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| 1 | The prognostic and therapeutic implications of circulating tumor cell phenotype detection based on epithelial-mesenchymal transition markers in the first-line chemotherapy of HER2-negative metastatic breast cancer显示文摘Background:Epithelial-mesenchymal transition(EMT)is implicated in the metastatic process and presents a chal-lenge to epithelial cell adhesion molecule-based detection of circulating tumor cells(CTCs),which have been demon-strated to be a prognostic indicator in metastatic breast cancer.Although evidence has indicated that heterogeneity of CTCs based on EMT markers is associated with disease progression,no standard recommendations have been established for clinical practice.This study aimed to evaluate the prognostic significance of dynamic CTC detection based on EMT for metastatic breast cancer patients.Methods:We enrolled 108 human epidermal growth factor receptor 2-negative metastatic breast cancer patients from the prospective phase III CAMELLIA study and applied the CanPatrol CTC enrichment technique to identify CTC phenotypes(including epithelial CTCs,biphenotypic epithelial/mesenchymal CTCs,and mesenchymal CTCs)in peripheral blood samples.Receiver operating characteristic curve analyses of total CTC count and the proportion of mesenchymal CTCs for predicting the 1-year progression-free survival(PFS)rate were conducted to determine the optimal cut-off values,and Kaplan-Meier analysis and Cox proportional hazards regression analysis were performed to investigate the prognostic value of the cut-off values of both total CTC count and the proportion of mesenchymal CTCs in combination.Results:For predicting the 1-year PFS rate,the optimal cut-off value of total CTC count was 9.5(Area under the curve[AUC]=0.538,95%confidence interval[CI]=0.418-0.657),and that of the proportion of mesenchymal CTCs was 10.7%(AUC=0.581,95%CI=0.463-0.699).We used the two cut-off values in combination to forecast PFS in which the total CTC count was equaled to or exceeded 10/5 mL with the proportion of mesenchymal CTCs surpassed 10.7%.Patients who met the combined criteria had significantly shorter median PFS than did those who did not meet the criteria(6.2 vs.9.9 months,P=0.010).A nomogram was constructed based on the criteria and significant clinicopatho-logical characteristics with a C-index of 0.613(P=0.010).Conclusions: The criteria, which combine the total CTC count and the proportion of mesenchymal CTCs, may be used to monitor therapeutic resistance and predict prognosis in patients with metastatic breast cancer. | Xiuwen Guan Fei Ma Chunxiao Li Shiyang Wu Shangying Hu Jiefen Huang Xiaoying Sun Jiayu Wang Yang Luo Ruigang Cai Ying Fan Qiao Li Shanshan Chen Pin Zhang Qing Li Binghe Xu | 2019 | Cancer Communications2019，39，1： | 15 |
| 2 | Methodology to Estimate Remaining Service Life of Steel Structure by Possibilistic Reliability Theory显示文摘Steel structure system of crane deteriorates over time due to environmental effects,material fatigue,and overloading.System structural reliability and remaining service life assessment methods are developed during the few decades.But until now estimating remaining service life methods of crane steel system by reliability theory begin to develop.Safety assessment of existing steel structure system requires the development of a methodology that allows for an accurate evaluation of reliability and prediction of the remaining life.Steel structures are the supporting elements in the special equipment such as hoisting machinery.Structure reliability and remaining service life safe assessment are important for steel structures.For finding the reason which caused the failure modes(such as fatigue strength failure,stiffness failure and stability failure),incremental loading method based on possibilistic reliability is applied into dynamic structure failure path research.Through reliability analyzing and calculating for crane,it is demonstrated that fatigue damage is the most common failure mode.Fuzzy fatigue damage accumulation