|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Evaluation and reflection on claudin 18.2 targeting therapy in advanced gastric cancer显示文摘Claudin 18.2(CLDN18.2)is a tight-junction protein.CLDN18.2-targeting strategy has cut a striking figure in CLDN18.2 positive patients with advanced gastric cancer.Zolbetuximab,the CLDN18.2 antibody,obtained a better clinical benefit in patients compared with the controlled.In phase II trials,combination treatment of epirubicin,oxaliplatin and capecitabine(EOX)+zolbetuximab achieved the optimal effects of overall survival which extended to 13.2 months with tolerable safety events,indicating its greater potential playing the second promising target in gastric cancer.This review will reveal the definitive clinical benefit CLDN18.2-targeting therapies have achieved and update the highlighting development(like chimeric antigen receptor T-cell immunotherapy)to CLDN18.2 positive patients.We then focus on 10 questions arisen from recent progress and anticipate to provide a future perspective for novel cancer treatment. | Jianwei Zhang Ruilan Dong Lin Shen | 2020 | Chinese Journal of Cancer Research2020，32，2： | 13 |
| 2 | Influenza A Virus(H1N1) Infection Induces Glycolysis to Facilitate Viral Replication显示文摘Viruses depend on host cellular metabolism to provide the energy and biosynthetic building blocks required for their replication. In this study, we observed that influenza A virus(H1N1), a single-stranded, negative-sense RNA virus with an eight-segmented genome, enhanced glycolysis both in mouse lung tissues and in human lung epithelial(A549) cells. In detail, the expression of hexokinase 2(HK2), the first enzyme in glycolysis, was upregulated in H1N1-infected A549 cells,and the expression of pyruvate kinase M2(PKM2) and pyruvate dehydrogenase kinase 3(PDK3) was upregulated in H1N1-infected mouse lung tissues. Pharmacologically inhibiting the glycolytic pathway or targeting hypoxia-inducible factor 1(HIF-1), the central transcriptional factor critical for glycolysis, significantly reduced H1N1 replication, revealing a requirement for glycolysis during H1N1 infection. In addition, pharmacologically enhancing the glycolytic pathway further promoted H1N1 replication. Furthermore, the change of H1N1 replication upon glycolysis inhibition or enhancement was independent of interferon signaling. Taken together, these findings suggest that influenza A virus induces the glycolytic pathway and thus facilitates efficient viral replication. This study raises the possibility that metabolic inhibitors, such as those that target glycolysis, could be used to treat influenza A virus infection in the future. | Lehao Ren Wanju Zhang Jing Zhang Jiaxiang Zhang Huiying Zhang Yong Zhu Xiaoxiao Meng Zhigang Yi Ruilan Wang | 2021 | Virologica Sinica2021，36，6： | 3 |
| 3 | Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylationmediated mitophagy显示文摘Parkin,an E3 ubiquitin ligase,plays a role in maintaining mitochondrial homeostasis through targeting damaged mitochondria for mitophagy.Accumulating evidence suggests that the acetylation modification of the key mitophagy machinery influences mitophagy level,but the underlying mechanism is poorly understood.Here,our study demonstrated that inhibition of histone deacetylase(HDAC)by treatment of HDACis activates mitophagy through mediating Parkin acetylation,leading to inhibition of cervical cancer cell proliferation.Bioinformatics analysis shows that Parkin expression is inversely correlated with HDAC2 expression in human cervical cancer,indicating the low acetylation level of Parkin.Using mass spectrometry,Parkin is identified to interact with two upstream molecules,acetylase acetyl-Co A acetyltransferase 1(ACAT1)and deacetylase HDAC2.Under treatment of suberoylanilide