaneous desulfurization and denitrification of flue gas was conducted in this study.The flue gas containing 200 mg·m^-3NO,1000-4000 mg·m^-3SO(2,)3%-9%O(2)and 10%-20%CO(2)was first oxidized b(y)O3 and then absorbed by ammonia in a bubbling reactor.Increasing the ammonia concentration or the SO2 content in flue gas can promote the absorption of NOx and extend the effective absorption time.On the contrary,both increasing the absorbent temperature or the O(2)content shorten the effective absorption time of NO((x.))The change of solution pH had substantial influence on NOx absorption.In the presence of CO(2)the NOx removal efficiency reached 89.2%when the absorbent temperature was raised to 60℃and the effective absorption time can be maintained for 8 h,which attribute to the buffering effect in the absorbent.Besides,both the addition of Na(2)S2 O3 and urea can promote the NOx removal efficiency when the absorbent temperature is 25℃and the addition of Na(2)S2 O3 had achieved better results.The advantage of adding Na(2)S2 O3 became less evident at higher absorbent temperature and coexistence of CO(2.)In all experiments,SO(2)removal efficiency was always above 99%,and it was basically not affected by the above factors. | Baowei Wang Shumei Yao Yeping Peng | 2020 | Chinese Journal of Chemical Engineering2020，28，9： | 5 |
| 11 | Effect of CuO on the Formation Mechanism of Calcium Sulphoaluminate显示文摘Calcium sulphoaluminate was prepared with chemical reagents in this paper.The formation mechanism of calcium sulphoaluminate and effect of CuO on the formation mechanism of calcium sulphoaluminate were investigated by the chemical analysis,X-ray diffraction(XRD),and differential scanning calorimetry(DSC).The results show that there are three ways in the formation of calcium sulphoaluminate. CuO can promote the decomposition of calcium carbonate and decrease the formation temperature of calcium sulphoaluminate(C4A3S).When the burning temperature is below 1 000℃,the addition of CuO can promote the formation of calcium sulphoaluminate,while CuO can not favor the formation of calcium sulphoaluminate above 1 000℃. | MA Suhua SHEN Xiaodong HUANG Yeping ZHONG Baiqian | 2008 | Journal of Wuhan University of Technology(Materials Science)2008，23，4： | 5 |
| 12 | FN-λ: A new spotlight in innate immunity against influenza virus infection显示文摘 | Yeping Sun Jingwen Jiang Po Tien Wenjun Liu Jing Li | 2018 | Protein & Cell2018，9，10： | 5 |
| 13 | OPTIMUM CONTROL OF VIBRATION AND STRUCTURE-BORNE NOISE FOR MACHINERY ON FLEXIBLE FOUNDATION显示文摘OPTIMUMCONTROLOFVIBRATIONANDSTRUCTURE-BORNENOISEFORMACHINERYONFLEXIBLEFOUN-DATIONOPTIMUMCONTROLOFVIBRATIONANDSTRUCTURE-BORNEN... | Xiong Yeping Song Kongjie Wang Chun ( Shandong University of Technology) | 1996 | Chinese Journal of Mechanical Engineering1996，9，1： | 4 |
| 14 | A formal model for integrity protection based on DTE technique显示文摘In order to provide integrity protection for the secure operating system to satisfy the structured protection class' requirements, a DTE technique based integrity protection formalization model is proposed after the implications and structures of the integrity policy have been analyzed in detail. This model consists of some basic rules for configuring DTE and a state transition model, which are used to instruct how the domains and types are set, and how security invariants obtained from initial configuration are maintained in the process of system transition respectively. In this model, ten invariants are introduced, especially, some new invariants dealing with information flow are proposed, and their relations with corresponding invariants described in literatures are also discussed. The thirteen transition rules with well-formed atomicity are presented in a well-operational manner. The basic security theorems correspond to these invariants and transition rules are proved. The rationalities for proposing the invariants are further annotated via analyzing the differences between this model and ones described in literatures. At last but not least, future works are prospected, especially, it is pointed out that it is possible to use this model to analyze SE-Linux security. | JI Qingguang QING Sihan HE Yeping | 2006 | Science in China(Series F)2006，49，5： | 4 |
| 15 | Urokinase-type plasminogen activator promotes synaptic repair in the ischemic brain显示文摘The central nervous system has a very high energy requirement.Accordingly,despite representing only 2%of the body’s mass,the brain uses20%of the total oxygen consumption.Importantly,because most of this energy is used to maintain synaptic activity,even a mild decrease in its supply to the brain has deleterious implications for synaptic function.For example,only one minute of interruption of the cerebral blood | ariel diaz manuel yepes | 2018 | Neural Regeneration Research2018，13，2： | 4 |
| 16 | Low-frequency Stimulation at the Subiculum is Anti-convulsant and Anti-drug-resistant in a Mouse Model of Lamotrigine-resistant Temporal Lobe Epilepsy显示文摘Dear Editor,Epilepsy is a common neurological disease.About 30%of epileptic patients develop resistance to antiepileptic drugs(AEDs),and are considered to have refractory or drugresistant epilepsy[1].Based on the time course over which drug-resistance develops,refractory epilepsy can be further divided into an early-onset type(drug-resistance more likely innate and correlated with gene mutations)and a delayed-onset type(drug-resistance emerges after a period of medication)[2]. | Yeping Ruan Cenglin Xu Jile Lan Jiazhen Nao Shuo Zhang Fei Fan Yi Wang Zhong Chen | 2020 | Neuroscience Bulletin2020，36，6： | 4 |