theory is used for basis theory and Paris-Eadogan equations are used for mathematical modeling.All fatigue parameter values of the welding box girder of bridge cranes are determined and fatigue remaining life formulas are deduced.After field test and collecting working parameters of numerous cranes,typical fatigue load spectrum was compiled for the dangerous point of box girders used in the area.Fatigue remaining life is assessed for different types and lifting capacities.Safety for steel structure system of bridge crane is assessed by two quantitative indexs:reliability and remaining life.Therefore,the evaluation means is more comprehensive and reasonable.The example shows that the two quantitative indexs are mutually correlated.Through analyzing the 120 t-22.5 m bridge crane of a certain enterprise,a new methodology to estimate remaining service life of steel structure by possibilistic reliability theory is introduced for safety evaluation of structure system. | XU Gening YANG Ruigang ZHOU Ke FAN Xiaoning | 2010 | Chinese Journal of Mechanical Engineering2010，23，6： | 7 |
| 3 | Trastuzumab plus adjuvant chemotherapy for human epidermal growth factor receptor 2(HER2)-positive early-stage breast cancer: A real-world retrospective study in Chinese patients显示文摘Objective: To assess the long-term effectiveness and safety of trastuzumab in adjuvant therapy for Chinese patients with early-stage human epidermal growth factor 2(HER2)-positive breast cancer in a real-world setting.Methods: This retrospective observational study analyzed the medical records of HER2-positive breast cancer patients between 2000 and 2012 at the Chinese Academy of Medical Sciences. Patients who received adjuvant chemotherapy alone or adjuvant chemotherapy followed by/combined with trastuzumab were included. The Kaplan-Meier method was used to estimate disease-free survival(DFS) and overall survival(OS). Hazard ratios(HR) and 95% confidence intervals(95% CI) were calculated using the Cox regression model.Results: Of the 1,348 patients analyzed, 909 received chemotherapy alone and 439 received chemotherapy plus trastuzumab. The 3-year, 5-year and 10-year DFS rates were 83.70%, 76.38% and 68.94%, respectively, in the chemotherapy-alone cohort, and 90.21%, 86.19% and 83.45% in the chemotherapy plus trastuzumab cohort. The3-year, 5-year and 10-year OS rates were 96.10%, 91.40% and 81.88% in the chemotherapy-alone cohort, and98.17%, 94.91% and 90.01% in the chemotherapy plus trastuzumab cohort. The chemotherapy plus trastuzumab group had a significantly lower risk of disease recurrence and death than the chemotherapy-alone group(DFS:HR=0.50, 95% CI, 0.37-0.68;P<0.001;OS: HR=0.53, 95% CI, 0.34-0.81;P=0.004) after adjusting for covariates.In the 439 patients treated with trastuzumab, multivariate analysis suggested that lymph node positivity, higher T stages, and hormone receptor-negative status were significantly associated with higher risks of disease recurrence,and lymph node positivity and hormone receptor-negative status were significantly associated with higher risks of death. Grade 3/4 adverse events(incidence ≥1%) were more common in patients receiving trastuzumab(54.44% vs.15.73%).Conclusions: Early-stage HER2-positive breast cancer patients treated with trastuzumab plus adjuvant chemotherapy have a significant survival benefit compared with chemotherapy-alone in real-world settings. Lymph node positivity, hormone receptor-negative status, and higher T stages may be associated with higher risks of recurrence, and effective therapy for patients with these factors is required. | Jihong Guo Qing Li Pin Zhang Peng Yuan Jiayu Wang Fei Ma Ying Fan Ruigang Cai Yang Luo Qiao Li Binghe Xu | 2019 | Chinese Journal of Cancer Research2019，31，5： | 6 |