hydroxamic acid(SAHA),Parkin is acetylated at lysine residues 129,220 and 349,located in different domains of Parkin protein.In in vitro experiments,combined mutation of Parkin largely attenuate the interaction of Parkin with PTEN induced putative kinase 1(PINK1)and the function of Parkin in mitophagy induction and tumor suppression.In tumor xenografts,the expression of mutant Parkin impairs the tumor suppressive effect of Parkin and decreases the anticancer activity of SAHA.Our results reveal an acetylation-dependent regulatory mechanism governing Parkin in mitophagy and cervical carcinogenesis,which offers a new mitophagy modulation strategy for cancer therapy. | Xin Sun Yuhan Shu Guiqin Ye Caixia Wu Mengting Xu Ruilan Gao Dongsheng Huang Jianbin Zhang | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 3 |
| 4 | Variable scale-convex-peak method for weak signal detection显示文摘Avariable scale-convex-peak method is constructed to identify the frequency of weak harmonic signal. The key of this method is to find a set of optimal identification coefficients to make the transition of dynamic behavior topologically persistent. By the stochastic Melnikov method, the lower bound of the chaotic threshold continuous function is obtained in the mean-square sense.The intermediate value theorem is applied to detect the optimal identification coefficients. For the designated identification system, there is a valuable co-frequency-convex-peak in bifurcation diagram, which indicates the state transition of chaosperiod-chaos. With the change of the weak signal amplitude and external noise intensity in a certain range, the convex peak phenomenon is still maintained, which leads to the identification of frequency. Furthermore, the proposition of the existence of reversible scaling transformation is introduced to detect the frequency of the harmonic signal in engineering. The feasibility of constructing the hardware and software platforms of the variable scale-convex-peak method is verified by the experimental results of circuit design and the results of early fault diagnosis of actual bearings, respectively. | TIAN RuiLan ZHAO ZhiJie XU Yong | 2021 | Science China(Technological Sciences)2021，64，2： | 2 |
| 5 | A cohort study of adolescents with depression in China:tracking multidimensional outcomes and early biomarkers for intervention显示文摘Background Depression in adolescents is recognised as a global public health concern,but little is known about the trajectory of its clinical symptoms and pathogenesis.Understanding the nature of adolescents with depression and identifying earlybiomarkers can facilitatepersonalised intervention andreducediseaseburden.Aims To track multidimensional outcomes of adolescents with depression and develop objective biomarkers for diagnosis,as well as response to treatment,prognosis and guidance for early identification and intervention.Methods This is a multidimensional cohort study on the Symptomatic trajectory and Biomarkers of Early Adolescent Depression(sBEAD).We planned to recruit more than 1000 adolescents with depression and 300 healthy controls within 5 years.Multidimensional clinical presentations and objective indicators are collected at baseline,weeks 4,8,12 and 24,and years 1,2,3,4 and 5.Conclusions To the best of our knowledge,this is the first longitudinal cohort study that examines multidimensional clinical manifestations and multilevel objective markers in Chinese adolescents with depression.This study aims at providing early individualised interventions for young,depressed patients to reduce the burden of disease. | Xiaofei Zhang Yanling Zhou Jiaqi Sun Ruilan Yang Jianshan Chen Xiaofang Cheng Zezhi Li Xinlei Chen Chanjuan Yang Xinhong Zhu Liping Cao | 2022 | General Psychiatry2022，35，4： | 2 |