| 17 | Intelligent Identification of Wear Mechanism via On-line Ferrograph Images显示文摘Condition based maintenance(CBM) issues a new challenge of real-time monitoring for machine health maintenance. Wear state monitoring becomes the bottle-neck of CBM due to the lack of on-line information acquiring means. The wear mechanism judgment with characteristic wear debris has been widely adopted in off-line wear analysis; however, on-line wear mechanism characterization remains a big problem. In this paper, the wear mechanism identification via on-line ferrograph images is studied. To obtain isolated wear debris in an on-line ferrograph image, the deposition mechanism of wear debris in on-line ferrograph sensor is studied. The study result shows wear debris chain is the main morphology due to local magnetic field around the deposited wear debris. Accordingly, an improved sampling route for on-line wear debris deposition is designed with focus on the self-adjustment deposition time. As a result, isolated wear debris can be obtained in an on-line image, which facilitates the feature extraction of characteristic wear debris. By referring to the knowledge of analytical ferrograph, four dimensionless morphological features, including equivalent dimension, length-width ratio, shape factor, and contour fractal dimension of characteristic wear debris are extracted for distinguishing four typical wear mechanisms including normal, cutting, fatigue, and severe sliding wear. Furthermore, a feed-forward neural network is adopted to construct an automatic wear mechanism identification model. By training with the samples from analytical ferrograph, the model might identify some typical characteristic wear debris in an on-line ferrograph image. This paper performs a meaningful exploratory for on-line wear mechanism analysis, and the obtained results will provide a feasible way for on-line wear state monitoring. | WU Tonghai PENG Yeping SHENG Chenxing WU Jiaoyi | 2014 | Chinese Journal of Mechanical Engineering2014，27，2： | 4 |
| 18 | Power flow in the coupled dynamic system of machinery and building floor显示文摘The transmision mechanism of vibrational power flow in the complex flekible coupled system of machinery mouned on a multi-storey plant building via isolators are studied in this paper from the viewpoint of energy. In view of practical isolation designs in engineering,an asymmetric isolation system with mtiltiple isolators on a fiekible foundation is modeled, in which the interactions between the machine and the floor, and among different mouating points are taken illto account. Moreover, the transmission characteristics of power flow in the system concerned are analyzed with the use of subsystem mobility synthetic techaique. Further more,the power flow spectra of the asymmetric system are calculated and compared with those of symmetric one to reveal the effects of asymmetricity and system parameters on the power flow.Finally, new approaches to the control of structural vibration and acoustics for this kin of problems are proposed. | XIONG Yeping Song K.J. and Wang C.(Institute o, Engineerng Medanics, Sandong University of Technology, Jinan, 250014) | 1996 | Chinese Journal of Acoustics1996，15，1： | 3 |
| 19 | Efficacy and Safety of Anticoagulation on Patients With Cirrhosis and Portal Vein Thrombosis显示文摘 | María Gabriela Delgado Susana Seijo Ismael Yepes Linette Achécar Maria Vega Catalina ángeles García–Criado Juan G. Abraldes Joaquín de la Pe?a Rafael Ba?ares Agustín Albillos Jaume Bosch Juan Carlos García–Pagán | 2012 | Clinical Gastroenterology and Hepatology2012，，7： | 3 |
| 20 | Power Flow Response Based Dynamic Topology Optimization of Bi-material Plate Structures显示文摘Work on dynamic topology optimization of engineering structures for vibration suppression has mainly addressed the maximization of eigenfrequencies and gaps between consecutive eigenfrequencies of free vibration, minimization of the dynamic compliance subject to forced vibration, and minimization of the structural frequency response. A dynamic topology optimization method of bi-material plate structures is presented based on power flow analysis. Topology optimization problems formulated directly with the design objective of minimizing the power flow response are dealt with. In comparison to the displacement or velocity response, the power flow response takes not only the amplitude of force and velocity into account, but also the phase relationship of the two vector quantities. The complex expression of power flow response is derived based on time-harmonic external mechanical loading and Rayleigh damping. The mathematical formulation of topology optimization is established based on power flow response and bi-material solid isotropic material with penalization(SIMP) model. Computational optimization procedure is developed by using adjoint design sensitivity analysis and the method of moving asymptotes(MMA). Several numerical examples are presented for bi-material plate structures with different loading frequencies, which verify the feasibility and effectiveness of this method. Additionally, optimum results between topological design of minimum power flow response and minimum dynamic compliance are compared, showing that the present method has strong adaptability for structural dynamic topology optimization problems. The proposed research provides a more accurate and effective approach for dynamic topology optimization of vibrating structures. | XUE Xiaoguang LI Guoxi XIONG Yeping GONG Jingzhong | 2013 | Chinese Journal of Mechanical Engineering2013，26，3： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员