| 4 | Load Reduction Test Method of Similarity Theory and BP Neural Networks of Large Cranes显示文摘Static load tests are an important means of supervising and detecting a crane's lift capacity. Due to space restrictions, however, there are difficulties and potential danger when testing large bridge cranes. To solve the loading problems of large-tonnage cranes during testing, an equivalency test is proposed based on the similarity theory and BP neural networks. The maximum stress and displacement of a large bridge crane is tested in small loads, combined with the training neural network of a similar structure crane through stress and displacement data which is collected by a physics simulation progressively loaded to a static load test load within the material scope of work. The maximum stress and displacement of a crane under a static load test load can be predicted through the relationship of stress, displacement, and load. By measuring the stress and displacement of small tonnage weights, the stress and displacement of large loads can be predicted, such as the maximum load capacity, which is 1.25 times the rated capacity. Experimental study shows that the load reduction test method can reflect the lift capacity of large bridge cranes. The load shedding predictive analysis for Sanxia 1200 t bridge crane test data indicates that when the load is 1.25 times the rated lifting capacity, the predicted displacement and actual displacement error is zero. The method solves the problem that lifting capacities are difficult to obtain and testing accidents are easily possible when 1.25 times related weight loads are tested for large tonnage cranes. | YANG Ruigang DUAN Zhibin LU Yi WANG Lei XU Gening | 2016 | Chinese Journal of Mechanical Engineering2016，29，1： | 4 |
| 5 | Challenges and strategies in high-accuracy manufacturing of the world’s largest SiC aspheric mirror显示文摘In the process of manufacturing the world’s largest silicon carbide(SiC)aspheric mirror,the primary difficulties are mirror blank preparation,asphere fabrication,and testing,as well as cladding and coating.Specifically,the challenges include the homogeneity of the complicated structure casting,accuracy and efficiency of the fabrication process,print-through effect,fidelity and precision of test procedure,stress and denseness of cladding process,the dynamic range of interferometric measurement,and air turbulence error due to the long optical path.To break through such a barrier of difficulties,we proposed the water-soluble room temperature vanishing mold and gel casting technology,homogeneous microstructure reaction-formed joint technology,nano-accuracy efficient compound fabrication,gravity unloading technology,high-denseness low-defect physical vapor deposition(PVD)Si-cladding technology,test data fusion method,and time-domain averaging method,etc.Based on the proposed technologies and methods,we have accomplished the world’s largest SiC aspheric mirror with a size of φ4.03 m.The impressive performance of the SiC aspheric mirror is validated by the characteristics of the fabricated SiC aspheric mirror.The aerial density of the SiC blank is less than 120 kg/m^(2),surface shape test accuracy is better than 6 nm RMS,thickness inhomogeneity of the cladding layer is less than 5%,and the final surface figure error and roughness are 15.2 nm RMS and 0.8 nm RMS,respectively. | Xuejun Zhang Haixiang Hu Xiaokun Wang Xiao Luo Ge Zhang Wenxing Zhao Xiaoyi Wang Zhenyu Liu Ling Xiong Erhui Qi Congcong Cui Yanchao Wang Yingjie Li Xu Wang Longxiang Li Yang Bai Qiang Cheng Zhiyu Zhang Ruigang Li Wa Tang Xuefeng Zeng Weijie Deng Feng Zhang | 2022 | Light(Science & Applications)2022，11，12： | 3 |
| 6 | Polymorphisms of MTHFR and TYMS predict capecitabine-induced hand-foot syndrome in patients with metastatic breast cancer显示文摘Background:Breast cancer is a global problem,and a large number of new cases are diagnosed every year.Capecit-abine is effective in patients with metastatic breast cancer(MBC).Hand-foot syndrome(HFS)is a common adverse effect of capecitabine.In this study,we investigated the association between single nucleotide polymorphisms(SNPs)in genes involved in capecitabine metabolism pathways and capecitabine-induced HFS in Chinese patients with MBC to identify some predictive genetic biomarkers.Methods:We selected 3 genes involved in capecitabine