| 6 | Fabrication and oxidation behavior of LaB6-ZrB2 composites 显示文摘 | Gao Ruilan Min Guanghui Yu Huashun | 2005 | Ceramics International2005，31，1： | 1 |
| 7 | LONG-TERM EFFECTS OF THE GEZHOUBA PROJECT ON FLOOD PROPAGATION IN THE YANGTZE RIVER显示文摘Based on hydrographs of '81.7'flood and topographies of 1980 and 1993, a 1-D mathematical model of flood is developed to study the effects of the Gezhouba Project on flood propagation along the Yichang-Jianli river reaches in the Yangtze River. Calculations and analysis show that, after 13 years’ operation of the Gezhouba Project, the flood peak stages have been lowered, the flood curves of stage-discharge relationship have been moved, however, the effects on the flood discharges and storages can be neglected relatively. | Yaohua DONG 1and Ruilan YIN2 1 Senior engineer ,Yangtze River Scientific Research Institute (YRSRD, Wuhan 430010, P.R.China. 2 Professor-senior engineer, Yangtze River Scientific Research Institute (YRSRI). | 2001 | International Journal of Sediment Research2001，16，2： | 1 |
| 8 | Amperometric determination of NADH at a Nile blue/ordered mesoporous carbon composite electrode显示文摘 | Liande Zhu Ruilan Yang Xiaoyan Jiang Dongxu Yang | 2008 | Electrochemistry Communications2008，，3： | 1 |
| 9 | Online dual updating with recursive PLS model and its application in predicting crystal size of purified terephthalic acid (PTA) process 显示文摘 | Shengjing Mu Yingzhi Zeng Ruilan Liu | 2006 | Journal of Process Control2006，16，16： | 1 |
| 10 | Repeated pulse intramuscular in- jection of pralidoxime chloride in severe acute organophosphorus pesticide poisoning显示文摘 | Xue Tang Ruilan Wang Hui Xie | 2013 | American Journal of Emergency Medicine2013，31，6： | 1 |
| 11 | Bienzymatic glucose biosensor based on co-immobilization of peroxidase and glu-cose oxidase on a carbon nanotubes electrode显示文摘 | Zhu Liande Yang Ruilan Zhai Jiangli | 2007 | Biosens Bioelectron2007，23，4： | 1 |
| 12 | Nitric Oxide Enhances Angiogenesis via the Synthesis of Vascular Endothelial Growth Factor and cGMP After Stroke in the Rat显示文摘 | RUILAN ZHANG LEI WANG LI ZHANG | 2003 | Circ Res2003，92，： | 1 |
| 13 | The codimension-two bifurcation for the recent proposed SD oscillator显示文摘 | Ruilan Tian Qingjie Cao Shaopu Yang | 2010 | Nonlinear Dynamics2010，，1： | 1 |
| 14 | Bifurcations and chaotic thresholds for the spring-pendulum oscillator with irrational and fractional nonlinear restoring forces显示文摘 | Ruilan Tian Qiliang Wu Yeping Xiong Xinwei Yang Wenjie Feng | 2014 | The European Physical Journal Plus2014，，5： | 1 |
| 15 | Nitric oxide enhances angiogenesis via the synthesis of vascular endothelial growth factor and cGMP after stroke in the rat research显示文摘 | Lei W Li Z | 2003 | Circulation Research2003，92，3： | 1 |
| 16 | CyclinB1 depletion inhibits proliferation and induces apoptosis in human tumor cells显示文摘 | Juping Y Ruilan Y Andrea K | 2004 | Oncogene2004，23，： | 1 |
| 17 | Combination therapy of stroke in rats with a nitric oxide donor and human bone marrow stromal cells enhances angiogenesis and neurogenesis显示文摘 | Jie Chen Yi Li Ruilan Zhang | 2004 | Brain Research2004，1005，2： | 1 |
| 18 | Cyclin B1 depletion inhibits proliferation and induces apoptosis in human tumor cells显示文摘 | Juping Y Ruilan Andrea K | 2004 | Oncogene2004，23，： | 1 |
| 19 | Effects of a selective CDI 1b/CD18 antagonist and recombinant human tissue plasminagen activator treatmenl alone and in combination in a rat embolic model of stroke显示文摘 | Zhang Li Zhang Zhenggang Zbang Ruilan | 2003 | Stroke2003，34，7： | 1 |
| 20 | New Fault Tolerant Robotic Central Controller for Space Robot System Based on ARM Processor显示文摘 | Xingsheng Wang Bin Liang Ruilan Wu | 2008 | Industrial Technology2008，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员