metabolism and screened genetic variants in these target genes.We genotyped a total of 22 SNPs in the thymidylate synthase gene(TYMS),the methylene tetrahydrofolate reductase gene(MTHFR),and the ribonucleotide reductase M1 gene(RRM1)in 342 MBC patients treated with capecit-abine-based chemotherapy.The genotype distributions of each SNP in patients with and without HFS were assessed using Pearson’sχ^(2)test,and the relationship between HFS and genotypes of SNPs was determined using logistic regression analysis.The association between SNPs and their corresponding gene expression was analyzed using the Blood expression quantitative trait loci(eQTL)browser online tools.Results:We found 4 positive sites for HFS in the TYMS and MTHFR genes:TYMS rs2606241(P=0.022),TYMS rs2853741(P=0.019),MTHFR rs3737964(P=0.029),and MTHFR rs4846048(P=0.030).Logistic regression analyses showed that the genotype AG of MTHFR rs3737964[odds ratio(OR)=0.54,95%confidence interval(CI)0.31-0.97,P=0.038]and MTHFR rs4846048(OR=0.54,95%CI 0.30-0.98,P=0.042)were protective factors of HFS,whereas the genotype CT of TYMS rs2853741(OR=2.25,95%CI 1.31-3.87,P=0.012)increased the risk of HFS.The association between the genotype GT of TYMS rs2606241(OR=1.27,95%CI 0.73-2.23,P=0.012)and HFS was uncertain.Further eQTL analyses confirmed that the alleles of rs3737964 and rs4846048 affected the gene expression levels of MTHFR in cis.Conclusions:We have identified four potentially useful pharmacogenetic markers,TYMS rs2606241,TYMS rs2853741,MTHFR rs3737964,and MTHFR rs4846048 to predict capecitabine-induced HFS in MBC patients. | Shaoyan Lin Jian Yue Xiuwen Guan Peng Yuan Jiayu Wang Yang Luo Ying Fan Ruigang Cai Qiao Li Shanshan Chen Pin Zhang Qing Li Fei Ma Binghe Xu | 2019 | Cancer Communications2019，39，1： | 3 |
| 7 | HYPERSTATIC STRUCTURE MAPPING MODEL BUILDING AND OPTIMIZING DESIGN显示文摘被结构的力学造的 Hyperstatic 结构飞机模型被学习。精确在结构的真实应力反映的空格模型被有限元素方法造(女性) 分析商业软件。就,印射复杂结构系统的模型作为在空间模型在飞机模型和全面信息被建立,随方便计算。Planemodel 和空间模型在一样的工作条件下面被计算。飞机模型内部力量被看作输入数据的模块化的建设;空格模型内部力量被看作输出数据的模块化的建设。因此,标本在输入数据和产量数据上被造。特性和联营是提取 through training 标本,与人工的神经网络的非线性的印射的能力的雇用。与插值和推测印射模型被获得,打为最佳设计的基础。高层的停车的系统(SSHLPS ) 的钢结构作为一个例子被计算。包括一隐藏的层的一个三层的背繁殖(BP ) 网络为五层的 SSHLPS 与九个输入节点和八个输出节点被构造。通过插值与完整重新分析对比的印射的模型的 Thethree 层结构优化结果,和七层通过推测与完整重新分析对比的印射的模型组织。在 1-8 之中的任何层 SSHLPS 能与许多精确性被计算。如果它被使用进一样的拓扑的结构, Amountof 计算能也被减少,与减少的失真并且保证了精确。 | XU Gening GAO Youshan ZHANG Xueliang YANG Ruigang | 2007 | Chinese Journal of Mechanical Engineering2007，20，1： | 2 |
| 8 | Research on 3D Braided Nickel Plated Carbon Fiber/epoxy Resin Composites and Their Electromagnetic Protection Properties显示文摘To develop electromagnetic protection composites with integrated structure -function properties, the three-dimension (3D) braided nickel plated carbon fiber/epoxy resin (Ni-CF3D/EP) composites were prepared based on 3D five-directional braiding, unitary nickel plating and mold compression shaping. The electromagnetic protection properties of Ni-CF3D/EP composites including shielding effective- ness (SE) and reflection loss against plane electromagnetic wave, shielding properties against electromagnetic pulse (EMP) were investigated. The test results show that the novel composites have good electromagnetic protection properties in a wide frequency range of 14 kHz~18 GHz with SE of 42 dB~95 dB, the absorption bandwidth of –5 dB in 2 GHz~18 GHz can reach 10 GHz and the pulse peak SE against EMP is 43.7 dB which can reduce the electromagnetic energy greatly. Meanwhile, the mechanic properties were also investi- gated and the results indicate that the Ni-CF3D/EP composites can replace metal materials for loading-bearing structural applications because of their excellent mechanic properties. | QU Zhaoming WANG Qingguo LEI Yisan ZHANG Ruigang | 2013 | 高电压技术2013，39，8： | 2 |
| 9 | Genetic polymorphisms of autophagy-related gene 5 (ATG5) rs473543 predict different disease-free survivals of triple-negative breast cancer patients receiving anthracycline- and/or taxane-based adjuvant chemotherapy显示文摘Background:Autophagy plays a crucial role in chemotherapy resistance of triple-negative breast cancer(TNBC).Hence,autophagy-related gene 5(ATG5),an essential molecule involved in autophagy regulation,is presumably associated with recurrence of TNBC.This study was aimed to investigate the potential influence of single-nucleotide polymorphisms in ATG5 on the disease-free survival(DFS)of early-stage TNBC patients treated with anthracycline-and/or taxane-based chemotherapy.Methods:We genotyped ATG5 SNP rs473543 in a cohort of 316 TNBC patients treated with anthracycline-and/or taxane-based chemotherapy using the sequenom’s MassARRAY system.Kaplan-Meier survival analysis and Cox proportional hazard regression analysis were used to analyze the association between ATG5 rs473543 genotypes and the clinical outcome of TNBC patients.Results:Three genotypes,AA,GA,and GG,were detected in the rs473543 of ATG5 gene.The distribution of ATG5 rs473543 genotypes was significantly different between patients with and without recurrence(P=0.024).Kaplan-Meier survival analysis showed that patients carrying A allele of ATG5 rs473543 had an increased risk of recurrence and shorter DFS compared with those carrying the variant genotype GG in rs473543(P=0.034).In addition,after adjust-ing for clinical factors,multivariate Cox regression analyses revealed that the AA/GA genotype of rs473543 was an independent predictor for DFS(hazard risk[HR],1.73;95%confidence interval[CI],1.04-2.87;P=0.034).In addition,DFS was shorter in node-negative patients with the presence of A allele(AA/GA)than in those with the absence of A allele(P=0.027).Conclusion:ATG5 rs473543 genotypes may serve as a potential marker for predicting recurrence of early-stage TNBC patients who received anthracycline-and/or taxane-based regimens as adjuvant chemotherapy. | Meiying Li Fei Ma Jiayu Wang Qing Li Pin Zhang Peng Yuan Yang Luo Ruigang Cai Ying Fan Shanshan Chen Qiao Li Binghe Xu | 2018 | Cancer Communications2018，38，1： | 2 |
| 10 | Arrangement of cellulose microfibrils in the wheat straw cell wall显示文摘 | Hui Yu Ruigang Liu Dawa Shen | 2008 | Carbohydrate Polymers2008，72，： | 1 |
| 11 | Bioinorganic chemistry of bismuth and an- timony : target sites of metallodrugs 显示文摘 | GE RuiGang SUN HongZhe | 2007 | Acc Chem Res2007，40，4： | 1 |
| 12 | Microstructure and mechanical properties of machinable Al2O/LaPO4 composites by hot pressing 显示文摘 | WANG Ruigang PAN Wei CHEN Jian | 2003 | Ceram lnt2003，29，1： | 1 |
| 13 | Fabrication and characterization of machinable Si3N4/h-BN fimctionally graded materials显示文摘 | WANG Ruigang PAN Wei CHEN Jian | 2002 | Mater Res Bull2002，37，： | 1 |
| 14 | Crystallization and morphology of poly( ethylene2,6-naphthalene diearboxylate) containing additives 显示文摘 | Gao Xia Liu Ruigang Yu Ying | 2003 | Macromolecular Materials and Engineering2003，288，： | 1 |
| 15 | Graded machinable Si3N4/h-BN and Al2O3/LaPO4 ceramic composites显示文摘 | WANG Ruigang PAN Wei CHEN Jian | 2002 | Mater Design2002，23，： | 1 |
| 16 | Investigation of the physical and mechanical properties of hot-pressed machinable Si3N4/h-BN composites and FGM显示文摘 | WANG Ruigang PAN Wei CHEN Jian | 2002 | Mater Sci Eng B2002，90，： | 1 |
| 17 | Automatic Real-Time Video Matting Using Time-of-Flight Camera and Multichannel Poisson Equations显示文摘 | Liang Wang Minglun Gong Chenxi Zhang Ruigang Yang Cha Zhang Yee-Hong Yang | 2012 | International Journal of Computer Vision2012，，1： | 1 |
| 18 | Controllable aggregation and reversible pH sensitivity of AuNPs regulated by carboxymethyl cellulose 显示文摘 | Tan Junjun Liu Ruigang Wang Wen Liu Wenyong Tian Ye Wu Min Huang Yong | 2010 | Langmuir2010，26，3： | 1 |
| 19 | In Situ Growth of Self-Assembled and Single In203 Nanosheets on the Surface of Indium Grains显示文摘 | YANG Heqing ZhANG Ruigang DONG Hongxing | 2008 | Cryst Growth Des2008，8，9： | 1 |
| 20 | Synthesis of high-purity Ti 3 SiC 2 polycrystals by hot-pressing of the elemental powders显示文摘 | Luo Yongming Pan Wei Li Shuqin Chen Jian Wang Ruigang Li Jianqiang | 2002 | Materials Letters2002，，4： | 1 |
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